{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:52:50Z","timestamp":1792810370492,"version":"4.5.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"15","license":[{"start":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T00:00:00Z","timestamp":1050537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T00:00:00Z","timestamp":1050537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2003,4,17]]},"DOI":"10.1038\/sj.onc.1206421","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T08:20:32Z","timestamp":1050567632000},"page":"2226-2235","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["Pathogenesis of DNA repair-deficient cancers: a statistical meta-analysis of putative Real Common Target genes"],"prefix":"10.1038","volume":"22","author":[{"given":"Stefan M","family":"Woerner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Benner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan P","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peer","family":"Bork","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus von Knebel","family":"Doeberitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes F","family":"Gebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,4,17]]},"reference":[{"key":"BF1206421_CR1","doi-asserted-by":"crossref","unstructured":"Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin JP, Jarvinen H, Powell SM, Jen J and Hamilton SR . (1993). Science, 260, 812\u2013816.","DOI":"10.1126\/science.8484121"},{"key":"BF1206421_CR2","doi-asserted-by":"crossref","unstructured":"Bicknell DC, Kaklamanis L, Hampson R, Bodmer WF and Karran P . (1996). Curr. Biol., 6, 1695\u20131697.","DOI":"10.1016\/S0960-9822(02)70795-1"},{"key":"BF1206421_CR3","unstructured":"Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, Meltzer SJ, Rodriguez-Bigas MA, Fodde R, Ranzani GN and Srivastava S . (1998). Cancer Res., 58, 5248\u20135257."},{"key":"BF1206421_CR4","doi-asserted-by":"crossref","unstructured":"Chadwick RB, Jiang GL, Bennington GA, Yuan B, Johnson CK, Stevens MW, Niemann TH, Peltomaki P, Huang S and de la Chapelle A . (2000). Proc. Natl. Acad. Sci. USA, 97, 2662\u20132667.","DOI":"10.1073\/pnas.040579497"},{"key":"BF1206421_CR5","unstructured":"Duval A, Gayet J, Zhou XP, Iacopetta B, Thomas G and Hamelin R . (1999). Cancer Res., 59, 4213\u20134215."},{"key":"BF1206421_CR6","unstructured":"Duval A, Rolland S, Compoint A, Tubacher E, Iacopetta B, Thomas G and Hamelin R . (2001). Hum. Mol. Genet., 10, 513\u2013518."},{"key":"BF1206421_CR7","unstructured":"Duval A and Hamelin R . (2002). Cancer Res., 62, 2447\u20132454."},{"key":"BF1206421_CR8","unstructured":"Duval A, Reperant M, Compoint A, Seruca R, Ranzani GN, Iacopetta B and Hamelin R . (2002). Cancer Res., 62, 1609\u20131612."},{"key":"BF1206421_CR9","doi-asserted-by":"crossref","unstructured":"Hediger MA . (2002). Nat. Med., 8, 445\u2013446.","DOI":"10.1038\/nm0502-445"},{"key":"BF1206421_CR10","volume-title":"A Practical Guide with \u03b4-Plus Examples","author":"S Huet","year":"1996","unstructured":"Huet S, Bouvier A, Gruet M and Jolivet E . (1996). Statistical tools for nonlinear regression. A Practical Guide with \u03b4-Plus Examples. Springer, New York."},{"key":"BF1206421_CR11","doi-asserted-by":"crossref","unstructured":"Ionov Y, Peinado MA, Malkhosyan S, Shibata D and Perucho M . (1993). Nature, 363, 558\u2013561.","DOI":"10.1038\/363558a0"},{"key":"BF1206421_CR12","doi-asserted-by":"crossref","unstructured":"Ionov Y, Yamamoto H, Krajewski S, Reed JC and Perucho M . (2000). Proc. Natl. Acad. Sci. USA, 97, 10872\u201310877.","DOI":"10.1073\/pnas.190210897"},{"key":"BF1206421_CR13","doi-asserted-by":"crossref","unstructured":"Konishi M, Kikuchi-Yanoshita R, Tanaka K, Muraoka M, Onda A, Okumura Y, Kishi N, Iwama T, Mori T, Koike M, Ushio K, Chiba M, Nomizu S, Konishi F, Utsunomiya J and Miyaki M . (1996). Gastroenterology, 111, 307\u2013317.","DOI":"10.1053\/gast.1996.v111.pm8690195"},{"key":"BF1206421_CR14","doi-asserted-by":"crossref","unstructured":"Kunkel TA and Bebenek K . (2000). Annu. Rev. Biochem., 69, 497\u2013529.","DOI":"10.1146\/annurev.biochem.69.1.497"},{"key":"BF1206421_CR15","doi-asserted-by":"crossref","unstructured":"Lengauer C, Kinzler KW and Vogelstein B . (1997). Nature, 386, 623\u2013627.","DOI":"10.1038\/386623a0"},{"key":"BF1206421_CR16","doi-asserted-by":"crossref","unstructured":"Lengauer C, Kinzler KW and Vogelstein B . (1998). Nature, 396, 643\u2013649.","DOI":"10.1038\/25292"},{"key":"BF1206421_CR17","doi-asserted-by":"crossref","unstructured":"Liu W, Dong X, Mai M, Seelan RS, Taniguchi K, Krishnadath KK, Halling KC, Cunningham JM, Boardman LA, Qian C, Christensen E, Schmidt SS, Roche PC, Smith DI and Thibodeau SN . (2000). Nat. Genet., 26, 146\u2013147.","DOI":"10.1038\/79859"},{"key":"BF1206421_CR18","unstructured":"Loeb LA . (2001). Cancer Res., 61, 3230\u20133239."},{"key":"BF1206421_CR19","doi-asserted-by":"crossref","unstructured":"Malkhosyan S, Rampino N, Yamamoto H and Perucho M . (1996). Nature, 382, 499\u2013500.","DOI":"10.1038\/382499a0"},{"key":"BF1206421_CR20","doi-asserted-by":"crossref","unstructured":"Markowitz S, Wang J, Myeroff L, Parsons R, Sun L, Lutterbaugh J, Fan RS, Zborowska E, Kinzler KW and Vogelstein B . (1995). Science, 268, 1336\u20131338.","DOI":"10.1126\/science.7761852"},{"key":"BF1206421_CR21","doi-asserted-by":"crossref","unstructured":"Mignone F, Gissi C, Liuni, S and Pesole G . (2002). Genome Biol., 3, REVIEWS0004, 1\u201310.","DOI":"10.1186\/gb-2002-3-3-reviews0004"},{"key":"BF1206421_CR22","unstructured":"Mori Y, Yin J, Rashid A, Leggett BA, Young J, Simms L, Kuehl PM, Langenberg P, Meltzer SJ and Stine OC . (2001). Cancer Res., 61, 6046\u20136049."},{"key":"BF1206421_CR23","unstructured":"Myeroff LL, Parsons R, Kim SJ, Hedrick L, Cho KR, Orth K, Mathis M, Kinzler KW, Lutterbaugh J and Park K . (1995). Cancer Res., 55, 5545\u20135547."},{"key":"BF1206421_CR24","doi-asserted-by":"crossref","unstructured":"O'Donnell M, Jeruzalmi D and Kuriyan J . (2001). Curr. Biol., 11, R935\u2013R946.","DOI":"10.1016\/S0960-9822(01)00559-0"},{"key":"BF1206421_CR25","doi-asserted-by":"crossref","unstructured":"Perucho M, Peinado MA, Ionov Y, Casares S, Malkhosyan S and Stanbridge E . (1994). Cold Spring Harb. Symp. Quant. Biol., 59, 339\u2013348.","DOI":"10.1101\/SQB.1994.059.01.038"},{"key":"BF1206421_CR26","doi-asserted-by":"crossref","unstructured":"Perucho M . (1999). Cancer Res., 59, 249\u2013256.","DOI":"10.1093\/analys\/59.4.249"},{"key":"BF1206421_CR27","unstructured":"Piao Z, Fang W, Malkhosyan S, Kim H, Horii A, Perucho M and Huang S . (2000). Cancer Res., 60, 4701\u20134704."},{"key":"BF1206421_CR28","doi-asserted-by":"crossref","unstructured":"Rampino N, Yamamoto H, Ionov Y, Li Y, Sawai H, Reed JC and Perucho M . (1997). Science, 275, 967\u2013969.","DOI":"10.1126\/science.275.5302.967"},{"key":"BF1206421_CR29","doi-asserted-by":"crossref","unstructured":"Sagher D, Hsu A and Strauss B . (1999). Mutat. Res., 423, 73\u201377.","DOI":"10.1016\/S0027-5107(98)00227-9"},{"key":"BF1206421_CR30","doi-asserted-by":"crossref","unstructured":"Sakurada K, Furukawa T, Kato Y, Kayama T, Huang S and, Horii A . (2001). Genes Chromosomes Cancer, 30, 207\u2013211.","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1080>3.0.CO;2-V"},{"key":"BF1206421_CR31","unstructured":"Schwartz Jr S, Yamamoto H, Navarro M, Maestro M, Reventos J and Perucho M . (1999). Cancer Res., 59, 2995\u20133002."},{"key":"BF1206421_CR32","doi-asserted-by":"crossref","unstructured":"Sia EA, Kokoska RJ, Dominska M, Greenwell P and Petes TD . (1997). Mol. Cell. Biol., 17, 2851\u20132858.","DOI":"10.1128\/MCB.17.5.2851"},{"key":"BF1206421_CR33","doi-asserted-by":"crossref","unstructured":"Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, Miller GF, Kwon O, Levine M, Guttentag SH and Nussbaum RL . (2002). Nat. Med., 8, 514\u2013517.","DOI":"10.1038\/0502-514"},{"key":"BF1206421_CR34","doi-asserted-by":"crossref","unstructured":"Souza RF, Appel R, Yin J, Wang S, Smolinski KN, Abraham JM, Zou TT, Shi YQ, Lei J, Cottrell J, Cymes K, Biden K, Simms L, Leggett B, Lynch PM, Frazier M, Powell SM, Harpaz N, Sugimura H, Young J and Meltzer SJ . (1996). Nat. Genet., 14, 255\u2013257.","DOI":"10.1038\/ng1196-255"},{"key":"BF1206421_CR35","doi-asserted-by":"crossref","unstructured":"Souza RF, Wang S, Thakar M, Smolinski KN, Yin J, Zou TT, Kong D, Abraham JM, Toretsky JA and Meltzer SJ . (1999). Oncogene, 18, 4063\u20134068.","DOI":"10.1038\/sj.onc.1202768"},{"key":"BF1206421_CR36","doi-asserted-by":"crossref","unstructured":"Thibodeau SN, Bren G and Schaid D . (1993). Science, 260, 816\u2013819.","DOI":"10.1126\/science.8484122"},{"key":"BF1206421_CR37","doi-asserted-by":"crossref","unstructured":"Woerner SM, Gebert J, Yuan YP, Sutter C, Ridder R, Bork P and von Knebel Doeberitz M . (2001). Int. J. Cancer, 93, 12\u201319.","DOI":"10.1002\/ijc.1299"},{"key":"BF1206421_CR38","unstructured":"Zhang L, Yu J, Willson JK, Markowitz SD, Kinzler KW and Vogelstein B . (2001). Cancer Res., 61, 3801\u20133805. References of Supplemental Tables (available at http:\/\/www.med.uni-heidelberg.de\/patho\/pathomol\/woerner\/model_real_targets\/)"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1206421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1206421","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1206421.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T02:18:25Z","timestamp":1647915505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1206421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4,17]]},"references-count":38,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2003,4,17]]}},"alternative-id":["BF1206421"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1206421","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,4,17]]},"assertion":[{"value":"25 July 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}