{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:00:28Z","timestamp":1790938828933,"version":"4.1.0"},"reference-count":128,"publisher":"Springer Science and Business Media LLC","issue":"48","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2006,10,16]]},"DOI":"10.1038\/sj.onc.1209882","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:55:39Z","timestamp":1161086139000},"page":"6361-6372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":255,"title":["Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase"],"prefix":"10.1038","volume":"25","author":[{"given":"J","family":"Avruch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Ortiz-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"BF1209882_CR1","doi-asserted-by":"crossref","unstructured":"Abraham RT . (2004). DNA Repair 3: 883\u2013887.","DOI":"10.1016\/j.dnarep.2004.04.002"},{"key":"BF1209882_CR2","doi-asserted-by":"crossref","unstructured":"Abraham RT, Wiederrecht GJ . (1996). Ann Rev Immunol 14: 483\u2013510.","DOI":"10.1146\/annurev.immunol.14.1.483"},{"key":"BF1209882_CR3","doi-asserted-by":"crossref","unstructured":"Alessi DR, Kozlowski MT, Weng QP, Morrice N, Avruch J. . (1998). Curr Biol 8: 69\u201381.","DOI":"10.1016\/S0960-9822(98)70037-5"},{"key":"BF1209882_CR4","doi-asserted-by":"crossref","unstructured":"Ali SM, Sabatini DM . (2005). J Biol Chem 280: 19445\u201319448.","DOI":"10.1074\/jbc.C500125200"},{"key":"BF1209882_CR5","doi-asserted-by":"crossref","unstructured":"Arsham AM, Howell JJ, Simon MC . (2003). J Biol Chem 278: 29655\u201329660.","DOI":"10.1074\/jbc.M212770200"},{"key":"BF1209882_CR6","doi-asserted-by":"crossref","unstructured":"Aspuria PJ, Tamanoi F . (2004). Cell Signal 16: 1105\u20131112.","DOI":"10.1016\/j.cellsig.2004.03.019"},{"key":"BF1209882_CR7","doi-asserted-by":"crossref","unstructured":"Avruch J, Lin Y, Long X, Murthy S, Ortiz-Vega S . (2005). Curr Opin Clin Nutr Metab Care 8: 67\u201372.","DOI":"10.1097\/00075197-200501000-00010"},{"key":"BF1209882_CR8","doi-asserted-by":"crossref","unstructured":"Avruch J, Zhang XF, Kyriakis JM . (1994). Trends Biol Sci 19: 279\u2013283.","DOI":"10.1016\/0968-0004(94)90005-1"},{"key":"BF1209882_CR9","doi-asserted-by":"crossref","unstructured":"Balendran A, Currie R, Armstrong CG, Avruch J, Alessi DR . (1999). J Biol Chem 274: 37400\u201337406.","DOI":"10.1074\/jbc.274.52.37400"},{"key":"BF1209882_CR10","doi-asserted-by":"crossref","unstructured":"Banerjee P, Ahmad MF, Grove JR, Kozlosky C, Price DJ, Avruch J . (1990). Proc Natl. Acad. Sci USA 87: 8550\u20138554.","DOI":"10.1073\/pnas.87.21.8550"},{"key":"BF1209882_CR11","doi-asserted-by":"crossref","unstructured":"Barbet NC, Schneider U, Helliwell SB, Stansfield I, Tuite MF, Hall MN . (1996). Mol Biol Cell 7: 25\u201342.","DOI":"10.1091\/mbc.7.1.25"},{"key":"BF1209882_CR12","doi-asserted-by":"crossref","unstructured":"Beugnet A, Wang X, Proud CG . (2003). J Biol Chem 278: 40717\u201340722.","DOI":"10.1074\/jbc.M308573200"},{"key":"BF1209882_CR13","unstructured":"Bierer BE, Jin YJ, Fruman DA, Calvo V, Burakoff SJ . (1991). Transplant Proc 6: 2850\u20132855."},{"key":"BF1209882_CR14","doi-asserted-by":"crossref","unstructured":"Biondi RM, Kieloch A, Currie RA, Deak M, Alessi DR . (2001). EMBO J 20: 4380\u20134390.","DOI":"10.1093\/emboj\/20.16.4380"},{"key":"BF1209882_CR15","doi-asserted-by":"crossref","unstructured":"Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. . (2002). J Biol Chem 277: 23977\u201323980.","DOI":"10.1074\/jbc.C200171200"},{"key":"BF1209882_CR16","doi-asserted-by":"crossref","unstructured":"Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS et al. (1994). Nature 369: 756\u2013758.","DOI":"10.1038\/369756a0"},{"key":"BF1209882_CR17","doi-asserted-by":"crossref","unstructured":"Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber S . (1995). Nature 377: 441\u2013446.","DOI":"10.1038\/377441a0"},{"key":"BF1209882_CR18","doi-asserted-by":"crossref","unstructured":"Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E et al. (2004). Genes Dev 18: 2893\u20132904.","DOI":"10.1101\/gad.1256804"},{"key":"BF1209882_CR19","doi-asserted-by":"crossref","unstructured":"Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin Jr WG . (2003). Cancer Cell 2: 147\u2013158.","DOI":"10.1016\/S1535-6108(03)00187-9"},{"key":"BF1209882_CR20","doi-asserted-by":"crossref","unstructured":"Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ . (1997). Science 277: 99\u2013101.","DOI":"10.1126\/science.277.5322.99"},{"key":"BF1209882_CR21","doi-asserted-by":"crossref","unstructured":"Burgering BM, Coffer PJ . (1995). Nature 376: 599\u2013602.","DOI":"10.1038\/376599a0"},{"key":"BF1209882_CR22","doi-asserted-by":"crossref","unstructured":"Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM . (1998). Proc Nat Acad Sci USA 95: 1432\u20131437.","DOI":"10.1073\/pnas.95.4.1432"},{"key":"BF1209882_CR23","doi-asserted-by":"crossref","unstructured":"Butow RA, Avadhani NG . (2004). Mol Cell 14: 1\u201315.","DOI":"10.1016\/S1097-2765(04)00179-0"},{"key":"BF1209882_CR24","doi-asserted-by":"crossref","unstructured":"Byfield MP, Murray JT, Backer JM . (2005). J Biol Chem 280: 33076\u201333082.","DOI":"10.1074\/jbc.M507201200"},{"key":"BF1209882_CR25","doi-asserted-by":"crossref","unstructured":"Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM et al. (1993). Mol Cell Biol 13: 6012\u20136023.","DOI":"10.1128\/MCB.13.10.6012"},{"key":"BF1209882_CR26","doi-asserted-by":"crossref","unstructured":"Castro AF, Rebhun JF, Clark GJ, Quilliam LA . (2003). J Biol Chem 278: 32493\u201332496.","DOI":"10.1074\/jbc.C300226200"},{"key":"BF1209882_CR27","doi-asserted-by":"crossref","unstructured":"Cheatham L, Monfar M, Chou MM, Blenis J . (1995). Proc Natl Acad Sci USA 92: 11696\u201311700.","DOI":"10.1073\/pnas.92.25.11696"},{"key":"BF1209882_CR28","doi-asserted-by":"crossref","unstructured":"Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR . (1994). Mol Cell Biol 14: 4902\u20134911.","DOI":"10.1128\/MCB.14.7.4902"},{"key":"BF1209882_CR29","doi-asserted-by":"crossref","unstructured":"Chen RH, Blenis J . (1990). Mol Cell Biol 10: 3204\u20133215.","DOI":"10.1128\/MCB.10.6.3204"},{"key":"BF1209882_CR30","doi-asserted-by":"crossref","unstructured":"Chen J, Zheng X-F, Brown EJ, Schreiber SL . (1995). Proc Natl Acad Sci USA 92: 4947\u20134951.","DOI":"10.1073\/pnas.92.11.4947"},{"key":"BF1209882_CR31","doi-asserted-by":"crossref","unstructured":"Chiu MI, Katz H, Berlin V. . (1994). Proc Natl Acad Sci USA 91: 12574\u201312578.","DOI":"10.1073\/pnas.91.26.12574"},{"key":"BF1209882_CR32","doi-asserted-by":"crossref","unstructured":"Choi J, Chen J, Schreiber SL, Clardy J . (1996). Science 273: 239\u2013242.","DOI":"10.1126\/science.273.5272.239"},{"key":"BF1209882_CR33","doi-asserted-by":"crossref","unstructured":"Choi KM, McMahon LP, Lawrence Jr JC . (2003). J Biol Chem 278: 19667\u201319673.","DOI":"10.1074\/jbc.M301142200"},{"key":"BF1209882_CR34","doi-asserted-by":"crossref","unstructured":"Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J . (1994). Nature 370: 71\u201375.","DOI":"10.1038\/370071a0"},{"key":"BF1209882_CR35","doi-asserted-by":"crossref","unstructured":"Colicelli J . (2004). Sci STKE 250: RE13.","DOI":"10.1126\/stke.2502004re13"},{"key":"BF1209882_CR36","doi-asserted-by":"crossref","unstructured":"Corradetti MN, Inoki K, Guan KL . (2005). J Biol Chem 280: 9769\u20139772.","DOI":"10.1074\/jbc.C400557200"},{"key":"BF1209882_CR37","doi-asserted-by":"crossref","unstructured":"Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC et al. (2002). J Biol Chem 277: 35364\u201335370.","DOI":"10.1074\/jbc.M205838200"},{"key":"BF1209882_CR38","doi-asserted-by":"crossref","unstructured":"Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G . (2001). Science 294: 1102\u20131105.","DOI":"10.1126\/science.1063518"},{"key":"BF1209882_CR39","doi-asserted-by":"crossref","unstructured":"Dong J, Pan D . (2004). Genes Dev 18: 2479\u20132484.","DOI":"10.1101\/gad.1240504"},{"key":"BF1209882_CR40","doi-asserted-by":"crossref","unstructured":"Drenan RM, Liu X, Bertram PG, Zheng XF . (2004). J Biol Chem 279: 772\u2013778.","DOI":"10.1074\/jbc.M305912200"},{"key":"BF1209882_CR41","doi-asserted-by":"crossref","unstructured":"Dumont FJ, Su G . (1995). Life Sci 58: 373\u2013395.","DOI":"10.1016\/0024-3205(95)02233-3"},{"key":"BF1209882_CR42","doi-asserted-by":"crossref","unstructured":"Erikson E, Maller JL . (1985). Proc Natl Acad Sci USA 82: 742\u2013746.","DOI":"10.1073\/pnas.82.3.742"},{"key":"BF1209882_CR43","doi-asserted-by":"crossref","unstructured":"Erikson E, Maller JL . (1986). J Biol Chem 261: 350\u2013355.","DOI":"10.1016\/S0021-9258(17)42478-1"},{"key":"BF1209882_CR44","doi-asserted-by":"crossref","unstructured":"Fang Y, Park IH, Wu AL, Du G, Huang P, Frohman MA et al. (2003). Curr Biol 13: 2037\u20132044.","DOI":"10.1016\/j.cub.2003.11.021"},{"key":"BF1209882_CR45","doi-asserted-by":"crossref","unstructured":"Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J . (2001). Science 294: 1942\u20131945.","DOI":"10.1126\/science.1066015"},{"key":"BF1209882_CR46","doi-asserted-by":"crossref","unstructured":"Gao X, Pan D . (2001). Genes Dev 15: 1383\u20131392.","DOI":"10.1101\/gad.901101"},{"key":"BF1209882_CR47","doi-asserted-by":"crossref","unstructured":"Gao X, Zhang Y, Arrazola P, Hino O, Kobayashi T, Yeung RS et al. (2002). Nat Cell Biol 4: 699\u2013704.","DOI":"10.1038\/ncb847"},{"key":"BF1209882_CR48","doi-asserted-by":"crossref","unstructured":"Garami A, Zwartkruis FJT, Nobukuni T, Joaquin M, Roccio M, Stocker H et al. (2003). Mol Cell 11: 1457\u20131466.","DOI":"10.1016\/S1097-2765(03)00220-X"},{"key":"BF1209882_CR49","doi-asserted-by":"crossref","unstructured":"Gautam N, Downs GB, Yan K, Kisselev O . (1998). Cell Signal 10: 447\u2013455.","DOI":"10.1016\/S0898-6568(98)00006-0"},{"key":"BF1209882_CR50","doi-asserted-by":"crossref","unstructured":"Giannattasio S, Liu Z, Thornton J, Butow RA . (2005). J Biol Chem 280: 42528\u201343535.","DOI":"10.1074\/jbc.M509187200"},{"key":"BF1209882_CR51","doi-asserted-by":"crossref","unstructured":"Grove JR, Banerjee P, Balasubramanyam A, Coffer PJ, Price DJ, Avruch J et al. (1991). Mol Cell Biol 11: 5541\u20135550.","DOI":"10.1128\/mcb.11.11.5541-5550.1991"},{"key":"BF1209882_CR52","doi-asserted-by":"crossref","unstructured":"Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N . (2005). J Biol Chem 280: 32081\u201332089.","DOI":"10.1074\/jbc.M502876200"},{"key":"BF1209882_CR53","doi-asserted-by":"crossref","unstructured":"Hara K, Yonezawa K, Kozlowski MT, Sugimoto T, Andrabi K, Weng Q-P et al. (1997). J Biol Chem 272: 26457\u201326463.","DOI":"10.1074\/jbc.272.42.26457"},{"key":"BF1209882_CR54","doi-asserted-by":"crossref","unstructured":"Hara K, Yonezawa K, Weng Q-P, Kozlowski MT, Belham C, Avruch J . (1998). J Biol Chem 272: 14484\u201314494.","DOI":"10.1074\/jbc.273.23.14484"},{"key":"BF1209882_CR55","doi-asserted-by":"crossref","unstructured":"Hara K, Maruki Y, Long X, Yoshino K-i, Oshiro N, Hidayat S et al. (2002). Cell 110: 177\u2013189.","DOI":"10.1016\/S0092-8674(02)00833-4"},{"key":"BF1209882_CR56","doi-asserted-by":"crossref","unstructured":"Heitman J, Movva NR, Hall MN . (1991). Science 253: 905\u2013909.","DOI":"10.1126\/science.1715094"},{"key":"BF1209882_CR57","doi-asserted-by":"crossref","unstructured":"Hu CD, Kariya K, Tamada M, Akasaka K, Shirouzu M, Yokoyama S et al. (1995). J Biol Chem 270: 30274\u201330277.","DOI":"10.1074\/jbc.270.51.30274"},{"key":"BF1209882_CR58","doi-asserted-by":"crossref","unstructured":"Im E, von Lintig FC, Chen J, Zhuang S, Qui W, Chowdhury S et al. (2002). Oncogene 21: 6356\u20136365.","DOI":"10.1038\/sj.onc.1205792"},{"key":"BF1209882_CR59","doi-asserted-by":"crossref","unstructured":"Inoki K, Li Y, Zhu T, Wu J, Guan KL . (2002). Nat Cell Biol 4: 648\u2013657.","DOI":"10.1038\/ncb839"},{"key":"BF1209882_CR60","doi-asserted-by":"crossref","unstructured":"Inoki K, Li Y, Xu T, Guan K-L . (2003a). Genes Dev 17: 1829\u20131834.","DOI":"10.1101\/gad.1110003"},{"key":"BF1209882_CR61","doi-asserted-by":"crossref","unstructured":"Inoki K, Zhu T, Guan KL . (2003b). Cell 115: 577\u2013590.","DOI":"10.1016\/S0092-8674(03)00929-2"},{"key":"BF1209882_CR62","doi-asserted-by":"crossref","unstructured":"Isotani S, Hara K, Tokunaga C, Inoue H, Avruch J, Yonezawa K . (1999). J Biol Chem 274: 34493\u201334498.","DOI":"10.1074\/jbc.274.48.34493"},{"key":"BF1209882_CR63","doi-asserted-by":"crossref","unstructured":"Jones SW, Erikson E, Blenis J, Maller JL, Erikson RL . (1988). Proc Natl Acad Sci USA 85: 3377\u20133381.","DOI":"10.1073\/pnas.85.10.3377"},{"key":"BF1209882_CR64","doi-asserted-by":"crossref","unstructured":"Kam Y, Exton JH . (2004). FASEB J 18: 311\u2013319.","DOI":"10.1096\/fj.03-0731com"},{"key":"BF1209882_CR65","doi-asserted-by":"crossref","unstructured":"Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP . (2004). J Biol Chem 279: 29930\u201329937.","DOI":"10.1074\/jbc.M402591200"},{"key":"BF1209882_CR66","doi-asserted-by":"crossref","unstructured":"Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H et al. (2002). Cell 110: 163\u2013175.","DOI":"10.1016\/S0092-8674(02)00808-5"},{"key":"BF1209882_CR67","doi-asserted-by":"crossref","unstructured":"Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H et al. (2003). Mol Cell 11: 895\u2013904.","DOI":"10.1016\/S1097-2765(03)00114-X"},{"key":"BF1209882_CR68","doi-asserted-by":"crossref","unstructured":"Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K et al. (2003). Genes Cells 8: 65\u201379.","DOI":"10.1046\/j.1365-2443.2003.00615.x"},{"key":"BF1209882_CR69","doi-asserted-by":"crossref","unstructured":"Koltin Y, Faucette L, Bergsma DJ, Levy MA, Cafferkey R, Koser PL et al. (1991). Mol Cell Biol 11: 1718\u20131723.","DOI":"10.1128\/MCB.11.3.1718"},{"key":"BF1209882_CR70","doi-asserted-by":"crossref","unstructured":"Kunz J, Henriquez R, Schneider U, Deuter-Reinhard M, Movva NR, Hall MN . (1993). Cell 73: 585\u2013596.","DOI":"10.1016\/0092-8674(93)90144-F"},{"key":"BF1209882_CR71","unstructured":"Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N et al. (2002). Hum Mol Genet 11: 525\u2013534."},{"key":"BF1209882_CR72","doi-asserted-by":"crossref","unstructured":"Kwiatkowski DJ . (2003). Ann Hum Genet 67: 87\u201396.","DOI":"10.1046\/j.1469-1809.2003.00012.x"},{"key":"BF1209882_CR73","doi-asserted-by":"crossref","unstructured":"Li Y, Inoki K, Guan KL . (2004). Mol Cell Biol 24: 7965\u20137975.","DOI":"10.1128\/MCB.24.18.7965-7975.2004"},{"key":"BF1209882_CR74","doi-asserted-by":"crossref","unstructured":"Liu Z, Sekito T, Epstein CB, Butow RA . (2001). EMBO J 20: 7209\u20137219.","DOI":"10.1093\/emboj\/20.24.7209"},{"key":"BF1209882_CR75","doi-asserted-by":"crossref","unstructured":"Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D et al. (2002). Mol Cell 10: 457\u2013468.","DOI":"10.1016\/S1097-2765(02)00636-6"},{"key":"BF1209882_CR76","doi-asserted-by":"crossref","unstructured":"Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J . (2005a). Curr Biol 15: 702\u2013713.","DOI":"10.1016\/j.cub.2005.02.053"},{"key":"BF1209882_CR77","doi-asserted-by":"crossref","unstructured":"Long X, Ortiz-Vega S, Lin Y, Avruch J . (2005b). J Biol Chem 280: 23433\u201323436.","DOI":"10.1074\/jbc.C500169200"},{"key":"BF1209882_CR78","doi-asserted-by":"crossref","unstructured":"Long X, Spycher C, Han ZS, Rose AM, Muller F, Avruch J . (2002). Curr Biol 12: 1448\u20131461.","DOI":"10.1016\/S0960-9822(02)01091-6"},{"key":"BF1209882_CR79","doi-asserted-by":"crossref","unstructured":"Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP . (2005). Cell 121: 179\u2013193.","DOI":"10.1016\/j.cell.2005.02.031"},{"key":"BF1209882_CR80","doi-asserted-by":"crossref","unstructured":"Manning BD, Tee AR, Logsdon MM, Blenis J, Cantley LC . (2002). Mol Cell 10: 151\u2013162.","DOI":"10.1016\/S1097-2765(02)00568-3"},{"key":"BF1209882_CR81","doi-asserted-by":"crossref","unstructured":"Mirshahi T, Mittal V, Zhang H, Linder ME, Logothetis DE . (2002). J Biol Chem 277: 36345\u201336350.","DOI":"10.1074\/jbc.M205359200"},{"key":"BF1209882_CR82","doi-asserted-by":"crossref","unstructured":"Nemenoff RA, Price DJ, Mendelson MJ, Carter EA, Avruch J . (1988). J Biol Chem 263: 19455\u201319460.","DOI":"10.1016\/S0021-9258(19)77655-8"},{"key":"BF1209882_CR83","doi-asserted-by":"crossref","unstructured":"Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P et al. (2005). Proc Natl Acad Sci USA 102: 14238\u201314343.","DOI":"10.1073\/pnas.0506925102"},{"key":"BF1209882_CR84","doi-asserted-by":"crossref","unstructured":"Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K et al. (2003). J Biol Chem 278: 15461\u201315464.","DOI":"10.1074\/jbc.C200665200"},{"key":"BF1209882_CR85","doi-asserted-by":"crossref","unstructured":"Oldham S, Hafen E . (2003). Trends Cell Biol 13: 79\u201385.","DOI":"10.1016\/S0962-8924(02)00042-9"},{"key":"BF1209882_CR86","doi-asserted-by":"crossref","unstructured":"Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S . (2004). Genes Cells 9: 359\u2013366.","DOI":"10.1111\/j.1356-9597.2004.00727.x"},{"key":"BF1209882_CR87","doi-asserted-by":"crossref","unstructured":"Patel PH, Thapar N, Guo L, Martinez M, Maris J, Gau CL et al. (2003). J Cell Sci 116: 3601\u20133610.","DOI":"10.1242\/jcs.00661"},{"key":"BF1209882_CR88","doi-asserted-by":"crossref","unstructured":"Pearson RB, Dennis PB, Han JW, Williamson NA, Kozma SC, Wettenhall RE et al. (1995). EMBO J 14: 5279\u20135287.","DOI":"10.1002\/j.1460-2075.1995.tb00212.x"},{"key":"BF1209882_CR89","doi-asserted-by":"crossref","unstructured":"Potter CJ, Huang H, Xu T . (2001). Cell 105: 357\u2013368.","DOI":"10.1016\/S0092-8674(01)00333-6"},{"key":"BF1209882_CR90","doi-asserted-by":"crossref","unstructured":"Price D, Grove JR, Calvo V, Avruch J, Bierer BE . (1992). Science 257: 973\u2013977.","DOI":"10.1126\/science.1380182"},{"key":"BF1209882_CR91","doi-asserted-by":"crossref","unstructured":"Price DJ, Gunsalus JR, Avruch J . (1990). Proc Natl Acad Sci USA 87: 7944\u20137948.","DOI":"10.1073\/pnas.87.20.7944"},{"key":"BF1209882_CR92","doi-asserted-by":"crossref","unstructured":"Price DJ, Mukhohpadhyay NK, Avruch J . (1991). J Biol Chem 266: 16281\u201316284.","DOI":"10.1016\/S0021-9258(18)55291-1"},{"key":"BF1209882_CR93","doi-asserted-by":"crossref","unstructured":"Price DJ, Nemenoff RA, Avruch J . (1989). J Biol Chem 264: 13825\u201313833.","DOI":"10.1016\/S0021-9258(18)80075-8"},{"key":"BF1209882_CR94","doi-asserted-by":"crossref","unstructured":"Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA . (1998). Science 279: 707\u2013710.","DOI":"10.1126\/science.279.5351.707"},{"key":"BF1209882_CR95","doi-asserted-by":"crossref","unstructured":"Radimerski T, Montagne J, Hemmings-Mieszczak M, Thomas G . (2002). Genes Dev 16: 2627\u20132632.","DOI":"10.1101\/gad.239102"},{"key":"BF1209882_CR96","doi-asserted-by":"crossref","unstructured":"Reiling JH, Hafen E . (2004). Genes Dev 18: 2879\u20132892.","DOI":"10.1101\/gad.322704"},{"key":"BF1209882_CR97","doi-asserted-by":"crossref","unstructured":"Roccio M, Bos JL, Zwartkruis FJ . (2006). Oncogene 25: 657\u2013664.","DOI":"10.1038\/sj.onc.1209106"},{"key":"BF1209882_CR98","unstructured":"Rodriguez-Viciana P, Marte BM, Warne PH, Downward J . (1996). Philos Trans R Soc London B Biol Sci 351: 225\u2013231."},{"key":"BF1209882_CR99","doi-asserted-by":"crossref","unstructured":"Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J . (2004). Proc Natl Acad Sci USA 101: 13489\u201313494.","DOI":"10.1073\/pnas.0405659101"},{"key":"BF1209882_CR100","doi-asserted-by":"crossref","unstructured":"Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH . (1994). Cell 78: 35\u201343.","DOI":"10.1016\/0092-8674(94)90570-3"},{"key":"BF1209882_CR101","doi-asserted-by":"crossref","unstructured":"Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G et al. (1995). J Biol Chem 270: 815\u2013822.","DOI":"10.1074\/jbc.270.2.815"},{"key":"BF1209882_CR102","doi-asserted-by":"crossref","unstructured":"Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA . (2003). Nat Cell Biol 5: 566\u2013571.","DOI":"10.1038\/ncb996"},{"key":"BF1209882_CR103","doi-asserted-by":"crossref","unstructured":"Schalm SS, Blenis J . (2002). Curr Biol 8: 632\u2013639.","DOI":"10.1016\/S0960-9822(02)00762-5"},{"key":"BF1209882_CR104","doi-asserted-by":"crossref","unstructured":"Schalm SS, Fingar DC, Sabatini DM, Blenis J . (2003). Curr Biol 13: 797\u2013806.","DOI":"10.1016\/S0960-9822(03)00329-4"},{"key":"BF1209882_CR105","doi-asserted-by":"crossref","unstructured":"Schreiber S . (1991). Science 251: 283\u2013287.","DOI":"10.1126\/science.1702904"},{"key":"BF1209882_CR106","doi-asserted-by":"crossref","unstructured":"Scott PH, Brunn GJ, Kohn AD, Roth RA, Lawrence Jr JC . (1998). Proc Natl Acad Sci USA 95: 7772\u20137777.","DOI":"10.1073\/pnas.95.13.7772"},{"key":"BF1209882_CR107","doi-asserted-by":"crossref","unstructured":"Sehgal SN . (2003). Transplant Proc 3 (35 suppl): 75\u2013145.","DOI":"10.5005\/jp\/books\/10131_23"},{"key":"BF1209882_CR108","unstructured":"Sekulic A, Hudson CC, Homme JL, Yin P, Otterness DM, Karnitz LM et al. (2000). Cancer Res 60: 3504\u20133513."},{"key":"BF1209882_CR109","doi-asserted-by":"crossref","unstructured":"Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG . (2005). J Biol Chem 280: 18718\u201318727.","DOI":"10.1074\/jbc.M414499200"},{"key":"BF1209882_CR110","doi-asserted-by":"crossref","unstructured":"Smith TF, Gaitatzes C, Saxena K, Neer EJ . (1999). Trends Biol Sci 24: 181\u2013185.","DOI":"10.1016\/S0968-0004(99)01384-5"},{"key":"BF1209882_CR111","doi-asserted-by":"crossref","unstructured":"Sofer A, Lei K, Johannessen CM, Ellisen LW . (2005). Mol Cell Biol 25: 5834\u20135845.","DOI":"10.1128\/MCB.25.14.5834-5845.2005"},{"key":"BF1209882_CR112","doi-asserted-by":"crossref","unstructured":"Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat F, Daram P, BG et al. (2003). Nat Cell Biol 5: 559\u2013565.","DOI":"10.1038\/ncb995"},{"key":"BF1209882_CR113","doi-asserted-by":"crossref","unstructured":"Sturgill TW, Ray LB, Erikson E, Maller JL . (1988). Nature 334: 715\u2013718.","DOI":"10.1038\/334715a0"},{"key":"BF1209882_CR114","doi-asserted-by":"crossref","unstructured":"Takahashi K, Nakagawa M, Young SG, Yamanaka S . (2005). J Biol Chem 280: 32768\u201332774.","DOI":"10.1074\/jbc.M506280200"},{"key":"BF1209882_CR115","doi-asserted-by":"crossref","unstructured":"Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK . (2001). Cell 105: 345\u2013355.","DOI":"10.1016\/S0092-8674(01)00332-4"},{"key":"BF1209882_CR116","doi-asserted-by":"crossref","unstructured":"Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J . (2002). Proc Natl Acad Sci USA 99: 13571\u201313576.","DOI":"10.1073\/pnas.202476899"},{"key":"BF1209882_CR117","doi-asserted-by":"crossref","unstructured":"Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J . (2003). Curr Biol 13: 1259\u20131268.","DOI":"10.1016\/S0960-9822(03)00506-2"},{"key":"BF1209882_CR118","doi-asserted-by":"crossref","unstructured":"Urano J, Comiso MJ, Guo L, Aspuria PJ, Deniskin R, Tabancay Jr AP et al. (2005). Mol Microbiol 58: 1074\u20131086.","DOI":"10.1111\/j.1365-2958.2005.04877.x"},{"key":"BF1209882_CR119","doi-asserted-by":"crossref","unstructured":"van Slegtenhorst M, Carr E, Stoyanova R, Kruger WD, Henske EP . (2004). J Biol Chem 279: 12706\u201312713.","DOI":"10.1074\/jbc.M313874200"},{"key":"BF1209882_CR120","doi-asserted-by":"crossref","unstructured":"Vezina C, Kudelski A, Sehgal SN . (1975). J Antibiotics 28: 721\u2013726.","DOI":"10.7164\/antibiotics.28.721"},{"key":"BF1209882_CR121","doi-asserted-by":"crossref","unstructured":"Wedaman KP, Reinke A, Anderson S, Yates III J, McCaffery JM, Powers T . (2003). Mol Biol Cell 14: 1204\u20131220.","DOI":"10.1091\/mbc.e02-09-0609"},{"key":"BF1209882_CR122","doi-asserted-by":"crossref","unstructured":"Weng QP, Andrabi K, Klippel A, Kozlowski MT, Williams LT, Avruch J . (1995a). Proc Natl Acad Sci USA 92: 5744\u20135748.","DOI":"10.1073\/pnas.92.12.5744"},{"key":"BF1209882_CR123","doi-asserted-by":"crossref","unstructured":"Weng QP, Andrabi K, Kozlowski MT, Grove JR, Avruch J . (1995b). Mol Cell Biol 15: 2333\u20132340.","DOI":"10.1128\/MCB.15.5.2333"},{"key":"BF1209882_CR124","doi-asserted-by":"crossref","unstructured":"Weng QP, Kozlowski M, Belham C, Zhang A, Comb MJ, Avruch J . (1998). J Biol Chem 273: 16621\u201316629.","DOI":"10.1074\/jbc.273.26.16621"},{"key":"BF1209882_CR125","doi-asserted-by":"crossref","unstructured":"Wu S, Mikhailov A, Kallo-Hosein H, Hara K, Yonezawa K, Avruch J . (2002). Biochim Biophys Acta 1542: 41\u201356.","DOI":"10.1016\/S0167-4889(01)00164-1"},{"key":"BF1209882_CR126","doi-asserted-by":"crossref","unstructured":"Yamagata K, Sanders LK, Kaufmann WE, Yee W, Barnes CA, Nathans D et al. (1994). J Biol Chem 269: 16333\u201316339.","DOI":"10.1016\/S0021-9258(17)34012-7"},{"key":"BF1209882_CR127","doi-asserted-by":"crossref","unstructured":"Yang W, Tabancay Jr AP, Urano J, Tamanoi F . (2001). Mol Microbiol 41: 1339\u20131347.","DOI":"10.1046\/j.1365-2958.2001.02599.x"},{"key":"BF1209882_CR128","doi-asserted-by":"crossref","unstructured":"Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D . (2003). Nat Cell Biol 5: 578\u2013581.","DOI":"10.1038\/ncb999"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1209882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1209882","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1209882.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T07:54:46Z","timestamp":1647935686000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1209882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,16]]},"references-count":128,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2006,10,16]]}},"alternative-id":["BF1209882"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1209882","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,16]]},"assertion":[{"value":"16 October 2006","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}