{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:00:04Z","timestamp":1790964004040,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"25","license":[{"start":{"date-parts":[[2003,6,17]],"date-time":"2003-06-17T00:00:00Z","timestamp":1055808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2003,6,17]],"date-time":"2003-06-17T00:00:00Z","timestamp":1055808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2003,6,19]]},"DOI":"10.1038\/sj.onc.1206426","type":"journal-article","created":{"date-parts":[[2003,6,18]],"date-time":"2003-06-18T11:01:10Z","timestamp":1055934070000},"page":"3875-3887","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":113,"title":["Activation of \u03b2-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation"],"prefix":"10.1038","volume":"22","author":[{"given":"Brian","family":"Bierie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Renou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M","family":"Shillingford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanta","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takami","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto M","family":"Taketo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Cardiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay-Uwe","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertraud W","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Hennighausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2003,6,17]]},"reference":[{"key":"BF1206426_CR1","doi-asserted-by":"crossref","unstructured":"Achtstatter T, Moll R, Moore B and Franke WW . (1985). J. Histochem. Cytochem., 33, 415\u2013426.","DOI":"10.1177\/33.5.2580881"},{"issue":"14","key":"BF1206426_CR2","doi-asserted-by":"publisher","first-page":"4075","DOI":"10.1093\/emboj\/17.14.4075","volume":"17","author":"Arthur S Alberts","year":"1998","unstructured":"Alberts AS and Treisman R . (1998). EMBO J., 17, 4075\u20134085.","journal-title":"The EMBO Journal"},{"key":"BF1206426_CR3","doi-asserted-by":"crossref","unstructured":"Barresi G and Tuccari G . (1984). Virchows Arch. A., 403, 59\u201366.","DOI":"10.1007\/BF00689338"},{"key":"BF1206426_CR4","doi-asserted-by":"crossref","unstructured":"Baruch RR, Melinscak H, Lo J, Liu Y, Yeung O and Hurta RA . (2001). Cell Biol. Int., 25, 411\u2013420.","DOI":"10.1006\/cbir.2000.0647"},{"key":"BF1206426_CR5","doi-asserted-by":"crossref","unstructured":"Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O and Kemler R . (2001). Development, 128, 1253\u20131264.","DOI":"10.1242\/dev.128.8.1253"},{"issue":"17","key":"BF1206426_CR6","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1038\/sj.onc.1205352","volume":"21","author":"Dennis R Chesire","year":"2002","unstructured":"Chesire DR, Ewing CM, Gage WR and Isaacs WB . (2002). Oncogene, 21, 2679\u20132694.","journal-title":"Oncogene"},{"issue":"4","key":"BF1206426_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/1097-0045(20001201)45:4<323::AID-PROS7>3.0.CO;2-W","volume":"45","author":"Dennis R. Chesire","year":"2000","unstructured":"Chesire DR, Ewing CM, Sauvageot J, Bova GS and Isaacs WB . (2000). Prostate, 45, 323\u2013334.","journal-title":"The Prostate"},{"key":"BF1206426_CR8","doi-asserted-by":"crossref","unstructured":"de Lau W and Clevers H . (2001). Nat. Genet., 28, 3\u20134.","DOI":"10.1038\/88233"},{"key":"BF1206426_CR9","unstructured":"DeOme KB, Faulkin Jr LJ, Bern HA and Blair PE . (1959). Cancer Res., 19, 515\u2013520."},{"key":"BF1206426_CR10","doi-asserted-by":"crossref","unstructured":"Fischer DF, van Drunen CM, Winkler GS, van de Putte P and Backendorf C . (1998). Nucleic Acids Res., 26, 5288\u20135294.","DOI":"10.1093\/nar\/26.23.5288"},{"key":"BF1206426_CR11","doi-asserted-by":"crossref","unstructured":"Fuchs E and Byrne C . (1994). Curr. Opin. Genet. Dev., 4, 725\u2013736.","DOI":"10.1016\/0959-437X(94)90140-X"},{"issue":"5","key":"BF1206426_CR12","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/S0092-8674(00)81631-1","volume":"95","author":"Uri Gat","year":"1998","unstructured":"Gat U, DasGupta R, Degenstein L and Fuchs E . (1998). Cell, 95, 605\u2013614.","journal-title":"Cell"},{"key":"BF1206426_CR13","doi-asserted-by":"crossref","unstructured":"Gerstein AV, Almeida TA, Zhao G, Chess E, Shih Ie M, Buhler K, Pienta K, Rubin MA, Vessella R and Papadopoulos N . (2002). Genes Chromosomes Cancer, 34, 9\u201316.","DOI":"10.1002\/gcc.10037"},{"issue":"26","key":"BF1206426_CR14","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1038\/sj.onc.1205562","volume":"21","author":"Fotini Gounari","year":"2002","unstructured":"Gounari F, Signoretti S, Bronson R, Klein L, Sellers WR, Kum J, Siermann A, Taketo MM, von Boehmer H and Khazaie K . (2002). Oncogene, 21, 4099\u20134107.","journal-title":"Oncogene"},{"key":"BF1206426_CR15","doi-asserted-by":"crossref","unstructured":"Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K and Kemler R . (1995). Development, 121, 3529\u20133537.","DOI":"10.1242\/dev.121.11.3529"},{"key":"BF1206426_CR16","unstructured":"Harada N, Miyoshi H, Murai N, Oshima H, Tamai Y, Oshima M and Taketo MM . (2002). Cancer Res., 62, 1971\u20131977."},{"key":"BF1206426_CR17","doi-asserted-by":"crossref","unstructured":"Harada N, Tamai Y, Ishikawa T, Sauer B, Takaku K, Oshima M and Taketo MM . (1999). EMBO J., 18, 5931\u20135942.","DOI":"10.1093\/emboj\/18.21.5931"},{"issue":"1","key":"BF1206426_CR18","first-page":"53","volume":"28","author":"Karine Hovanes","year":"2001","unstructured":"Hovanes K, Li TW, Munguia JE, Truong T, Milovanovic T, Lawrence Marsh J, Holcombe RF and Waterman ML . (2001). Nat. Genet., 28, 53\u201357.","journal-title":"Nature Genetics"},{"key":"BF1206426_CR19","doi-asserted-by":"crossref","unstructured":"Huelsken J and Birchmeier W . (2001). Curr. Opin. Genet. Dev., 11, 547\u2013553.","DOI":"10.1016\/S0959-437X(00)00231-8"},{"key":"BF1206426_CR20","doi-asserted-by":"crossref","unstructured":"Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C and Birchmeier W . (2000). J. Cell Biol., 148, 567\u2013578.","DOI":"10.1083\/jcb.148.3.567"},{"issue":"4","key":"BF1206426_CR21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(01)00336-1","volume":"105","author":"Joerg Huelsken","year":"2001","unstructured":"Huelsken J, Vogel R, Erdmann B, Cotsarelis G and Birchmeier W . (2001). Cell, 105, 533\u2013545.","journal-title":"Cell"},{"key":"BF1206426_CR22","unstructured":"Humphreys RC and Hennighausen L . (1999). Cell Growth Differ., 10, 685\u2013694."},{"key":"BF1206426_CR23","unstructured":"Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS . (2001). Clin. Cancer Res., 7, 3113\u20133119."},{"issue":"6802","key":"BF1206426_CR24","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/35030112","volume":"407","author":"Motonari Kondo","year":"2000","unstructured":"Kondo M, Scherer DC, Miyamoto T, King AG, Akashi K, Sugamura K and Weissman IL (2000). Nature, 407, 383\u2013386.","journal-title":"Nature"},{"issue":"45","key":"BF1206426_CR25","doi-asserted-by":"publisher","first-page":"43216","DOI":"10.1074\/jbc.M207662200","volume":"277","author":"Andrea Krempler","year":"2002","unstructured":"Krempler A, Henry MD, Triplet AA and Wagner KU . (2002). J. Biol. Chem., 277, 43216\u201343223.","journal-title":"Journal of Biological Chemistry"},{"issue":"38","key":"BF1206426_CR26","doi-asserted-by":"publisher","first-page":"27249","DOI":"10.1074\/jbc.274.38.27249","volume":"274","author":"Xin-Fang Li","year":"1999","unstructured":"Li XF, Thinakaran G, Sisodia SS and Yu FS . (1999). J. Biol. Chem., 274, 27249\u201327256.","journal-title":"Journal of Biological Chemistry"},{"key":"BF1206426_CR27","doi-asserted-by":"crossref","unstructured":"Liu X, Robinson GW and Hennighausen L . (1996). Mol. Endocrinol., 10, 1496\u20131506.","DOI":"10.1210\/mend.10.12.8961260"},{"key":"BF1206426_CR28","doi-asserted-by":"crossref","unstructured":"Liu X, Robinson GW, Wagner KU, Garrett L, Wynshaw-Boris A and Hennighausen L . (1997). Genes Dev., 11, 179\u2013186.","DOI":"10.1101\/gad.11.2.179"},{"issue":"5036","key":"BF1206426_CR29","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1126\/science.1962194","volume":"254","author":"P. McCrea","year":"1991","unstructured":"McCrea PD, Turck CW and Gumbiner B . (1991). Science, 254, 1359\u20131361.","journal-title":"Science"},{"key":"BF1206426_CR30","doi-asserted-by":"crossref","unstructured":"Merrill BJ, Gat U, DasGupta R and Fuchs E . (2001). Genes Dev., 15, 1688\u20131705.","DOI":"10.1101\/gad.891401"},{"key":"BF1206426_CR31","doi-asserted-by":"crossref","unstructured":"Miyoshi K, Shillingford JM, Smith GH, Grimm SL, Wagner KU, Oka T, Rosen JM, Robinson GW and Hennighausen, L . (2001). J. Cell Biol., 155, 531\u2013542.","DOI":"10.1083\/jcb.200107065"},{"key":"BF1206426_CR32","doi-asserted-by":"crossref","unstructured":"Miyoshi K, Meyer B, Gruss P, Cui Y, Renou JP, Morgan FV, Smith GH, Reichenstein M, Shani, M and Hennighausen, L and Robinson, GW . (2002b). Mol. Endocrinol., 16, 2892\u20132901.","DOI":"10.1210\/me.2002-0128"},{"key":"BF1206426_CR33","doi-asserted-by":"crossref","unstructured":"Miyoshi K, Rosner A, Nozawa M, Byrd C, Morgan F, Landesman-Bollag E, Xu X, Seldin DC, Schmidt EV, Taketo MM, Robinson GW, Cardiff RD and Hennighausen L . (2000c). Oncogene, 21, 5548\u20135556.","DOI":"10.1038\/sj.onc.1205686"},{"key":"BF1206426_CR34","doi-asserted-by":"crossref","unstructured":"Miyoshi K, Shillingford JM, Le Provost F, Gounari F, Bronson R, von Boehmer H, Taketo MM, Cardiff RD, Hennighausen L and Khazaie K . (2002a). Proc. Natl. Acad. Sci. USA, 99, 219\u2013224.","DOI":"10.1073\/pnas.012414099"},{"key":"BF1206426_CR35","doi-asserted-by":"crossref","unstructured":"Nevalainen MT, Ahonen TJ, Yamashita H, Chandrashekar V, Bartke A, Grimley PM, Robinson GW, Hennighausen L and Rui H . (2000). Lab. Invest., 80, 993\u20131006.","DOI":"10.1038\/labinvest.3780105"},{"key":"BF1206426_CR36","doi-asserted-by":"crossref","unstructured":"Niemann C, Owens DM, Hulsken J, Birchmeier W and Watt PM . (2002). Development, 129, 95\u2013109.","DOI":"10.1242\/dev.129.1.95"},{"key":"BF1206426_CR37","doi-asserted-by":"crossref","unstructured":"Oettgen P, Kas K, Dube A, Gu X, Grall F, Thamrongsak U, Akbarali Y, Finger E, Boltax J, Endress G, Munger K, Kunsch C and Libermann TA . (1999). J. Biol. Client., 274, 29439\u201329452.","DOI":"10.1074\/jbc.274.41.29439"},{"key":"BF1206426_CR38","doi-asserted-by":"crossref","unstructured":"Polakis P . (2000). Genes Dev., 14, 1837\u20131851.","DOI":"10.1101\/gad.14.15.1837"},{"issue":"1","key":"BF1206426_CR39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/pros.2990200109","volume":"20","author":"Jeffrey H. Reese","year":"1992","unstructured":"Reese JH, McNeal JE, Goldenberg SL, Redwine EA and Sellers RG . (1992). Prostate, 20, 73\u201385.","journal-title":"The Prostate"},{"key":"BF1206426_CR40","doi-asserted-by":"crossref","unstructured":"Robinson GW, McKnight RA, Smith GH, Hennighausen L . (1995). Development, 121, 2079\u20132090.","DOI":"10.1242\/dev.121.7.2079"},{"key":"BF1206426_CR41","doi-asserted-by":"crossref","unstructured":"Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J and Iruela-Arispe ML . (2001). Proc. Natl. Acad. Sci. USA, 98, 12485\u201312490.","DOI":"10.1073\/pnas.171460498"},{"key":"BF1206426_CR42","doi-asserted-by":"crossref","unstructured":"Roose J, Huls G, van Beest M, Moerer P, van der Horn K, Goldschmeding R, Logtenberg T and Clevers H . (1999). Science, 285, 1923\u20131926.","DOI":"10.1126\/science.285.5435.1923"},{"key":"BF1206426_CR43","doi-asserted-by":"crossref","unstructured":"Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL and MacDougald OA (2000). Science, 289, 950\u2013953.","DOI":"10.1126\/science.289.5481.950"},{"issue":"18","key":"BF1206426_CR44","doi-asserted-by":"publisher","first-page":"15362","DOI":"10.1074\/jbc.M009534200","volume":"276","author":"Xing Shen","year":"2001","unstructured":"Shen X, Li J, Hu PP, Waddell D, Zhang J and Wang XF . (2001). J. Biol. Chem., 276, 15362\u201315368.","journal-title":"Journal of Biological Chemistry"},{"key":"BF1206426_CR45","doi-asserted-by":"crossref","unstructured":"Shillingford JM, Miyoshi K, Flagella M, Shull GE and, Hennighausen L . (2002a). Mol. Endocrinol., 16, 1309\u20131321.","DOI":"10.1210\/mend.16.6.0857"},{"key":"BF1206426_CR46","doi-asserted-by":"crossref","unstructured":"Shillingford JM, Miyoshi K, Robinson GW, Grimm SL, Rosen JM, Neubauer H, Pfeffer K and Hennighausen L . (2002b). Mol. Endocrinol., 16, 563\u2013570.","DOI":"10.1210\/mend.16.3.0805"},{"key":"BF1206426_CR47","doi-asserted-by":"crossref","unstructured":"Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE and Sisodia, SS .(1994). J. Biol. Chem., 269, 2637\u20132644.","DOI":"10.1016\/S0021-9258(17)41992-2"},{"issue":"1","key":"BF1206426_CR48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1006\/geno.1998.5607","volume":"55","author":"Hae-Jun Song","year":"1999","unstructured":"Song HJ, Poy G, Darwiche N, Lichti U, Kuroki T, Steinert PM and Kartasova T (1999). Genomics, 55, 28\u201342.","journal-title":"Genomics"},{"key":"BF1206426_CR49","unstructured":"Voeller HJ, Truica CI and Gelmann EP . (1998). Cancer Res., 58, 2520\u20132523."},{"key":"BF1206426_CR50","doi-asserted-by":"crossref","unstructured":"Wagner KU, McAllister K, Ward T, Davis B, Wiseman R and Hennighausen L (2001). Transgenic Res., 10, 545\u2013553.","DOI":"10.1023\/A:1013063514007"},{"key":"BF1206426_CR51","doi-asserted-by":"crossref","unstructured":"Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA and Hennighausen L . (1997). Nucleic Acids Res., 25, 4323\u20134330.","DOI":"10.1093\/nar\/25.21.4323"},{"issue":"5457","key":"BF1206426_CR52","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.287.5457.1427","volume":"287","author":"F. M. Watt","year":"2000","unstructured":"Watt FM and Hogan BL . (2000). Science, 287, 1427\u20131430.","journal-title":"Science"},{"key":"BF1206426_CR53","doi-asserted-by":"crossref","unstructured":"Widelitz RB, Jiang TX, Lu J and Chuong CM . (2000). Dev. Biol., 219, 98\u2013114.","DOI":"10.1006\/dbio.1999.9580"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1206426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1206426","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1206426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T01:33:32Z","timestamp":1647912812000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1206426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,17]]},"references-count":53,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2003,6,19]]}},"alternative-id":["BF1206426"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1206426","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,17]]},"assertion":[{"value":"29 July 2002","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2003","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2003","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2003","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}