{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:39:57Z","timestamp":1772311197238,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2002,8,21]],"date-time":"2002-08-21T00:00:00Z","timestamp":1029888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Spinal Cord"],"published-print":{"date-parts":[[2002,9]]},"DOI":"10.1038\/sj.sc.3101316","type":"journal-article","created":{"date-parts":[[2002,9,25]],"date-time":"2002-09-25T10:57:52Z","timestamp":1032951472000},"page":"468-473","source":"Crossref","is-referenced-by-count":9,"title":["A PET study on the characterization of partially reversible radiogenic lower motor neurone disease"],"prefix":"10.1038","volume":"40","author":[{"given":"O","family":"\u00c9sik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"S\u00e1fr\u00e1ny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"V\u00f6n\u00f6czky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"\u00c1goston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Sz\u00e9kely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"M\u00e1ri\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Tr\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Bodrogi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2002,8,21]]},"reference":[{"key":"BF3101316_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0022-510X(71)90174-2","volume":"14","author":"K Jellinger","year":"1971","unstructured":"Jellinger K, Sturm KW . Delayed radiation myelopathy in man. Report of twelve necropsy cases J Neurol Sci 1971 14: 389\u2013408","journal-title":"J Neurol Sci"},{"key":"BF3101316_CR2","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/BF00688156","volume":"9","author":"K Kristensson","year":"1967","unstructured":"Kristensson K, Molin B, Sourander P . Delayed radiation lesions of the human spinal cord. Report of five cases Acta Neuropathol 1967 9: 34\u201344","journal-title":"Acta Neuropathol"},{"key":"BF3101316_CR3","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/brain\/95.1.109","volume":"95","author":"JJ Palmer","year":"1972","unstructured":"Palmer JJ . Radiation myelopathy Brain 1972 95: 109\u2013122","journal-title":"Brain"},{"key":"BF3101316_CR4","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1001\/jama.1968.03140020034009","volume":"203","author":"TJ Reagan","year":"1968","unstructured":"Reagan TJ, Thomas JE, Colby Jr MY . Chronic progressive radiation myelopathy. Its clinical aspects and differential diagnosis JAMA 1968 203: 128\u2013132","journal-title":"JAMA"},{"key":"BF3101316_CR5","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/0360-3016(84)90184-6","volume":"10","author":"TE Schultheiss","year":"1984","unstructured":"Schultheiss TE, Higgins EM, El-Mahdi AM . The latent period in clinical radiation myelopathy Int J Radiat Oncol Biol Phys 1984 10: 1109\u20131115","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BF3101316_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0360-3016(88)90046-6","volume":"14","author":"TE Schultheiss","year":"1988","unstructured":"Schultheiss TE, Sephens LC, Maor MH . Analysis of the histopathology of radiation myelopathy Int J Radiat Oncol Biol Phys 1988 14: 27\u201332","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BF3101316_CR7","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/0360-3016(94)00655-5","volume":"31","author":"TE Schultheiss","year":"1995","unstructured":"Schultheiss TE et al. Radiation response of the central nervous system Int J Radiat Oncol Biol Phys 1995 31: 1093\u20131112","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"BF3101316_CR8","first-page":"39","volume":"163","author":"O \u00c9sik","year":"1999","unstructured":"\u00c9sik O et al. Radiation myelopathy with partial functional recovery: PET evidence of long-term increased metabolic activity of the spinal cord J Neurol ci 1999 163: 39\u201343","journal-title":"J Neurol ci"},{"key":"BF3101316_CR9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1136\/jnnp.42.5.413","volume":"42","author":"B Sanyal","year":"1979","unstructured":"Sanyal B et al. Radiation myelopathy J Neurol Neurosurg Psy 1979 42: 413\u2013418","journal-title":"J Neurol Neurosurg Psy"},{"key":"BF3101316_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000116125","volume":"27","author":"P Berlit","year":"1987","unstructured":"Berlit P, Schwechheimer K . Neuropathological findings in radiation myelopathy of the lumbosacral cord Eur Neurol 1987 27: 29\u201334","journal-title":"Eur Neurol"},{"key":"BF3101316_CR11","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1093\/brain\/119.5.1429","volume":"119","author":"J Bowen","year":"1996","unstructured":"Bowen J et al. The post-irradiation lower motor neuron syndrome. Neuronopathy or radiculopathy? Brain 1996 119: 1429\u20131439","journal-title":"Brain"},{"key":"BF3101316_CR12","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1136\/jnnp.49.6.718-a","volume":"49","author":"P de Carolis","year":"1986","unstructured":"de Carolis P et al. Isolated lower motoneuron involvement following radiotherapy J Neurol Neurosurg Psy 1986 49: 718\u2013719","journal-title":"J Neurol Neurosurg Psy"},{"key":"BF3101316_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0303-8467(84)90277-4","volume":"86","author":"JLP de Greve","year":"1984","unstructured":"de Greve JLP et al. Lower motor neuron disease in a patient with Hodgkin's disease treated with radiotherapy Clin Neurol Neurosurg 1984 86: 43\u201346","journal-title":"Clin Neurol Neurosurg"},{"key":"BF3101316_CR14","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1600-0404.1989.tb03878.x","volume":"80","author":"H Feistner","year":"1989","unstructured":"Feistner H et al. Post-irradiation lesions of the caudal roots Acta Neurol Scand 1989 80: 277\u2013281","journal-title":"Acta Neurol Scand"},{"key":"BF3101316_CR15","first-page":"390","volume-title":"Proceeding of the Second National Cancer Conference","author":"M Friedman","year":"1954","unstructured":"Friedman M . Calculated risks of radiation injury of normal tissue in the treatment of cancer of the testis In: Proceeding of the Second National Cancer Conference Vol 1: New York: American Cancer Society 1954 pp. 390\u2013400"},{"key":"BF3101316_CR16","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1002\/ana.410190321","volume":"19","author":"J G\u00e1llego","year":"1986","unstructured":"G\u00e1llego J et al. Delayed postirradiation lower motor neuron syndrome Ann Neurol 1986 19: 308\u2013309","journal-title":"Ann Neurol"},{"key":"BF3101316_CR17","first-page":"617","volume":"60","author":"MM Greenfield","year":"1948","unstructured":"Greenfield MM, Stark FM . Post-irradiation neuropathy Am J Roentgenol 1948 60: 617\u2013622","journal-title":"Am J Roentgenol"},{"key":"BF3101316_CR18","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1136\/jnnp.55.8.741-a","volume":"55","author":"RA Gr\u00fcnewald","year":"1992","unstructured":"Gr\u00fcnewald RA et al. Late onset radiation-induced motor neuron syndrome J Neurol Neurosurg Psy 1992 55: 741\u2013742","journal-title":"J Neurol Neurosurg Psy"},{"key":"BF3101316_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1017\/S0317167100044589","volume":"10","author":"SL Horowitz","year":"1983","unstructured":"Horowitz SL, Stewart JD . Lower motor neuron syndrome following radiotherapy Can J Neurol Sci 1983 10: 56\u201358","journal-title":"Can J Neurol Sci"},{"key":"BF3101316_CR20","first-page":"1185","volume":"13","author":"MB Katirji","year":"1990","unstructured":"Katirji MB . Delayed postirradiation focal motor neuron syndrome Muscle Nerve 1990 13: 1185\u20131186","journal-title":"Muscle Nerve"},{"key":"BF3101316_CR21","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1600-0404.1977.tb01427.x","volume":"56","author":"O Kristensen","year":"1977","unstructured":"Kristensen O, Melgard B, Schi\u00f8dt AV . Radiation myelopathy of the lumbo-sacral spinal cord Acta Neur Scand 1977 56: 217\u2013222","journal-title":"Acta Neur Scand"},{"key":"BF3101316_CR22","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1136\/jnnp.54.7.648","volume":"54","author":"C Lamy","year":"1991","unstructured":"Lamy C et al. Postradiation lower motor neuron syndrome presenting as monomelic amyotrophy J Neurol Neurosurg Psy 1991 54: 648\u2013649","journal-title":"J Neurol Neurosurg Psy"},{"key":"BF3101316_CR23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1148\/23.1.153","volume":"93","author":"JG Maier","year":"1969","unstructured":"Maier JG et al. Radiation myelitis of the dorsolumbar spinal cord Radiology 1969 93: 153\u2013160","journal-title":"Radiology"},{"key":"BF3101316_CR24","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1001\/archneur.1976.00500110054010","volume":"33","author":"CH Sadowsky","year":"1976","unstructured":"Sadowsky CH, Sachs Jr E, Ochoa J . Postradiation motor neuron syndrome Arch Neurol 1976 33: 786\u2013787","journal-title":"Arch Neurol"},{"key":"BF3101316_CR25","first-page":"369","volume":"17","author":"AV Schi\u00f8dt","year":"1978","unstructured":"Schi\u00f8dt AV, Kristensen O . Neurologic complications after irradiation of malignant tumors of the testis Acta Radiol Oncol 1978 17: 369\u2013378","journal-title":"Acta Radiol Oncol"},{"key":"BF3101316_CR26","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/ana.410050310","volume":"5","author":"SC Schold","year":"1979","unstructured":"Schold SC et al. Subacute motor neuropathy: a remote effect of lymphoma Ann Neurol 1979 5: 271\u2013287","journal-title":"Ann Neurol"},{"key":"BF3101316_CR27","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3109\/02841869709001276","volume":"36","author":"CME Tallaksen","year":"1997","unstructured":"Tallaksen CME, Jetne V, Foss\u00e5 S . Postradiation lower motor neuron syndrome. A case report and brief literature review Acta Oncol 1997 36: 345\u2013347","journal-title":"Acta Oncol"},{"key":"BF3101316_CR28","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1136\/jnnp.54.5.469-a","volume":"54","author":"SV Tan","year":"1991","unstructured":"Tan SV, Pye IF . Postradiation motor neuron syndrome of the upper cervical region \u2013 a manifestation of the combined effect of cranial irradiation and intrathecal chemotherapy? J Neurol Neurosurg Psy 1991 54: 469\u2013470","journal-title":"J Neurol Neurosurg Psy"},{"key":"BF3101316_CR29","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1259\/0007-1285-62-740-679","volume":"62","author":"JF Fowler","year":"1989","unstructured":"Fowler JF . The linear-quadratic formula and progress in fractionated radiotherapy Br J Radiol 1989 62: 679\u2013694","journal-title":"Br J Radiol"},{"key":"BF3101316_CR30","first-page":"113","volume-title":"Culture of animal cells: a manual of basic techniques","author":"RI Freshney","year":"1987","unstructured":"Freshney RI . Culture of animal cells: a manual of basic techniques New York: AR Liss Inc 1987 pp. 113\u2013115"},{"key":"BF3101316_CR31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/0921-8777(95)00063-1","volume":"363","author":"M Klaude","year":"1996","unstructured":"Klaude M et al. The comet assay: mechanisms and technical considerations Mutat Res 1996 363: 86\u201389","journal-title":"Mutat Res"},{"key":"BF3101316_CR32","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/095530098142392","volume":"73","author":"GZ Guo","year":"1998","unstructured":"Guo GZ et al. Simultaneous evaluation of radiation-induced apoptosis and micronuclei in five cell lines Int J Radiat Biol 1998 73: 297\u2013302","journal-title":"Int J Radiat Biol"},{"key":"BF3101316_CR33","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/0165-1218(93)90014-5","volume":"319","author":"GJ K\u00f6teles","year":"1993","unstructured":"K\u00f6teles GJ et al. Micronucleus frequency in cultured lymphocytes of an urban population Mutat Res 1993 319: 267\u2013271","journal-title":"Mutat Res"},{"key":"BF3101316_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0027-5107(88)90227-8","volume":"199","author":"C Kormos","year":"1988","unstructured":"Kormos C, K\u00f6teles GJ . Micronuclei in X-irradiated human lymphocytes Mutat Res 1988 199: 31\u201335","journal-title":"Mutat Res"},{"key":"BF3101316_CR35","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0027-5107(89)90009-2","volume":"211","author":"M Bauchinger","year":"1989","unstructured":"Bauchinger M et al. Time-effect relationship of chromosome aberrations in peripheral lymphocytes after radiation therapy for seminoma Mutat Res 1989 211: 265\u2013272","journal-title":"Mutat Res"},{"key":"BF3101316_CR36","first-page":"78","volume":"83","author":"JB Dynes","year":"1960","unstructured":"Dynes JB, Smedal MI . Radiation myelitis Am J Roentgenol 1960 83: 78\u201387","journal-title":"Am J Roentgenol"},{"key":"BF3101316_CR37","first-page":"363","volume":"152","author":"C Glanzmann","year":"1976","unstructured":"Glanzmann C, Aberle HG, Horst W . The risk of chronic progressive radiation myelopathy Strahlentherapie 1976 152: 363\u2013372","journal-title":"Strahlentherapie"},{"key":"BF3101316_CR38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3109\/02841867109130776","volume":"10","author":"\u00d8P Solheim","year":"1971","unstructured":"Solheim \u00d8P . Radiation injury of the spinal cord Acta Radiol Ther Phys Biol 1971 10: 474\u2013480","journal-title":"Acta Radiol Ther Phys Biol"},{"key":"BF3101316_CR39","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1097\/00004728-198312000-00001","volume":"7","author":"G Di Chiro","year":"1983","unstructured":"Di Chiro G et al. Metabolic imaging of the brain stem and spinal cord: studies with positron emission tomography using 18F-2-deoxyglucose in normal and pathological cases J Comput Assist Tomogr 1983 7: 937\u2013945","journal-title":"J Comput Assist Tomogr"},{"key":"BF3101316_CR40","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/00004728-199805000-00023","volume":"22","author":"Y Kamoto","year":"1998","unstructured":"Kamoto Y et al. Visualization of the cervical spinal cord with FDG and high-resolution PET J Comput Assist Tomogr 1998 22: 487\u2013491","journal-title":"J Comput Assist Tomogr"},{"key":"BF3101316_CR41","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/BF00593221","volume":"38","author":"T Sasajima","year":"1996","unstructured":"Sasajima T et al. Spinal cord ependymoma: a positron emission tomographic study with (11C-methyl)-L-methionine Neuroradiology (Germany) 1996 38: 53\u201355","journal-title":"Neuroradiology (Germany)"},{"key":"BF3101316_CR42","first-page":"469","volume-title":"Brain Activation","author":"PE Roland","year":"1993","unstructured":"Roland PE . Brain Activation New York: Wiley-Liss Inc 1993 pp. 469\u2013504"},{"key":"BF3101316_CR43","first-page":"211","volume-title":"Radiation injury to the nervous system","author":"PE Valk","year":"1991","unstructured":"Valk PE, Dillon WP . Diagnostic imaging of central nervous system radiation injury In: Gutin PH, Leibel SA, Sheline GE (eds) Radiation injury to the nervous system New York: Raven Press Ltd 1991 pp. 211\u2013237"},{"key":"BF3101316_CR44","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1523\/JNEUROSCI.17-19-07267.1997","volume":"17","author":"PA Felts","year":"1997","unstructured":"Felts PA, Baker TA, Smith KJ . Conduction in segmentally demyelinated mammalian central axons J Neurosci 1997 17: 7267\u20137277","journal-title":"J Neurosci"},{"key":"BF3101316_CR45","first-page":"323","volume":"338","author":"SG Waxman","year":"1998","unstructured":"Waxman SG . Demyelinating diseases\u2013new pathological insights, new therapeutic targets N Eng J Med 1998 338: 323\u2013325","journal-title":"N Eng J Med"},{"key":"BF3101316_CR46","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S0360-3016(98)00107-2","volume":"41","author":"MWT Chao","year":"1998","unstructured":"Chao MWT et al. Radiation myelopathy following transplantation and radiotherapy for non-Hodgkin's lymphoma Int J Radiat Oncol Biol Phys 1998 41: 1057\u20131061","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["Spinal Cord"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/3101316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3101316","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/3101316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:35:54Z","timestamp":1684287354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/3101316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8,21]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002,9]]}},"alternative-id":["BF3101316"],"URL":"https:\/\/doi.org\/10.1038\/sj.sc.3101316","relation":{},"ISSN":["1362-4393","1476-5624"],"issn-type":[{"value":"1362-4393","type":"print"},{"value":"1476-5624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,8,21]]}}}