{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T01:22:52Z","timestamp":1787966572124,"version":"build-2784847793"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2005,9,28]],"date-time":"2005-09-28T00:00:00Z","timestamp":1127865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1038\/sj.npp.1300906","type":"journal-article","created":{"date-parts":[[2005,9,28]],"date-time":"2005-09-28T16:18:57Z","timestamp":1127924337000},"page":"1294-1300","source":"Crossref","is-referenced-by-count":29,"title":["Differential Effects of the Muscarinic M1 Receptor Agonist RS-86 and the Acetylcholine-Esterase Inhibitor Donepezil on REM Sleep Regulation in Healthy Volunteers"],"prefix":"10.1038","volume":"31","author":[{"given":"Christoph","family":"Nissen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A","family":"Nofzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Feige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Waldheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Philipp","family":"Radosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Riemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,9,28]]},"reference":[{"key":"BF1300906_CR1","first-page":"896","volume":"273","author":"HA Baghdoyan","year":"1997","unstructured":"Baghdoyan HA (1997). Location and quantification of muscarinic receptor subtypes in rat pons: implications for REM sleep generation. Am J Physiol 273: 896\u2013904.","journal-title":"Am J Physiol"},{"key":"BF1300906_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1093\/sleep\/22.7.835","volume":"22","author":"HA Baghdoyan","year":"1999","unstructured":"Baghdoyan HA, Lydic R (1999). M2 muscarinic receptor subtype in the feline medial pontine reticular formation modulates the amount of rapid eye movement sleep. Sleep 22: 835\u2013847.","journal-title":"Sleep"},{"key":"BF1300906_CR3","first-page":"17","volume-title":"Sleep and Epilepsy: The Clinical Spectrum","author":"HA Baghdoyan","year":"2002","unstructured":"Baghdoyan HA, Lydic R (2002). Neurotransmitters and neuromodulators regulating sleep. In: Bazil CW et al (eds). Sleep and Epilepsy: The Clinical Spectrum. Elsevier Science: New York. pp 17\u201344."},{"key":"BF1300906_CR4","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1097\/00001756-199408150-00022","volume":"5","author":"HA Baghdoyan","year":"1994","unstructured":"Baghdoyan HA, Mallios VJ, Duckrow RB, Mash DC (1994). Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. Neuroreport 5: 1631\u20131634.","journal-title":"Neuroreport"},{"key":"BF1300906_CR5","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0165-1781(90)90064-C","volume":"33","author":"A Berkowitz","year":"1990","unstructured":"Berkowitz A, Sutton L, Janowsky DS, Gillin JC (1990). Pilocarpine, an orally active muscarinic cholinergic agonist, induces REM sleep and reduces delta sleep in normal volunteers. Psychiatry Res 33: 113\u2013119.","journal-title":"Psychiatry Res"},{"key":"BF1300906_CR6","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/brain\/120.7.1173","volume":"120","author":"AR Braun","year":"1997","unstructured":"Braun AR, Balkin TJ, Wesenten NJ, Carson RE, Varga M, Baldwin P et al (1997). Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study. Brain 120: 1173\u20131197.","journal-title":"Brain"},{"key":"BF1300906_CR7","first-page":"285","volume":"130","author":"JM Calvo","year":"1992","unstructured":"Calvo JM, Datta S, Quattrochi J, Hobson JA (1992). Cholinergic microstimulation of the peribrachial nucleus in the cat. II. Delayed and prolonged increases in REM sleep. Arch Ital Biol 130: 285\u2013301.","journal-title":"Arch Ital Biol"},{"key":"BF1300906_CR8","first-page":"279","volume":"50","author":"MP Caulfield","year":"1998","unstructured":"Caulfield MP, Birdsall NJ (1998). International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50: 279\u2013290.","journal-title":"Pharmacol Rev"},{"key":"BF1300906_CR9","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neuroscience.2004.04.029","volume":"126","author":"CG Coleman","year":"2004","unstructured":"Coleman CG, Lydic R, Baghdoyan HA (2004). M2 muscarinic receptors in pontine reticular formation of C57BL\/6J mouse contribute to rapid eye movement sleep generation. Neuroscience 126: 821\u2013830.","journal-title":"Neuroscience"},{"key":"BF1300906_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/0006-8993(86)90449-X","volume":"362","author":"R Cortes","year":"1986","unstructured":"Cortes R, Probst A, Tobler HJ, Palacios JM (1986). Muscarinic cholinergic receptor subtypes in the human brain. II. Quantitative autoradiographic studies. Brain Res 362: 239\u2013253.","journal-title":"Brain Res"},{"key":"BF1300906_CR11","first-page":"263","volume":"130","author":"S Datta","year":"1992","unstructured":"Datta S, Calvo JM, Quattrochi J, Hobson JA (1992). Cholinergic microstimulation of the peribrachial nucleus in the cat. I. Immediate and prolonged increases in ponto-geniculo-occipital waves. Arch Ital Biol 130: 263\u2013284.","journal-title":"Arch Ital Biol"},{"key":"BF1300906_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1093\/sleep\/16.suppl_8.S8","volume":"16","author":"S Datta","year":"1993","unstructured":"Datta S, Quattrochi JJ, Hobson JA (1993). Effect of specific muscarinic M2 receptor antagonist on carbachol induced long-term REM sleep. Sleep 16: 8\u201314.","journal-title":"Sleep"},{"key":"BF1300906_CR13","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/BF00248908","volume":"76","author":"M el Mansari","year":"1989","unstructured":"el Mansari M, Sakai K, Jouvet M (1989). Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep\u2013waking cycle in freely moving cats. Exp Brain Res 76: 519\u2013529.","journal-title":"Exp Brain Res"},{"key":"BF1300906_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0006-3223(91)90169-M","volume":"30","author":"JC Gillin","year":"1991","unstructured":"Gillin JC, Sutton L, Ruiz C, Golshan S, Hirsch S, Warmann C et al (1991). Dose dependent inhibition of REM sleep in normal volunteers by biperiden, a muscarinic antagonist. Biol Psychiatry 30: 151\u2013156.","journal-title":"Biol Psychiatry"},{"key":"BF1300906_CR15","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1046\/j.1440-1819.2002.01008.x","volume":"56","author":"T Kanbayashi","year":"2002","unstructured":"Kanbayashi T, Sugiyama T, Aizawa R, Saito Y, Ogawa Y, Kitajima T et al (2002). Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects. Psychiatry Clin Neurosci 56: 307\u2013308.","journal-title":"Psychiatry Clin Neurosci"},{"key":"BF1300906_CR16","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/01.jcp.0000125744.22031.3a","volume":"24","author":"CJ Lauer","year":"2004","unstructured":"Lauer CJ, Modell S, Schreiber W, Krieg JC, Holsboer F (2004). Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86. J Clin Psychopharmacol 24: 356\u2013357.","journal-title":"J Clin Psychopharmacol"},{"key":"BF1300906_CR17","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1523\/JNEUROSCI.17-02-00774.1997","volume":"17","author":"TO Leonard","year":"1997","unstructured":"Leonard TO, Lydic R (1997). Pontine nitric oxide modulates acetylcholine release, rapid eye movement sleep generation, and respiratory rate. J Neurosci 17: 774\u2013785.","journal-title":"J Neurosci"},{"key":"BF1300906_CR18","doi-asserted-by":"publisher","first-page":"13541","DOI":"10.1073\/pnas.93.24.13541","volume":"93","author":"AI Levey","year":"1996","unstructured":"Levey AI (1996). Muscarinic acetylcholine receptor expression in memory circuits: implications for treatment of Alzheimer disease. Proc Natl Acad Sci USA 93: 13541\u201313546.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1300906_CR19","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1523\/JNEUROSCI.11-10-03218.1991","volume":"11","author":"AI Levey","year":"1991","unstructured":"Levey AI, Kitt CA, Simonds WF, Price DL, Brann MR (1991). Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci 11: 3218\u20133226.","journal-title":"J Neurosci"},{"key":"BF1300906_CR20","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1152\/ajpcell.1993.264.3.C544","volume":"264","author":"R Lydic","year":"1993","unstructured":"Lydic R, Baghdoyan HA (1993). Pedunculopontine stimulation alters respiration and increases ACh release in the pontine reticular formation. Am J Physiol 264: 544\u2013554.","journal-title":"Am J Physiol"},{"key":"BF1300906_CR21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/383163a0","volume":"383","author":"P Maquet","year":"1996","unstructured":"Maquet P, Peters J, Aerts J, Delfiore G, Degueldre C, Luxen A et al (1996). Functional neuroanatomy of human rapid-eye-movement sleep and dreaming. Nature 383: 163\u2013166.","journal-title":"Nature"},{"key":"BF1300906_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0306-4522(00)00093-2","volume":"98","author":"GA Marks","year":"2000","unstructured":"Marks GA, Birabil CG (2000). Infusion of adenylyl cyclase inhibitor SQ22,536 into the medial pontine reticular formation of rats enhances rapid eye movement sleep. Neuroscience 98: 311\u2013315.","journal-title":"Neuroscience"},{"key":"BF1300906_CR23","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/cne.902780209","volume":"278","author":"DC Mash","year":"1988","unstructured":"Mash DC, White WF, Mesulam MM (1988). Distribution of muscarinic receptor subtypes within architectonic subregions of the primate cerebral cortex. J Comp Neurol 278: 265\u2013274.","journal-title":"J Comp Neurol"},{"key":"BF1300906_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0006-8993(97)00807-X","volume":"770","author":"EA Nofzinger","year":"1997","unstructured":"Nofzinger EA, Mintun MA, Wiseman M, Kupfer DJ, Moore RY (1997). Forebrain activation in REM sleep: an FDG PET study. Brain Res 770: 192\u2013201.","journal-title":"Brain Res"},{"key":"BF1300906_CR25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0014-2999(86)90082-8","volume":"125","author":"JM Palacios","year":"1986","unstructured":"Palacios JM, Bolliger G, Closse A, Enz A, Gmelin G, Malanowski J (1986). The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist. Eur J Pharmacol 125: 45\u201362.","journal-title":"Eur J Pharmacol"},{"key":"BF1300906_CR26","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/BF02423502","volume":"81","author":"D Pare","year":"1990","unstructured":"Pare D, Curro DR, Datta S, Steriade M (1990). Brainstem genesis of reserpine-induced ponto-geniculo-occipital waves: an electrophysiological and morphological investigation. Exp Brain Res 81: 533\u2013544.","journal-title":"Exp Brain Res"},{"key":"BF1300906_CR27","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/S0006-3223(01)01287-2","volume":"51","author":"ML Perlis","year":"2002","unstructured":"Perlis ML, Smith MT, Orff HJ, Andrews PJ, Gillin JC, Giles DE (2002). The effects of an orally administered cholinergic agonist on REM sleep in major depression. Biol Psychiatry 51: 457\u2013462.","journal-title":"Biol Psychiatry"},{"key":"BF1300906_CR28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1046\/j.1365-2869.1999.00173.x","volume":"8","author":"JJ Quattrochi","year":"1999","unstructured":"Quattrochi JJ, Hobson JA (1999). Carbachol microinjection into the caudal peribrachial area induces long-term enhancement of PGO wave activity but not REM sleep. J Sleep Res 8: 281\u2013290.","journal-title":"J Sleep Res"},{"key":"BF1300906_CR29","volume-title":"A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects","author":"A Rechtschaffen","year":"1968","unstructured":"Rechtschaffen A, Kales A (1968). A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. US Department of Health Education and Welfare: Bethesda."},{"key":"BF1300906_CR30","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0165-1781(94)90013-2","volume":"51","author":"D Riemann","year":"1994","unstructured":"Riemann D, Gann H, Dressing H, Muller WE, Aldenhoff JB (1994). Influence of the cholinesterase inhibitor galanthamine hydrobromide on normal sleep. Psychiatry Res 51: 253\u2013267.","journal-title":"Psychiatry Res"},{"key":"BF1300906_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0165-1781(88)90056-X","volume":"24","author":"D Riemann","year":"1988","unstructured":"Riemann D, Joy D, Hochli D, Lauer C, Zulley J, Berger M (1988). Influence of the cholinergic agonist RS 86 on normal sleep: sex and age effects. Psychiatry Res 24: 137\u2013147.","journal-title":"Psychiatry Res"},{"key":"BF1300906_CR32","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/0006-3223(95)00224-3","volume":"39","author":"D Riemann","year":"1996","unstructured":"Riemann D, Lis S, Fritsch-Montero R, Meier T, Krieger S, Hohagen F et al (1996). Effect of tetrahydroaminoacridine on sleep in healthy subjects. Biol Psychiatry 39: 796\u2013802.","journal-title":"Biol Psychiatry"},{"key":"BF1300906_CR33","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/0022-510X(92)90031-F","volume":"110","author":"NM Rupniak","year":"1992","unstructured":"Rupniak NM, Tye SJ, Iversen SD (1992). Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates. J Neurol Sci 110: 222\u2013227.","journal-title":"J Neurol Sci"},{"key":"BF1300906_CR34","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/cpt1969104522","volume":"10","author":"T Sagales","year":"1969","unstructured":"Sagales T, Erill S, Domino EF (1969). Differential effects of scopolamine and chlorpromazine on REM and NREM sleep in normal male subjects. Clin Pharmacol Ther 10: 522\u2013529.","journal-title":"Clin Pharmacol Ther"},{"key":"BF1300906_CR35","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1460-9568.1997.tb01619.x","volume":"9","author":"K Sakai","year":"1997","unstructured":"Sakai K, Onoe H (1997). Critical role for M3 muscarinic receptors in paradoxical sleep generation in the cat. Eur J Neurosci 9: 415\u2013423.","journal-title":"Eur J Neurosci"},{"key":"BF1300906_CR36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/S0531-5565(00)00206-0","volume":"36","author":"M Schredl","year":"2001","unstructured":"Schredl M, Weber B, Leins ML, Heuser I (2001). Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons. Exp Gerontol 36: 353\u2013361.","journal-title":"Exp Gerontol"},{"key":"BF1300906_CR37","first-page":"308","volume":"269","author":"SL Shuman","year":"1995","unstructured":"Shuman SL, Capece ML, Baghdoyan HA, Lydic R (1995). Pertussis toxin-sensitive G proteins mediate carbachol-induced REM sleep and respiratory depression. Am J Physiol 269: 308\u2013317.","journal-title":"Am J Physiol"},{"key":"BF1300906_CR38","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1126\/science.176724","volume":"191","author":"N Sitaram","year":"1976","unstructured":"Sitaram N, Wyatt RJ, Dawson S, Gillin JC (1976). REM sleep induction by physostigmine infusion during sleep. Science 191: 1281\u20131283.","journal-title":"Science"},{"key":"BF1300906_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0165-1781(84)90103-3","volume":"11","author":"R Spiegel","year":"1984","unstructured":"Spiegel R (1984). Effects of RS 86, an orally active cholinergic agonist, on sleep in man. Psychiatry Res 11: 1\u201313.","journal-title":"Psychiatry Res"},{"key":"BF1300906_CR40","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/0006-8993(91)91064-8","volume":"543","author":"J Velazquez-Moctezuma","year":"1991","unstructured":"Velazquez-Moctezuma J, Shalauta M, Gillin JC, Shiromani PJ (1991). Cholinergic antagonists and REM sleep generation. Brain Res 543: 175\u2013179.","journal-title":"Brain Res"},{"key":"BF1300906_CR41","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0014-2999(90)90374-F","volume":"187","author":"F Wanibuchi","year":"1990","unstructured":"Wanibuchi F, Konishi T, Harada M, Terai M, Hidaka K, Tamura T et al (1990). Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954. Eur J Pharmacol 187: 479\u2013486.","journal-title":"Eur J Pharmacol"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1300906.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300906","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1300906.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:50:08Z","timestamp":1684219808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1300906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9,28]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["BF1300906"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1300906","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9,28]]}}}