{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:10:01Z","timestamp":1792062601158,"version":"4.4.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T00:00:00Z","timestamp":1103068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1038\/sj.npp.1300627","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T00:13:35Z","timestamp":1103156015000},"page":"582-589","source":"Crossref","is-referenced-by-count":358,"title":["A Placebo Controlled Crossover Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism"],"prefix":"10.1038","volume":"30","author":[{"given":"Eric","family":"Hollander","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Chaplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Zagursky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherie","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Wasserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupa","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"BF1300627_CR1","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1002\/ana.410420420","volume":"42","author":"DC Chugani","year":"1997","unstructured":"Chugani DC, Muzik O, Rothermel R, Behen M, Chakraborty P, Magner T et al (1997). Altered serotonin synthesis in the dentathalmocortical pathway in autistic boys. Ann Neurol 42: 666\u2013669.","journal-title":"Ann Neurol"},{"key":"BF1300627_CR2","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/00008480-199608000-00008","volume":"8","author":"EH Cook","year":"1996","unstructured":"Cook EH, Leventhal BL (1996). The serotonin system in autism. Curr Opin Pediatr 8: 348\u2013354.","journal-title":"Curr Opin Pediatr"},{"key":"BF1300627_CR3","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1111\/j.1469-8749.2002.tb00266.x","volume":"44","author":"GR DeLong","year":"2002","unstructured":"DeLong GR, Ritch CR, Burch S (2002). Fluoxetine response in children with autistic spectrum disorders: correlation with familial major affective disorder and intellectual achievement. Dev Med Child Neurol 44: 652\u2013659.","journal-title":"Dev Med Child Neurol"},{"key":"BF1300627_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1023\/A:1026008602540","volume":"28","author":"SH Fatemi","year":"1998","unstructured":"Fatemi SH, Realmuto GM, Khan L, Thuras P (1998). Fluoxetine in treatment of adolescent patients with autism: a longitudinal open trial. J Autism Dev Disord 28: 303\u2013307.","journal-title":"J Autism Dev Disord"},{"key":"BF1300627_CR5","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nrn1256","volume":"4","author":"P Gaspar","year":"2003","unstructured":"Gaspar P, Cases O, Maroteaux L (2003). The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002\u20131012.","journal-title":"Nat Rev Neurosci"},{"key":"BF1300627_CR6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","volume":"4","author":"WK Goodman","year":"1989","unstructured":"Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischman RL, Hill CL et al (1989). The Yale-brown obsessive compulsive scale I. Development, use, and reliability. Arch Gen Psychiatry 4: 1006\u20131011.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1300627_CR7","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1001\/archpsyc.1993.01820180039004","volume":"50","author":"CT Gordon","year":"1993","unstructured":"Gordon CT, State RC, Nelson JE, Hamburger SD, Rapoport JL (1993). A double-blind comparison of clomiprmine, despramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry 50: 441\u2013447.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1300627_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1001\/archpsyc.1995.03950160039008","volume":"52","author":"J Greist","year":"1995","unstructured":"Greist J, Chouinard G, DuBoff E, Halaris A, Kim SW, Koran L et al (1995). Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder. Arch Gen Psychiatry 52: 289\u2013295.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1300627_CR9","volume-title":"ECDEU Assessment Manual for Psychopharmacology","author":"W Guy","year":"1976","unstructured":"Guy W (1976). ECDEU Assessment Manual for Psychopharmacology, NIMH Publication DHEW Publ No. 76-388. National Institute of Mental Health: Bethesda, MD."},{"key":"BF1300627_CR10","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0169-2607(96)01723-3","volume":"49","author":"D Hedeker","year":"1996","unstructured":"Hedeker D, Gibbons RD (1996). MIXREG: a computer program for mixed effects regression analysis with autocorrelated errors. Comput Methods Programs Biomed 49: 229\u2013252.","journal-title":"Comput Methods Programs Biomed"},{"key":"BF1300627_CR11","doi-asserted-by":"publisher","first-page":"640","DOI":"10.4088\/JCP.v64n0604","volume":"64","author":"E Hollander","year":"2003","unstructured":"Hollander E, Koran LM, Goodman WK, Greist JH, Ninan PT, Yang H et al (2003a). A double blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorder. J Clin Psychiatry 64: 640\u2013647.","journal-title":"J Clin Psychiatry"},{"key":"BF1300627_CR12","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0893-133X(99)00121-9","volume":"22","author":"E Hollander","year":"2000","unstructured":"Hollander E, Novotny S, Allen A, Aronowitz B, Cartwright C, DeCaria C (2000). The relationship between repetitive behaviors and growth hormone response to sumatriptan challenge in adult autistic disorder. Neuropsychopharmacology 22: 163\u2013167.","journal-title":"Neuropsychopharmacology"},{"key":"BF1300627_CR13","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/S0140-6736(03)14236-5","volume":"362","author":"E Hollander","year":"2003","unstructured":"Hollander E, Phillips AT, Yeh C (2003b). Targeted treatments for symptom domains in child and adolescent autism. Lancet 362: 732\u2013734.","journal-title":"Lancet"},{"key":"BF1300627_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00004714-199202000-00005","volume":"12","author":"PI Markowitz","year":"1992","unstructured":"Markowitz PI (1992). Effect of fluoxetine on self-injurious behavior in the developmentally disabled: a preliminary study. J Clin Psychopharmacol 12: 27\u201331.","journal-title":"J Clin Psychopharmacol"},{"key":"BF1300627_CR15","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1023\/A:1005551523657","volume":"30","author":"CJ McDougle","year":"2000","unstructured":"McDougle CJ, Kresch LE, Posey DJ (2000). Repetitive thoughts and behavior in pervasive developmental disorders: treatment with serotonin reuptake inhibitors. J Autism Dev Disord 30: 427\u2013435.","journal-title":"J Autism Dev Disord"},{"key":"BF1300627_CR16","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1001\/archpsyc.1996.01830110029004","volume":"53","author":"CJ McDougle","year":"1996","unstructured":"McDougle CJ, Naylor ST, Cohen DJ, Aghajanian GK, Heninger GR, Price LH (1996a). Effects of trytophan depletion in drug-free adults with autistic disorder. Arch Gen Psychiatry 53: 993\u20131000.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1300627_CR17","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1001\/archpsyc.1996.01830110037005","volume":"53","author":"CJ McDougle","year":"1996","unstructured":"McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH (1996b). A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 53: 1001\u20131008.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1300627_CR18","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1097\/00004703-200304000-00005","volume":"24","author":"LB Namerow","year":"2003","unstructured":"Namerow LB, Prakash T, Bostic JQ, Prince J, Monuteaux MC (2003). Use of citalopram in pervasive developmental disorders. J Dev Behav Pediatr 24: 104\u2013108.","journal-title":"J Dev Behav Pediatr"},{"key":"BF1300627_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0165-1781(00)00134-7","volume":"94","author":"S Novotny","year":"2000","unstructured":"Novotny S, Hollander E, Allen A, Mosovich S, Aronowitz B, Cartwright C et al (2000). Increased growth hormone response to sumatriptan challenge in adult autistic disorders. Psychiatry Res 94: 173\u2013177.","journal-title":"Psychiatry Res"},{"key":"BF1300627_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1046\/j.1468-2982.1996.1605317.x","volume":"16","author":"J Pascual","year":"1996","unstructured":"Pascual J, del Arco C, Romon T, del Olmo E, Castro E, Pazos A (1996). Autoradographic distribution of (3H) sumatriptan-binding sites in post-mortem human brain. Cephalagia 16: 317\u2013322.","journal-title":"Cephalagia"},{"key":"BF1300627_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1136\/bmj.328.7430.3","volume":"328","author":"P Ramchandani","year":"2004","unstructured":"Ramchandani P (2004). Treatment of major depressive disorder in children and adolescents. Br Med J 328: 3\u20134.","journal-title":"Br Med J"},{"key":"BF1300627_CR22","doi-asserted-by":"crossref","unstructured":"Research Units on Pediatric Psychopharmacology Autism Network (2002). Risperidone in children with autism and serious behavioral problems. N Engl J Med 347: 314\u2013321.","DOI":"10.1056\/NEJM200212053472316"},{"key":"BF1300627_CR23","doi-asserted-by":"crossref","unstructured":"The Clomipramine Collaborative Study Group (1991). Clomiprmine in the treatment of patients with obsessive-compulsive disorder. Arch Gen Psychiatry 48: 730\u2013738.","DOI":"10.1001\/archpsyc.1991.01810320054008"},{"key":"BF1300627_CR24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1001\/archpsyc.1994.03950070051010","volume":"51","author":"GD Tollefson","year":"1994","unstructured":"Tollefson GD, Rampey Jr AH, Potvin JH, Jenike MA, Rush AJ, Kominguez RA et al (1994). A multicenter investigation of fixed dose fluoxetine in the treatment of obsessive-compulsive disorder. Arch Gen Psychiatry 51: 559\u2013567.","journal-title":"Arch Gen Psychiatry"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1300627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300627","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:47:51Z","timestamp":1684205271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1300627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,15]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["BF1300627"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1300627","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,15]]}}}