{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:39:20Z","timestamp":1791383960242,"version":"4.3.3"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2002,1,1]]},"DOI":"10.1038\/sj.tpj.6500088","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T14:54:25Z","timestamp":1031237665000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil"],"prefix":"10.1038","volume":"2","author":[{"given":"Y","family":"Dauvilliers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Neidhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Billiard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tafti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2002,3,14]]},"reference":[{"key":"BF6500088_CR1","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0301-0082(96)00070-6","volume":"52","author":"S Nishino","year":"1997","unstructured":"Nishino S, Mignot E . Pharmacological aspects of human and canine narcolepsy Prog Neurobiol 1997 52: 27\u201378","journal-title":"Prog Neurobiol"},{"key":"BF6500088_CR2","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1038\/sj.mp.4000911","volume":"6","author":"Y Dauvilliers","year":"2001","unstructured":"Dauvilliers Y, Neidhart E, Lecendreux M, Billiard M, Tafti M . MAO-A and COMT polymorphisms and gene effects in narcolepsy Mol Psychiatry 2001 6: 367\u2013372","journal-title":"Mol Psychiatry"},{"key":"BF6500088_CR3","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0278-5846(88)90014-0","volume":"12","author":"H Bastuji","year":"1988","unstructured":"Bastuji H, Jouvet M . Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil Prog Neuropsychopharmacol Biol Psychiatry 1988 12: 695\u2013700","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BF6500088_CR4","doi-asserted-by":"publisher","first-page":"S107","DOI":"10.1093\/sleep\/17.suppl_8.S107","volume":"17","author":"M Billiard","year":"1994","unstructured":"Billiard M, Besset A, Montplaisir J, Laffont F, Goldenberg F, Weill JS, Lubin S . Modafinil: a double-blind multicentric study Sleep 1994 17: S107\u2013S112","journal-title":"Sleep"},{"key":"BF6500088_CR5","doi-asserted-by":"crossref","unstructured":"US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy Ann Neurol 1998 43: 88\u201397","DOI":"10.1002\/ana.410430115"},{"key":"BF6500088_CR6","doi-asserted-by":"crossref","unstructured":"US Modafinil in Narcolepsy Multicenter Study Group. Randomized trial of modafinil as a treatment for the excessive daytime somnolence of narcolepsy Neurology 2000 54: 1166\u20131175","DOI":"10.1212\/WNL.54.5.1166"},{"key":"BF6500088_CR7","doi-asserted-by":"publisher","first-page":"14128","DOI":"10.1073\/pnas.93.24.14128","volume":"93","author":"JS Lin","year":"1996","unstructured":"Lin JS, Hou Y, Jouvet M . Potential brain neuronal targets for amphetamine-, methylphenidate-, and modafinil-induced wakefulness, evidenced by c-fos immunocytochemistry in the cat Proc Natl Acad Sci U S A 1996 93: 14128\u201314133","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BF6500088_CR8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/S0893-133X(98)00085-2","volume":"20","author":"L Ferraro","year":"1999","unstructured":"Ferraro L, Antonelli T, Tanganelli S, O'Connor WT, Perez de la Mora M, Mendez-Franco J et al . The vigilance promoting drug modafinil increases extracellular glutamate levels in the medial preoptic area and the posterior hypothalamus of the conscious rat: prevention by local GABAA receptor blockade Neuropsychopharmacology 1999 20: 346\u2013356","journal-title":"Neuropsychopharmacology"},{"key":"BF6500088_CR9","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/S0306-4522(98)00015-3","volume":"87","author":"TM Engber","year":"1998","unstructured":"Engber TM, Dennis SA, Jones BE, Miller MS, Contreras PC . Brain regional substrates for the actions of the novel wake-promoting agent modafinil in the rat: comparison with amphetamine Neuroscience 1998 87: 905\u2013911","journal-title":"Neuroscience"},{"key":"BF6500088_CR10","doi-asserted-by":"publisher","first-page":"8620","DOI":"10.1523\/JNEUROSCI.20-22-08620.2000","volume":"20","author":"TE Scammell","year":"2000","unstructured":"Scammell TE, Estabrooke IV, McCarthy MT, Chemelli RM, Yanagisawa M, Miller MS et al . Hypothalamic arousal regions are activated during modafinil-induced wakefulness J Neurosci 2000 20: 8620\u20138628","journal-title":"J Neurosci"},{"key":"BF6500088_CR11","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1093\/sleep\/17.5.436","volume":"17","author":"E Mignot","year":"1994","unstructured":"Mignot E, Nishino S, Guilleminault C, Dement WC . Modafinil binds to the dopamine uptake carrier site with low affinity Sleep 1994 17: 436\u2013437","journal-title":"Sleep"},{"key":"BF6500088_CR12","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1523\/JNEUROSCI.21-05-01787.2001","volume":"21","author":"JP Wisor","year":"2001","unstructured":"Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM . Dopaminergic role in stimulant-induced wakefulness J Neurosci 2001 21: 1787\u20131794","journal-title":"J Neurosci"},{"key":"BF6500088_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-4347(99)00149-8","volume":"25","author":"SH Gorman","year":"1999","unstructured":"Gorman SH . Determination of the D- and L-enantiomers of modafinil in human plasma utilizing liquid-liquid extraction and high-performance liquid chromatography J Chromatogr B Biomed Sci Appl 1999 25: 1\u20137","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"BF6500088_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1177\/00912709922007534","volume":"39","author":"YN Wong","year":"1999","unstructured":"Wong YN, King SP, Simcoe D, Gorman S, Laughton W, McCormick GC et al . Open-label, single-dose pharmacokinetic study of modafinil tablets: influence of age and gender in normal subjects J Clin Pharmacol 1999 39: 281\u2013288","journal-title":"J Clin Pharmacol"},{"key":"BF6500088_CR15","first-page":"664","volume":"28","author":"P Robertson","year":"2000","unstructured":"Robertson P, DeCory HH, Madan A, Parkinson A . In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil Drug Metab Dispos 2000 28: 664\u2013671","journal-title":"Drug Metab Dispos"},{"key":"BF6500088_CR16","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-2125.2001.01328.x","volume":"51","author":"S Hagg","year":"2001","unstructured":"Hagg S, Spigset O, Dahlqvist R . Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers Br J Clin Pharmacol 2001 51: 169\u2013173","journal-title":"Br J Clin Pharmacol"},{"key":"BF6500088_CR17","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1046\/j.1365-2710.2000.00281.x","volume":"25","author":"N Poolsup","year":"2000","unstructured":"Poolsup N, Li Wan Po A, Knight TL . Pharmacogenetics and psychopharmacotherapy J Clin Pharm Ther 2000 25: 197\u2013220","journal-title":"J Clin Pharm Ther"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6500088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500088","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T07:18:28Z","timestamp":1647933508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6500088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1,1]]}},"alternative-id":["BF6500088"],"URL":"https:\/\/doi.org\/10.1038\/sj.tpj.6500088","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1,1]]},"assertion":[{"value":"14 December 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2001","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2002","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}