{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:57:34Z","timestamp":1787003854399,"version":"build-2736575974"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychopharmacol"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1038\/sj.npp.1301596","type":"journal-article","created":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T06:32:45Z","timestamp":1192602765000},"page":"1896-1908","source":"Crossref","is-referenced-by-count":60,"title":["Maintenance Treatment with Fluoxetine is Necessary to Sustain Normal Levels of Synaptic Markers in an Experimental Model of Depression: Correlation with Behavioral Response"],"prefix":"10.1038","volume":"33","author":[{"given":"Anal\u00eda","family":"Rein\u00e9s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cereseto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ferrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sifonios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fernanda","family":"Podest\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Wikinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,10,17]]},"reference":[{"key":"BF1301596_CR1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1046\/j.1365-2710.1999.00231.x","volume":"24","author":"S Akhondzadeh","year":"1999","unstructured":"Akhondzadeh S (1999). Hippocampal synaptic plasticity and cognition. J Clin Pharm Ther 24: 241\u2013248.","journal-title":"J Clin Pharm Ther"},{"key":"BF1301596_CR2","doi-asserted-by":"crossref","unstructured":"Anisman H, Merali Z (2001). Rodent models of depression: learned helplessness induced in mice. Curr Protoc Neurosci, Unit 8.10C.","DOI":"10.1002\/0471142301.ns0810cs14"},{"key":"BF1301596_CR3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0166-2236(96)10072-2","volume":"20","author":"LI Benowitz","year":"1997","unstructured":"Benowitz LI, Routtenberg A (1997). GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends Neurosci 20: 84\u201391.","journal-title":"Trends Neurosci"},{"key":"BF1301596_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1176\/ajp.157.1.115","volume":"157","author":"JD Bremner","year":"2000","unstructured":"Bremner JD, Narayan M, Anderson ER, Staib LH, Miller HL, Charney DS (2000). Hippocampal volume reduction in major depression. Am J Psychiatry 157: 115\u2013118.","journal-title":"Am J Psychiatry"},{"key":"BF1301596_CR5","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1523\/JNEUROSCI.22-04-01316.2002","volume":"22","author":"AR Carter","year":"2002","unstructured":"Carter AR, Chen C, Schwartz PM, Segal RA (2002). Brain-derived neurotrophic factor modulates cerebellar plasticity and synaptic ultrastructure. J Neurosci 22: 1316\u20131327.","journal-title":"J Neurosci"},{"key":"BF1301596_CR6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/S0006-3223(01)01083-6","volume":"15","author":"B Chen","year":"2001","unstructured":"Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT (2001). Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 15: 260\u2013265.","journal-title":"Biol Psychiatry"},{"key":"BF1301596_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/0896-6273(92)90245-9","volume":"9","author":"OK Cho","year":"1992","unstructured":"Cho OK, Hunt CA, Kennedy MB (1992). The rat brain postsynaptic density fraction contains a homolog of the drosophila dics-large tumor suppressor protein. Neuron 9: 929\u2013942.","journal-title":"Neuron"},{"key":"BF1301596_CR8","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1046\/j.0953-816x.2001.01500.x","volume":"13","author":"C Collin","year":"2001","unstructured":"Collin C, Vicario-Abejon C, Rubio ME, Wenthold RJ, McKay RD, Segal M (2001). Neurotrophins act at presynaptic terminals to activate synapses among cultured hippocampal neurons. Eur J Neurosci 13: 1273\u20131282.","journal-title":"Eur J Neurosci"},{"key":"BF1301596_CR9","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s00406-007-0728-0","volume":"257","author":"B Cz\u00e9h","year":"2007","unstructured":"Cz\u00e9h B, Lucassen PJ (2007). What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated? Eur Arch Psychiatry Clin Neurosci 257: 250\u2013260.","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"BF1301596_CR10","doi-asserted-by":"publisher","first-page":"12796","DOI":"10.1073\/pnas.211427898","volume":"98","author":"B Cz\u00e9h","year":"2001","unstructured":"Cz\u00e9h B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kamper M et al (2001). Stress-induced changes in cerebral metabolites, hippocampal volume and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natt Acad Sci USA 98: 12796\u201312801.","journal-title":"Proc Natt Acad Sci USA"},{"key":"BF1301596_CR11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.neuroscience.2004.06.054","volume":"128","author":"G De Foubert","year":"2004","unstructured":"De Foubert G, Carney SL, Robinson CS, Destexhe EJ, Tomlinson R, Hicks CA et al (2004). Fluoxetine-induced change in rat brain expression of brain-derived neurotrophic factor varies depending on length of treatment. Neuroscience 128: 597\u2013604.","journal-title":"Neuroscience"},{"key":"BF1301596_CR12","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.neuroscience.2006.02.072","volume":"140","author":"HS Donohue","year":"2006","unstructured":"Donohue HS, Gabbott LA, Davies HS, Rodriguez JJ, Cordero MI, Sandi C et al (2006). Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study. Neuroscience 140: 597\u2013606.","journal-title":"Neuroscience"},{"key":"BF1301596_CR13","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/sj.npp.1300433","volume":"29","author":"SC Dulawa","year":"2004","unstructured":"Dulawa SC, Holick KA, Gundersen B, Hen R (2004). Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology 29: 1321\u20131330.","journal-title":"Neuropsychopharmacology"},{"key":"BF1301596_CR14","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/S0924-9338(02)00654-5","volume":"17","author":"RS Duman","year":"2002","unstructured":"Duman RS (2002). Pathophysiology of depression: the concept of synaptic plasticity. Eur Psychiatry 17: 306\u2013310.","journal-title":"Eur Psychiatry"},{"key":"BF1301596_CR15","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0361-9230(01)00530-5","volume":"55","author":"SL Eastwood","year":"2001","unstructured":"Eastwood SL, Harrison PJ (2001). Synaptic pathology in the anterior cingulated cortex in schizophrenia and mood disorders. A review and western blot study of synaptophysin, GAP-43 and the complexins. Brain Res Bull 55: 569\u2013578.","journal-title":"Brain Res Bull"},{"key":"BF1301596_CR16","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/0163-1047(92)90724-I","volume":"57","author":"H Eichenbaum","year":"1992","unstructured":"Eichenbaum H, Otto T (1992). The hippocampus\u2014what does it do? Behav Neural Biol 57: 2\u201336.","journal-title":"Behav Neural Biol"},{"key":"BF1301596_CR17","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/19978","volume":"399","author":"F Engert","year":"1999","unstructured":"Engert F, Bonhoeffer T (1999). Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature 399: 66\u201370.","journal-title":"Nature"},{"key":"BF1301596_CR18","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1016\/j.pnpbp.2007.06.014","volume":"31","author":"AJ Ferrero","year":"2007","unstructured":"Ferrero AJ, Cereseto M, Sifonios LL, Reines A, Peixoto E, Rubio MC et al (2007). Cytoskeleton of hippocampal neurons as a target for valproic acid in an experimental model of depression. Prog Neuropsychopharmacol Biol Psychiatry 31: 1419\u20131428.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BF1301596_CR19","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.neuroscience.2005.08.019","volume":"136","author":"CA Grillo","year":"2005","unstructured":"Grillo CA, Piroli GG, Wood GE, Reznikov LR, McEwen BS, Reagan LP (2005). Immunocytochemical analysis of synaptic proteins provides new insights into diabetes-mediated plasticity in the rat hippocampus. Neuroscience 136: 477\u2013486.","journal-title":"Neuroscience"},{"key":"BF1301596_CR20","volume-title":"Goodman and Gilman, The Pharmacological Basis of Therapeutics","author":"JG Hardman","year":"2001","unstructured":"Hardman JG, Limbird LE (2001). Goodman and Gilman, The Pharmacological Basis of Therapeutics, 10th edn. McGraw-Hill Co: Atlampa, Mexico."},{"key":"BF1301596_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1046\/j.1365-2443.2000.00318.x","volume":"5","author":"K Hirao","year":"2000","unstructured":"Hirao K, Hata Y, Deguchi M, Yao I, Ogura M, Rokukawa C et al (2000). Association of synapse-associated protein 90\/postsynaptic density-95-associated protein (SAPAP) with neurofilaments. Genes Cells 5: 203\u2013210.","journal-title":"Genes Cells"},{"key":"BF1301596_CR22","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.biopsych.2006.07.007","volume":"62","author":"R Holderbach","year":"2006","unstructured":"Holderbach R, Clark K, Moreau J-L, Bischofberger J, Normann C (2006). Enhanced long-term synaptic depression in an animal model of depression. Biol Psychiat 62: 92\u2013100.","journal-title":"Biol Psychiat"},{"key":"BF1301596_CR23","doi-asserted-by":"publisher","first-page":"4285","DOI":"10.1242\/dev.02017","volume":"132","author":"B Hu","year":"2005","unstructured":"Hu B, Nikolakopoulou AM, Cohen-Cory S (2005). BDNF stabilizes synapses and maintains the structural complexity of optic axons in vivo. Development 132: 4285\u20134298.","journal-title":"Development"},{"key":"BF1301596_CR24","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1523\/JNEUROSCI.16-04-01380.1996","volume":"16","author":"CA Hunt","year":"1996","unstructured":"Hunt CA, Schenker LJ, Kennedy MB (1996). PSD-95 is associated with the postsynaptic density and not with the presynaptic membrane at forebrain synapses. J Neurosci 16: 1380\u20131388.","journal-title":"J Neurosci"},{"key":"BF1301596_CR25","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.neuroscience.2006.04.060","volume":"141","author":"M Iwata","year":"2006","unstructured":"Iwata M, Shirayama Y, Ishida H, Kawahara R (2006). Hippocampal synapsin I, growth-associated protein-43, and microtubule-associated protein-2 immunoreactivity in learned helplessness rats and antidepressant-treated rats. Neuroscience 141: 1301\u20131313.","journal-title":"Neuroscience"},{"key":"BF1301596_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4088\/JCP.v62n0101","volume":"62","author":"MB Keller","year":"2001","unstructured":"Keller MB (2001). Long-term treatment of recurrent and chronic depression. J Clin Psychiatry 62: 3\u20135.","journal-title":"J Clin Psychiatry"},{"key":"BF1301596_CR27","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0169-328X(98)00130-2","volume":"59","author":"Y Kuroda","year":"1998","unstructured":"Kuroda Y, McEwen BS (1998). Effect of chronic restraint stress and tianeptine on growth factors, growth-associated protein-43 and microtubule-associated protein 2 mRNA expression in the rat hippocampus. Brain Res Mol Brain Res 59: 35\u201339.","journal-title":"Brain Res Mol Brain Res"},{"key":"BF1301596_CR28","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1016\/S0306-4522(02)00485-2","volume":"115","author":"S Li","year":"2002","unstructured":"Li S, Reinprecht I, Fahnestock M, Racine RJ (2002). Activity-dependent changes in synaptophysin immunoreactivity in hippocampus, piriform cortex, and entorhinal cortex of the rat. Neuroscience 115: 1221\u20131229.","journal-title":"Neuroscience"},{"key":"BF1301596_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(94)90197-X","volume":"60","author":"MA Lynch","year":"1994","unstructured":"Lynch MA, Voss KL, Rodriguez J, Bliss TV (1994). Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus. Neuroscience 60: 1\u20135.","journal-title":"Neuroscience"},{"key":"BF1301596_CR30","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0014-2999(99)00163-6","volume":"371","author":"AM Magari\u00f1os","year":"1999","unstructured":"Magari\u00f1os AM, Deslandes A, McEwen BS (1999). Effects of antidepressant and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress. Eur J Pharmacol 371: 113\u2013122.","journal-title":"Eur J Pharmacol"},{"key":"BF1301596_CR31","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1523\/JNEUROSCI.16-10-03534.1996","volume":"16","author":"AM Magari\u00f1os","year":"1996","unstructured":"Magari\u00f1os AM, McEwen BS, Flugge G, Fuchs E (1996). Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 16: 3534\u20133540.","journal-title":"J Neurosci"},{"key":"BF1301596_CR32","doi-asserted-by":"publisher","first-page":"9104","DOI":"10.1523\/JNEUROSCI.20-24-09104.2000","volume":"20","author":"JE Malberg","year":"2000","unstructured":"Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000). Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20: 9104\u20139110.","journal-title":"J Neurosci"},{"key":"BF1301596_CR33","first-page":"1603","volume-title":"Comprehensive Textbook of Psychiatry","author":"JC Markowitz","year":"2005","unstructured":"Markowitz JC, Milrod B (2005). Mood disorders: intrapsychic and interpersonal aspects. In: Sadock BJ, Sadock VA (eds). Comprehensive Textbook of Psychiatry. Lippincott Williams & Wilkins: Philadelphia, pp 1603\u20131611."},{"key":"BF1301596_CR34","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.tins.2004.08.001","volume":"27","author":"MP Mattson","year":"2004","unstructured":"Mattson MP, Maudsley S, Martin B (2004). BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27: 589\u2013594.","journal-title":"Trends Neurosci"},{"key":"BF1301596_CR35","first-page":"117","volume":"30","author":"E Mervaala","year":"2002","unstructured":"Mervaala E, Fohr J, Kononen M, Valkonen-Korhonen M, Vainio P, Partanen K et al (2002). Quantitative MRI of the hippocampus and amygdala in severe depression. Psychopharmacol Med 30: 117\u2013125.","journal-title":"Psychopharmacol Med"},{"key":"BF1301596_CR36","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0028-3908(97)00073-7","volume":"36","author":"P Mullany","year":"1997","unstructured":"Mullany P, Lynch MA (1997). Changes in protein synthesis and synthesis of the synaptic vesicle protein, synaptophysin, in enthorinal cortex following induction of long-term potentiation in dentate gyrus: an age-related study in the rat. Neuropharmacology 36: 973\u2013980.","journal-title":"Neuropharmacology"},{"key":"BF1301596_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(99)00567-1","volume":"381","author":"Y Nakagawa","year":"1999","unstructured":"Nakagawa Y, Sasaki A, Takashima T (1999). The GabaB receptor antagonist CGP36742 improves learned helplessness in rats. Eur J Pharmacol 381: 1\u20137.","journal-title":"Eur J Pharmacol"},{"key":"BF1301596_CR38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.4088\/JCP.0707e17","volume":"68","author":"CB Nemeroff","year":"2007","unstructured":"Nemeroff CB (2007). Prevalence and management of treatment-resistant depression. J Clin Psychiatry 68: 17\u201325.","journal-title":"J Clin Psychiatry"},{"key":"BF1301596_CR39","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.biopsych.2005.01.016","volume":"57","author":"A Neumeister","year":"2005","unstructured":"Neumeister A, Wood S, Bonne O, Nugent AC, Luckenbaugh DA, Young T et al (2005). Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects. Biol Psychiatry 57: 935\u2013937.","journal-title":"Biol Psychiatry"},{"key":"BF1301596_CR40","doi-asserted-by":"publisher","first-page":"7539","DOI":"10.1523\/JNEUROSCI.15-11-07539.1995","volume":"15","author":"M Nibuya","year":"1995","unstructured":"Nibuya M, Morinobu S, Duman RS (1995). Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15: 7539\u20137547.","journal-title":"J Neurosci"},{"key":"BF1301596_CR41","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1523\/JNEUROSCI.16-07-02365.1996","volume":"16","author":"M Nibuya","year":"1996","unstructured":"Nibuya M, Nestler EJ, Duman RS (1996). Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 16: 2365\u20132372.","journal-title":"J Neurosci"},{"key":"BF1301596_CR42","volume-title":"The Rat Brain in Stereotaxis Coordinates","author":"G Paxinos","year":"1986","unstructured":"Paxinos G, Watson C (1986). The Rat Brain in Stereotaxis Coordinates, 4th edn. Academic Press: San Diego, CA."},{"key":"BF1301596_CR43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1192\/bjp.bp.106.028555","volume":"190","author":"MA Posternak","year":"2007","unstructured":"Posternak MA, Zimmerman M (2007). Therapeutic effect of follow-up assessments on antidepressant and placebo response rates in antidepressant efficacy trials: meta-analysis. Br J Psychiatry 190: 287\u2013292.","journal-title":"Br J Psychiatry"},{"key":"BF1301596_CR44","doi-asserted-by":"publisher","first-page":"4972","DOI":"10.1523\/JNEUROSCI.19-12-04972.1999","volume":"19","author":"LD Pozzo-Miller","year":"1999","unstructured":"Pozzo-Miller LD, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R et al (1999). Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice. J Neurosci 19: 4972\u20134983.","journal-title":"J Neurosci"},{"key":"BF1301596_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0006-8993(00)02862-6","volume":"883","author":"AJ Ramos","year":"2000","unstructured":"Ramos AJ, Tagliaferro P, Lopez EM, Pecci Saavedra JP (2000). Neuroglial interactions in a model of para-clorphenylalanine-induced serotonin depletion. Brain Res 883: 1\u201314.","journal-title":"Brain Res"},{"key":"BF1301596_CR46","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuroscience.2004.08.026","volume":"129","author":"A Rein\u00e9s","year":"2004","unstructured":"Rein\u00e9s A, Cereseto M, Ferrero A, Bonavita C, Wikinski S (2004). Neuronal cytoskeletal alterations in an experimental model of depression. Neuroscience 129: 529\u2013538.","journal-title":"Neuroscience"},{"key":"BF1301596_CR47","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.brainres.2005.01.065","volume":"1040","author":"H Rosenbrock","year":"2005","unstructured":"Rosenbrock H, Koros E, Bloching A, Podhorna J, Borsini F (2005). Effect of chronic intermittent restraint stress on hippocampal expression of markers for synaptic plasticity and progenitor cell proliferation in rats. Brain Res 1040: 55\u201363.","journal-title":"Brain Res"},{"key":"BF1301596_CR48","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/S0306-4522(03)00514-1","volume":"121","author":"S Scaccianoce","year":"2003","unstructured":"Scaccianoce S, Del Bianco P, Caricasole A, Nicoletti F, Catalani A (2003). Relationship between learning, stress, and hippocampal brain-derived neurotrophic factor. Neuroscience 121: 825\u2013828.","journal-title":"Neuroscience"},{"key":"BF1301596_CR49","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1242\/jeb.02567","volume":"209","author":"DJ Schulz","year":"2006","unstructured":"Schulz DJ (2006). Plasticity and stability in neuronal output via changes in intrinsic excitability: it's what's inside that counts. J Exp Biol 209: 4821\u20134827.","journal-title":"J Exp Biol"},{"key":"BF1301596_CR50","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0006-3223(00)00994-X","volume":"48","author":"Y Sheline","year":"2000","unstructured":"Sheline Y, Sanghavi M, Mintun MA, Gado MH (2000). MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry 48: 791\u2013800.","journal-title":"Biol Psychiatry"},{"key":"BF1301596_CR51","first-page":"29","volume":"65","author":"CI Shelton","year":"2004","unstructured":"Shelton CI (2004). Long-term management of major depressive disorder: are differences among antidepressant treatments meaningful? J Clin Psychiatry 65: 29\u201333.","journal-title":"J Clin Psychiatry"},{"key":"BF1301596_CR52","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1523\/JNEUROSCI.22-08-03251.2002","volume":"22","author":"Y Shirayama","year":"2002","unstructured":"Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioural models of depression. J Neurosci 22: 3251\u20133261.","journal-title":"J Neurosci"},{"key":"BF1301596_CR53","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1523\/JNEUROSCI.15-03-01768.1995","volume":"15","author":"MA Smith","year":"1995","unstructured":"Smith MA, Makino S, Kvetnansky R, Post RM (1995). Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci 15: 1768\u20131777.","journal-title":"J Neurosci"},{"key":"BF1301596_CR54","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/j.1749-6632.2002.tb04175.x","volume":"965","author":"P Tagliaferro","year":"2002","unstructured":"Tagliaferro P, Vega MD, Evrard SG, Ramos AJ, Brusco A (2002). Alcohol exposure during adulthood induces neuronal and astroglial alterations in the hippocampal CA-1 area. Ann NY Acad Sci 965: 334\u2013363.","journal-title":"Ann NY Acad Sci"},{"key":"BF1301596_CR55","doi-asserted-by":"publisher","first-page":"37585","DOI":"10.1074\/jbc.M101683200","volume":"276","author":"N Tartaglia","year":"2001","unstructured":"Tartaglia N, Du J, Tyler WJ, Neale E, Pozzo-Miller L, Lu B (2001). Protein synthesis-dependent and -independent regulation of hippocampal synapses by brain-derived neurotrophic factor. J Biol Chem 276: 37585\u201337593.","journal-title":"J Biol Chem"},{"key":"BF1301596_CR56","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1074\/jbc.275.4.2439","volume":"275","author":"RT Terry-Lorenzo","year":"2000","unstructured":"Terry-Lorenzo RT, Inoue M, Connor JH, Haystead TAJ, Armbruster BN, Gupta RP et al (2000). Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J Biol Chem 275: 2439\u20132446.","journal-title":"J Biol Chem"},{"key":"BF1301596_CR57","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/S0006-3223(01)01229-X","volume":"50","author":"J Thome","year":"2001","unstructured":"Thome J, Pesold B, Baader M, Hu M, Gewirtz JC, Duman RS et al (2001). Stress differentially regulates synaptophysin and synaptotagmin expression in hippocampus. Biol Psychiatry 50: 809\u2013812.","journal-title":"Biol Psychiatry"},{"key":"BF1301596_CR58","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/46574","volume":"402","author":"N Toni","year":"1999","unstructured":"Toni N, Buchs PA, Nikonenko I, Bron CR, Muller D (1999). LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite. Nature 402: 421\u2013425.","journal-title":"Nature"},{"key":"BF1301596_CR59","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1523\/JNEUROSCI.21-12-04249.2001","volume":"21","author":"WJ Tyler","year":"2001","unstructured":"Tyler WJ, Pozzo-Miller LD (2001). BDNF enhances quantal neurotransmitter release and increases the number of docked vesicles at the active zones of hippocampal excitatory synapses. J Neurosci 21: 4249\u20134258.","journal-title":"J Neurosci"},{"key":"BF1301596_CR60","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1176\/appi.ajp.161.11.1957","volume":"161","author":"P Videbech","year":"2004","unstructured":"Videbech P, Ravnkilde B (2004). Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 161: 1957\u20131966.","journal-title":"Am J Psychiatry"},{"key":"BF1301596_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1385-299X(01)00067-8","volume":"8","author":"B Vollmayr","year":"2001","unstructured":"Vollmayr B, Henn FA (2001). Learned helplessness in the rat: improvements in validity and reliability. Brain Res Protoc 8: 1\u20137.","journal-title":"Brain Res Protoc"},{"key":"BF1301596_CR62","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/0006-8993(92)91597-8","volume":"588","author":"Y Watanabe","year":"1992","unstructured":"Watanabe Y, Gould E, McEwen BS (1992). Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588: 341\u2013345.","journal-title":"Brain Res"},{"key":"BF1301596_CR63","unstructured":"World Health Organization (2001). The World Health Report 2001. \n                    http:\/\/www.who.int\/mental_health\/management\/depression\/definition\/en\/print.html\n                    \n                  ."},{"key":"BF1301596_CR64","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1111\/j.1471-4159.2004.02827.x","volume":"91","author":"H Xu","year":"2004","unstructured":"Xu H, He J, Richardson JS, Li XM (2004). The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. J Neurochem 91: 1380\u20131388.","journal-title":"J Neurochem"},{"key":"BF1301596_CR65","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.neuropharm.2006.10.014","volume":"52","author":"A Zazpe","year":"2007","unstructured":"Zazpe A, Artaiz I, Labeaga L, Lucero ML, Orjales A (2007). Reversal of learned helplessness by selective serotonin reuptake inhibitors in rats is not dependent on 5-HT availability. Neuropharmacology 52: 975\u2013984.","journal-title":"Neuropharmacology"}],"container-title":["Neuropsychopharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/1301596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1301596","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/1301596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T02:56:52Z","timestamp":1684205812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1301596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,17]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["BF1301596"],"URL":"https:\/\/doi.org\/10.1038\/sj.npp.1301596","relation":{},"ISSN":["0893-133X","1740-634X"],"issn-type":[{"value":"0893-133X","type":"print"},{"value":"1740-634X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,17]]}}}