{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:53:46Z","timestamp":1791118426312,"version":"4.1.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T00:00:00Z","timestamp":1172448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2007,2,26]]},"DOI":"10.1038\/sj.onc.1210240","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T09:55:24Z","timestamp":1172483724000},"page":"1297-1305","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Epstein\u2013Barr virus infection in humans: from harmless to life endangering virus\u2013lymphocyte interactions"],"prefix":"10.1038","volume":"26","author":[{"given":"E","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L L","family":"Kis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,2,26]]},"reference":[{"key":"BF1210240_CR1","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1128\/jvi.64.5.2126-2134.1990","volume":"64","author":"SD Abbot","year":"1990","unstructured":"Abbot SD, Rowe M, Cadwallader K, Ricksten A, Gordon J, Wang F et al. (1990). Epstein\u2013Barr virus nuclear antigen 2 induces expression of the virus-encoded latent membrane protein. J Virol 64: 2126\u20132134.","journal-title":"J Virol"},{"key":"BF1210240_CR2","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1073\/pnas.89.3.905","volume":"89","author":"E Altiok","year":"1992","unstructured":"Altiok E, Minarovits J, Hu LF, Contreras-Brodin B, Klein G, Ernberg I . (1992). Host-cell-phenotype-dependent control of the BCR2\/BWR1 promoter complex regulates the expression of Epstein\u2013Barr virus nuclear antigens 2\u20136 [published erratum appears in Proc Natl Acad Sci USA 1992; 89: 6225]. Proc Natl Acad Sci USA 89: 905\u2013909.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/path.1894","volume":"208","author":"C Atayar","year":"2006","unstructured":"Atayar C, Poppema S, Visser L, van den Berg A . (2006). Cytokine gene expression profile distinguishes CD4+\/CD57+ T cells of the nodular lymphocyte predominance type of Hodgkin's lymphoma from their tonsillar counterparts. J Pathol 208: 423\u2013430.","journal-title":"J Pathol"},{"key":"BF1210240_CR4","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/S1074-7613(00)80622-6","volume":"9","author":"GJ Babcock","year":"1998","unstructured":"Babcock GJ, Decker LL, Volk M, Thorley-Lawson DA . (1998). EBV persistence in memory B cells in vivo. Immunity 9: 395\u2013404.","journal-title":"Immunity"},{"key":"BF1210240_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11262-004-6774-z","volume":"30","author":"K Bandobashi","year":"2005","unstructured":"Bandobashi K, Liu A, Nagy N, Kis LL, Nishikawa J, Bjorkholm M et al. (2005). EBV infection induces expression of the transcription factors ATF-2\/c-Jun in B lymphocytes but not in B-CLL cells. Virus Genes 30: 323\u2013330.","journal-title":"Virus Genes"},{"key":"BF1210240_CR6","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1182\/blood-2005-02-0471","volume":"106","author":"KR Baumforth","year":"2005","unstructured":"Baumforth KR, Flavell JR, Reynolds GM, Davies G, Pettit TR, Wei W et al. (2005). Induction of autotaxin by the Epstein\u2013Barr virus promotes the growth and survival of Hodgkin lymphoma cells. Blood 106: 2138\u20132146.","journal-title":"Blood"},{"key":"BF1210240_CR7","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1172\/JCI119849","volume":"100","author":"RC Bargou","year":"1997","unstructured":"Bargou RC, Emmerich F, Krappmann D, Bommert K, Mapara MY, Arnold W et al. (1997). Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J Clin Invest 100: 2961\u20132969.","journal-title":"J Clin Invest"},{"key":"BF1210240_CR8","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1182\/blood-2005-06-2342","volume":"106","author":"D Bechtel","year":"2005","unstructured":"Bechtel D, Kurth J, Unkel C, Kuppers R . (2005). Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas. Blood 106: 4345\u20134350.","journal-title":"Blood"},{"key":"BF1210240_CR9","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1038\/sj.onc.1202893","volume":"18","author":"E Cabannes","year":"1999","unstructured":"Cabannes E, Khan G, Aillet F, Jarrett RF, Hay RT . (1999). Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha. Oncogene 18: 3063\u20133070.","journal-title":"Oncogene"},{"key":"BF1210240_CR10","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1200\/JCO.1999.17.1.399","volume":"17","author":"F Caligaris-Cappio","year":"1999","unstructured":"Caligaris-Cappio F, Hamblin TJ . (1999). B-cell chronic lymphocytic leukemia: a bird of a different feather. J Clin Oncol 17: 399\u2013408.","journal-title":"J Clin Oncol"},{"key":"BF1210240_CR11","first-page":"912","volume":"147","author":"A Carbone","year":"1995","unstructured":"Carbone A, Gloghini A, Gruss HJ, Pinto A . (1995). CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease. Am J Pathol 147: 912\u2013922.","journal-title":"Am J Pathol"},{"key":"BF1210240_CR12","doi-asserted-by":"crossref","first-page":"3752","DOI":"10.1128\/jvi.69.6.3752-3758.1995","volume":"69","author":"F Chen","year":"1995","unstructured":"Chen F, Zou JZ, di Renzo L, Winberg G, Hu LF, Klein E et al. (1995). A subpopulation of normal B cells latently infected with Epstein\u2013Barr virus resembles Burkitt lymphoma cells in expressing EBNA-1 but not EBNA-2 or LMP1. J Virol 69: 3752\u20133758.","journal-title":"J Virol"},{"key":"BF1210240_CR13","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1002\/(SICI)1097-0215(19961104)68:3<285::AID-IJC3>3.0.CO;2-Y","volume":"68","author":"AK Chiang","year":"1996","unstructured":"Chiang AK, Tao Q, Srivastava G, Ho FC . (1996). Nasal NK- and T-cell lymphomas share the same type of Epstein\u2013Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease. Int J Cancer 68: 285\u2013290.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR14","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1099\/0022-1317-77-6-1159","volume":"77","author":"B Contreras-Brodin","year":"1996","unstructured":"Contreras-Brodin B, Karlsson A, Nilsson T, Rymo L, Klein G . (1996). B cell-specific activation of the Epstein\u2013Barr virus-encoded C promoter compared with the wide-range activation of the W promoter. J Gen Virol 77: 1159\u20131162.","journal-title":"J Gen Virol"},{"key":"BF1210240_CR15","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.1099\/0022-1317-72-12-3025","volume":"72","author":"BA Contreras-Brodin","year":"1991","unstructured":"Contreras-Brodin BA, Anvret M, Imreh S, Altiok E, Klein G, Masucci MG . (1991). B cell phenotype-dependent expression of the Epstein\u2013Barr virus nuclear antigens EBNA-2 to EBNA-6: studies with somatic cell hybrids. J Gen Virol 72: 3025\u20133033.","journal-title":"J Gen Virol"},{"key":"BF1210240_CR16","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1182\/blood-2005-06-2327","volume":"106","author":"S Chaganti","year":"2005","unstructured":"Chaganti S, Bell AI, Pastor NB, Milner AE, Drayson M, Gordon J et al. (2005). Epstein\u2013Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes. Blood 106: 4249\u20134252.","journal-title":"Blood"},{"key":"BF1210240_CR17","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1084\/jem.177.2.339","volume":"177","author":"EM Deacon","year":"1993","unstructured":"Deacon EM, Pallesen G, Niedobitek G, Crocker J, Brooks L, Rickinson AB et al. (1993). Epstein\u2013Barr virus and Hodgkin's disease: transcriptional analysis of virus latency in the malignant cells. J Exp Med 177: 339\u2013349.","journal-title":"J Exp Med"},{"key":"BF1210240_CR18","first-page":"1858","volume":"7","author":"MG Doyle","year":"1993","unstructured":"Doyle MG, Catovsky D, Crawford DH . (1993). Infection of leukaemic B lymphocytes by Epstein\u2013Barr virus. Leukemia 7: 1858\u20131864.","journal-title":"Leukemia"},{"key":"BF1210240_CR19","doi-asserted-by":"publisher","first-page":"663","DOI":"10.4049\/jimmunol.165.2.663","volume":"165","author":"DF Dukers","year":"2000","unstructured":"Dukers DF, Meij P, Vervoort MB, Vos W, Scheper RJ, Meijer CJ et al. (2000). Direct immunosuppressive effects of EBV-encoded latent membrane protein 1. J Immunol 165: 663\u2013670.","journal-title":"J Immunol"},{"key":"BF1210240_CR20","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/S0140-6736(64)91524-7","volume":"15","author":"MA Epstein","year":"1964","unstructured":"Epstein MA, Achong BG, Barr YM. . (1964). Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet 15: 702\u2013703.","journal-title":"Lancet"},{"key":"BF1210240_CR21","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/ijc.2910420305","volume":"42","author":"R Fahraeus","year":"1988","unstructured":"Fahraeus R, Fu HL, Ernberg I, Finke J, Rowe M, Klein G et al. (1988). Expression of Epstein\u2013Barr virus-encoded proteins in nasopharyngeal carcinoma. Int J Cancer 42: 329\u2013338.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR22","doi-asserted-by":"publisher","first-page":"7390","DOI":"10.1073\/pnas.87.19.7390","volume":"87","author":"R Fahraeus","year":"1990","unstructured":"Fahraeus R, Jansson A, Ricksten A, Sj\u00f6blom A, Rymo L . (1990). Epstein\u2013Barr virus-encoded nuclear antigen 2 activates the viral latent membrane protein promoter by modulating the activity of a negative regulatory element. Proc Natl Acad Sci USA 87: 7390\u20137394.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR23","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/jmv.1890460410","volume":"46","author":"K Falk","year":"1995","unstructured":"Falk K, Linde A, Johnson D, Lennette E, Ernberg I, Lundkvist A . (1995). Synthetic peptides deduced from the amino acid sequence of Epstein\u2013Barr virus nuclear antigen 6 (EBNA 6): antigenic properties, production of monoreactive reagents, and analysis of antibody responses in man. J Med Virol 46: 349\u2013357.","journal-title":"J Med Virol"},{"key":"BF1210240_CR24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1182\/blood.V86.4.1493.bloodjournal8641493","volume":"86","author":"T Frisan","year":"1995","unstructured":"Frisan T, Sjoberg J, Dolcetti R, Boiocchi M, De Re V, Carbone A et al. (1995). Local suppression of Epstein\u2013Barr virus (EBV)-specific cytotoxicity in biopsies of EBV-positive Hodgkin's disease. Blood 86: 1493\u20131501.","journal-title":"Blood"},{"key":"BF1210240_CR25","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/340393a0","volume":"340","author":"W Hammerschmidt","year":"1989","unstructured":"Hammerschmidt W, Sugden B . (1989). Genetic analysis of immortalizing functions of Epstein\u2013Barr virus in human B lymphocytes. Nature 340: 393\u2013397.","journal-title":"Nature"},{"key":"BF1210240_CR26","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/0140-6736(90)90002-M","volume":"335","author":"Y Harabuchi","year":"1990","unstructured":"Harabuchi Y, Yamanaka N, Kataura A, Imai S, Kinoshita T, Mizuno F et al. (1990). Epstein\u2013Barr virus in nasal T-cell lymphomas in patients with lethal midline granuloma. Lancet 335: 128\u2013130.","journal-title":"Lancet"},{"key":"BF1210240_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/scientificamerican0779-48","volume":"241","author":"W Henle","year":"1979","unstructured":"Henle W, Henle G, Lennette ET . (1979). The Epstein\u2013Barr virus. Sci Am 241: 48\u201359.","journal-title":"Sci Am"},{"key":"BF1210240_CR28","doi-asserted-by":"publisher","first-page":"4908","DOI":"10.1038\/sj.onc.1205629","volume":"21","author":"CB Hertel","year":"2002","unstructured":"Hertel CB, Zhou XG, Hamilton-Dutoit SJ, Junker S . (2002). Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin\/Reed-Sternberg cells of classical Hodgkin lymphoma. Oncogene 21: 4908\u20134920.","journal-title":"Oncogene"},{"key":"BF1210240_CR29","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1056\/NEJMoa023141","volume":"349","author":"H Hjalgrim","year":"2003","unstructured":"Hjalgrim H, Askling J, Rostgaard K, Hamilton-Dutoit S, Frisch M, Zhang JS et al. (2003). Characteristics of Hodgkin's lymphoma after infectious mononucleosis. N Engl J Med 349: 1324\u20131332.","journal-title":"N Engl J Med"},{"key":"BF1210240_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1073\/pnas.2237267100","volume":"101","author":"D Hochberg","year":"2004","unstructured":"Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA . (2004). Demonstration of the Burkitt's lymphoma Epstein\u2013Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci USA 101: 239\u2013244.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR31","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1038\/sj.onc.1205337","volume":"21","author":"R Horie","year":"2002","unstructured":"Horie R, Watanabe T, Morishita Y, Ito K, Ishida T, Kanegae Y et al. (2002). Ligand-independent signaling by overexpressed CD30 drives NF-kappaB activation in Hodgkin\u2013Reed-Sternberg cells. Oncogene 21: 2493\u20132503.","journal-title":"Oncogene"},{"key":"BF1210240_CR32","doi-asserted-by":"publisher","first-page":"5716","DOI":"10.1158\/0008-5472.CAN-06-0261","volume":"66","author":"T Ishida","year":"2006","unstructured":"Ishida T, Ishii T, Inagaki A, Yano H, Komatsu H, Iida S et al. (2006). Specific recruitment of CC chemokine receptor 4-positive regulatory T cells in Hodgkin lymphoma fosters immune privilege. Cancer Res 66: 5716\u20135722.","journal-title":"Cancer Res"},{"key":"BF1210240_CR33","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","volume":"184","author":"H Kanzler","year":"1996","unstructured":"Kanzler H, Kuppers R, Hansmann ML, Rajewsky K . (1996). Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J Exp Med 184: 1495\u20131505.","journal-title":"J Exp Med"},{"key":"BF1210240_CR34","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V95.3.1023.003k07_1023_1031","volume":"95","author":"H Kanzler","year":"2000","unstructured":"Kanzler H, Kuppers R, Helmes S, Wacker HH, Chott A, Hansmann ML et al. (2000). Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones: potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Blood 95: 1023\u20131031.","journal-title":"Blood"},{"key":"BF1210240_CR35","doi-asserted-by":"publisher","first-page":"14269","DOI":"10.1073\/pnas.2336099100","volume":"100","author":"G Kennedy","year":"2003","unstructured":"Kennedy G, Komano J, Sugden B . (2003). Epstein\u2013Barr virus provides a survival factor to Burkitt's lymphomas. Proc Natl Acad Sci USA 100: 14269\u201314274.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR36","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1002\/ijc.20654","volume":"113","author":"LL Kis","year":"2005","unstructured":"Kis LL, Nishikawa J, Takahara M, Nagy N, Matskova L, Takada K et al. (2005). In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2. Int J Cancer 113: 937\u2013945.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR37","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.1182\/blood-2005-06-2569","volume":"107","author":"LL Kis","year":"2006","unstructured":"Kis LL, Takahara M, Nagy N, Klein G, Klein E . (2006a). IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma- and NK lymphoma-derived cell lines. Blood 107: 2928\u20132935.","journal-title":"Blood"},{"key":"BF1210240_CR38","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.imlet.2005.11.003","volume":"104","author":"LL Kis","year":"2006","unstructured":"Kis LL, Takahara M, Nagy N, Klein G, Klein E . (2006b). Cytokine mediated induction of the major Epstein\u2013Barr virus (EBV)-encoded transforming protein, LMP-1. Immunol Lett 104: 83\u201388.","journal-title":"Immunol Lett"},{"key":"BF1210240_CR39","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/0092-8674(94)90125-2","volume":"77","author":"G Klein","year":"1994","unstructured":"Klein G . (1994). Epstein\u2013Barr virus strategy in normal and neoplastic B cells. Cell 77: 791\u2013793.","journal-title":"Cell"},{"key":"BF1210240_CR40","doi-asserted-by":"crossref","first-page":"9827","DOI":"10.1128\/JVI.73.12.9827-9831.1999","volume":"73","author":"J Komano","year":"1999","unstructured":"Komano J, Maruo S, Kurozumi K, Oda T, Takada K . (1999). Oncogenic role of Epstein\u2013Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata. J Virol 73: 9827\u20139831.","journal-title":"J Virol"},{"key":"BF1210240_CR41","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0065-230X(02)84009-X","volume":"84","author":"R Kuppers","year":"2002","unstructured":"Kuppers R . (2002). Molecular biology of Hodgkin's lymphoma. Adv Cancer Res 84: 277\u2013312.","journal-title":"Adv Cancer Res"},{"key":"BF1210240_CR42","doi-asserted-by":"publisher","first-page":"10962","DOI":"10.1073\/pnas.91.23.10962","volume":"91","author":"R Kuppers","year":"1994","unstructured":"Kuppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R et al. (1994). Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 91: 10962\u201310966.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR43","doi-asserted-by":"publisher","first-page":"4730","DOI":"10.1073\/pnas.2627966100","volume":"100","author":"J Kurth","year":"2003","unstructured":"Kurth J, Hansmann ML, Rajewsky K, Kuppers R . (2003). Epstein\u2013Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction. Proc Natl Acad Sci USA 100: 4730\u20134735.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR44","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S1074-7613(00)00048-0","volume":"13","author":"J Kurth","year":"2000","unstructured":"Kurth J, Spieker T, Wustrow J, Strickler GJ, Hansmann LM, Rajewsky K et al. (2000). EBV-infected B cells in infectious mononucleosis: viral strategies for spreading in the B cell compartment and establishing latency. Immunity 13: 485\u2013495.","journal-title":"Immunity"},{"key":"BF1210240_CR45","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/0959-8049(93)90299-U","volume":"29A","author":"ET Lennette","year":"1993","unstructured":"Lennette ET, Rymo L, Yadav M, Masucci G, Merk K, Timar L et al. (1993). Disease-related differences in antibody patterns against EBV-encoded nuclear antigens EBNA 1, EBNA 2 and EBNA 6. Eur J Cancer 29A: 1584\u20131589.","journal-title":"Eur J Cancer"},{"key":"BF1210240_CR46","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/375685a0","volume":"375","author":"J Levitskaya","year":"1995","unstructured":"Levitskaya J, Coram M, Levitsky V, Imreh S, Steigerwald-Mullen PM, Klein G et al. (1995). Inhibition of antigen processing by the internal repeat region of the Epstein\u2013Barr virus nuclear antigen-1. Nature 375: 685\u2013688.","journal-title":"Nature"},{"key":"BF1210240_CR47","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1002\/ijc.2910480112","volume":"48","author":"N Lewin","year":"1991","unstructured":"Lewin N, Minarovits J, Weber G, Ehlin-Henriksson B, Wen T, Mellstedt H et al. (1991). Clonality and methylation status of the Epstein\u2013Barr virus (EBV) genomes in in vivo-infected EBV-carrying chronic lymphocytic leukemia (CLL) cell lines. Int J Cancer 48: 62\u201366.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR48","first-page":"227","volume":"4","author":"A Maeda","year":"2001","unstructured":"Maeda A, Bandobashi K, Nagy N, Teramoto N, Gogolak P, Pokrovskaja K et al. (2001). Epstein\u2013Barr virus can infect B-chronic lymphocytic leukemia cells but it does not orchestrate the cell cycle regulatory proteins. J Hum Virol 4: 227\u2013237.","journal-title":"J Hum Virol"},{"key":"BF1210240_CR49","doi-asserted-by":"publisher","first-page":"4339","DOI":"10.1182\/blood-2005-06-2341","volume":"106","author":"C Mancao","year":"2005","unstructured":"Mancao C, Altmann M, Jungnickel B, Hammerschmidt W . (2005). Rescue of \u2018crippled\u2019 germinal center B cells from apoptosis by Epstein\u2013Barr virus. Blood 106: 4339\u20134344.","journal-title":"Blood"},{"key":"BF1210240_CR50","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1182\/blood-2003-07-2594","volume":"103","author":"NA Marshall","year":"2004","unstructured":"Marshall NA, Christie LE, Munro LR, Culligan DJ, Johnston PW, Barker RN et al. (2004). Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma. Blood 103: 1755\u20131762.","journal-title":"Blood"},{"key":"BF1210240_CR51","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1182\/blood.V99.4.1474","volume":"99","author":"JI Martin-Subero","year":"2002","unstructured":"Martin-Subero JI, Gesk S, Harder L, Sonoki T, Tucker PW, Schlegelberger B et al. (2002). Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma. Blood 99: 1474\u20131477.","journal-title":"Blood"},{"key":"BF1210240_CR52","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1128\/JVI.78.4.1665-1674.2004","volume":"78","author":"T Nakayama","year":"2004","unstructured":"Nakayama T, Hieshima K, Nagakubo D, Sato E, Nakayama M, Kawa K et al. (2004). Selective induction of Th2-attracting chemokines CCL17 and CCL22 in human B cells by latent membrane protein 1 of Epstein\u2013Barr virus. J Virol 78: 1665\u20131674.","journal-title":"J Virol"},{"key":"BF1210240_CR53","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/ijc.2910150217","volume":"15","author":"K Nilsson","year":"1975","unstructured":"Nilsson K, Ponten J . (1975). Classification and biological nature of established human hematopoietic cell lines. Int J Cancer 15: 321\u2013341.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR54","first-page":"923","volume":"147","author":"JJ Oudejans","year":"1995","unstructured":"Oudejans JJ, Jiwa M, van den Brule AJ, Grasser FA, Horstman A, Vos W et al. (1995). Detection of heterogeneous Epstein\u2013Barr virus gene expression patterns within individual post-transplantation lymphoproliferative disorders. Am J Pathol 147: 923\u2013933.","journal-title":"Am J Pathol"},{"key":"BF1210240_CR55","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/0140-6736(91)90943-J","volume":"337","author":"G Pallesen","year":"1991","unstructured":"Pallesen G, Hamilton-Dutoit SJ, Rowe M, Young LS . (1991). Expression of Epstein\u2013Barr virus latent gene products in tumour cells of Hodgkin's disease. Lancet 337: 320\u2013322.","journal-title":"Lancet"},{"key":"BF1210240_CR56","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/ijc.2910030619","volume":"3","author":"JH Pope","year":"1968","unstructured":"Pope JH, Horne MK, Scott W . (1968). Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus. Int J Cancer 3: 857\u2013866.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR57","first-page":"347","volume":"50","author":"AB Rickinson","year":"1982","unstructured":"Rickinson AB, Finerty S, Epstein MA . (1982). Interaction of Epstein\u2013Barr virus with leukaemic B cells in vitro. I. Abortive infection and rare cell line establishment from chronic lymphocytic leukaemic cells. Clin Exp Immunol 50: 347\u2013354.","journal-title":"Clin Exp Immunol"},{"key":"BF1210240_CR58","first-page":"2575","volume-title":"Fields Virology","author":"AB Rickinson","year":"2001","unstructured":"Rickinson AB, Kieff E . (2001). Epstein\u2013Barr virus. In: Knipe DM and Howley PM (eds). Fields Virology, 4th edn. Vol. 2. Lippincott Williams and Wilkins: Philadelphia, pp 2575\u20132628."},{"key":"BF1210240_CR59","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.1038\/sj.onc.1201156","volume":"14","author":"V Roschke","year":"1997","unstructured":"Roschke V, Kopantzev E, Dertzbaugh M, Rudikoff S . (1997). Chromosomal translocations deregulating c-myc are associated with normal immune responses. Oncogene 14: 3011\u20133016.","journal-title":"Oncogene"},{"key":"BF1210240_CR60","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/jvi.66.1.122-131.1992","volume":"66","author":"M Rowe","year":"1992","unstructured":"Rowe M, Lear AL, Croom-Carter D, Davies AH, Rickinson AB . (1992). Three pathways of Epstein\u2013Barr virus gene activation from EBNA1-positive latency in B lymphocytes. J Virol 66: 122\u2013131.","journal-title":"J Virol"},{"key":"BF1210240_CR61","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1002\/j.1460-2075.1987.tb02568.x","volume":"6","author":"M Rowe","year":"1987","unstructured":"Rowe M, Rowe DT, Gregory CD, Young LS, Farrell PJ, Rupani H et al. (1987). Differences in B cell growth phenotype reflect novel patterns of Epstein\u2013Barr virus latent gene expression in Burkitt's lymphoma cells. EMBO J 6: 2743\u20132751.","journal-title":"EMBO J"},{"key":"BF1210240_CR62","doi-asserted-by":"publisher","first-page":"10565","DOI":"10.1073\/pnas.92.23.10565","volume":"92","author":"BC Schaefer","year":"1995","unstructured":"Schaefer BC, Strominger JL, Speck SH . (1995). Redefining the Epstein\u2013Barr virus-encoded nuclear antigen EBNA-1 gene promoter and transcription initiation site in group I Burkitt lymphoma cell lines. Proc Natl Acad Sci USA 92: 10565\u201310569.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF1210240_CR63","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1182\/blood-2002-03-0839","volume":"101","author":"I Schwering","year":"2003","unstructured":"Schwering I, Brauninger A, Klein U, Jungnickel B, Tinguely M, Diehl V et al. (2003). Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 101: 1505\u20131512.","journal-title":"Blood"},{"key":"BF1210240_CR64","first-page":"339","volume-title":"Human Cell Culture","author":"A Staratschek-Jox","year":"2000","unstructured":"Staratschek-Jox A, Wolf J, Diehl V . (2000). Hodgkin's disease. In: Masters JRW, Palsson BO (eds). Human Cell Culture. Vol. 3. Kluwer Academic Publishers: Dordrecht, pp 339\u2013353."},{"key":"BF1210240_CR65","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1159\/000149129","volume":"13","author":"K Takada","year":"1980","unstructured":"Takada K, Yamamoto K, Osato T . (1980). Analysis of the transformation of human lymphocytes by Epstein\u2013Barr virus. II. Abortive response of leukemic cells to the transforming virus. Intervirology 13: 223\u2013231.","journal-title":"Intervirology"},{"key":"BF1210240_CR66","doi-asserted-by":"publisher","first-page":"2775","DOI":"10.1002\/ijc.22139","volume":"119","author":"M Takahara","year":"2006","unstructured":"Takahara M, Kis LL, Nagy N, Liu A, Harabuchi Y, Klein G et al. (2006). Concomitant increase of LMP1 and CD25 (IL-2-receptor alpha) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3. Int J Cancer 119: 2775\u20132783.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR67","first-page":"125","volume":"3","author":"N Teramoto","year":"2000","unstructured":"Teramoto N, Gogolak P, Nagy N, Maeda A, Kvarnung K, Bjorkholm M et al. (2000). Epstein\u2013Barr virus-infected B-chronic lymphocyte leukemia cells express the virally encoded nuclear proteins but they do not enter the cell cycle. J Hum Virol 3: 125\u2013136.","journal-title":"J Hum Virol"},{"key":"BF1210240_CR68","doi-asserted-by":"publisher","first-page":"10458","DOI":"10.1128\/JVI.74.22.10458-10467.2000","volume":"74","author":"R Tierney","year":"2000","unstructured":"Tierney R, Kirby H, Nagra J, Rickinson A, Bell A . (2000). The Epstein\u2013Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP\/Pax5. J Virol 74: 10458\u201310467.","journal-title":"J Virol"},{"key":"BF1210240_CR69","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/35095584","volume":"1","author":"DA Thorley-Lawson","year":"2001","unstructured":"Thorley-Lawson DA . (2001). Epstein\u2013Barr virus: exploiting the immune system. Nat Rev Immunol 1: 75\u201382.","journal-title":"Nat Rev Immunol"},{"key":"BF1210240_CR70","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0165-2478(97)00142-9","volume":"60","author":"Y Tomita","year":"1998","unstructured":"Tomita Y, Avila-Carino J, Yamamoto K, Mellstedt H, Klein E . (1998). Recognition of B-CLL cells experimentally infected with EBV by autologous T lymphocytes. Immunol Lett 60: 73\u201379.","journal-title":"Immunol Lett"},{"key":"BF1210240_CR71","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1080\/10428190500398856","volume":"47","author":"AM Tsimberidou","year":"2006","unstructured":"Tsimberidou AM, Keating MJ, Bueso-Ramos CE, Kurzrock R . (2006). Epstein\u2013Barr virus in patients with chronic lymphocytic leukemia: a pilot study. Leuk Lymphoma 47: 827\u2013836.","journal-title":"Leuk Lymphoma"},{"key":"BF1210240_CR72","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1046\/j.1365-2249.1999.00836.x","volume":"115","author":"I Tsuge","year":"1999","unstructured":"Tsuge I, Morishima T, Morita M, Kimura H, Kuzushima K, Matsuoka H . (1999). Characterization of Epstein\u2013Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line. Clin Exp Immunol 115: 385\u2013392.","journal-title":"Clin Exp Immunol"},{"key":"BF1210240_CR73","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1016\/S0002-9440(10)65424-7","volume":"154","author":"A van den Berg","year":"1999","unstructured":"van den Berg A, Visser L, Poppema S . (1999). High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltration Hodgkin's lymphoma. Am J Pathol 154: 1685\u20131691.","journal-title":"Am J Pathol"},{"key":"BF1210240_CR74","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1046\/j.1365-2141.2002.03894.x","volume":"119","author":"M Vockerodt","year":"2002","unstructured":"Vockerodt M, Belge G, Kube D, Irsch J, Siebert R, Tesch H et al. (2002). An unbalanced translocation involving chromosome 14 is the probable cause for loss of potentially functional rearranged immunoglobulin heavy chain genes in the Epstein\u2013Barr virus-positive Hodgkin's lymphoma-derived cell line L591. Br J Haematol 119: 640\u2013646.","journal-title":"Br J Haematol"},{"key":"BF1210240_CR75","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1002\/ijc.2910440517","volume":"44","author":"EV Walls","year":"1989","unstructured":"Walls EV, Doyle MG, Patel KK, Allday MJ, Catovsky D, Crawford DH . (1989). Activation and immortalization of leukaemic B cells by Epstein\u2013Barr virus. Int J Cancer 44: 846\u2013853.","journal-title":"Int J Cancer"},{"key":"BF1210240_CR76","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1128\/jvi.64.7.3407-3416.1990","volume":"64","author":"F Wang","year":"1990","unstructured":"Wang F, Tsang SF, Kurilla MG, Cohen JI, Kieff E . (1990). Epstein\u2013Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1. J Virol 64: 3407\u20133416.","journal-title":"J Virol"},{"key":"BF1210240_CR77","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1056\/NEJM198910193211604","volume":"321","author":"L Young","year":"1989","unstructured":"Young L, Alfieri C, Hennessy K, Evans H, O'Hara C, Anderson KC et al. (1989). Expression of Epstein\u2013Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease. N Engl J Med 321: 1080\u20131085.","journal-title":"N Engl J Med"},{"key":"BF1210240_CR78","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1046\/j.1365-2141.2003.04359.x","volume":"121","author":"Y Zhang","year":"2003","unstructured":"Zhang Y, Nagata H, Ikeuchi T, Mukai H, Oyoshi MK, Demachi A et al. (2003). Common cytological and cytogenetic features of Epstein\u2013Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T\/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br J Haematol 121: 805\u2013814.","journal-title":"Br J Haematol"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1210240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210240","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210240.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T10:26:19Z","timestamp":1647944779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1210240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,26]]},"references-count":78,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,2,26]]}},"alternative-id":["BF1210240"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1210240","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,26]]},"assertion":[{"value":"26 February 2007","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}