{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:50:39Z","timestamp":1791287439141,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"54","license":[{"start":{"date-parts":[[2000,12,14]],"date-time":"2000-12-14T00:00:00Z","timestamp":976752000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2000,12,14]],"date-time":"2000-12-14T00:00:00Z","timestamp":976752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2000,12,14]]},"DOI":"10.1038\/sj.onc.1204009","type":"journal-article","created":{"date-parts":[[2002,9,4]],"date-time":"2002-09-04T19:51:06Z","timestamp":1031169066000},"page":"6306-6316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":216,"title":["The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination"],"prefix":"10.1038","volume":"19","author":[{"given":"Giovanna","family":"Benvenuto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Braverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C","family":"Vass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P","family":"Cheadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dicky JJ","family":"Halley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian R","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Wienecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E","family":"DeClue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2000,12,14]]},"reference":[{"key":"BF1204009_CR1","doi-asserted-by":"crossref","unstructured":"Ciechanover A. . 1998 EMBO J. 17: 7151\u20137160.","DOI":"10.1093\/emboj\/17.24.7151"},{"key":"BF1204009_CR2","doi-asserted-by":"crossref","unstructured":"Ciechanover A, Orian A and Schwartz AL. . 2000 J. Cell. Biochem. 77: 40\u201351.","DOI":"10.1002\/(SICI)1097-4644(2000)77:34+<40::AID-JCB9>3.0.CO;2-6"},{"key":"BF1204009_CR3","doi-asserted-by":"crossref","unstructured":"European Chromosome 16 Tuberous Sclerosis Consortium. . 1993 Cell 75: 1305\u20131313.","DOI":"10.1016\/0092-8674(93)90618-Z"},{"key":"BF1204009_CR4","unstructured":"TSC1 Consortium.1997 Science 277: 805\u2013808."},{"key":"BF1204009_CR5","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195122107.001.0001","volume-title":"Tuberous Sclerosis, 3rd ed","author":"MR Gomez","year":"1999","unstructured":"Gomez MR, Sampson JR and Whittemore VH. . 1999 Tuberous Sclerosis, 3rd ed Oxford University Press: New York."},{"key":"BF1204009_CR6","doi-asserted-by":"crossref","unstructured":"Green AJ, Smith M and Yates JRW. . 1994 Nature Genet. 6: 193\u2013196.","DOI":"10.1038\/ng0294-193"},{"key":"BF1204009_CR7","doi-asserted-by":"crossref","unstructured":"Green S, Issemann I and Sheer E. . 1988 Nuc. Acids Res. 16: 369.","DOI":"10.1093\/nar\/16.1.369"},{"key":"BF1204009_CR8","doi-asserted-by":"crossref","unstructured":"Gutmann DH, Zhang Y, Hasbani MJ, Goldberg MP, Plank TL and Henske EP. . 2000 Acta Neuropathol. 99: 223\u2013230.","DOI":"10.1007\/PL00007431"},{"key":"BF1204009_CR9","doi-asserted-by":"crossref","unstructured":"Haupt Y, Maya R, Kazaz A and Oren M. . 1997 Nature 387: 296\u2013299.","DOI":"10.1038\/387296a0"},{"key":"BF1204009_CR10","doi-asserted-by":"crossref","unstructured":"Henske EP, Neumann HPH, Scheithauer BW, Herbst EW, Short MP and Kwiatkowski DJ. . 1995 Genes Chrom. Cancer 13: 295\u2013298.","DOI":"10.1002\/gcc.2870130411"},{"key":"BF1204009_CR11","unstructured":"Henske EP, Scheithauer BW, Short MP, Wollmann R, Nahmias J, Hornigold N, van Slegtenhorst M, Welsh CT and Kwiatkowski DJ. . 1996 Am. J. Hum. Genet. 59: 400\u2013406."},{"key":"BF1204009_CR12","doi-asserted-by":"crossref","unstructured":"Huang H-JS, Yee J-K, Shew J-H, Chen P-L, Bookstein R, Friedman T, Lee EY-HP and Lee W-H. . 1988 Science 242: 1563\u20131566.","DOI":"10.1126\/science.3201247"},{"key":"BF1204009_CR13","doi-asserted-by":"crossref","unstructured":"Ito N and Rubin GM. . 1999 Cell 96: 529\u2013536.","DOI":"10.1016\/S0092-8674(00)80657-1"},{"key":"BF1204009_CR14","doi-asserted-by":"crossref","unstructured":"Jin F, Wienecke R, Xiao G-H, Maize Jr JC, DeClue JE and Yeung RS. . 1996 Proc. Natl. Acad. Sci. USA 93: 9154\u20139159.","DOI":"10.1073\/pnas.93.17.9154"},{"key":"BF1204009_CR15","doi-asserted-by":"crossref","unstructured":"Johnson MR, DeClue JE, Felzmann S, Vass WC, Xu G, White R and Lowy DR. . 1994 Mol. Cell. Biol. 14: 641\u2013645.","DOI":"10.1128\/mcb.14.1.641-645.1994"},{"key":"BF1204009_CR16","doi-asserted-by":"crossref","unstructured":"Knudson AG. . 1993 Proc. Natl. Acad. Sci. USA 90: 10914\u201310921.","DOI":"10.1073\/pnas.90.23.10914"},{"key":"BF1204009_CR17","doi-asserted-by":"crossref","unstructured":"Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y and Hino O. . 1995 Nature Genet. 9: 70\u201374.","DOI":"10.1038\/ng0195-70"},{"key":"BF1204009_CR18","doi-asserted-by":"crossref","unstructured":"Koepp DM, Harper JW and Elledge SJ. . 1999 Cell 97: 431\u2013434.","DOI":"10.1016\/S0092-8674(00)80753-9"},{"key":"BF1204009_CR19","doi-asserted-by":"crossref","unstructured":"Kubbutat MHG, Jones SN and Vousden KH. . 1997 Nature 387: 299\u2013303.","DOI":"10.1038\/387299a0"},{"key":"BF1204009_CR20","doi-asserted-by":"crossref","unstructured":"Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG and Hall A. . 2000 Nature Cell Biol. 2: 281\u2013287.","DOI":"10.1038\/35010550"},{"key":"BF1204009_CR21","unstructured":"Maki CG, Huibregtse JM and Howley PM. . 1996 Cancer Res. 56: 2649\u20132654."},{"key":"BF1204009_CR22","doi-asserted-by":"crossref","unstructured":"Michalovitz D, Halevy O and Oren M. . 1990 Cell 62: 671\u2013680.","DOI":"10.1016\/0092-8674(90)90113-S"},{"key":"BF1204009_CR23","doi-asserted-by":"crossref","unstructured":"Mizuguchi M, Ikeda K and Takashima S. . 2000 Acta Neuropathol. 99: 503\u2013510.","DOI":"10.1007\/s004010051152"},{"key":"BF1204009_CR24","doi-asserted-by":"crossref","unstructured":"Nellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AMW, Halley DJJ and van der Sluijs P. . 1999 J. Biol. Chem. 274: 35647\u201335652.","DOI":"10.1074\/jbc.274.50.35647"},{"key":"BF1204009_CR25","doi-asserted-by":"crossref","unstructured":"Nielsen KH, Papageorge AG, Vass WC, Willumsen BM and Lowy DR. . 1997 Mol. Cell. Biol. 17: 7132\u20137138.","DOI":"10.1128\/MCB.17.12.7132"},{"key":"BF1204009_CR26","doi-asserted-by":"crossref","unstructured":"Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T and Hino O. . 1996 Biochem. Biophys. Res. Comm. 219: 70\u201375.","DOI":"10.1006\/bbrc.1996.0183"},{"key":"BF1204009_CR27","doi-asserted-by":"crossref","unstructured":"Palombella VJ, Rando OJ, Goldberg AL and Maniatis T. . 1994 Cell 78: 773\u2013785.","DOI":"10.1016\/S0092-8674(94)90482-0"},{"key":"BF1204009_CR28","unstructured":"Plank TL, Logginidou H, Klein-Szanto A and Henske EP. . 1999 Modern Pathol. 12: 539\u2013545."},{"key":"BF1204009_CR29","unstructured":"Plank TL, Yeung RS and Henske EP. . 1998 Cancer Res. 58: 4766\u20134770."},{"key":"BF1204009_CR30","doi-asserted-by":"crossref","unstructured":"Qian X, Vass WC, Papageorge AG, Anborgh PH and Lowy DR. . 1998 Mol. Cell. Biol. 18: 771\u2013778.","DOI":"10.1128\/MCB.18.2.771"},{"key":"BF1204009_CR31","doi-asserted-by":"crossref","unstructured":"Roach ES, Gomez MR and Northrup H. . 1998 J. Child Neurol. 13: 624\u2013628.","DOI":"10.1177\/088307389801301206"},{"key":"BF1204009_CR32","doi-asserted-by":"crossref","unstructured":"Soucek T, Pusch O, Wienecke R, DeClue JE and Hengstschlager M. . 1997 J. Biol. Chem. 272: 29301\u201329308.","DOI":"10.1074\/jbc.272.46.29301"},{"key":"BF1204009_CR33","doi-asserted-by":"crossref","unstructured":"Soucek T, Yeung RS and Hengstschlager M. . 1998 Proc. Natl. Acad. Sci. USA 95: 15653\u201315658.","DOI":"10.1073\/pnas.95.26.15653"},{"key":"BF1204009_CR34","doi-asserted-by":"crossref","unstructured":"Treier M, Staszewski LM and Bohmann D. . 1994 Cell 78: 787\u2013798.","DOI":"10.1016\/S0092-8674(94)90502-9"},{"key":"BF1204009_CR35","unstructured":"van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D and van der Sluijs P. . 1998 Human Mol. Genet. 7: 1053\u20131057."},{"key":"BF1204009_CR36","doi-asserted-by":"crossref","unstructured":"Velu TJ, Vass WC, Lowy DR and Tambourin PE. . 1989 J. Virol. 63: 1384\u20131392.","DOI":"10.1128\/jvi.63.3.1384-1392.1989"},{"key":"BF1204009_CR37","doi-asserted-by":"crossref","unstructured":"Wiederholt WC, Gomez MR and Kurland LT. . 1985 Neurology 35: 600\u2013603.","DOI":"10.1212\/WNL.35.4.600"},{"key":"BF1204009_CR38","doi-asserted-by":"crossref","unstructured":"Wienecke R, K\u00f6nig A and DeClue J. . 1995 J. Biol. Chem. 270: 16409\u201316414.","DOI":"10.1074\/jbc.270.27.16409"},{"key":"BF1204009_CR39","unstructured":"Wienecke R, Maize JC, Reed J, de Gunzburg J, Yeung RS and DeClue JE. . 1997 Am. J. Pathol. 150: 43\u201350."},{"key":"BF1204009_CR40","unstructured":"Wienecke R, Maize JC, Shoarinejad F, Vass WC, Reed J, Bonifacino JS, Resau JH, de Gunzburg J, Yeung RS and DeClue JE. . 1996 Oncogene 13: 913\u2013923."},{"key":"BF1204009_CR41","doi-asserted-by":"crossref","unstructured":"Xiao G, Shoarinejad F, Jin F, Golemis E and Yeung R. . 1997 J. Biol. Chem. 272: 6097\u20136100.","DOI":"10.1074\/jbc.272.10.6097"},{"key":"BF1204009_CR42","doi-asserted-by":"crossref","unstructured":"Yeung RS, Xiao G-H, Jin F, Lee W-C, Testa JR and Knudson AG. . 1994 Proc. Natl. Acad. Sci. USA 91: 11413\u201311416.","DOI":"10.1073\/pnas.91.24.11413"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1204009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204009","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1204009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T12:13:54Z","timestamp":1704284034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1204009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,14]]},"references-count":42,"journal-issue":{"issue":"54","published-print":{"date-parts":[[2000,12,14]]}},"alternative-id":["BF1204009"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1204009","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12,14]]},"assertion":[{"value":"26 July 2000","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2000","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2000","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2000","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}