{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:08:39Z","timestamp":1759615719243},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2006,2,8]],"date-time":"2006-02-08T00:00:00Z","timestamp":1139356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2006,9]]},"DOI":"10.1038\/sj.npp.1301043","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T15:47:29Z","timestamp":1140018449000},"page":"2011-2021","source":"Crossref","is-referenced-by-count":53,"title":["Antipsychotic Effects on Prepulse Inhibition in Normal \u2018Low Gating\u2019 Humans and Rats"],"prefix":"10.1038","volume":"31","author":[{"given":"Neal R","family":"Swerdlow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Talledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley N","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody M","family":"Shoemaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,2,8]]},"reference":[{"key":"BF1301043_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1177\/026988119801200302","volume":"12","author":"KA Abduljawad","year":"1998","unstructured":"Abduljawad KA, Langley RW, Bradshaw CM, Szabadi E (1998). Effects of bromocriptine and haloperidol on prepulse inhibition of the acoustic startle response in man. J Psychopharmacol 12: 239\u2013245.","journal-title":"J Psychopharmacol"},{"key":"BF1301043_CR2","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s00702-004-0223-y","volume":"112","author":"K Becker","year":"2005","unstructured":"Becker K, Laucht M, El-Faddagh M, Schmidt MH (2005). The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample. J Neural Transm 112: 847\u2013858.","journal-title":"J Neural Transm"},{"key":"BF1301043_CR3","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s00213-005-0056-x","volume":"182","author":"P Bitsios","year":"2005","unstructured":"Bitsios P, Giakoumaki SG, Frangou S (2005). The effects of dopamine agonists on prepulse inhibition in healthy men depend on baseline PPI values. Psychopharmacology 182: 144\u2013152.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0167-8760(99)00019-7","volume":"32","author":"AH Bohmelt","year":"1999","unstructured":"Bohmelt AH, Schell AM, Dawson ME (1999). Attentional modulation of short- and long-lead-interval modification of the acoustic startle eyeblink response: comparing auditory and visual prestimuli. Int J Psychophysiol 32: 239\u2013250.","journal-title":"Int J Psychophysiol"},{"key":"BF1301043_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1111\/j.1469-8986.1978.tb01390.x","volume":"15","author":"D Braff","year":"1978","unstructured":"Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L (1978). Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology 15: 339\u2013343.","journal-title":"Psychophysiology"},{"key":"BF1301043_CR6","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s002130100810","volume":"156","author":"DL Braff","year":"2001","unstructured":"Braff DL, Geyer MA, Swerdlow NR (2001). Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156: 234\u2013258.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR7","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1176\/appi.ajp.157.10.1660","volume":"157","author":"KS Cadenhead","year":"2000","unstructured":"Cadenhead KS, Swerdlow NR, Shafer KM, Diaz M, Braff DL (2000). Modulation of the startle response and startle laterality in relatives of schizophrenia patients and schizotypal personality disordered subjects: evidence of inhibitory deficits. Am J Psychiatry 157: 1660\u20131668.","journal-title":"Am J Psychiatry"},{"key":"BF1301043_CR8","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/0006-3223(95)00101-8","volume":"39","author":"FX Castellanos","year":"1996","unstructured":"Castellanos FX, Fine EJ, Kaysen DL, Marsh WL, Rapoport JL, Hallett M (1996). Sensorimotor gating in boys with Tourette's syndrome and ADHD: preliminary results. Biol Psychiatry 39: 33\u201341.","journal-title":"Biol Psychiatry"},{"key":"BF1301043_CR9","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1001\/archpsyc.1987.01800180093014","volume":"44","author":"CR Cloninger","year":"1987","unstructured":"Cloninger CR (1987). A systematic method for clinical description and classification of personality variants. A proposal. Arch Gen Psychiatry 44: 573\u2013588.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1301043_CR10","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"J Cohen","year":"1988","unstructured":"Cohen J (1988). Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum: Hillsdale, NJ."},{"key":"BF1301043_CR11","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1037\/0735-7044.119.4.1052","volume":"119","author":"LH Conti","year":"2005","unstructured":"Conti LH, Costill JE, Flynn S, Taylor JE (2005). Effects of a typical and an atypical antipychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain. Behav Neurosci 119: 1052\u20131060.","journal-title":"Behav Neurosci"},{"key":"BF1301043_CR12","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/0301-0511(93)90001-O","volume":"35","author":"DL Filion","year":"1993","unstructured":"Filion DL, Dawson ME, Schell AM (1993). Modification of the acoustic startle-reflex eyeblink: a tool for investigating early and late attentional processes. Biol Psychol 35: 185\u2013200.","journal-title":"Biol Psychol"},{"key":"BF1301043_CR13","volume-title":"Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patient Edition (SCID-I\/NP)","author":"MB First","year":"1997","unstructured":"First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV Axis I Disorders, Research Version, Non-patient Edition (SCID-I\/NP). Biometrics Research, New York State Psychiatric Institute: New York."},{"key":"BF1301043_CR14","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s002130100811","volume":"156","author":"MA Geyer","year":"2001","unstructured":"Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR (2001). Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology 156: 117\u2013154.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR15","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1001\/archneur.55.9.1233","volume":"55","author":"E Gomez-Wong","year":"1998","unstructured":"Gomez-Wong E, Marti MJ, Tolosa E, Valls-Sole J (1998). Sensory modulation of the blink reflex in patients with blepharospasm. Arch Neurol 55: 1233\u20131237.","journal-title":"Arch Neurol"},{"key":"BF1301043_CR16","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1469-8986.1975.tb01284.x","volume":"12","author":"F Graham","year":"1975","unstructured":"Graham F (1975). The more or less startling effects of weak prestimuli. Psychophysiology 12: 238\u2013248.","journal-title":"Psychophysiology"},{"key":"BF1301043_CR17","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/0269881104042615","volume":"18","author":"SJ Graham","year":"2004","unstructured":"Graham SJ, Scaife JC, Balboa Verduzco AM, Langley RW, Bradshaw CM, Szabadi E (2004). Effects of quetiapine and haloperidol on prepulse inhibition of the acoustic startle (eyeblink) response and N1\/P2 auditory evoked response in man. J Psychopharm 18: 173\u2013180.","journal-title":"J Psychopharm"},{"key":"BF1301043_CR18","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1037\/0735-7044.119.1.66","volume":"119","author":"DA Hince","year":"2005","unstructured":"Hince DA, Martin-Iverson MT (2005). Differences in prepulse inhibition (PPI) between Wistar and Sprague\u2013Dawley rats clarified by a new method of PPI standardization. Behav Neurosci 119: 66\u201377.","journal-title":"Behav Neurosci"},{"key":"BF1301043_CR19","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0140-6736(75)90206-8","volume":"2","author":"J Idanpaan-Heikkila","year":"1975","unstructured":"Idanpaan-Heikkila J, Alhava E, Olkinuora M, Palva I (1975). Letter: Clozapine and agranulocytosis. Lancet 2: 611.","journal-title":"Lancet"},{"key":"BF1301043_CR20","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1097\/00008877-199811000-00012","volume":"9","author":"V Kumari","year":"1998","unstructured":"Kumari V, Mulligan OF, Cotter PA, Poon L, Toone BK, Checkley SA et al (1998). Effects of single oral administrations of haloperidol and d-amphetamine on prepulse inhibition of the acoustic startle reflex in healthy male volunteers. Behav Pharmacol 9: 567\u2013576.","journal-title":"Behav Pharmacol"},{"key":"BF1301043_CR21","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1176\/ajp.156.7.1046","volume":"156","author":"V Kumari","year":"1999","unstructured":"Kumari V, Soni W, Sharma T (1999). Normalization of information processing deficits in schizophrenia with clozapine. Am J Psychiatry 156: 1046\u20131051.","journal-title":"Am J Psychiatry"},{"key":"BF1301043_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.psychres.2004.04.002","volume":"127","author":"B Oranje","year":"2004","unstructured":"Oranje B, Kahn RS, Kemner C, Verbaten MN (2004). Modulating sensorimotor gating in healthy volunteers: the effects of desipramine and haloperidol. Psychiatric Res 127: 195\u2013205.","journal-title":"Psychiatric Res"},{"key":"BF1301043_CR23","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1037\/0735-7044.114.2.374","volume":"114","author":"AA Palmer","year":"2000","unstructured":"Palmer AA, Dulawa SC, Mottiwala AA, Conti LH, Geyer MA, Printz MP (2000). Prepulse startle deficit in the Brown Norway rat: a potential genetic model. Behav Neurosci 114: 374\u2013388.","journal-title":"Behav Neurosci"},{"key":"BF1301043_CR24","first-page":"1290","volume":"279","author":"NR Swerdlow","year":"1996","unstructured":"Swerdlow NR, Bakshi V, Geyer MA (1996). Seroquel restores sensorimotor gating in phencyclidine treated rats. J Pharmacol Exp Ther 279: 1290\u20131299.","journal-title":"J Pharmacol Exp Ther"},{"key":"BF1301043_CR25","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/0006-3223(93)90300-3","volume":"33","author":"NR Swerdlow","year":"1993","unstructured":"Swerdlow NR, Benbow CH, Zisook S, Geyer MA, Braff DL (1993). A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder. Biol Psychiatry 33: 298\u2013301.","journal-title":"Biol Psychiatry"},{"key":"BF1301043_CR26","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1097\/00008877-200006000-00002","volume":"111","author":"NR Swerdlow","year":"2000","unstructured":"Swerdlow NR, Braff DL, Geyer MA (2000). Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol 111: 185\u2013204.","journal-title":"Behav Pharmacol"},{"key":"BF1301043_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1001\/archpsyc.1994.03950020063007","volume":"51","author":"NR Swerdlow","year":"1994","unstructured":"Swerdlow NR, Braff DL, Taaid N, Geyer MA (1994a). Assessing the validity of an animal model of sensorimotor gating deficits in schizophrenic patients. Arch Gen Psychiatry 51: 139\u2013154.","journal-title":"Arch Gen Psychiatry"},{"key":"BF1301043_CR28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s00213-002-1040-3","volume":"161","author":"NR Swerdlow","year":"2002","unstructured":"Swerdlow NR, Eastvold A, Karban B, Ploum Y, Stephany N, Geyer MA et al (2002a). Dopamine agonist effects on startle and sensorimotor gating in normal control subjects: time course studies. Psychopharmacology 161: 189\u2013201.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR29","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/00008877-200102000-00005","volume":"12","author":"NR Swerdlow","year":"2001","unstructured":"Swerdlow NR, Eastvold A, Uyan KM, Ploum Y, Cadenhead K (2001a). Matching strategies for drug studies of prepulse inhibition in humans. Behav Pharmacol 12: 45\u201352.","journal-title":"Behav Pharmacol"},{"key":"BF1301043_CR30","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/0006-3223(94)00138-S","volume":"37","author":"NR Swerdlow","year":"1995","unstructured":"Swerdlow NR, Filion D, Geyer MA, Braff DL (1995a). \u2018Normal\u2019 personality correlates of sensorimotor, cognitive and visuo-spatial gating. Biol Psychiatry 37: 286\u2013299.","journal-title":"Biol Psychiatry"},{"key":"BF1301043_CR31","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/0091-3057(93)90193-W","volume":"44","author":"NR Swerdlow","year":"1993","unstructured":"Swerdlow NR, Geyer MA (1993). Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav 44: 741\u2013744.","journal-title":"Pharmacol Biochem Behav"},{"key":"BF1301043_CR32","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1136\/jnnp.58.2.192","volume":"58","author":"NR Swerdlow","year":"1995","unstructured":"Swerdlow NR, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR (1995b). Impaired prepulse inhibition of acoustic and tactile startle in patients with Huntington's disease. J Neurol Neurosurg Psychiatry 58: 192\u2013200.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BF1301043_CR33","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s002130100856","volume":"158","author":"NR Swerdlow","year":"2001","unstructured":"Swerdlow NR, Platten A, Shoemaker J, Pitcher L, Auerbach P (2001b). Effects of pergolide on sensorimotor gating of the startle reflex in rats. Psychopharmacology 158: 230\u2013240.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR34","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s00213-003-1480-4","volume":"174","author":"NR Swerdlow","year":"2004","unstructured":"Swerdlow NR, Shoemaker JM, Auerbach PP, Pitcher L, Goins J, Platten A (2004). Heritable differences in the dopaminergic regulation of sensorimotor gating: II. Temporal, pharmacologic and generational analyses of apomorphine effects on prepulse inhibition. Psychopharmacology 174: 452\u2013462.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR35","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1007\/s00213-002-1172-5","volume":"164","author":"NR Swerdlow","year":"2002","unstructured":"Swerdlow NR, Stephany N, Shoemaker JM, Ross L, Wasserman LC, Talledo J et al (2002b). Effects of amantadine and bromocriptine on startle and sensorimotor gating: parametric studies and cross species comparisons. Psychopharmacology 164: 82\u201392.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR36","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/sj.npp.1300086","volume":"28","author":"NR Swerdlow","year":"2003","unstructured":"Swerdlow NR, Stephany N, Wasserman LC, Talledo J, Shoemaker JM, Auerbach PP (2003a). Amphetamine effects on prepulse inhibition across species: replication and parametric extension. Neuropsychopharmacology 28: 640\u2013650.","journal-title":"Neuropsychopharmacology"},{"key":"BF1301043_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0301-0511(02)00090-X","volume":"62","author":"NR Swerdlow","year":"2003","unstructured":"Swerdlow NR, Wasserman L, Talledo J, Casas R, Bruins P, Braff DL et al (2003b). Prestimulus modification of the startle reflex: relationship to personality and physiological markers of dopamine function. Biol Psychol 62: 17\u201326.","journal-title":"Biol Psychol"},{"key":"BF1301043_CR38","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/BF02245001","volume":"114","author":"NR Swerdlow","year":"1994","unstructured":"Swerdlow NR, Zisook D, Taaid N (1994b). Seroquel (ICI 204, 636) restores prepulse inhibition of acoustic startle in apomorphine-treated rats: similarities to clozapine. Psychopharmacology 114: 675\u2013678.","journal-title":"Psychopharmacology"},{"key":"BF1301043_CR39","unstructured":"Wasserman LC, Stephany NL, Talledo J, Auerbach PP, Swerdlow NR (2002). Psychophysiological effects of quetiapine in normal humans. Program No. 682.2. 2002 Abstract Viewer\/Itinerary Planner. Society for Neuroscience: Washington, DC. Online."},{"key":"BF1301043_CR40","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0006-3223(99)00229-2","volume":"47","author":"AI Weike","year":"2000","unstructured":"Weike AI, Bauer U, Hamm AO (2000). Effective neuroleptic medication removes prepulse inhibition deficits in schizophrenia patients. Biol Psychiatry 47: 61\u201370.","journal-title":"Biol Psychiatry"},{"key":"BF1301043_CR41","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/S0006-3223(98)00100-0","volume":"44","author":"DA Wirshing","year":"1998","unstructured":"Wirshing DA, Spellberg BJ, Erhart SM, Marder SR, Wirshing WC (1998). Novel antipsychotics and new onset diabetes. Biol Psychiatry 44: 778\u2013783.","journal-title":"Biol Psychiatry"},{"key":"BF1301043_CR42","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1037\/h0026047","volume":"32","author":"M Zuckerman","year":"1968","unstructured":"Zuckerman M, Link K (1968). Construct validity for the sensation-seeking scale. J Consult Clin Psychol 32: 420\u2013426.","journal-title":"J Consult Clin Psychol"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1301043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1301043","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1301043.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T06:51:09Z","timestamp":1684219869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1301043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,2,8]]},"references-count":42,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["BF1301043"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1301043","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,2,8]]}}}