{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:25:49Z","timestamp":1772025949944,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T00:00:00Z","timestamp":1184112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T00:00:00Z","timestamp":1184112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1038\/sj.npp.1301500","type":"journal-article","created":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T12:30:12Z","timestamp":1184157012000},"page":"1259-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["RETRACTED ARTICLE: Safety and Efficacy of Dapoxetine in the Treatment of Premature Ejaculation: A Double-Blind, Placebo-Controlled, Fixed-Dose, Randomized Study"],"prefix":"10.1038","volume":"33","author":[{"given":"Mohammad R","family":"Safarinejad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,7,11]]},"reference":[{"key":"BF1301500_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/0091-3057(81)90023-X","volume":"15","author":"S Ahlenius","year":"1981","unstructured":"Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Lindberg P et al (1981). Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav 15: 785\u2013792.","journal-title":"Pharmacol Biochem Behav"},{"key":"BF1301500_CR2","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1001\/archpsyc.1990.01810140091015","volume":"47","author":"RJ Baldesarani","year":"2003","unstructured":"Baldesarani RJ, Mars E (2003). Fluoxetine and side effects. Arch General Psychiatry 47: 191\u2013192.","journal-title":"Arch General Psychiatry"},{"key":"BF1301500_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1023\/A:1023417718557","volume":"32","author":"ES Byers","year":"2003","unstructured":"Byers ES, Grenier G (2003). Premature or rapid ejaculation: heterosexual couples' perceptions of men's ejaculatory behavior. Arch Sex Behav 32: 261\u2013270.","journal-title":"Arch Sex Behav"},{"key":"BF1301500_CR4","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.clpt.2003.11.123","volume":"75","author":"M Dresser","year":"2004","unstructured":"Dresser M, Lindert K, Lin D, Gidwani S, Gupta SK, Modi NB (2004). Pharmacokinetics of single and multiple escalating doses of dapoxetine in healthy volunteers [abstract]. Clin Pharmacol Ther 75: 113.","journal-title":"Clin Pharmacol Ther"},{"key":"BF1301500_CR5","first-page":"227","volume":"40","author":"B Feret","year":"2005","unstructured":"Feret B (2005). Focus on dapoxetine: a novel, fast-acting serotonin reuptake inhibitor. Formulary 40: 227\u2013230.","journal-title":"Formulary"},{"key":"BF1301500_CR6","first-page":"43","volume":"15","author":"E Fisher","year":"1986","unstructured":"Fisher E (1986). Common sexual problems in general practice. Aust Fam Physician 15: 43\u201347.","journal-title":"Aust Fam Physician"},{"key":"BF1301500_CR7","first-page":"49","volume-title":"The Design and Analysis of Clinical Experiments","author":"J Fleiss","year":"1986","unstructured":"Fleiss J (1986). The Design and Analysis of Clinical Experiments. John Wiley & Sons Inc.: New York, NY, pp 49\u201351."},{"key":"BF1301500_CR8","first-page":"1029","volume":"46","author":"MC Frink","year":"1996","unstructured":"Frink MC, Hennies HH, Englberger W, Haurand M, Wilffert B (1996). Influence of tramadol on neurotransmitter systems of the rat brain. Arzneimittelforschung 46: 1029\u20131036.","journal-title":"Arzneimittelforschung"},{"issue":"Suppl","key":"BF1301500_CR9","first-page":"239","volume":"173","author":"PJ Gengo","year":"2005","unstructured":"Gengo PJ, View M, Giuliano F, McKenna KE, Chester A, Lovenberg T (2005). Monoaminergic transport binding and inhibition profile of dapoxetine, a medication for the treatment of premature ejaculation. J Urol 173 (Suppl): 239. (abstract 878).","journal-title":"J Urol"},{"issue":"Suppl","key":"BF1301500_CR10","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/S0022-5347(18)35046-8","volume":"173","author":"WJ Hellstrom","year":"2005","unstructured":"Hellstrom WJ, Althof S, Gittelman M, Steidle C, Ho KF, Kell S et al (2005). Dapoxetine for the treatment of men with premature ejaculation (PE): dose-finding analysis. J Urol 173 (Suppl): 238 (abstract 877).","journal-title":"J Urol"},{"issue":"Suppl","key":"BF1301500_CR11","first-page":"59","volume":"1","author":"W Hellstrom","year":"2004","unstructured":"Hellstrom W, Gittelman M, Althof S, Ho KF, Kell S (2004). Dapoxetine HCl for the treatment of premature ejaculation: a phase II, randomized, double-blind, placebo-controlled study. J Sex Med 1 (Suppl): 59. (abstract 097).","journal-title":"J Sex Med"},{"key":"BF1301500_CR12","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1038\/sj.bjp.0702239","volume":"125","author":"V Hillegaart","year":"1998","unstructured":"Hillegaart V, Ahlenius S (1998). Facilitation and inhibition of male rat ejaculatory behaviour by the respective 5-HT1A and 5-HT1B receptor agonists. Brit J Pharmacol 125: 1733\u20131743.","journal-title":"Brit J Pharmacol"},{"key":"BF1301500_CR13","volume-title":"The New Sex Therapy: Active Treatment of Sexual Dysfunctions","author":"HS Kaplan","year":"1974","unstructured":"Kaplan HS (1974). The New Sex Therapy: Active Treatment of Sexual Dysfunctions. Brunner\/Maazel: New York."},{"key":"BF1301500_CR14","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/S0090-4295(99)00187-9","volume":"54","author":"SW Kim","year":"1999","unstructured":"Kim SW, Paick JS (1999). Short-term analysis of the effects of as needed use of sertraline at 5 pm for the treatment of premature ejaculation. Urology 54: 544\u2013547.","journal-title":"Urology"},{"key":"BF1301500_CR15","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1001\/jama.281.6.537","volume":"281","author":"EO Laumann","year":"1999","unstructured":"Laumann EO, Paik A, Rosen RC (1999). Sexual dysfunction in the United States: prevalence and predictors. JAMA 281: 537\u2013544.","journal-title":"JAMA"},{"key":"BF1301500_CR16","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1097\/01.ju.0000071040.12407.32","volume":"170","author":"P Manasia","year":"2003","unstructured":"Manasia P, Pomerol J, Ribe N, Gutierrez del Pozo R, Alcover Garcia J (2003). Comparison of the efficacy and safety of 90 vs 20\u2009mg fluoxetine in the treatment of premature ejaculation. J Urol 170: 164\u2013165.","journal-title":"J Urol"},{"key":"BF1301500_CR17","first-page":"92","volume-title":"Human Sexual Inadequacy","author":"WH Masters","year":"1970","unstructured":"Masters WH, Johnson VE (1970). Human Sexual Inadequacy. Little, Brown: Boston, pp 92\u2013142."},{"key":"BF1301500_CR18","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1016\/S0022-5347(01)63201-4","volume":"159","author":"CG McMahon","year":"1998","unstructured":"McMahon CG (1998). Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 159: 1935\u20131938.","journal-title":"J Urol"},{"key":"BF1301500_CR19","doi-asserted-by":"crossref","unstructured":"McMahon CG (2004). Pharmacological treatment of ejaculatory disorders. J Sex Med (Suppl 1): 19\u201321.","DOI":"10.1111\/j.1743-6109.2004.04051_17.x"},{"key":"BF1301500_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1177\/0091270005284850","volume":"46","author":"NB Modi","year":"2006","unstructured":"Modi NB, Dresser MJ, Simon M, Lin D, Desai D, Gupta S (2006). Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation. J Clin Pharmacol 46: 301\u2013309.","journal-title":"J Clin Pharmacol"},{"issue":"Suppl 2","key":"BF1301500_CR21","first-page":"121","volume":"214","author":"HE Molewijk","year":"1989","unstructured":"Molewijk HE, van der Heyden JAM, Olivier B (1989). Lower lip retraction is selective mediated by activation of the 5-HT1A receptor. Eur J Neurosci 214 (Suppl 2): 121.","journal-title":"Eur J Neurosci"},{"key":"BF1301500_CR22","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-1-4613-1087-7_9","volume-title":"Atlas of Male Sexual Dysfunction","author":"MA Perelman","year":"2004","unstructured":"Perelman MA, McMahon CG, Barada JH (2004). Evaluation and treatment of the ejaculatory disorders. In: Lue T (ed). Atlas of Male Sexual Dysfunction. Current Medicine, Inc.: Philadelphia, PA. pp 127\u2013157."},{"key":"BF1301500_CR23","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0140-6736(06)69373-2","volume":"9","author":"JL Pryor","year":"2006","unstructured":"Pryor JL, Althof SE, Steidle C, Rosen RC, Hellstrom WJ, Shabsigh R, Dapoxetine Study Group et al (2006). Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 9: 929\u2013937.","journal-title":"Lancet"},{"key":"BF1301500_CR24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1111\/j.1476-5381.1986.tb14580.x","volume":"87","author":"L Remy","year":"1986","unstructured":"Remy L (1986). The effect of selective 5HT reuptake inhibitors on 5-methoxy-N,N-dimethyltriptamine induced ejaculation in the rat. Br J Pharmacol 87: 639\u2013648.","journal-title":"Br J Pharmacol"},{"key":"BF1301500_CR25","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S0090-4295(97)00238-0","volume":"49","author":"RC Rosen","year":"1997","unstructured":"Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A (1997). The International Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 49: 822\u2013830.","journal-title":"Urology"},{"key":"BF1301500_CR26","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1023\/A:1002714812709","volume":"30","author":"DL Rowland","year":"2001","unstructured":"Rowland DL, Cooper SE, Schneider M (2001). Defining premature ejaculation for experimental and clinical investigations. Arch Sex Behav 30: 235\u2013253.","journal-title":"Arch Sex Behav"},{"key":"BF1301500_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0022-5347(01)63940-5","volume":"159","author":"K Sae Chul","year":"1998","unstructured":"Sae Chul K, Kyung S (1998). Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. J Urol 159: 425\u2013427.","journal-title":"J Urol"},{"key":"BF1301500_CR28","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/01.WNF.0000228210.12194.46","volume":"29","author":"MR Safarinejad","year":"2006","unstructured":"Safarinejad MR (2006). Comparison of dapoxetine vs paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study. Clin Neuropharmacol 29: 243\u2013252.","journal-title":"Clin Neuropharmacol"},{"key":"BF1301500_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/sj.ijir.3901384","volume":"18","author":"MR Safarinejad","year":"2006","unstructured":"Safarinejad MR, Hosseini SY (2006). Safety and efficacy of citalopram in the treatment of premature ejaculation: a double-blind placebo-controlled, fixed dose, randomized study. Int J Impot Res 18: 164\u2013169.","journal-title":"Int J Impot Res"},{"key":"BF1301500_CR30","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/BF01541933","volume":"19","author":"IP Spector","year":"1990","unstructured":"Spector IP, Carey MP (1990). Incidence and prevalence of sexual dysfunctions. A critical review of the empirical literature. Arch Sex Behav 19: 389\u2013408.","journal-title":"Arch Sex Behav"},{"key":"BF1301500_CR31","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1080\/00926230390224738","volume":"29","author":"T Symonds","year":"2003","unstructured":"Symonds T, Roblin D, Hart K, Althof S (2003). How does premature ejaculation impact a man's life? J Sex Marital Ther 29: 361\u2013370.","journal-title":"J Sex Marital Ther"},{"key":"BF1301500_CR32","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/0024-3205(88)90584-X","volume":"43","author":"FG Szele","year":"1988","unstructured":"Szele FG, Murphy DL, Garrick NA (1988). Effects of fenfluramine, m-chlorophenylpiperazine and other serotonin-related agonists and antagonists on penile erections in non-human primates. Life Sci 43: 1297\u20131303.","journal-title":"Life Sci"},{"key":"BF1301500_CR33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/sj.ijir.3901023","volume":"15","author":"MD Waldinger","year":"2003","unstructured":"Waldinger MD (2003). Towards evidence-based drug treatment research on premature ejaculation: a critical evaluation of methodology. Int J Impot Res 15: 309\u2013313.","journal-title":"Int J Impot Res"},{"key":"BF1301500_CR34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1464-410X.2004.04495.x","volume":"93","author":"MD Waldinger","year":"2004","unstructured":"Waldinger MD (2004). Life-long premature ejaculation: from authority based to evidence based medicine. Br J Urol, Int Update Series 93: 201\u2013207.","journal-title":"Br J Urol, Int Update Series"},{"key":"BF1301500_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0166-4328(97)00183-6","volume":"92","author":"MD Waldinger","year":"1998","unstructured":"Waldinger MD, Berendsen HHG, Blok BFM, Olivier B, Holstege G (1998a). Premature ejaculation and serotonergic antidepressant-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 92: 111\u2013118.","journal-title":"Behav Brain Res"},{"key":"BF1301500_CR36","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1176\/ajp.151.9.1377","volume":"151","author":"MD Waldinger","year":"1994","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH (1994). Paroxetine treatment of premature ejaculation: a double-blind, randomised, placebo-controlled study. Am J Psychiatry 151: 1377\u20131379.","journal-title":"Am J Psychiatry"},{"key":"BF1301500_CR37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1097\/00004714-199808000-00004","volume":"18","author":"MD Waldinger","year":"1998","unstructured":"Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B (1998b). Effect of SSRI antidepressants on ejaculation: a double-blind, randomised, placebo controlled study with fluoxetine, fluvoxamine, paroxetine and sertraline. J Clin Psychopharm 18: 274\u2013281.","journal-title":"J Clin Psychopharm"},{"key":"BF1301500_CR38","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1097\/00004714-200106000-00007","volume":"21","author":"MD Waldinger","year":"2001","unstructured":"Waldinger MD, Zwinderman AH, Olivier B (2001). Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. J Clin Psychopharm 21: 293\u2013297.","journal-title":"J Clin Psychopharm"},{"key":"BF1301500_CR39","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/sj.ijir.3901172","volume":"16","author":"MD Waldinger","year":"2004","unstructured":"Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B (2004a). Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 16: 369\u2013381.","journal-title":"Int J Impot Res"}],"updated-by":[{"DOI":"10.1038\/s41386-023-01550-2","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"record-id":"44758"},{"DOI":"10.1038\/s41386-023-01550-2","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000}}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1301500.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1301500","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1301500.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T13:04:45Z","timestamp":1683119085000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1301500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,11]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["BF1301500"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1301500","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,11]]},"assertion":[{"value":"2 November 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2023","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This article has been retracted. Please see the Retraction Notice for more detail:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41386-023-01550-2","URL":"https:\/\/doi.org\/10.1038\/s41386-023-01550-2","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}