{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:28:16Z","timestamp":1791181696585,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"55","license":[{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2004,10,11]],"date-time":"2004-10-11T00:00:00Z","timestamp":1097452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2004,11,25]]},"DOI":"10.1038\/sj.onc.1208084","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T16:27:13Z","timestamp":1097598433000},"page":"8941-8949","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes"],"prefix":"10.1038","volume":"23","author":[{"given":"Ana","family":"Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Marc\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Bellosillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Villamor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"L\u00f3pez-Guillermo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Espinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emili","family":"Montserrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,10,11]]},"reference":[{"key":"BF1208084_CR1","doi-asserted-by":"crossref","unstructured":"Argatoff LH, Connors JM, Klasa RJ, Horsman DE and Gascoyne RD . (1997). Blood, 89, 2067\u20132078.","DOI":"10.1182\/blood.V89.6.2067"},{"key":"BF1208084_CR2","doi-asserted-by":"crossref","unstructured":"Bailly JD, Skladanowski A, Bettaieb A, Mansat V, Larsen AK and Laurent G . (1997). Leukemia, 11, 1523\u20131532.","DOI":"10.1038\/sj.leu.2400762"},{"key":"BF1208084_CR3","doi-asserted-by":"crossref","unstructured":"Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, Chessa L, Smorodinsky NI, Prives C, Reiss Y, Shiloh Y and Ziv Y . (1998). Science, 281, 1674\u20131677.","DOI":"10.1126\/science.281.5383.1674"},{"key":"BF1208084_CR4","doi-asserted-by":"crossref","unstructured":"Bellosillo B, Colomer D, Pons G and Gil J . (1998). Br. J. Haematol., 100, 142\u2013146.","DOI":"10.1046\/j.1365-2141.1998.00520.x"},{"key":"BF1208084_CR5","doi-asserted-by":"crossref","unstructured":"Bellosillo B, Villamor N, Colomer D, Pons G, Montserrat E and Gil J . (1999). Blood, 94, 2836\u20132843.","DOI":"10.1182\/blood.V94.8.2836.420k35_2836_2843"},{"key":"BF1208084_CR6","doi-asserted-by":"crossref","unstructured":"Bellosillo B, Villamor N, Lopez-Guillermo A, Marce S, Esteve J, Campo E, Colomer D and Montserrat E . (2001). Blood, 98, 2771\u20132777.","DOI":"10.1182\/blood.V98.9.2771"},{"key":"BF1208084_CR7","doi-asserted-by":"crossref","unstructured":"Bellosillo B, Villamor N, Lopez-Guillermo A, Marce S, Bosch F, Campo E, Montserrat E and Colomer D . (2002). Blood, 100, 1810\u20131816.","DOI":"10.1182\/blood-2001-12-0327"},{"key":"BF1208084_CR8","doi-asserted-by":"crossref","unstructured":"Bertoni F, Zucca E and Cotter FE . (2004). Br. J. Haematol., 124, 130\u2013140.","DOI":"10.1046\/j.1365-2141.2003.04761.x"},{"key":"BF1208084_CR9","doi-asserted-by":"crossref","unstructured":"Bogner C, Ringshausen I, Schneller F, Fend F, Quintanilla-Martinez L, Hacker G, Goetze K, Oostendorp R, Peschel C and Decker T . (2003). Br. J. Haematol., 122, 260\u2013268.","DOI":"10.1046\/j.1365-2141.2003.04438.x"},{"key":"BF1208084_CR10","doi-asserted-by":"crossref","unstructured":"Bosch F, Jares P, Campo E, Lopez-Guillermo A, Piris MA, Villamor N, Tassies D, Jaffe ES, Montserrat E and Rozman C . (1994). Blood, 84, 2726\u20132732.","DOI":"10.1182\/blood.V84.8.2726.bloodjournal8482726"},{"key":"BF1208084_CR11","doi-asserted-by":"crossref","unstructured":"Bosch F, Ferrer A, Lopez-Guillermo A, Gine E, Bellosillo B, Villamor N, Colomer D, Cobo F, Perales M, Esteve J, Altes A, Besalduch J, Ribera JM and Montserrat E . (2002). Br. J. Haematol., 119, 976\u2013984.","DOI":"10.1046\/j.1365-2141.2002.03959.x"},{"key":"BF1208084_CR12","doi-asserted-by":"crossref","unstructured":"Bosch F, Lopez-Guillermo A, Campo E, Ribera JM, Conde E, Piris MA, Vallespi T, Woessner S and Montserrat E . (1998). Cancer, 82, 567\u2013575.","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<567::AID-CNCR20>3.0.CO;2-Z"},{"key":"BF1208084_CR13","doi-asserted-by":"crossref","unstructured":"Camacho E, Hernandez L, Hernandez S, Tort F, Bellosillo B, Bea S, Bosch F, Montserrat E, Cardesa A, Fernandez PL and Campo E . (2002). Blood, 99, 238\u2013244.","DOI":"10.1182\/blood.V99.1.238"},{"key":"BF1208084_CR14","doi-asserted-by":"crossref","unstructured":"Campo E . (2003). Hum. Pathol., 34, 330\u2013335.","DOI":"10.1053\/hupa.2003.97"},{"key":"BF1208084_CR15","unstructured":"Campo E, Raffeld M and Jaffe ES . (1999). Semin. Hematol., 36, 115\u2013127."},{"key":"BF1208084_CR16","doi-asserted-by":"crossref","unstructured":"Chou TC and Talalay P . (1984). Adv. Enzyme Regul., 22, 27\u201355.","DOI":"10.1016\/0065-2571(84)90007-4"},{"key":"BF1208084_CR17","doi-asserted-by":"crossref","unstructured":"Cory S and Adams JM . (2002). Nat. Rev. Cancer, 2, 647\u2013656.","DOI":"10.1038\/nrc883"},{"key":"BF1208084_CR18","doi-asserted-by":"crossref","unstructured":"Cory S, Huang DC and Adams JM . (2003). Oncogene, 22, 8590\u20138607.","DOI":"10.1038\/sj.onc.1207102"},{"key":"BF1208084_CR19","doi-asserted-by":"crossref","unstructured":"De Isabella P, Capranico G and Zunino F . (1991). Life Sci., 48, 2195\u20132205.","DOI":"10.1016\/0024-3205(91)90333-7"},{"key":"BF1208084_CR20","doi-asserted-by":"crossref","unstructured":"Dohner H, Fischer K, Bentz M, Hansen K, Benner A, Cabot G, Diehl D, Schlenk R, Coy J and Stilgenbauer S . (1995). Blood, 85, 1580\u20131589.","DOI":"10.1182\/blood.V85.6.1580.bloodjournal8561580"},{"key":"BF1208084_CR21","doi-asserted-by":"crossref","unstructured":"Fang NY, Greiner TC, Weisenburger DD, Chan WC, Vose JM, Smith LM, Armitage JO, Mayer RA, Pike BL, Collins FS and Hacia JG . (2003). Proc. Natl. Acad. Sci. USA, 100, 5372\u20135377.","DOI":"10.1073\/pnas.0831102100"},{"key":"BF1208084_CR22","doi-asserted-by":"crossref","unstructured":"Fedier A, Schlamminger M, Schwarz VA, Haller U, Howell SB and Fink D . (2003). Ann. Oncol., 14, 938\u2013945.","DOI":"10.1093\/annonc\/mdg240"},{"key":"BF1208084_CR23","doi-asserted-by":"crossref","unstructured":"Flinn IW, Byrd JC, Morrison C, Jamison J, Diehl LF, Murphy T, Piantadosi S, Seifter E, Ambinder RF, Vogelsang G and Grever MR . (2000). Blood, 96, 71\u201375.","DOI":"10.1182\/blood.V96.1.71"},{"key":"BF1208084_CR24","doi-asserted-by":"crossref","unstructured":"Hernandez L, Fest T, Cazorla M, Teruya-Feldstein J, Bosch F, Peinado MA, Piris MA, Montserrat E, Cardesa A, Jaffe ES, Campo E and Raffold M . (1996). Blood, 87, 3351\u20133359.","DOI":"10.1182\/blood.V87.8.3351.bloodjournal8783351"},{"key":"BF1208084_CR25","doi-asserted-by":"crossref","unstructured":"Hofmann WK, De Vos S, Tsukasaki K, Wachsman W, Pinkus GS, Said JW and Koeffler HP . (2001). Blood, 98, 787\u2013794.","DOI":"10.1182\/blood.V98.3.787"},{"key":"BF1208084_CR26","doi-asserted-by":"crossref","unstructured":"Khoury JD, Medeiros LJ, Rassidakis GZ, McDonnell TJ, Abruzzo LV and Lai R . (2003). J. Pathol., 199, 90\u201397.","DOI":"10.1002\/path.1254"},{"key":"BF1208084_CR27","doi-asserted-by":"crossref","unstructured":"M'kacher R, Bennaceur A, Farace F, Lauge A, Plassa LF, Wittmer E, Dossou J, Violot D, Deutsch E, Bourhis J, Stoppa-Lyonnet D, Ribrag V, Carde P, Parmentier C, Bernheim A and Turhan AG . (2003). Oncogene, 22, 5961\u20135968.","DOI":"10.1038\/sj.onc.1206826"},{"key":"BF1208084_CR28","unstructured":"Martinez N, Camacho FI, Algara P, Rodriguez A, Dopazo A, Ruiz-Ballesteros E, Martin P, Martinez-Climent JA, Garcia-Conde J, Menarguez J, Solano F, Mollejo M and Piris MA . (2003). Cancer Res., 63, 8226\u20138232."},{"key":"BF1208084_CR29","doi-asserted-by":"crossref","unstructured":"Molina-Arcas M, Bellosillo B, Casado FJ, Montserrat E, Gil J, Colomer D and Pastor-Anglada M . (2003). Blood, 101, 2328\u20132334.","DOI":"10.1182\/blood-2002-07-2236"},{"key":"BF1208084_CR30","doi-asserted-by":"crossref","unstructured":"Nicoletti I, Migliorati G, Pagliacci MC, Grignani F and Riccardi C . (1991). J. Immunol. Methods, 139, 271\u2013279.","DOI":"10.1016\/0022-1759(91)90198-O"},{"key":"BF1208084_CR31","doi-asserted-by":"crossref","unstructured":"Pham LV, Tamayo AT, Yoshimura LC, Lo P and Ford RJ . (2003). J. Immunol., 171, 88\u201395.","DOI":"10.4049\/jimmunol.171.1.88"},{"key":"BF1208084_CR32","doi-asserted-by":"crossref","unstructured":"Pinyol M, Hernandez L, Cazorla M, Balbin M, Jares P, Fernandez PL, Montserrat E, Cardesa A, Lopez-Otin C and Campo E . (1997). Blood, 89, 272\u2013280.","DOI":"10.1182\/blood.V89.1.272.272_272_280"},{"key":"BF1208084_CR33","doi-asserted-by":"crossref","unstructured":"Pinyol M, Hernandez L, Martinez A, Cobo F, Hernandez S, Bea S, Lopez-Guillermo A, Nayach I, Palacin A, Nadal A, Fernandez PL, Montserrat E, Cardesa A and Campo E . (2000). Am. J. Pathol., 156, 1987\u20131996.","DOI":"10.1016\/S0002-9440(10)65071-7"},{"key":"BF1208084_CR34","doi-asserted-by":"crossref","unstructured":"Rasheed ZA and Rubin EH . (2003). Oncogene, 22, 7296\u20137304.","DOI":"10.1038\/sj.onc.1206935"},{"key":"BF1208084_CR35","doi-asserted-by":"crossref","unstructured":"Reiman T, Graham KA, Wong J, Belch AR, Coupland R, Young J, Cass CE and Mackey JR . (2002). Leukemia, 16, 1886\u20131887.","DOI":"10.1038\/sj.leu.2402579"},{"key":"BF1208084_CR36","doi-asserted-by":"crossref","unstructured":"Rosenwald A, Wright G, Wiestner A, Chan WC, Connors JM, Campo E, Gascoyne RD, Grogan TM, Muller-Hermelink HK, Smeland EB, Chiorazzi M, Giltnane JM, Hurt EM, Zhao H, Averett L, Henrickson S, Yang L, Powell J, Wilson WH, Jaffe ES, Simon R, Klausner RD, Montserrat E, Bosch F, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Fisher RI, Miller TP, LeBlanc M, Ott G, Kvaloy S, Holte H, Delabie J and Staudt LM . (2003). Cancer Cell, 3, 185\u2013197.","DOI":"10.1016\/S1535-6108(03)00028-X"},{"key":"BF1208084_CR37","unstructured":"Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, Bartels H, Sonnen R, Hopfinger G, Nader A, Ott G, Muller-Hermelink K, Feller A and Heinz R . (1999). Blood, 94, 3114\u20133120."},{"key":"BF1208084_CR38","doi-asserted-by":"crossref","unstructured":"Schrader C, Meusers P, Brittinger G, Teymoortash A, Siebmann JU, Janssen D, Parwaresch R and Tiemann M . (2004). Leukemia, 18, 1200\u20131206.","DOI":"10.1038\/sj.leu.2403387"},{"key":"BF1208084_CR39","doi-asserted-by":"crossref","unstructured":"Slee EA, Adrain C and Martin SJ . (1999). Cell Death. Differ., 6, 1067\u20131074.","DOI":"10.1038\/sj.cdd.4400601"},{"key":"BF1208084_CR40","doi-asserted-by":"crossref","unstructured":"Solal-Celigny P, Brice P, Brousse N, Caspard H, Bastion Y, Haioun C, Bosly A, Tilly H, Bordessoule D, Sebban C, Harousseau JL, Morel P, Dupas B, Plassart F, Vasile N, Fort N and Leporrier M . (1996). J. Clin. Oncol., 14, 514\u2013519.","DOI":"10.1200\/JCO.1996.14.2.514"},{"key":"BF1208084_CR41","doi-asserted-by":"crossref","unstructured":"Stankovic T, Hubank M, Cronin D, Stewart GS, Fletcher D, Bignell CR, Alvi AJ, Austen B, Weston VJ, Fegan C, Byrd PJ, Moss PA and Taylor AM . (2004). Blood, 103, 291\u2013300.","DOI":"10.1182\/blood-2003-04-1161"},{"key":"BF1208084_CR42","first-page":"168","volume-title":"Pathology & Genetics. Tumours of haematopoietic and lymphoid tissues","author":"SH Swerdlow","year":"2001","unstructured":"Swerdlow SH, Berger F, Isaacson P, Muller-Hermelink HK, Nathwani BN, Piris MA and Harris NL . (2001). Pathology & Genetics. Tumours of haematopoietic and lymphoid tissues Jaffe ES, Harris NL, Stein H and Vardiman JW (ed). IARC press. Lyon, 168\u2013170."},{"key":"BF1208084_CR43","doi-asserted-by":"crossref","unstructured":"Vorechovsky I, Luo L, Dyer MJ, Catovsky D, Amlot PL, Yaxley JC, Foroni L, Hammarstrom L, Webster AD and Yuille MA . (1997). Nat. Genet., 17, 96\u201399.","DOI":"10.1038\/ng0997-96"},{"key":"BF1208084_CR44","doi-asserted-by":"crossref","unstructured":"Wattel E, Preudhomme C, Hecquet B, Vanrumbeke M, Quesnel B, Dervite I, Morel P and Fenaux P . (1994). Blood, 84, 3148\u20133157.","DOI":"10.1182\/blood.V84.9.3148.bloodjournal8493148"},{"key":"BF1208084_CR45","doi-asserted-by":"crossref","unstructured":"Xue LY, Chiu SM and Oleinick NL . (2003). Exp. Cell Res., 283, 135\u2013145.","DOI":"10.1016\/S0014-4827(02)00032-0"},{"key":"BF1208084_CR46","doi-asserted-by":"crossref","unstructured":"Zhao WL, Daneshpouy ME, Mounier N, Briere J, Leboeuf C, Plassa LF, Turpin E, Cayuela JM, Ameisen JC, Gisselbrecht C and Janin A . (2004). Blood, 103, 695\u2013697.","DOI":"10.1182\/blood-2003-06-1901"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1208084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208084","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208084.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T07:44:07Z","timestamp":1647935047000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1208084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,11]]},"references-count":46,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2004,11,25]]}},"alternative-id":["BF1208084"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1208084","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10,11]]},"assertion":[{"value":"24 March 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2004","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2004","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2004","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}