{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:22:19Z","timestamp":1790400139265,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"26","license":[{"start":{"date-parts":[[2002,6,5]],"date-time":"2002-06-05T00:00:00Z","timestamp":1023235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,6,5]],"date-time":"2002-06-05T00:00:00Z","timestamp":1023235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2002,6,13]]},"DOI":"10.1038\/sj.onc.1205520","type":"journal-article","created":{"date-parts":[[2002,9,3]],"date-time":"2002-09-03T22:14:18Z","timestamp":1031091258000},"page":"4171-4175","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pathological splice mutations outside the invariant AG\/GT splice sites of BRCA1 exon 5 increase alternative transcript levels in the 5\u2032 end of the BRCA1 gene"],"prefix":"10.1038","volume":"21","author":[{"given":"Kathleen","family":"Claes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Vandesompele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Poppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Coene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"De Paepe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludwine","family":"Messiaen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,6,5]]},"reference":[{"key":"BF1205520_CR1","doi-asserted-by":"crossref","unstructured":"Abel KJ, Xu J, Yin GY, Lyons RH, Meisler MH, Weber BL . 1995 Hum. Mol. Genet. 4: 2265\u20132273","DOI":"10.1093\/hmg\/4.12.2265"},{"key":"BF1205520_CR2","doi-asserted-by":"crossref","unstructured":"Berget SM . 1995 J. Biol. Chem. 270: 2411\u20132414","DOI":"10.1074\/jbc.270.6.2411"},{"key":"BF1205520_CR3","doi-asserted-by":"crossref","unstructured":"Claes K. Machackova E, De Vos M, Poppe B, De Paepe A, Messiaen L . 1999 Dis. Markers 15: 69\u201373","DOI":"10.1155\/1999\/241046"},{"key":"BF1205520_CR4","unstructured":"Easton DF, Bishop DT, Ford D, Crockford GP . 1993 Am. J. Hum. Genet. 52: 678\u2013701"},{"key":"BF1205520_CR5","doi-asserted-by":"crossref","unstructured":"Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM . 2001a Oncogene 20: 77\u201387","DOI":"10.1038\/sj.onc.1204073"},{"key":"BF1205520_CR6","doi-asserted-by":"crossref","unstructured":"Fan S, Yuan Rq RQ, Ma YX, Meng Q, Goldberg ID, Rosen EM . 2001b Oncogene 20: 8215\u20138235","DOI":"10.1038\/sj.onc.1205033"},{"key":"BF1205520_CR7","doi-asserted-by":"crossref","unstructured":"Ge K, DuHadaway J, Du W, Herlyn M, Rodeck U, Prendergast GC . 1999 Proc. Natl. Acad. Sci. USA 96: 9689\u20139694","DOI":"10.1073\/pnas.96.17.9689"},{"key":"BF1205520_CR8","unstructured":"Gudas JM, Li T, Nguyen H, Jensen D, Rauscher III FJ, Cowan KH . 1996 Cell. Growth Differ. 7: 717\u2013723"},{"key":"BF1205520_CR9","doi-asserted-by":"crossref","unstructured":"Kudoh T, Ishidate T, Moriyama M, Toyoshima K, Akiyama T . 1995 Proc. Natl. Acad. Sci. USA 92: 4517\u20134521","DOI":"10.1073\/pnas.92.10.4517"},{"key":"BF1205520_CR10","doi-asserted-by":"crossref","unstructured":"Marquis ST, Rajan JV, Wynshaw-Boris A, Xu J, Yin GY, Abel KJ, Weber BL, Chodosh LA . 1995 Nat. Genet. 11: 17\u201326","DOI":"10.1038\/ng0995-17"},{"key":"BF1205520_CR11","doi-asserted-by":"crossref","unstructured":"Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholanni Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barret JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Skolnick MH . 1994 Science 266: 66\u201371","DOI":"10.1126\/science.7545954"},{"key":"BF1205520_CR12","doi-asserted-by":"crossref","unstructured":"Ohno K, Brengman JM, Felice KJ, Cornblath DR, Engel AG . 1999 Am. J. Hum. Genet. 65: 635\u2013644","DOI":"10.1086\/302551"},{"key":"BF1205520_CR13","doi-asserted-by":"crossref","unstructured":"Pummi K, Yla-Outinen H, Peltonen J . 2000 Arch. Dermatol. Res. 292: 422\u2013424","DOI":"10.1007\/s004030000155"},{"key":"BF1205520_CR14","doi-asserted-by":"crossref","unstructured":"Shapiro MB, Senapathy P . 1987 Nuc. Acids Res. 15: 7155\u20137174","DOI":"10.1093\/nar\/15.17.7155"},{"key":"BF1205520_CR15","doi-asserted-by":"crossref","unstructured":"Singh R, Valcarcel J, Green MR . 1995 Science 268: 1173\u20131176","DOI":"10.1126\/science.7761834"},{"key":"BF1205520_CR16","unstructured":"Tomlinson GE, Chen TT, Stastny VA, Virmani AK, Spillman MA, Tonk V, Blum JL, Schneider NR, Wistuba II, Shay JW, Minna JD, Gazdar AF . 1998 Cancer Res. 58: 3237\u20133242"},{"key":"BF1205520_CR17","unstructured":"Vandenbroucke I, Vandesompele J, De Paepe A, Messiaen L . 2001 Nucl. Acids Res. 29: E68\u2013E68"},{"key":"BF1205520_CR18","unstructured":"Vandesompele et al . 2002 In press"},{"key":"BF1205520_CR19","unstructured":"Vaughn JP, Davis PL, Jarboe MD, Huper G, Evans AC, Wiseman RW, Berchuck A, Iglehart JD, Futreal PA, Marks JR . 1996 Cell. Growth Differ. 7: 711\u2013715"},{"key":"BF1205520_CR20","doi-asserted-by":"crossref","unstructured":"Welcsh PL, King MC . 2001 Hum. Mol. Genet. 10: 705\u2013713","DOI":"10.1093\/hmg\/10.7.705"},{"key":"BF1205520_CR21","doi-asserted-by":"crossref","unstructured":"Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G . 1995 Nature 378: 789\u2013792","DOI":"10.1038\/378789a0"},{"key":"BF1205520_CR22","doi-asserted-by":"crossref","unstructured":"Yan H, Dobbie Z, Gruber SB, Markowitz S, Romans K, Giardiello FM, Kinzler KW, Vogelstein B . 2001 Nat. Genet. 30: 25\u201326","DOI":"10.1038\/ng799"},{"key":"BF1205520_CR23","doi-asserted-by":"crossref","unstructured":"Zamore PD, Patton JG, Green MR . 1992 Nature 355: 609\u2013614","DOI":"10.1038\/355609a0"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1205520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1205520","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1205520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T03:18:41Z","timestamp":1647919121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1205520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6,5]]},"references-count":23,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2002,6,13]]}},"alternative-id":["BF1205520"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1205520","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6,5]]},"assertion":[{"value":"29 January 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2002","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2002","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2002","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}