{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:11:17Z","timestamp":1791263477144,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"19","license":[{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T00:00:00Z","timestamp":1194825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Oncogene"],"published-print":{"date-parts":[[2008,4,24]]},"DOI":"10.1038\/sj.onc.1210927","type":"journal-article","created":{"date-parts":[[2007,11,12]],"date-time":"2007-11-12T13:01:33Z","timestamp":1194872493000},"page":"2746-2753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["HIF\u03b1 expression in VHL-deficient renal cancer cells is dependent on phospholipase D"],"prefix":"10.1038","volume":"27","author":[{"given":"A","family":"Toschi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Edelstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Rockwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ohh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,11,12]]},"reference":[{"key":"BF1210927_CR1","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/nature05029","volume":"442","author":"R Bernardi","year":"2006","unstructured":"Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J et al. (2006). PML inhibits HIF-1\u03b1 translation and neoangiogenesis through repression of mTOR. Nature 442: 779\u2013785.","journal-title":"Nature"},{"key":"BF1210927_CR2","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/sj.onc.1208099","volume":"24","author":"Y Chen","year":"2005","unstructured":"Chen Y, Rodrik V, Foster DA . (2005). Alternative phospholipase D\/mTOR survival signal in human breast cancer cells. Oncogene 24: 672\u2013679.","journal-title":"Oncogene"},{"key":"BF1210927_CR3","doi-asserted-by":"publisher","first-page":"3937","DOI":"10.1038\/sj.onc.1206565","volume":"22","author":"Y Chen","year":"2003","unstructured":"Chen Y, Zheng Y, Foster DA . (2003). Phospholipase D confers rapamycin resistance in human breast cancer cells. Oncogene 22: 3937\u20133942.","journal-title":"Oncogene"},{"key":"BF1210927_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0960-9822(97)70090-3","volume":"7","author":"WC Colley","year":"1997","unstructured":"Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y et al. (1997). Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 7: 191\u2013201.","journal-title":"Curr Biol"},{"key":"BF1210927_CR5","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1126\/science.1066015","volume":"294","author":"Y Fang","year":"2001","unstructured":"Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J . (2001). Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 294: 1942\u20131945.","journal-title":"Science"},{"key":"BF1210927_CR6","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1586\/14737140.4.4.691","volume":"4","author":"DA Foster","year":"2004","unstructured":"Foster DA . (2004). Targeting mTOR-mediated survival signals in anticancer therapeutic strategies. Exp Rev Anticancer Ther 4: 691\u2013701.","journal-title":"Exp Rev Anticancer Ther"},{"key":"BF1210927_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2174\/157436206778226941","volume":"1","author":"DA Foster","year":"2006","unstructured":"Foster DA . (2006). Phospholipase D survival signals as a therapeutic target in cancer. Curr Sig Trans Ther 1: 295\u2013303.","journal-title":"Curr Sig Trans Ther"},{"key":"BF1210927_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1158\/0008-5472.CAN-06-3016","volume":"67","author":"DA Foster","year":"2007","unstructured":"Foster DA . (2007). Regulation of mTOR by phosphatidic acid? Cancer Res 67: 1\u20134.","journal-title":"Cancer Res"},{"key":"BF1210927_CR9","first-page":"789","volume":"1","author":"DA Foster","year":"2003","unstructured":"Foster DA, Xu L . (2003). Phospholipase D in cell proliferation and cancer. Mol Cancer Res 1: 789\u2013800.","journal-title":"Mol Cancer Res"},{"key":"BF1210927_CR10","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1038\/nrc1478","volume":"4","author":"RA Gatenby","year":"2004","unstructured":"Gatenby RA, Gillies RJ . (2004). Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891\u2013899.","journal-title":"Nat Rev Cancer"},{"key":"BF1210927_CR11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.gde.2006.12.006","volume":"17","author":"JD Gordan","year":"2007","unstructured":"Gordan JD, Simon MC . (2007). Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 17: 71\u201377.","journal-title":"Curr Opin Genet Dev"},{"key":"BF1210927_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA . (2000). The hallmarks of cancer. Cell 100: 57\u201370.","journal-title":"Cell"},{"key":"BF1210927_CR13","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0070-2153(06)76007-0","volume":"76","author":"MM Hickey","year":"2006","unstructured":"Hickey MM, Simon MC . (2006). Regulation of angiogenesis by hypoxia and hypoxia-inducible factors. Curr Top Dev Biol 76: 217\u2013257.","journal-title":"Curr Top Dev Biol"},{"key":"BF1210927_CR14","doi-asserted-by":"publisher","first-page":"5677","DOI":"10.1128\/MCB.24.13.5677-5686.2004","volume":"24","author":"L Hui","year":"2004","unstructured":"Hui L, Abbas T, Pielak R, Joseph T, Bargonetti J, Foster DA . (2004). Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53. Mol Cell Biol 24: 5677\u20135688.","journal-title":"Mol Cell Biol"},{"key":"BF1210927_CR15","doi-asserted-by":"publisher","first-page":"35829","DOI":"10.1074\/jbc.M504192200","volume":"280","author":"L Hui","year":"2005","unstructured":"Hui L, Rodrik V, Pielak RM, Zheng Y, Foster DA . (2005). mTOR-dependent suppression of protein phosphatase 2A is critical for phospholipase D survival signals in human breast cancer cells. J Biol Chem 280: 35829\u201335835.","journal-title":"J Biol Chem"},{"key":"BF1210927_CR16","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.bbrc.2005.08.165","volume":"338","author":"WG Kaelin Jr","year":"2005","unstructured":"Kaelin Jr WG . (2005). The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 338: 627\u2013638.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF1210927_CR17","doi-asserted-by":"publisher","first-page":"680s","DOI":"10.1158\/1078-0432.CCR-06-1865","volume":"13","author":"WG Kaelin Jr","year":"2007","unstructured":"Kaelin Jr WG . (2007). The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 13: 680s\u2013684s.","journal-title":"Clin Cancer Res"},{"key":"BF1210927_CR18","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1371\/journal.pbio.0000083","volume":"1","author":"K Kondo","year":"2003","unstructured":"Kondo K, Kim WY, Lechpammer M, Kaelin Jr WG . (2003). Inhibition of HIF2\u03b1 is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 1: 439\u2013444.","journal-title":"PLoS Biol"},{"key":"BF1210927_CR19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S1535-6108(02)00043-0","volume":"1","author":"K Kondo","year":"2002","unstructured":"Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin Jr WG . (2002). Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 1: 237\u2013246.","journal-title":"Cancer Cell"},{"key":"BF1210927_CR20","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1128\/MCB.18.2.732","volume":"18","author":"KM Lonergan","year":"1998","unstructured":"Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW et al. (1998). Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B\/C and Cul2. Mol Cell Biol 18: 732\u2013741.","journal-title":"Mol Cell Biol"},{"key":"BF1210927_CR21","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/j.semcdb.2005.03.001","volume":"16","author":"PH Maxwell","year":"2005","unstructured":"Maxwell PH . (2005). The HIF pathway in cancer. Semin Cell Dev Biol 16: 523\u2013530.","journal-title":"Semin Cell Dev Biol"},{"key":"BF1210927_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000075346","volume":"24","author":"MA Maynard","year":"2004","unstructured":"Maynard MA, Ohh M . (2004). Von Hippel-Lindau tumor suppressor protein and hypoxia-inducible factor in kidney cancer. Am J Nephrol 24: 1\u201313.","journal-title":"Am J Nephrol"},{"key":"BF1210927_CR23","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1593\/neo.06442","volume":"8","author":"M Ohh","year":"2006","unstructured":"Ohh M . (2006). Ubiquitin pathway in VHL cancer syndrome. Neoplasia 8: 623\u2013629.","journal-title":"Neoplasia"},{"key":"BF1210927_CR24","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S1097-2765(00)80096-9","volume":"1","author":"M Ohh","year":"1998","unstructured":"Ohh M, Yauch RL, Lonergan K, Whaley JM, Stemmer-Rachamimov AO, Louis DN et al. (1998). The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1: 959\u2013968.","journal-title":"Mol Cell"},{"key":"BF1210927_CR25","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1074\/jbc.274.2.1131","volume":"274","author":"MA Rizzo","year":"1999","unstructured":"Rizzo MA, Shome K, Vasudevan C, Stolz DB, Sung TC, Frohman MA et al. (1999). Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem 274: 1131\u20131139.","journal-title":"J Biol Chem"},{"key":"BF1210927_CR26","doi-asserted-by":"publisher","first-page":"5647","DOI":"10.1016\/j.febslet.2006.09.013","volume":"580","author":"V Rodrik","year":"2006","unstructured":"Rodrik V, Gomes E, Hui L, Rockwell P, Foster DA . (2006). Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells. FEBS Lett 580: 5647\u20135652.","journal-title":"FEBS Lett"},{"key":"BF1210927_CR27","doi-asserted-by":"publisher","first-page":"7917","DOI":"10.1128\/MCB.25.17.7917-7925.2005","volume":"25","author":"V Rodrik","year":"2005","unstructured":"Rodrik V, Zheng Y, Harrow F, Chen Y, Foster DA . (2005). Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol Cell Biol 25: 7917\u20137925.","journal-title":"Mol Cell Biol"},{"key":"BF1210927_CR28","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S1535-6108(03)00275-7","volume":"4","author":"CL Sawyers","year":"2003","unstructured":"Sawyers CL . (2003). Will mTOR inhibitors make it as cancer drugs? Cancer Cell 4: 343\u2013348.","journal-title":"Cancer Cell"},{"key":"BF1210927_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0955-0674(00)00194-0","volume":"13","author":"GL Semenza","year":"2001","unstructured":"Semenza GL . (2001). HIF-1 and mechanisms of hypoxia sensing. Curr Opin Cell Biol 13: 167\u2013171.","journal-title":"Curr Opin Cell Biol"},{"key":"BF1210927_CR30","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.ceb.2006.10.005","volume":"18","author":"RJ Shaw","year":"2006","unstructured":"Shaw RJ . (2006). Glucose metabolism and cancer. Curr Opin Cell Biol 18: 598\u2013608.","journal-title":"Curr Opin Cell Biol"},{"key":"BF1210927_CR31","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1128\/MCB.21.2.595-602.2001","volume":"21","author":"Y Shen","year":"2001","unstructured":"Shen Y, Xu L, Foster DA . (2001). Phospholipase D requirement for receptor-mediated endocytosis. Mol Cell Biol 21: 595\u2013602.","journal-title":"Mol Cell Biol"},{"key":"BF1210927_CR32","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1128\/MCB.24.8.3251-3261.2004","volume":"24","author":"NH Stickle","year":"2004","unstructured":"Stickle NH, Chung J, Klco JM, Hill RP, Kaelin Jr WG, Ohh M . (2004). pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development. Mol Cell Biol 24: 3251\u20133261.","journal-title":"Mol Cell Biol"},{"key":"BF1210927_CR33","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1074\/jbc.274.1.494","volume":"274","author":"TC Sung","year":"1999","unstructured":"Sung TC, Altshuller YM, Morris AJ, Frohman MA . (1999). Molecular analysis of mammalian phospholipase D2. J Biol Chem 274: 494\u2013502.","journal-title":"J Biol Chem"},{"key":"BF1210927_CR34","doi-asserted-by":"publisher","first-page":"4519","DOI":"10.1093\/emboj\/16.15.4519","volume":"16","author":"TC Sung","year":"1997","unstructured":"Sung TC, Roper RL, Zhang Y, Rudge SA, Temel R, Hammond SM et al. (1997). Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J 16: 4519\u20134530.","journal-title":"EMBO J"},{"key":"BF1210927_CR35","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/bbrc.2000.3719","volume":"278","author":"Y Zhao","year":"2000","unstructured":"Zhao Y, Ehara H, Akao Y, Shamoto M, Nakagawa Y, Banno Y et al. (2000). Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem Biophys Res Commun 278: 140\u2013143.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF1210927_CR36","doi-asserted-by":"publisher","first-page":"15862","DOI":"10.1074\/jbc.M600660200","volume":"281","author":"Y Zheng","year":"2006","unstructured":"Zheng Y, Rodrik V, Toschi A, Shi M, Hui L, Shen Y et al. (2006). Phospholipase D couples survival and migration signals in response to stress in human breast cancer cells. J Biol Chem 281: 15862\u201315868.","journal-title":"J Biol Chem"},{"key":"BF1210927_CR37","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0006-291X(03)00229-8","volume":"302","author":"M Zhong","year":"2003","unstructured":"Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Beychenok S et al. (2003). Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochem Biophys Res Comm 302: 615\u2013619.","journal-title":"Biochem Biophys Res Comm"}],"container-title":["Oncogene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/1210927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210927","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/1210927.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T09:46:37Z","timestamp":1647942397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/1210927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,12]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2008,4,24]]}},"alternative-id":["BF1210927"],"URL":"https:\/\/doi.org\/10.1038\/sj.onc.1210927","relation":{},"ISSN":["0950-9232","1476-5594"],"issn-type":[{"value":"0950-9232","type":"print"},{"value":"1476-5594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,12]]},"assertion":[{"value":"20 July 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}