{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:09:24Z","timestamp":1791299364596,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1038\/sj.sc.3101178","type":"journal-article","created":{"date-parts":[[2002,9,20]],"date-time":"2002-09-20T19:12:35Z","timestamp":1032549155000},"page":"413-419","source":"Crossref","is-referenced-by-count":56,"title":["Intrathecal baclofen in tetraplegia of spinal origin: efficacy for upper extremity hypertonia"],"prefix":"10.1038","volume":"39","author":[{"given":"AS","family":"Burns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JM","family":"Meythaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,8,20]]},"reference":[{"key":"BF3101178_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0003-9993(99)90301-5","volume":"80","author":"JM Meythaler","year":"1999","unstructured":"Meythaler JM, Guin-Renfroe S, Grabb P, Hadley MN . Long-term continuously infused intrathecal baclofen for spastic-dystonic hypertonia in traumatic brain injury: 1-yr experience Arch Phys Med Rehabil 1999 80: 13\u201319","journal-title":"Arch Phys Med Rehabil"},{"key":"BF3101178_CR2","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1056\/NEJM198105143042010","volume":"304","author":"RR Young","year":"1981","unstructured":"Young RR, Delwaide PJ . Spasticity (part one of two parts) N Engl J Med 1981 304: 28\u201333","journal-title":"N Engl J Med"},{"key":"BF3101178_CR3","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1056\/NEJM198105143042010","volume":"304","author":"RR Young","year":"1981","unstructured":"Young RR, Delwaide PJ . Spasticity (part two of two parts) N Engl J Med 1981 304: 96\u201399","journal-title":"N Engl J Med"},{"key":"BF3101178_CR4","unstructured":"Adams RD, Victor M (eds) . Principles of neurology. 5th edn McGraw-Hill, Inc.: New York 1993 p.\u200968"},{"key":"BF3101178_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/00002060-199212000-00003","volume":"71","author":"JM Meythaler","year":"1992","unstructured":"Meythaler JM et al. Continuous intrathecal baclofen in spinal cord spasticity: a prospective study Am J Phys Med Rehabil 1992 71: 321\u2013327","journal-title":"Am J Phys Med Rehabil"},{"key":"BF3101178_CR6","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1056\/NEJM198906083202303","volume":"320","author":"RD Penn","year":"1989","unstructured":"Penn RD et al. Intrathecal baclofen for severe spinal spasticity N Engl J Med 1989 320: 1517\u20131522","journal-title":"N Engl J Med"},{"key":"BF3101178_CR7","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3171\/jns.1990.72.3.0393","volume":"72","author":"Y Lazorthes","year":"1990","unstructured":"Lazorthes Y et al. Chronic intrathecal baclofen administration for control of severe spasticity J Neurosurg 1990 72: 393\u2013402","journal-title":"J Neurosurg"},{"key":"BF3101178_CR8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3171\/jns.1993.78.2.0226","volume":"78","author":"RJ Coffey","year":"1999","unstructured":"Coffey RJ, Cahill D, Steers W . Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study J Neurosurg 1999 78: 226\u2013232","journal-title":"J Neurosurg"},{"key":"BF3101178_CR9","first-page":"794","volume":"73","author":"JM Meythaler","year":"1992","unstructured":"Meythaler JM et al. Intrathecal baclofen in hereditary spastic paraparesis Arch Phys Med Rehabil 1992 73: 794\u2013797","journal-title":"Arch Phys Med Rehabil"},{"key":"BF3101178_CR10","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3171\/jns.1987.66.2.0181","volume":"66","author":"RD Penn","year":"1987","unstructured":"Penn RD, Kroin JS . Long-term intrathecal baclofen infusion for treatment of spasticity J Neurosurg 1987 66: 181\u2013185","journal-title":"J Neurosurg"},{"key":"BF3101178_CR11","doi-asserted-by":"publisher","first-page":"452","DOI":"10.3171\/jns.1996.85.3.0452","volume":"85","author":"JL Ordia","year":"1996","unstructured":"Ordia JL, Fischer E, Adamski E, Spatz EL . Chronic intrathecal delivery of baclofen by a programmable pump for the treatment of severe spasticity J Neurosurg 1996 85: 452\u2013457","journal-title":"J Neurosurg"},{"key":"BF3101178_CR12","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/jnnp.52.8.933","volume":"52","author":"G Ochs","year":"1989","unstructured":"Ochs G et al. Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study J Neurol Neurosurg Psychiatry 1989 52: 933\u2013939","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BF3101178_CR13","first-page":"48","volume":"29","author":"PG Loubser","year":"1991","unstructured":"Loubser PG et al. Continuous infusion of intrathecal baclofen: long-term effects on spasticity in spinal cord injury Paraplegia 1991 29: 48\u201364","journal-title":"Paraplegia"},{"key":"BF3101178_CR14","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-7091-9029-6_9","volume":"46","author":"J Broseta","year":"1989","unstructured":"Broseta J et al. Use of intrathecal baclofen administered by programmable infusion pumps in resistant spasticity Acta Neurochir 1989 46: 39\u201345","journal-title":"Acta Neurochir"},{"key":"BF3101178_CR15","unstructured":"Kroin JS, Penn RD . Cerebrospinal fluid pharmacokinectics of lumbar intrathecal baclofen. In: Lakke JPWF, Delhaas EM, Rutgers AWF (eds). Parenteral drug therapy in spasticity and Parkinson's disease Canforth, United Kingdom: Pathenon Publishing 1991 pp 73\u201383"},{"key":"BF3101178_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1017\/S0317167100047776","volume":"20","author":"H Hugenholtz","year":"1993","unstructured":"Hugenholtz H, Nelson RF, Dehoux E . Intrathecal baclofen \u2013 the importance of catheter position Can J Neurol Sci 1993 20: 165\u2013167","journal-title":"Can J Neurol Sci"},{"key":"BF3101178_CR17","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3171\/jns.1989.71.2.0273","volume":"71","author":"G Muller-Schwefe","year":"1989","unstructured":"Muller-Schwefe G, Penn RD . Physostigmine in the treatment of intrathecal baclofen overdose J Neurosurg 1989 71: 273\u2013275","journal-title":"J Neurosurg"},{"key":"BF3101178_CR18","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/00006123-199910000-00020","volume":"45","author":"PA Grabb","year":"1999","unstructured":"Grabb PA, Guin-Renfroe S, Meythaler JM . Midthoracic catheter tip placement for intrathecal baclofen administration in children with quadriparetic spasticity Neurosurgery 1999 45: 833\u2013837","journal-title":"Neurosurgery"},{"key":"BF3101178_CR19","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S0003-9993(96)90034-9","volume":"77","author":"JM Meythaler","year":"1996","unstructured":"Meythaler JM, DeVivo MJ, Hadley M . Prospective study on the use of bolus intrathecal baclofen for spastic hypertonia due to acquired brain injury Arch Phys Med Rehabil 1996 77: 461\u2013466","journal-title":"Arch Phys Med Rehabil"},{"key":"BF3101178_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3171\/jns.1997.87.3.0415","volume":"87","author":"JM Meythaler","year":"1997","unstructured":"Meythaler JM, Hadley M, McCrary A . Prospective study on the use of continuously infused intrathecal baclofen for spasticity due to acquired brain injury: A preliminary report J Neurosurg 1997 87: 415\u2013419","journal-title":"J Neurosurg"},{"key":"BF3101178_CR21","first-page":"173","volume":"77","author":"JM Meythaler","year":"1998","unstructured":"Meythaler JM, Guin-Renfro S, Hadley M . Continuously infused intrathecal baclofen (ITB) for spastic-hypertonia in adult cerebral palsy [abstract] Am J Phys Med Rehabil 1998 77: 173","journal-title":"Am J Phys Med Rehabil"},{"key":"BF3101178_CR22","volume-title":"Biometry","author":"RR Sokol","year":"1969","unstructured":"Sokol RR, Rohlf FJ Biometry San Francisco (CA): W.H. Freeman 1969"},{"key":"BF3101178_CR23","first-page":"540","volume":"192","author":"B Ashworth","year":"1964","unstructured":"Ashworth B . Preliminary trial of carisoprodol in multiple sclerosis Practitioner 1964 192: 540\u2013542","journal-title":"Practitioner"},{"key":"BF3101178_CR24","first-page":"205","volume":"3","author":"KC Lee","year":"1989","unstructured":"Lee KC, Carson L, Kinnin E, Patterson V . The Ashworth scale: a reliable and reproducible method of measuring spasticity J Neurol Rehabil 1989 3: 205\u2013209","journal-title":"J Neurol Rehabil"},{"issue":"3","key":"BF3101178_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/00002060-199905000-00012","volume":"78","author":"Jay M. Meythaler","year":"1999","unstructured":"Meythaler JM, Guin-Renfroe, Hadley MN . Continuously infused intrathecal baclofen for spastic\/dystonic hemiplegia: a preliminary report Am J Phys Med Rehabil 78: 247\u2013254","journal-title":"American Journal of Physical Medicine & Rehabilitation"},{"key":"BF3101178_CR26","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1002\/mds.870120416","volume":"12","author":"D Dressler","year":"1997","unstructured":"Dressler D, Oeljeschlager RO, Ruther E . Severe tardive dystonia: treatment with continuous intrathecal baclofen administration Movement Disorders 1997 12: 585\u2013587","journal-title":"Movement Disorders"},{"key":"BF3101178_CR27","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1212\/WNL.49.6.1591","volume":"49","author":"C Stayer","year":"1997","unstructured":"Stayer C et al. Intrathecal baclofen therapy for stiffman syndrome and progressive encephalopathy with rigidity and myoclonus Neurology 1997 49: 1591\u20131597","journal-title":"Neurology"},{"key":"BF3101178_CR28","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1177\/088307380001500201","volume":"15","author":"R Gilmartin","year":"2000","unstructured":"Gilmartin R et al. Intrathecal baclofen for management of spastic cerebral palsy: a multicenter trial J Child Neurol 2000 15: 71\u201377","journal-title":"J Child Neurol"},{"key":"BF3101178_CR29","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/00006123-200003000-00017","volume":"46","author":"P Van Schaeybroeck","year":"2000","unstructured":"Van Schaeybroeck P et al. Intrathecal baclofen for intractable cerebral spasticity: a prospective placebo-controlled, double-blind study Neurosurgery 2000 46: 603\u2013609","journal-title":"Neurosurgery"},{"key":"BF3101178_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3171\/jns.1998.88.1.0073","volume":"88","author":"AL Albright","year":"1998","unstructured":"Albright AL et al. Infusion of intrathecal baclofen for generalized dystonia in cerebral palsy J Neurosurg 1998 88: 73\u201376","journal-title":"J Neurosurg"},{"key":"BF3101178_CR31","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3171\/jns.1997.87.3.0409","volume":"87","author":"RW Armstrong","year":"1997","unstructured":"Armstrong RW et al. Intrathecally administered baclofen for treatment of children with spasticity of cerebral origin J Neurosurg 1997 87: 409\u2013414","journal-title":"J Neurosurg"},{"key":"BF3101178_CR32","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1097\/00000542-199906000-00036","volume":"90","author":"N Engrand","year":"1999","unstructured":"Engrand N, Guerot E, Rouamaba A . The efficacy of intrathecal baclofen in severe tetanus Anesthesiology 1999 90: 1773\u20131776","journal-title":"Anesthesiology"},{"key":"BF3101178_CR33","first-page":"516","volume":"31","author":"MN Akman","year":"1993","unstructured":"Akman MN et al. Intrathecal baclofen: does tolerance occur? Paraplegia 1993 31: 516\u2013520","journal-title":"Paraplegia"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3101178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3101178","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3101178.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:34:35Z","timestamp":1684287275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3101178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["BF3101178"],"URL":"https:\/\/doi.org\/10.1038\/sj.sc.3101178","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}