{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T07:26:25Z","timestamp":1791012385708,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"41","license":[{"start":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T00:00:00Z","timestamp":1119225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T00:00:00Z","timestamp":1119225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2005,9,15]]},"DOI":"10.1038\/sj.onc.1208758","type":"journal-article","created":{"date-parts":[[2005,7,12]],"date-time":"2005-07-12T10:14:09Z","timestamp":1121163249000},"page":"6292-6302","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V600E) B-RAF"],"prefix":"10.1038","volume":"24","author":[{"given":"Claus","family":"Christensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Guldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,6,20]]},"reference":[{"key":"BF1208758_CR1","unstructured":"Albino AP, Davis BM and Nanus DM . (1991). Cancer Res., 51, 4815\u20134820."},{"key":"BF1208758_CR2","unstructured":"Bastian BC, LeBoit PE, Hamm H, Br\u00f6cker EB and Pinkel D . (1998). Cancer Res., 58, 2170\u20132175."},{"key":"BF1208758_CR3","doi-asserted-by":"crossref","unstructured":"Berking C, Takemoto R, Satyamoorthy K, Elenitsas R and Herlyn M . (2001). Am. J. Pathol., 158, 943\u2013953.","DOI":"10.1016\/S0002-9440(10)64041-2"},{"key":"BF1208758_CR4","doi-asserted-by":"crossref","unstructured":"Bielenberg DR, Bucana CD, Sanchez R, Donawho CK, Kripke ML and Fidler IJ . (1998). J. Invest. Dermatol., 111, 864\u2013872.","DOI":"10.1046\/j.1523-1747.1998.00378.x"},{"key":"BF1208758_CR5","doi-asserted-by":"crossref","unstructured":"Bridge AJ, Pebernard S, Ducraux A, Nicoulaz AL and Iggo R . (2003). Nat. Genet., 34, 263\u2013264.","DOI":"10.1038\/ng1173"},{"key":"BF1208758_CR6","doi-asserted-by":"crossref","unstructured":"Brummelkamp TR, Bernards R and Agami R . (2002). Science, 296, 550\u2013553.","DOI":"10.1126\/science.1068999"},{"key":"BF1208758_CR7","unstructured":"Collisson EA, De A, Suzuki H, Gambhir SS and Kolodney MS . (2003). Cancer Res., 63, 5669\u20135673."},{"key":"BF1208758_CR8","doi-asserted-by":"crossref","unstructured":"Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR and Futreal PA . (2002). Nature, 417, 949\u2013954.","DOI":"10.1038\/nature00766"},{"key":"BF1208758_CR9","doi-asserted-by":"crossref","unstructured":"Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I and Pereira-Smith O . (1995). Proc. Natl. Acad. Sci. USA, 92, 9363\u20139367.","DOI":"10.1073\/pnas.92.20.9363"},{"key":"BF1208758_CR10","unstructured":"Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z and Aaronson SA . (2003). Cancer Res., 63, 3883\u20133885."},{"key":"BF1208758_CR11","doi-asserted-by":"crossref","unstructured":"Easty DJ and Bennett DC . (2000). Melanoma Res., 10, 401\u2013411.","DOI":"10.1097\/00008390-200010000-00001"},{"key":"BF1208758_CR12","doi-asserted-by":"crossref","unstructured":"Eisinger M, Marko O, Ogata S and Old LJ . (1985). Science, 229, 984\u2013986.","DOI":"10.1126\/science.4023718"},{"key":"BF1208758_CR13","doi-asserted-by":"crossref","unstructured":"Garnett MJ and Marais R . (2004). Cancer Cell, 6, 313\u2013319.","DOI":"10.1016\/j.ccr.2004.09.022"},{"key":"BF1208758_CR14","unstructured":"Gorden A, Osman I, Gai W, He D, Huang W, Davidson A, Houghton AN, Busam K and Polsky D . (2003). Cancer Res., 63, 3955\u20133957."},{"key":"BF1208758_CR15","unstructured":"Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF and Zeuthen J . (1997). Cancer Res., 57, 3660\u20133663."},{"key":"BF1208758_CR16","unstructured":"Halaban R . (1996). Semin. Oncol., 23, 673\u2013681."},{"key":"BF1208758_CR17","doi-asserted-by":"crossref","unstructured":"Halaban R . (2000). Pigment Cell Res., 13, 4\u201314.","DOI":"10.1034\/j.1600-0749.2000.130103.x"},{"key":"BF1208758_CR18","unstructured":"Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M and Tuveson DA . (2003). Cancer Res., 63, 5198\u20135202."},{"key":"BF1208758_CR19","unstructured":"Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD and Bar-Eli M . (1996). Oncogene, 13, 2339\u20132347."},{"key":"BF1208758_CR20","doi-asserted-by":"crossref","unstructured":"Huser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, Sun XM, Brown J, Marais R and Pritchard C . (2001). EMBO J., 20, 1940\u20131951.","DOI":"10.1093\/emboj\/20.8.1940"},{"key":"BF1208758_CR21","doi-asserted-by":"crossref","unstructured":"Imokawa G, Kobayasi T and Miyagishi M . (2000). J. Biol. Chem., 275, 33321\u201333328.","DOI":"10.1074\/jbc.M004346200"},{"key":"BF1208758_CR22","doi-asserted-by":"crossref","unstructured":"Imokawa G, Yada Y and Miyagishi M . (1992). J. Biol. Chem., 267, 24675\u201324680.","DOI":"10.1016\/S0021-9258(18)35817-4"},{"key":"BF1208758_CR23","doi-asserted-by":"crossref","unstructured":"Karasarides M, Chiloeches A, Hayward R, Niculescu-Duvaz D, Scanlon I, Friedlos F, Ogilvie L, Hedley D, Martin J, Marshall CJ, Springer CJ and Marais R . (2004). Oncogene, 23, 6292\u20136298.","DOI":"10.1038\/sj.onc.1207785"},{"key":"BF1208758_CR24","unstructured":"Kumar R, Angelini S, Czene K, Sauroja I, Hahka-Kemppinen M, Pyrhonen S and Hemminki K . (2003). Clin. Cancer Res., 9, 3362\u20133368."},{"key":"BF1208758_CR25","doi-asserted-by":"crossref","unstructured":"Li G, Satyamoorthy K, Meier F, Berking C, Bogenrieder T and Herlyn M . (2003). Oncogene, 22, 3162\u20133171.","DOI":"10.1038\/sj.onc.1206455"},{"key":"BF1208758_CR26","doi-asserted-by":"crossref","unstructured":"Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K and Herlyn M . (2001). Oncogene, 20, 8125\u20138135.","DOI":"10.1038\/sj.onc.1205034"},{"key":"BF1208758_CR27","doi-asserted-by":"crossref","unstructured":"Meier F, Nesbit M, Hsu MY, Martin B, Van Belle P, Elder DE, Schaumburg-Lever G, Garbe C, Walz TM, Donatien P, Crombleholme TM and Herlyn M . (2000). Am. J. Pathol., 156, 193\u2013200.","DOI":"10.1016\/S0002-9440(10)64719-0"},{"key":"BF1208758_CR28","doi-asserted-by":"crossref","unstructured":"Mercer K, Chiloeches A, Huser M, Kiernan M, Marais R and Pritchard C . (2002). Oncogene, 21, 347\u2013355.","DOI":"10.1038\/sj.onc.1205101"},{"key":"BF1208758_CR29","doi-asserted-by":"crossref","unstructured":"Nesbit M, Nesbit HK, Bennett J, Andl T, Hsu MY, Dejesus E, McBrian M, Gupta AR, Eck SL and Herlyn M . (1999). Oncogene, 18, 6469\u20136476.","DOI":"10.1038\/sj.onc.1203066"},{"key":"BF1208758_CR30","unstructured":"Otsuka T, Takayama H, Sharp R, Celli G, LaRochelle WJ, Bottaro DP, Ellmore N, Vieira W, Owens JW, Anver M and Merlino G . (1998). Cancer Res., 58, 5157\u20135167."},{"key":"BF1208758_CR31","doi-asserted-by":"crossref","unstructured":"Peyssonnaux C and Eychene A . (2001). Biol. Cell, 93, 53\u201362.","DOI":"10.1016\/S0248-4900(01)01125-X"},{"key":"BF1208758_CR32","doi-asserted-by":"crossref","unstructured":"Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, Salem G, Pohida T, Heenan P, Duray P, Kallioniemi O, Hayward NK, Trent JM and Meltzer PS . (2003). Nat. Genet., 33, 19\u201320.","DOI":"10.1038\/ng1054"},{"key":"BF1208758_CR33","doi-asserted-by":"crossref","unstructured":"Pritchard CA, Samuels ML, Bosch E and McMahon M . (1995). Mol. Cell. Biol., 15, 6430\u20136442.","DOI":"10.1128\/MCB.15.11.6430"},{"key":"BF1208758_CR34","unstructured":"Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, Weber BL, Van Belle P, Elder DE and Herlyn M . (2003). Cancer Res., 63, 756\u2013759."},{"key":"BF1208758_CR35","unstructured":"Satyamoorthy K, Li G, Vaidya B, Patel D and Herlyn M . (2001). Cancer Res., 61, 7318\u20137324."},{"key":"BF1208758_CR36","doi-asserted-by":"crossref","unstructured":"Scott PH, Cairns CA, Sutcliffe JE, Alzuherri HM, McLees A, Winter AG and White RJ . (2001). J. Biol. Chem., 276, 1005\u20131014.","DOI":"10.1074\/jbc.M005417200"},{"key":"BF1208758_CR37","doi-asserted-by":"crossref","unstructured":"Sledz CA, Holko M, de Veer MJ, Silverman RH and Williams BR . (2003). Nat. Cell Biol., 5, 834\u2013839.","DOI":"10.1038\/ncb1038"},{"key":"BF1208758_CR38","doi-asserted-by":"crossref","unstructured":"Smalley KS . (2003). Int. J. Cancer, 104, 527\u2013532.","DOI":"10.1002\/ijc.10978"},{"key":"BF1208758_CR39","unstructured":"Storm SM, Cleveland JL and Rapp UR . (1990). Oncogene, 5, 345\u2013351."},{"key":"BF1208758_CR40","doi-asserted-by":"crossref","unstructured":"Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A, Taira K and Kawakami Y . (2004). Oncogene, 23, 6031\u20136039.","DOI":"10.1038\/sj.onc.1207812"},{"key":"BF1208758_CR41","doi-asserted-by":"crossref","unstructured":"Sutcliffe JE, Brown TR, Allison SJ, Scott PH and White RJ . (2000). Mol. Cell. Biol., 20, 9192\u20139202.","DOI":"10.1128\/MCB.20.24.9192-9202.2000"},{"key":"BF1208758_CR42","doi-asserted-by":"crossref","unstructured":"Tuveson DA, Weber BL and Herlyn M . (2003). Cancer Cell, 4, 95\u201398.","DOI":"10.1016\/S1535-6108(03)00189-2"},{"key":"BF1208758_CR43","doi-asserted-by":"crossref","unstructured":"Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM, Jones CM, Marshall CJ, Springer CJ, Barford D and Marais R . (2004). Cell, 116, 855\u2013867.","DOI":"10.1016\/S0092-8674(04)00215-6"},{"key":"BF1208758_CR44","doi-asserted-by":"crossref","unstructured":"Wellbrock C, Karasarides M and Marais R . (2004a). Nat. Rev. Mol. Cell. Biol., 5, 875\u2013885.","DOI":"10.1038\/nrm1498"},{"key":"BF1208758_CR45","doi-asserted-by":"crossref","unstructured":"Wellbrock C, Ogilvie L, Hedley D, Karasarides M, Martin J, Niculescu-Duvaz D, Springer CJ and Marais R . (2004b). Cancer Res., 64, 2338\u20132342.","DOI":"10.1158\/0008-5472.CAN-03-3433"},{"key":"BF1208758_CR46","doi-asserted-by":"crossref","unstructured":"Zhang XD, Borrow JM, Zhang XY, Nguyen T and Hersey P . (2003). Oncogene, 22, 2869\u20132881.","DOI":"10.1038\/sj.onc.1206427"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1208758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208758","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1208758.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T08:10:27Z","timestamp":1647936627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1208758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,20]]},"references-count":46,"journal-issue":{"issue":"41","published-print":{"date-parts":[[2005,9,15]]}},"alternative-id":["BF1208758"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1208758","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6,20]]},"assertion":[{"value":"9 January 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}