{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:55:00Z","timestamp":1791053700410,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,3]],"date-time":"2002-01-03T00:00:00Z","timestamp":1010016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,1,3]],"date-time":"2002-01-03T00:00:00Z","timestamp":1010016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2002,1,3]]},"DOI":"10.1038\/sj.onc.1205016","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T21:49:22Z","timestamp":1032472162000},"page":"32-43","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-xL proteins"],"prefix":"10.1038","volume":"21","author":[{"given":"Feng","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Jaruga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Ishac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuening","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,1,15]]},"reference":[{"key":"BF1205016_CR1","doi-asserted-by":"crossref","unstructured":"Abittan CS, Lieber CS . 1999 Curr. Treat Options Gastroenterol. 2: 72\u201380","DOI":"10.1007\/s11938-999-0022-5"},{"key":"BF1205016_CR2","doi-asserted-by":"crossref","unstructured":"Adams JM, Cory S . 2001 Trends Biochem. Sci. 26: 61\u201366","DOI":"10.1016\/S0968-0004(00)01740-0"},{"key":"BF1205016_CR3","doi-asserted-by":"crossref","unstructured":"Benedetti A, Brunelli E, Risicato R, Cilluffo T, Jezequel AM, Orlandi F . 1988 J. Hepatol. 6: 137\u2013143","DOI":"10.1016\/S0168-8278(88)80024-2"},{"key":"BF1205016_CR4","unstructured":"Bird G . 1994 Acta. Gastroenterol. Belg. 57: 255\u2013259"},{"key":"BF1205016_CR5","doi-asserted-by":"crossref","unstructured":"Chang YC, Xu YH . 2000 Cell Res. 10: 233\u2013242","DOI":"10.1080\/09581590050075961"},{"key":"BF1205016_CR6","doi-asserted-by":"crossref","unstructured":"Chen J, Bao H, Sawyer S, Kunos G, Gao B . 1997 Biochem. Biophys. Res. Commun. 239: 666\u2013669","DOI":"10.1006\/bbrc.1997.7531"},{"key":"BF1205016_CR7","doi-asserted-by":"crossref","unstructured":"Chen J, Ishac EJ, Dent P, Kunos G, Gao B . 1998 Biochem. J. 334: 669\u2013676","DOI":"10.1042\/bj3340669"},{"key":"BF1205016_CR8","doi-asserted-by":"crossref","unstructured":"Chen J, Kunos G, Gao B . 1999a FEBS Lett. 457: 162\u2013168","DOI":"10.1016\/S0014-5793(99)01031-5"},{"key":"BF1205016_CR9","doi-asserted-by":"crossref","unstructured":"Chen MC, Hsu TL, Luh TY, Hsieh SL . 2000 J. Biol. Chem. 275: 38794\u201338801","DOI":"10.1074\/jbc.M003292200"},{"key":"BF1205016_CR10","doi-asserted-by":"crossref","unstructured":"Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML . 1999b J. Biol. Chem. 274: 23013\u201323019","DOI":"10.1074\/jbc.274.33.23013"},{"key":"BF1205016_CR11","doi-asserted-by":"crossref","unstructured":"Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Poli V, Taub R . 1996 Science 274: 1379\u20131383","DOI":"10.1126\/science.274.5291.1379"},{"key":"BF1205016_CR12","doi-asserted-by":"crossref","unstructured":"Deaciuc IV, Alappat JM, McDonough KH, D'Souza NB . 1996 Alcohol. Clin. Exp. Res. 20: 293\u2013301","DOI":"10.1111\/j.1530-0277.1996.tb01642.x"},{"key":"BF1205016_CR13","doi-asserted-by":"crossref","unstructured":"Deaciuc IV, Fortunato F, D'Souza N, Hill D, McClain C . 2001 Hepatol. Res. 19: 306\u2013324","DOI":"10.1016\/S1386-6346(00)00112-1"},{"key":"BF1205016_CR14","doi-asserted-by":"crossref","unstructured":"Diehl AM . 1989 Med. Clin. North Am. 73: 815\u2013830","DOI":"10.1016\/S0025-7125(16)30640-X"},{"key":"BF1205016_CR15","doi-asserted-by":"crossref","unstructured":"Diehl AM . 1999a Alcohol. Clin. Exp. Res. 23: 1419\u20131424","DOI":"10.1111\/j.1530-0277.1999.tb04662.x"},{"key":"BF1205016_CR16","doi-asserted-by":"crossref","unstructured":"Diehl AM . 1999b Clin. Biochem. 32: 571\u2013578","DOI":"10.1016\/S0009-9120(99)00057-0"},{"key":"BF1205016_CR17","doi-asserted-by":"crossref","unstructured":"Ezure T, Sakamoto T, Tsuji H, Lunz III JG, Murase N, Fung JJ, Demetris AJ . 2000 Am. J. Pathol. 156: 1627\u20131639","DOI":"10.1016\/S0002-9440(10)65034-1"},{"key":"BF1205016_CR18","doi-asserted-by":"crossref","unstructured":"Fontanilla CV, Faunce DE, Gregory MS, Messingham KA, Durbin EA, Duffner LA, Kovacs EJ . 2000 Alcohol. Clin. Exp. Res. 24: 1392\u20131399","DOI":"10.1111\/j.1530-0277.2000.tb02108.x"},{"key":"BF1205016_CR19","doi-asserted-by":"crossref","unstructured":"Fuchs D, Gruber A, Uberall F, Wachter H . 1994 Immunol. Today 15: 496","DOI":"10.1016\/0167-5699(94)90197-X"},{"key":"BF1205016_CR20","doi-asserted-by":"crossref","unstructured":"Galun E, Zeira E, Pappo O, Peters M, Rose-John S . 2000 FASEB J. 14: 1979\u20131987","DOI":"10.1096\/fj.99-0913com"},{"key":"BF1205016_CR21","doi-asserted-by":"crossref","unstructured":"Goldin RD, Hunt NC, Clark J, Wickramasinghe SN . 1993 J. Pathol. 171: 73\u201376","DOI":"10.1002\/path.1711710115"},{"key":"BF1205016_CR22","doi-asserted-by":"crossref","unstructured":"Gonzalez-Quintela A, Dominguez-Santalla MJ, Perez LF, Vidal C, Lojo S, Barrio E . 2000 Cytokine 12: 1437\u20131440","DOI":"10.1006\/cyto.2000.0715"},{"key":"BF1205016_CR23","doi-asserted-by":"crossref","unstructured":"Grad J, Zeng X, Boise L . 2000 Curr. Opin. Oncol. 12: 543\u2013549","DOI":"10.1097\/00001622-200011000-00006"},{"key":"BF1205016_CR24","doi-asserted-by":"crossref","unstructured":"Hall PD . 1994 Alcohol. Suppl. 2: 303\u2013313","DOI":"10.1093\/rheumatology\/33.3.303"},{"key":"BF1205016_CR25","doi-asserted-by":"crossref","unstructured":"Halsted CH, Villanueva J, Chandler CJ, Stabler SP, Allen RH, Muskhelishvili L, James SJ, Poirier L . 1996 Hepatology 23: 497\u2013505","DOI":"10.1002\/hep.510230314"},{"key":"BF1205016_CR26","doi-asserted-by":"crossref","unstructured":"Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH . 2001 Mol. Ther. 3: 683\u2013687","DOI":"10.1006\/mthe.2001.0313"},{"key":"BF1205016_CR27","unstructured":"Hill DB, Marsano L, Cohen D, Allen J, Shedlofsky S, McClain CJ . 1992 J. Lab. Clin. Med. 119: 547\u2013552"},{"key":"BF1205016_CR28","doi-asserted-by":"crossref","unstructured":"Hong F, Nguyrn VA, Gao B . 2001 FASEB J. 15: 1595\u20131597","DOI":"10.1096\/fj.00-0908fje"},{"key":"BF1205016_CR29","doi-asserted-by":"crossref","unstructured":"Hong F, Nguyen VA, Shen X, Kunos G, Gao B . 2000 Biochem. Biophys. Res. Commun. 279: 974\u2013979","DOI":"10.1006\/bbrc.2000.4044"},{"key":"BF1205016_CR30","doi-asserted-by":"crossref","unstructured":"Kamimura S, Tsukamoto H . 1995 Hepatology 22: 1304\u20131309","DOI":"10.1002\/hep.1840220441"},{"key":"BF1205016_CR31","doi-asserted-by":"crossref","unstructured":"Kim W, Hong F, Jaruga B, Hu Z, Fan S, Liang J, Gao B . 2001 FASEB J. 15: in press","DOI":"10.1096\/fj.01-0217"},{"key":"BF1205016_CR32","doi-asserted-by":"crossref","unstructured":"Kovalovich K, DeAngelis RA, Li W, Furth EE, Ciliberto G, Taub R . 2000 Hepatology 31: 149\u2013159","DOI":"10.1002\/hep.510310123"},{"key":"BF1205016_CR33","doi-asserted-by":"crossref","unstructured":"Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G, Taub R . 2001 J. Biol. Chem. 276: 26605\u201326613","DOI":"10.1074\/jbc.M100740200"},{"key":"BF1205016_CR34","doi-asserted-by":"crossref","unstructured":"Kuo ML, Chuang SE, Lin MT, Yang SY . 2001 Oncogene 20: 677\u2013685","DOI":"10.1038\/sj.onc.1204140"},{"key":"BF1205016_CR35","doi-asserted-by":"crossref","unstructured":"Kurose I, Higuchi H, Miura S, Saito H, Watanabe N, Hokari R, Hirokawa M, Takaishi M, Zeki S, Nakamura T, Ebinuma H, Kato S, Ishii H . 1997 Hepatology 25: 368\u2013378","DOI":"10.1002\/hep.510250219"},{"key":"BF1205016_CR36","doi-asserted-by":"crossref","unstructured":"Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A . 1996 Nat. Med. 2: 80\u201386","DOI":"10.1038\/nm0196-80"},{"key":"BF1205016_CR37","doi-asserted-by":"crossref","unstructured":"Laso FJ, Iglesias-Osma C, Ciudad J, Lopez A, Pastor I, Orfao A . 1999 Alcohol. Clin. Exp. Res. 23: 1306\u20131311","DOI":"10.1111\/j.1530-0277.1999.tb04351.x"},{"key":"BF1205016_CR38","doi-asserted-by":"crossref","unstructured":"Maddrey WC . 2000 Clin. Liver Dis. 4: 115\u2013131 vii","DOI":"10.1016\/S1089-3261(05)70099-4"},{"key":"BF1205016_CR39","doi-asserted-by":"crossref","unstructured":"Martinez F, Abril ER, Earnest DL, Watson RR . 1992 Alcohol 9: 455\u2013458","DOI":"10.1016\/0741-8329(92)90080-T"},{"key":"BF1205016_CR40","doi-asserted-by":"crossref","unstructured":"McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D . 1999 Semin. Liver Dis. 19: 205\u2013219","DOI":"10.1055\/s-2007-1007110"},{"key":"BF1205016_CR41","doi-asserted-by":"crossref","unstructured":"Mi LJ, Mak KM, Lieber CS . 2000 Alcohol. Clin. Exp. Res. 24: 207\u2013212","DOI":"10.1111\/j.1530-0277.2000.tb04592.x"},{"key":"BF1205016_CR42","doi-asserted-by":"crossref","unstructured":"Panesar N, Tolman K, Mazuski JE . 1999 J. Surg. Res. 85: 251\u2013258","DOI":"10.1006\/jsre.1999.5648"},{"key":"BF1205016_CR43","doi-asserted-by":"crossref","unstructured":"Pastorino JG, Hoek JB . 2000 Hepatology 31: 1141\u20131152","DOI":"10.1053\/he.2000.7013"},{"key":"BF1205016_CR44","doi-asserted-by":"crossref","unstructured":"Pennington HL, Hall PM, Wilce PA, Worrall S . 1997 J. Gastroenterol. Hepatol. 12: 305\u2013313","DOI":"10.1111\/j.1440-1746.1997.tb00426.x"},{"key":"BF1205016_CR45","doi-asserted-by":"crossref","unstructured":"Rashid A, Wu TC, Huang CC, Chen CH, Lin HZ, Yang SQ, Lee FY, Diehl AM . 1999 Hepatology 29: 1131\u20131138","DOI":"10.1002\/hep.510290428"},{"key":"BF1205016_CR46","doi-asserted-by":"crossref","unstructured":"Rollwagen FM, Yu ZY, Li YY, Pacheco ND . 1998 Clin. Immunol. Immunopathol 89: 205\u2013213","DOI":"10.1006\/clin.1998.4600"},{"key":"BF1205016_CR47","doi-asserted-by":"crossref","unstructured":"Sasaki Y, Wands JR . 1994 Biochem. Biophys. Res. Commun. 199: 403\u2013409","DOI":"10.1006\/bbrc.1994.1243"},{"key":"BF1205016_CR48","unstructured":"Sheron N, Bird G, Goka J, Alexander G, Williams R . 1991 Clin. Exp. Immunol. 84: 449\u2013453"},{"key":"BF1205016_CR49","doi-asserted-by":"crossref","unstructured":"Slomiany A, Piotrowski E, Grabska M, Piotrowski J, Slomiany BL . 1999 Alcohol. Clin. Exp. Res. 23: 334\u2013343","DOI":"10.1111\/j.1530-0277.1999.tb04119.x"},{"key":"BF1205016_CR50","doi-asserted-by":"crossref","unstructured":"Tuma DJ, Todero SL, Barak-Bernhagen M, Sorrell MF . 1996 Alcohol. Clin. Exp. Res. 20: 579\u2013583","DOI":"10.1111\/j.1530-0277.1996.tb01096.x"},{"key":"BF1205016_CR51","doi-asserted-by":"crossref","unstructured":"Walsh K, Alexander G . 2000 Postgrad. Med. J. 76: 280\u2013286","DOI":"10.1136\/pmj.76.895.280"},{"key":"BF1205016_CR52","doi-asserted-by":"crossref","unstructured":"Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA . 2000 Am. J. Respir. Cell. Mol. Biol. 22: 535\u2013542","DOI":"10.1165\/ajrcmb.22.5.3808"},{"key":"BF1205016_CR53","doi-asserted-by":"crossref","unstructured":"Yacoub LK, Fogt F, Griniuviene B, Nanji AA . 1995 Alcohol. Clin. Exp. Res. 19: 854\u2013859","DOI":"10.1111\/j.1530-0277.1995.tb00958.x"},{"key":"BF1205016_CR54","doi-asserted-by":"crossref","unstructured":"Yin M, Wheeler MD, Kono H, Bradford BU, Gallucci RM, Luster MI, Thurman RG . 1999 Gastroenterology 117: 942\u2013952","DOI":"10.1016\/S0016-5085(99)70354-9"},{"key":"BF1205016_CR55","unstructured":"Zhang B, Zhang D, Ren H . 2000 Zhonghua Gan Zang Bing Za Zhi 8: 215\u2013217"},{"key":"BF1205016_CR56","doi-asserted-by":"crossref","unstructured":"Zhao M, Laissue JA, Zimmermann A . 1997 Virchows Arch 431: 337\u2013344","DOI":"10.1007\/s004280050108"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1205016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1205016","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1205016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:57:19Z","timestamp":1647910639000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1205016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,3]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,3]]}},"alternative-id":["BF1205016"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1205016","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,3]]},"assertion":[{"value":"22 June 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}