{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:59:48Z","timestamp":1789736388129,"version":"4.0.1"},"reference-count":85,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2005,10,3]],"date-time":"2005-10-03T00:00:00Z","timestamp":1128297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2006,2,16]]},"DOI":"10.1038\/sj.onc.1209146","type":"journal-article","created":{"date-parts":[[2005,10,4]],"date-time":"2005-10-04T10:38:55Z","timestamp":1128422335000},"page":"1053-1069","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Silymarin and silibinin cause G1 and G2\u2013M cell cycle arrest via distinct circuitries in human prostate cancer PC3 cells: a comparison of flavanone silibinin with flavanolignan mixture silymarin"],"prefix":"10.1038","volume":"25","author":[{"given":"G","family":"Deep","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R P","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Kroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,10,3]]},"reference":[{"key":"BF1209146_CR1","doi-asserted-by":"crossref","unstructured":"Abraham RT . (2001). Genes Dev 15: 2177\u20132196.","DOI":"10.1101\/gad.914401"},{"key":"BF1209146_CR2","doi-asserted-by":"crossref","unstructured":"Adelaide J, Monges G, Derderian C, Seitz JF, Birnbaum D . (1995). Br J Cancer 71: 64\u201368.","DOI":"10.1038\/bjc.1995.13"},{"key":"BF1209146_CR3","doi-asserted-by":"crossref","unstructured":"Agarwal C, Singh RP, Dhanalakshmi S, Tyagi AK, Tecklenburg M, Sclafani RA et al. (2003). Oncogene 22: 8271\u20138282.","DOI":"10.1038\/sj.onc.1207158"},{"key":"BF1209146_CR4","unstructured":"American Cancer Society (2005). Cancer Facts and Figures 2005: 1\u201360."},{"key":"BF1209146_CR5","doi-asserted-by":"crossref","unstructured":"Arber N, Hibshoosh H, Moss SF, Sutter T, Zhang Y, Begg M et al. (1996). Gastroenterology 110: 669\u2013674.","DOI":"10.1053\/gast.1996.v110.pm8608874"},{"key":"BF1209146_CR6","doi-asserted-by":"crossref","unstructured":"Bartek J, Lukas J . (2003). Cancer Cell 3: 421\u2013429.","DOI":"10.1016\/S1535-6108(03)00110-7"},{"key":"BF1209146_CR7","unstructured":"Bartkova J, Lukas J, Muller H, Strauss M, Gusterson B, Bartek J . (1995). Cancer Res 55: 949\u2013956."},{"key":"BF1209146_CR8","doi-asserted-by":"crossref","unstructured":"Bhatia N, Zhao J, Wolf DM, Agarwal R . (1999). Cancer Lett 147: 77\u201384.","DOI":"10.1016\/S0304-3835(99)00276-1"},{"key":"BF1209146_CR9","doi-asserted-by":"crossref","unstructured":"Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A . (2003). J Biol Chem 278: 25752\u201325757.","DOI":"10.1074\/jbc.M301774200"},{"key":"BF1209146_CR10","doi-asserted-by":"crossref","unstructured":"Brown AL, Lee CH, Schwarz JK, Mitiku N, Piwnica-Worms H, Chung JH . (1999). Proc Natl Acad Sci USA 96: 3745\u20133750.","DOI":"10.1073\/pnas.96.7.3745"},{"key":"BF1209146_CR11","doi-asserted-by":"crossref","unstructured":"Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ . (1995). Nature 377: 552\u2013557.","DOI":"10.1038\/377552a0"},{"key":"BF1209146_CR12","doi-asserted-by":"crossref","unstructured":"Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J et al. (2004). Oncogene 23: 7691\u20137700.","DOI":"10.1038\/sj.onc.1207986"},{"key":"BF1209146_CR13","doi-asserted-by":"crossref","unstructured":"Caputi M, Groeger AM, Esposito V, Dean C, De Luca A, Pacilio C et al. (1999). Am J Respir Cell Mol Biol 20: 746\u2013750.","DOI":"10.1165\/ajrcmb.20.4.3366"},{"key":"BF1209146_CR14","doi-asserted-by":"crossref","unstructured":"Chaturvedi P, Eng WK, Zhu Y, Mattern MR, Mishra R, Hurle MR et al. (1999). Oncogene 18: 4047\u20134054.","DOI":"10.1038\/sj.onc.1202925"},{"key":"BF1209146_CR15","doi-asserted-by":"crossref","unstructured":"Deng C, Zhang P, Harper JW, Elledge SJ, Leder P . (1995). Cell 82: 675\u2013684.","DOI":"10.1016\/0092-8674(95)90039-X"},{"key":"BF1209146_CR16","doi-asserted-by":"crossref","unstructured":"Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R . (2002). Oncogene 21: 1759\u20131767.","DOI":"10.1038\/sj.onc.1205240"},{"key":"BF1209146_CR17","doi-asserted-by":"crossref","unstructured":"Dong X, Wang L, Taniguchi K, Wang X, Cunningham JM, McDonnell SK et al. (2003). Am J Hum Genet 72: 270\u2013280.","DOI":"10.1086\/346094"},{"key":"BF1209146_CR18","unstructured":"Drobnjak M, Osman I, Scher HI, Fazzari M, Cordon-Cardo C . (2000). Clin Cancer Res 6: 1891\u20131895."},{"key":"BF1209146_CR19","doi-asserted-by":"crossref","unstructured":"Feldman BJ, Feldman D . (2001). Nat Rev Cancer 1: 34\u201345.","DOI":"10.1038\/35094009"},{"key":"BF1209146_CR20","doi-asserted-by":"crossref","unstructured":"Flora K, Hahn M, Rosen H, Benner K . (1998). Am J Gastroenterol 93: 139\u2013143.","DOI":"10.1111\/j.1572-0241.1998.00139.x"},{"key":"BF1209146_CR21","doi-asserted-by":"crossref","unstructured":"Gabrielli BG, de Souza CP, Tonks ID, Clark JM, Hayward NK, Ellem KA . (1996). J Cell Sci 109: 1081\u20131093.","DOI":"10.1242\/jcs.109.5.1081"},{"key":"BF1209146_CR22","doi-asserted-by":"crossref","unstructured":"Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW . (1991). Cell 67: 197\u2013211.","DOI":"10.1016\/0092-8674(91)90583-K"},{"key":"BF1209146_CR23","unstructured":"Gillett C, Fantl V, Smith R, Fisher C, Bartek J, Dickson C et al. (1994). Cancer Res 54: 1812\u20131817."},{"key":"BF1209146_CR24","unstructured":"Grana X, Reddy P . (1995). Oncogene 11: 211\u2013219."},{"key":"BF1209146_CR25","doi-asserted-by":"crossref","unstructured":"Gstaiger M, Jordan R, Lim M, Catzavelos C, Mestan J, Slingerland J et al. (2001). Proc Natl Acad Sci USA 98: 5043\u20135048.","DOI":"10.1073\/pnas.081474898"},{"key":"BF1209146_CR26","doi-asserted-by":"crossref","unstructured":"Hanahan D, Weinberg RA . (2000). Cell 100: 57\u201370.","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"BF1209146_CR27","doi-asserted-by":"crossref","unstructured":"Hoffman I, Draetta G, Karsenti E . (1994). EMBO J 13: 4302\u20134310.","DOI":"10.1002\/j.1460-2075.1994.tb06750.x"},{"key":"BF1209146_CR28","doi-asserted-by":"crossref","unstructured":"Hou DX, Fujii M, Terahara N, Yoshimoto M . (2004). J Biomed Biotechnol 2004: 321\u2013325.","DOI":"10.1155\/S1110724304403040"},{"key":"BF1209146_CR29","doi-asserted-by":"crossref","unstructured":"Kastan MB, Canman CE, Leonard CJ . (1995). Cancer Metastasis Rev 14: 3\u201315.","DOI":"10.1007\/BF00690207"},{"key":"BF1209146_CR30","doi-asserted-by":"crossref","unstructured":"Kawabe T . (2004). Mol Cancer Ther 3: 513\u2013519.","DOI":"10.1158\/1535-7163.513.3.4"},{"key":"BF1209146_CR31","doi-asserted-by":"crossref","unstructured":"Kim NC, Graf TN, Sparacino CM, Wani MC, Wall ME . (2003). Org Biomol Chem 1: 1684\u20131689.","DOI":"10.1039\/b300099k"},{"key":"BF1209146_CR32","unstructured":"Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP . (1998). Am J Pathol 152: 1\u20139."},{"key":"BF1209146_CR33","doi-asserted-by":"crossref","unstructured":"Kossatz U, Dietrich N, Zender L, Buer J, Manns MP, Malek NP . (2004). Genes Dev 18: 2602\u20132607.","DOI":"10.1101\/gad.321004"},{"key":"BF1209146_CR34","doi-asserted-by":"crossref","unstructured":"Lammer C, Wagerer S, Saffrich R, Mertens D, Ansorge W, Hoffmann I . (1998). J Cell Sci 111: 2445\u20132453.","DOI":"10.1242\/jcs.111.16.2445"},{"key":"BF1209146_CR35","doi-asserted-by":"crossref","unstructured":"Langner C, von Wasielewski R, Ratschek M, Rehak P, Zigeuner R . (2004). Virchows Arch 445: 631\u2013636.","DOI":"10.1007\/s00428-004-1121-2"},{"key":"BF1209146_CR36","doi-asserted-by":"crossref","unstructured":"Li Q, Murphy M, Ross J, Sheehan C, Carlson JA . (2004). J Cutan Pathol 31: 633\u2013642.","DOI":"10.1111\/j.0303-6987.2004.00243.x"},{"key":"BF1209146_CR37","doi-asserted-by":"crossref","unstructured":"Lloyd RV, Erickson LA, Jin L, Kulig E, Qian X, Cheville JC et al. (1999). Am J Pathol 154: 313\u2013323.","DOI":"10.1016\/S0002-9440(10)65277-7"},{"key":"BF1209146_CR38","doi-asserted-by":"crossref","unstructured":"Lopez-Girona A, Furnari B, Mondesert O, Russell P . (1999). Nature 397: 172\u2013175.","DOI":"10.1038\/16488"},{"key":"BF1209146_CR39","doi-asserted-by":"crossref","unstructured":"Lyon MA, Ducret AP, Wipf P, Lazo JS . (2002). Nat Rev Drug Discov 1: 961\u2013976.","DOI":"10.1038\/nrd963"},{"key":"BF1209146_CR40","doi-asserted-by":"crossref","unstructured":"Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R . (2004). Cancer Res 64: 6349\u20136356.","DOI":"10.1158\/0008-5472.CAN-04-1632"},{"key":"BF1209146_CR41","doi-asserted-by":"crossref","unstructured":"Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ . (2000). Proc Natl Acad Sci USA 97: 10389\u201310394.","DOI":"10.1073\/pnas.190030497"},{"key":"BF1209146_CR42","unstructured":"McDonald III ER, El-Deiry WS . (2000). Int J Oncol 16: 871\u2013886."},{"key":"BF1209146_CR43","doi-asserted-by":"crossref","unstructured":"Melchionna R, Chen XB, Blasina A, McGowan CH . (2000). Nat Cell Biol 2: 762\u2013765.","DOI":"10.1038\/35036406"},{"key":"BF1209146_CR44","doi-asserted-by":"crossref","unstructured":"Millar JB, Blevitt J, Gerace L, Sadhu K, Featherstone C, Russell P . (1991). Proc Natl Acad Sci USA 88: 10500\u201310504.","DOI":"10.1073\/pnas.88.23.10500"},{"key":"BF1209146_CR45","doi-asserted-by":"crossref","unstructured":"Morgan DO . (1995). Nature (London) 374: 131\u2013134.","DOI":"10.1038\/374131a0"},{"key":"BF1209146_CR46","doi-asserted-by":"crossref","unstructured":"Nakayama K, Nagahama H, Minamishima YA, Miyake S, Ishida N, Hatakeyama S et al. (2004). Dev Cell 6: 661\u2013672.","DOI":"10.1016\/S1534-5807(04)00131-5"},{"key":"BF1209146_CR47","doi-asserted-by":"crossref","unstructured":"Neuhouser ML . (2004). Nutr Cancer 50: 1\u20137.","DOI":"10.1207\/s15327914nc5001_1"},{"key":"BF1209146_CR48","doi-asserted-by":"crossref","unstructured":"Nilsson I, Hoffmann I . (2000). Prog Cell Cycle Res 4: 107\u2013114.","DOI":"10.1007\/978-1-4615-4253-7_10"},{"key":"BF1209146_CR49","doi-asserted-by":"crossref","unstructured":"Obaya AJ, Sedivy JM . (2002). Cell Mol Life Sci 59: 126\u2013142.","DOI":"10.1007\/s00018-002-8410-1"},{"key":"BF1209146_CR50","doi-asserted-by":"crossref","unstructured":"Owa T, Yoshino H, Yoshimatsu K, Nagasu T . (2001). Curr Med Chem 8: 1487\u20131503.","DOI":"10.2174\/0929867013371996"},{"key":"BF1209146_CR51","doi-asserted-by":"crossref","unstructured":"Pares A, Planas R, Torres M, Caballeria J, Viver JM, Acero D et al. (1998). J Hepatol 28: 615\u2013621.","DOI":"10.1016\/S0168-8278(98)80285-7"},{"key":"BF1209146_CR52","doi-asserted-by":"crossref","unstructured":"Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H . (1997). Science 277: 1501\u20131505.","DOI":"10.1126\/science.277.5331.1501"},{"key":"BF1209146_CR53","doi-asserted-by":"crossref","unstructured":"Polyak K, Kato JY, Soloman MJ, Sherr CJ, Massague J, Roberts JM et al. (1994). Genes Dev 8: 9\u201322.","DOI":"10.1101\/gad.8.1.9"},{"key":"BF1209146_CR54","doi-asserted-by":"crossref","unstructured":"Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM . (1998). J Biol Chem 273: 5858\u20135868.","DOI":"10.1074\/jbc.273.10.5858"},{"key":"BF1209146_CR55","doi-asserted-by":"crossref","unstructured":"Sebastian B, Kakizuka A, Hunter T . (1993). Proc Natl Acad Sci USA 90: 3521\u20133524.","DOI":"10.1073\/pnas.90.8.3521"},{"key":"BF1209146_CR56","doi-asserted-by":"crossref","unstructured":"Seki T, Yamashita K, Nishitani H, Takagi T, Russell P, Nishimoto T . (1992). Mol Biol Cell 12: 1373\u20131388.","DOI":"10.1091\/mbc.3.12.1373"},{"key":"BF1209146_CR57","doi-asserted-by":"crossref","unstructured":"Sepp\u00e4l\u00e4 EH, Ikonen T, Mononen N, Autio V, R\u00f6kman A, Matikainen MA et al. (2003). Br J Cancer 89: 1966\u20131970.","DOI":"10.1038\/sj.bjc.6601425"},{"key":"BF1209146_CR58","unstructured":"Sharma G, Singh RP, Chan DC, Agarwal R . (2003). Anticancer Res 23: 2649\u20132655."},{"key":"BF1209146_CR59","doi-asserted-by":"crossref","unstructured":"Sherr CJ . (1995). Trends Biochem Sci 20: 187\u2013190.","DOI":"10.1016\/S0968-0004(00)89005-2"},{"key":"BF1209146_CR60","doi-asserted-by":"crossref","unstructured":"Sherr CJ, Roberts JM . (1999). Genes Dev 13: 1501\u20131512.","DOI":"10.1101\/gad.13.12.1501"},{"key":"BF1209146_CR61","doi-asserted-by":"crossref","unstructured":"Singh RP, Agarwal R . (2004). Curr Cancer Drug Targets 4: 1\u201311.","DOI":"10.2174\/1568009043481605"},{"key":"BF1209146_CR62","doi-asserted-by":"crossref","unstructured":"Singh RP, Mallikarjuna GU, Sharma G, Dhanalakshmi S, Tyagi AK, Chan DC et al. (2004). Clin Cancer Res 10: 8641\u20138647.","DOI":"10.1158\/1078-0432.CCR-04-1435"},{"key":"BF1209146_CR63","doi-asserted-by":"crossref","unstructured":"Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R et al. (2004). J Biol Chem 279: 25813\u201325822.","DOI":"10.1074\/jbc.M313538200"},{"key":"BF1209146_CR64","doi-asserted-by":"crossref","unstructured":"Sumrejkanchanakij P, Tamamori-Adachi M, Matsunaga Y, Eto K, Ikeda MA . (2003). Oncogene 22: 8723\u20138730.","DOI":"10.1038\/sj.onc.1206870"},{"key":"BF1209146_CR65","doi-asserted-by":"crossref","unstructured":"Surh YJ . (2003). Nat Rev Cancer 3: 768\u2013780.","DOI":"10.1038\/nrc1189"},{"key":"BF1209146_CR66","unstructured":"Takagaki N, Sowa Y, Oki T, Nakanishi R, Yogosawa S, Sakai T . (2005). Int J Oncol 26: 185\u2013189."},{"key":"BF1209146_CR67","doi-asserted-by":"crossref","unstructured":"Taylor WR, Stark GR . (2001). Oncogene 20: 1803\u20131815.","DOI":"10.1038\/sj.onc.1204252"},{"key":"BF1209146_CR68","doi-asserted-by":"crossref","unstructured":"Thelen P, Wuttke W, Jarry H, Grzmil M, Ringert RH . (2004). J Urol 171: 1934\u20131938.","DOI":"10.1097\/01.ju.0000121329.37206.1b"},{"key":"BF1209146_CR69","doi-asserted-by":"crossref","unstructured":"Turowski P, Franckhauser C, Morris MC, Vaglio P, Fernandez A, Lamb NJ . (2003). Mol Biol Cell 14: 2984\u20132998.","DOI":"10.1091\/mbc.e02-08-0515"},{"key":"BF1209146_CR70","doi-asserted-by":"crossref","unstructured":"Vahteristo P, Bartkova J, Eerola H, Syrj\u00e4koski K, Ojala S, Kilpivaara O et al. (2002). Am J Hum Genet 71: 432\u2013438.","DOI":"10.1086\/341943"},{"key":"BF1209146_CR71","doi-asserted-by":"crossref","unstructured":"von Zglinicki T, Saretzki G, Ladhoff J, d'Adda di Fagagna F, Jackson SP . (2005). Mech Ageing Dev 126: 111\u2013117.","DOI":"10.1016\/j.mad.2004.09.034"},{"key":"BF1209146_CR72","doi-asserted-by":"crossref","unstructured":"Wagner H, Diesel P, Seitz M . (1974). Arzneimittelforsch 24: 466\u2013471.","DOI":"10.2307\/1935247"},{"key":"BF1209146_CR73","doi-asserted-by":"crossref","unstructured":"Wellington K, Jarvis B . (2001). BioDrugs 15: 465\u2013489.","DOI":"10.2165\/00063030-200115070-00005"},{"key":"BF1209146_CR74","doi-asserted-by":"crossref","unstructured":"Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D . (1993). Nature 366: 701\u2013704.","DOI":"10.1038\/366701a0"},{"key":"BF1209146_CR75","doi-asserted-by":"crossref","unstructured":"Yang ES, Burnstein KL . (2003). J Biol Chem 278: 46862\u201346868.","DOI":"10.1074\/jbc.M306340200"},{"key":"BF1209146_CR76","doi-asserted-by":"crossref","unstructured":"Ye R, Bodero A, Zhou BB, Khanna KK, Lavin MF, Lees-Miller SP . (2001). J Biol Chem 276: 4828\u20134833.","DOI":"10.1074\/jbc.M004894200"},{"key":"BF1209146_CR77","doi-asserted-by":"crossref","unstructured":"Ye R, Goodarzi AA, Kurz EU, Saito S, Higashimoto Y, Lavin MF et al. (2004). DNA Repair (Amst) 3: 235\u2013244.","DOI":"10.1016\/j.dnarep.2003.10.014"},{"key":"BF1209146_CR78","unstructured":"Yih LH, Lee TC . (2000). Cancer Res 60: 6346\u20136352."},{"key":"BF1209146_CR79","doi-asserted-by":"crossref","unstructured":"Yim D, Singh RP, Agarwal C, Lee S, Chi H, Agarwal R . (2005). Cancer Res 65: 1035\u20131044.","DOI":"10.1158\/0008-5472.1035.65.3"},{"key":"BF1209146_CR80","doi-asserted-by":"crossref","unstructured":"Zhang Y, Ma WY, Kaji A, Bode AM, Dong Z . (2002). J Biol Chem 277: 3124\u20133131.","DOI":"10.1074\/jbc.M110245200"},{"key":"BF1209146_CR81","doi-asserted-by":"crossref","unstructured":"Zhao H, Watkins JL, Piwnica-Worms H . (2002). Proc Natl Acad Sci USA 99: 14795\u201314800.","DOI":"10.1073\/pnas.182557299"},{"key":"BF1209146_CR82","unstructured":"Zheng XY, Ding W, Xie LP, Chen ZD . (2004). Ai Zheng 23: 215\u2013218."},{"key":"BF1209146_CR83","doi-asserted-by":"crossref","unstructured":"Zi X, Agarwal R . (1999). Proc Natl Acad Sci USA 96: 7490\u20137495.","DOI":"10.1073\/pnas.96.13.7490"},{"key":"BF1209146_CR84","unstructured":"Zi X, Feyes DK, Agarwal R . (1998a). Clin Cancer Res 4: 1055\u20131064."},{"key":"BF1209146_CR85","unstructured":"Zi X, Grasso AW, Kung HJ, Agarwal R . (1998b). Cancer Res 58: 1920\u20131929."}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1209146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1209146","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1209146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T22:40:27Z","timestamp":1683240027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1209146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10,3]]},"references-count":85,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,2,16]]}},"alternative-id":["BF1209146"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1209146","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,10,3]]},"assertion":[{"value":"11 July 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}