{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:47:05Z","timestamp":1791287225223,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"16","license":[{"start":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T00:00:00Z","timestamp":1159747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T00:00:00Z","timestamp":1159747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2007,4,5]]},"DOI":"10.1038\/sj.onc.1210017","type":"journal-article","created":{"date-parts":[[2006,10,2]],"date-time":"2006-10-02T15:20:54Z","timestamp":1159802454000},"page":"2263-2271","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["RING-dependent tumor suppression and G2\/M arrest induced by the TRC8 hereditary kidney cancer gene"],"prefix":"10.1038","volume":"26","author":[{"given":"A","family":"Brauweiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K L","family":"Lorick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y C","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Weissman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Drabkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Gemmill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,10,2]]},"reference":[{"key":"BF1210017_CR1","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1212\/01.wnl.0000192261.02023.b8","volume":"66","author":"A Ciechanover","year":"2006","unstructured":"Ciechanover A . (2006). The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology 66: S7\u2013S19.","journal-title":"Neurology"},{"key":"BF1210017_CR2","first-page":"2958","volume":"46","author":"RV Clayman","year":"1986","unstructured":"Clayman RV, Bilhartz LE, Buja LM, Spady DK, Dietschy JM . (1986). Renal cell carcinoma in the Wistar\u2013Lewis rat: a model for studying the mechanisms of cholesterol acquisition by a tumor in vivo. Cancer Res 46: 2958\u20132963.","journal-title":"Cancer Res"},{"key":"BF1210017_CR3","doi-asserted-by":"publisher","first-page":"5067","DOI":"10.1038\/sj.onc.1204602","volume":"20","author":"SC Clifford","year":"2001","unstructured":"Clifford SC, Astuti D, Hooper L, Maxwell PH, Ratcliffe PJ, Maher ER . (2001). The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma. Oncogene 20: 5067\u20135074.","journal-title":"Oncogene"},{"key":"BF1210017_CR4","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1056\/NEJM197909133011107","volume":"301","author":"AJ Cohen","year":"1979","unstructured":"Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC et al. (1979). Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 301: 592\u2013595.","journal-title":"N Engl J Med"},{"key":"BF1210017_CR5","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1158\/0008-5472.CAN-2148-2","volume":"64","author":"SL Ettinger","year":"2004","unstructured":"Ettinger SL, Sobel R, Whitmore TG, Akbari M, Bradley DR, Gleave ME et al. (2004). Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence. Cancer Res 64: 2212\u20132221.","journal-title":"Cancer Res"},{"key":"BF1210017_CR6","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/35071124","volume":"410","author":"J Falck","year":"2001","unstructured":"Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J . (2001). The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410: 842\u2013847.","journal-title":"Nature"},{"key":"BF1210017_CR7","doi-asserted-by":"publisher","first-page":"14422","DOI":"10.1073\/pnas.251401598","volume":"98","author":"S Fang","year":"2001","unstructured":"Fang S, Ferrone M, Yang C, Jensen JP, Tiwari S, Weissman AM . (2001). The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc Natl Acad Sci USA 98: 14422\u201314427.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210017_CR8","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0022-2275(20)38606-5","volume":"28","author":"RL Gebhard","year":"1987","unstructured":"Gebhard RL, Clayman RV, Prigge WF, Figenshau R, Staley NA, Reesey C et al. (1987). Abnormal cholesterol metabolism in renal clear cell carcinoma. J Lipid Res 28: 1177\u20131184.","journal-title":"J Lipid Res"},{"key":"BF1210017_CR9","doi-asserted-by":"publisher","first-page":"3507","DOI":"10.1038\/sj.onc.1205437","volume":"21","author":"RM Gemmill","year":"2002","unstructured":"Gemmill RM, Bemis LT, Lee JP, Sozen MA, Baron A, Zeng C et al. (2002). The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway. Oncogene 21: 3507\u20133516.","journal-title":"Oncogene"},{"key":"BF1210017_CR10","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1038\/sj.onc.1208509","volume":"24","author":"RM Gemmill","year":"2005","unstructured":"Gemmill RM, Lee JP, Chamovitz DA, Segal D, Hooper JE, Drabkin HA . (2005). Growth suppression induced by the TRC8 hereditary kidney cancer gene is dependent upon JAB1\/CSN5. Oncogene 24: 3503\u20133511.","journal-title":"Oncogene"},{"key":"BF1210017_CR11","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1073\/pnas.95.16.9572","volume":"95","author":"RM Gemmill","year":"1998","unstructured":"Gemmill RM, West JD, Boldog F, Tanaka N, Robinson LJ, Smith DI et al. (1998). The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. Proc Natl Acad Sci USA 95: 9572\u20139577.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210017_CR12","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.cell.2005.12.022","volume":"124","author":"JL Goldstein","year":"2006","unstructured":"Goldstein JL, DeBose-Boyd RA, Brown MS . (2006). Protein sensors for membrane sterols. Cell 124: 35\u201346.","journal-title":"Cell"},{"key":"BF1210017_CR13","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS . (2002). SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125\u20131131.","journal-title":"J Clin Invest"},{"key":"BF1210017_CR14","doi-asserted-by":"publisher","first-page":"12027","DOI":"10.1073\/pnas.1534923100","volume":"100","author":"JD Horton","year":"2003","unstructured":"Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS et al. (2003). Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100: 12027\u201312032.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210017_CR15","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.cell.2005.01.012","volume":"120","author":"AL Hughes","year":"2005","unstructured":"Hughes AL, Todd BL, Espenshade PJ . (2005). SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell 120: 831\u2013842.","journal-title":"Cell"},{"key":"BF1210017_CR16","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/nature02989","volume":"431","author":"K Ito","year":"2004","unstructured":"Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, Hamaguchi I et al. (2004). Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431: 997\u20131002.","journal-title":"Nature"},{"key":"BF1210017_CR17","doi-asserted-by":"publisher","first-page":"6290S","DOI":"10.1158\/1078-0432.CCR-sup-040025","volume":"10","author":"WG Kaelin Jr","year":"2004","unstructured":"Kaelin Jr WG . (2004). The von Hippel\u2013Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res 10: 6290S\u20136295S.","journal-title":"Clin Cancer Res"},{"key":"BF1210017_CR18","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.bbrc.2005.08.165","volume":"338","author":"WG Kaelin Jr","year":"2005","unstructured":"Kaelin Jr WG . (2005). The von Hippel\u2013Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 338: 627\u2013638.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF1210017_CR19","doi-asserted-by":"publisher","first-page":"15341","DOI":"10.1074\/jbc.M210531200","volume":"278","author":"S Katoh","year":"2003","unstructured":"Katoh S, Hong C, Tsunoda Y, Murata K, Takai R, Minami E et al. (2003). High precision NMR structure and function of the RING-H2 finger domain of EL5, a rice protein whose expression is increased upon exposure to pathogen-derived oligosaccharides. J Biol Chem 278: 15341\u201315348.","journal-title":"J Biol Chem"},{"key":"BF1210017_CR20","doi-asserted-by":"publisher","first-page":"106","DOI":"10.7326\/0003-4819-118-2-199301150-00005","volume":"118","author":"FP Li","year":"1993","unstructured":"Li FP, Decker HJ, Zbar B, Stanton Jr VP, Kovacs G, Seizinger BR et al. (1993). Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Genetics of familial renal carcinoma. Ann Intern Med 118: 106\u2013111.","journal-title":"Ann Intern Med"},{"key":"BF1210017_CR21","doi-asserted-by":"publisher","first-page":"11364","DOI":"10.1073\/pnas.96.20.11364","volume":"96","author":"KL Lorick","year":"1999","unstructured":"Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM . (1999). RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc Natl Acad Sci USA 96: 11364\u201311369.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210017_CR22","doi-asserted-by":"publisher","first-page":"5523","DOI":"10.1158\/0008-5472.CAN-04-2582","volume":"65","author":"D Ma","year":"2005","unstructured":"Ma D, Nutt CL, Shanehsaz P, Peng X, Louis DN, Kaetzel DM . (2005). Autocrine platelet-derived growth factor-dependent gene expression in glioblastoma cells is mediated largely by activation of the transcription factor sterol regulatory element binding protein and is associated with altered genotype and patient survival in human brain tumors. Cancer Res 65: 5523\u20135534.","journal-title":"Cancer Res"},{"key":"BF1210017_CR23","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1535-6108(02)00071-5","volume":"1","author":"SJ Mandriota","year":"2002","unstructured":"Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM et al. (2002). HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron. Cancer Cell 1: 459\u2013468.","journal-title":"Cancer Cell"},{"key":"BF1210017_CR24","first-page":"278","volume":"312","author":"PM Martel","year":"2006","unstructured":"Martel PM, Bingham CM, McGraw CJ, Baker CL, Morganelli PM, Meng ML et al. (2006). S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth. Exp Cell Res 312: 278\u2013288.","journal-title":"Exp Cell Res"},{"key":"BF1210017_CR25","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1126\/science.282.5395.1893","volume":"282","author":"S Matsuoka","year":"1998","unstructured":"Matsuoka S, Huang M, Elledge SJ . (1998). Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282: 1893\u20131897.","journal-title":"Science"},{"key":"BF1210017_CR26","doi-asserted-by":"publisher","first-page":"10429","DOI":"10.1073\/pnas.1734137100","volume":"100","author":"T Ohira","year":"2003","unstructured":"Ohira T, Gemmill RM, Ferguson K, Kusy S, Roche J, Brambilla E et al. (2003). WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci USA 100: 10429\u201310434.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210017_CR27","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1128\/MCB.26.7.2817-2831.2006","volume":"26","author":"BL Todd","year":"2006","unstructured":"Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ . (2006). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol 26: 2817\u20132831.","journal-title":"Mol Cell Biol"},{"key":"BF1210017_CR28","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0092-8674(00)00057-X","volume":"102","author":"N Zheng","year":"2000","unstructured":"Zheng N, Wang P, Jeffrey PD, Pavletich NP . (2000). Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin\u2013protein ligases. Cell 102: 533\u2013539.","journal-title":"Cell"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1210017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210017","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T09:38:34Z","timestamp":1647941914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1210017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,2]]},"references-count":28,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2007,4,5]]}},"alternative-id":["BF1210017"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1210017","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,2]]},"assertion":[{"value":"19 June 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}