{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:40:16Z","timestamp":1736383216867,"version":"3.32.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T00:00:00Z","timestamp":1147132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T00:00:00Z","timestamp":1147132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2007,2,1]]},"DOI":"10.1038\/sj.tpj.6500396","type":"journal-article","created":{"date-parts":[[2006,5,16]],"date-time":"2006-05-16T08:34:02Z","timestamp":1147768442000},"page":"2-9","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacogenetic of antirheumatic treatments: clinical implications"],"prefix":"10.1038","volume":"7","author":[{"given":"G","family":"Ferraccioli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Tolusso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"De Santis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,5,9]]},"reference":[{"key":"BF6500396_CR1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/1479-7364-1-5-375","volume":"1","author":"W Kalow","year":"2004","unstructured":"Kalow W . Human pharmacogenomics: the development of a science. Hum Genom 2004; 1: 375\u2013380.","journal-title":"Hum Genom"},{"key":"BF6500396_CR2","first-page":"2270","volume":"286","author":"SB Haga","year":"2004","unstructured":"Haga SB, Burke W . Using pharmacogenetics to improve drug safety and efficacy. JAMA 2004; 286: 2270\u20132279.","journal-title":"JAMA"},{"key":"BF6500396_CR3","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/01.bor.0000160780.13012.be","volume":"17","author":"AH van der Helm-van Mil","year":"2005","unstructured":"van der Helm-van Mil AH, Wesoly JZ, Huizinga TW . Understanding the genetic contribution to rheumatoid arthritis. Curr Opin Rheumatol 2005; 17: 299\u2013304.","journal-title":"Curr Opin Rheumatol"},{"key":"BF6500396_CR4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/nature03726","volume":"435","author":"CG Fathman","year":"2005","unstructured":"Fathman CG, Soares L, Chan SM, Utz PJ . An array of possibilities for the study of autoimmunity. Nature 2005; 435: 605\u2013611.","journal-title":"Nature"},{"key":"BF6500396_CR5","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature03723","volume":"435","author":"JD Rioux","year":"2005","unstructured":"Rioux JD, Abbas AK . Paths to understanding the genetic basis of autoimmune disease. Nature 2005; 435: 584\u2013589.","journal-title":"Nature"},{"key":"BF6500396_CR6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature02624","volume":"429","author":"J Bell","year":"2004","unstructured":"Bell J . Predicting disease using genomics. Nature 2004; 429: 453\u2013456.","journal-title":"Nature"},{"key":"BF6500396_CR7","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1002\/art.21385","volume":"52","author":"TW Huizinga","year":"2005","unstructured":"Huizinga TW, Amos CI, Van der Helm-vanMil AH, Chen W, Van Gaalen FA, Jawaheer D et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005; 52: 3433\u20133438.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0889-857X(03)00067-X","volume":"28","author":"R Wassmuth","year":"2002","unstructured":"Wassmuth R, Wagner U . Prognostic use of human leukocyte antigen genotyping for rheumatoid arthritis susceptibility, disease course, and clinical stratification. Rheum Dis Clin N Am 2002; 28: 17\u201337.","journal-title":"Rheum Dis Clin N Am"},{"key":"BF6500396_CR9","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.20152","volume":"50","author":"SL Bridges Jr","year":"2004","unstructured":"Bridges Jr SL . Genetic markers of treatment response in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1019\u20131022.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR10","first-page":"1832","volume":"32","author":"H Schmeling","year":"2005","unstructured":"Schmeling H, Biber D, Heins S, Horneff G . Influence of methylenetetrahydrofolate reductase polymorphism on efficacy and toxicity of methotrexate in patients with juvenile idiopathic arthritis. J Rheumatol 2005; 32: 1832\u20131836.","journal-title":"J Rheumatol"},{"key":"BF6500396_CR11","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1517\/14622416.5.5.559","volume":"5","author":"P Ranganathan","year":"2004","unstructured":"Ranganathan P, Culverhouse R, Marsh S, Ahluwalia R, Shannon WD, Eisen S et al. Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and rheumatoid arthritis. Pharmacogenomics 2004; 5: 559\u2013569.","journal-title":"Pharmacogenomics"},{"key":"BF6500396_CR12","first-page":"593","volume":"11","author":"K Kumagai","year":"2003","unstructured":"Kumagai K, Hiyama K, Oyama T, Maeda H, Kohno N . Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. Int J Mol Med 2003; 11: 593\u2013600.","journal-title":"Int J Mol Med"},{"key":"BF6500396_CR13","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1002\/art.20460","volume":"50","author":"T Dervieux","year":"2004","unstructured":"Dervieux T, Furst D, Lein DO, Capps R, Smith K, Walsh M et al. Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004; 50: 2766\u20132774.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/art.21573","volume":"54","author":"MH Weisman","year":"2006","unstructured":"Weisman MH, Furst DE, Park GS, Kremer JM, Smith KM, Wallace DJ et al. Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum 2006; 54: 607\u2013612.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR15","first-page":"11","volume":"32","author":"S Hider","year":"2005","unstructured":"Hider S, Buckley C, Silman AJ, Symmons DP, Bruce IN . Factors influencing response to disease modifying antirheumatic drugs in patients with rheumatoid arthritis. J Rheumatol 2005; 32: 11\u201316.","journal-title":"J Rheumatol"},{"key":"BF6500396_CR16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0006-291X(02)00608-3","volume":"28","author":"N Watanabe","year":"2002","unstructured":"Watanabe N, Ando K, Yoshida S, Inuzulka S, Kobayashi M, Matusi N et al. Gene expression profile analysis of rheumatoid synovial fibroblast cultures revealing the overexpression of genes responsible for tumor-like growth of rheumatoid synovium. Biochem Biophys Res Commun 2002; 28: 1121\u20131129.","journal-title":"Biochem Biophys Res Commun"},{"key":"BF6500396_CR17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejrad.2004.03.013","volume":"53","author":"CZ Erdem","year":"2005","unstructured":"Erdem CZ, Sarikaya S, Erdem LO, Ozdolap S, Gundogdu S . MR imaging features of foot involvement in ankylosing spondylitis. Eur J Radiol 2005; 53: 110\u2013119.","journal-title":"Eur J Radiol"},{"key":"BF6500396_CR18","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.2003.tb06042.x","volume":"987","author":"CM Weyand","year":"2003","unstructured":"Weyand CM, Goronzy JJ . Ectopic germinal center formation in rheumatoid synovitis. Ann NY Acad Sci 2003; 987: 140\u2013149.","journal-title":"Ann NY Acad Sci"},{"key":"BF6500396_CR19","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2249.2005.02850.x","volume":"141","author":"T Tsubaki","year":"2005","unstructured":"Tsubaki T, Takegawa S, Hanamoto H, Arita N, Kamogawa J, Yamamoto H et al. Accumulation of plasma cells expressing CXCR3 in the synovial sublining regions of early rheumatoid arthritis in association with production of Mig\/CXCL9 by synovial fibroblasts. Clin Exp Immunol 2005; 141: 363\u2013371.","journal-title":"Clin Exp Immunol"},{"key":"BF6500396_CR20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/path.1891","volume":"208","author":"I Adamopoulos","year":"2006","unstructured":"Adamopoulos I, Sabokbar A, Wordsorth B, Carr A, Ferguson D, Athanasou N . Synovial fluid macrophages are capable of osteoclast formation and resorption. J Pathol 2006; 208: 35\u201343.","journal-title":"J Pathol"},{"doi-asserted-by":"crossref","unstructured":"Milner CM, Campbell RD . Genetic organization of the human MHC class III region. Front Biosci 2001 (Suppl 6): D914\u2013D926.","key":"BF6500396_CR21","DOI":"10.2741\/A653"},{"key":"BF6500396_CR22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1006\/geno.2000.6371","volume":"71","author":"M Ota","year":"2001","unstructured":"Ota M, Katsuyama Y, Kimura A, Tuschiya K, Kondo M, Naruse T et al. A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region. Genomics 2001; 71: 263\u2013270.","journal-title":"Genomics"},{"key":"BF6500396_CR23","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0198-8859(01)00315-9","volume":"62","author":"K Vos","year":"2001","unstructured":"Vos K, Visser H, Schreuder GM, De Vries RR, Zwinderman AH, Breedveld FC et al. Human leukocyte antigen-DQ and DR polymorphisms predict rheumatoid arthritis outcome better than DR alone. Hum Immunol 2001; 62: 1217\u20131225.","journal-title":"Hum Immunol"},{"key":"BF6500396_CR24","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/art.1780301102","volume":"30","author":"PK Gregersen","year":"1987","unstructured":"Gregersen PK, Silver J, Winchester RJ . The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30: 1205\u20131213.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1521-6616(02)00045-1","volume":"107","author":"PK Gregersen","year":"2003","unstructured":"Gregersen PK . Teasing apart the complex genetics of human autoimmunity: lessons from rheumatoid arthritis. Clin Immunol 2003; 107: 1\u20139.","journal-title":"Clin Immunol"},{"key":"BF6500396_CR26","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/art.1780330704","volume":"33","author":"XJ Gao","year":"1990","unstructured":"Gao XJ, Olsen NJ, Pincus T, Stastny P . HLA-DR alleles with naturally occurring aminoacid substitutions and risk for development of rheumatoid arthritis. Arthritis Rheum 1990; 33: 939\u2013946.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR27","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/art.20989","volume":"52","author":"ST du Montcel","year":"2005","unstructured":"du Montcel ST, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum 2005; 52: 1063\u20131068.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1086\/422195","volume":"75","author":"S John","year":"2004","unstructured":"John S, Shephard N, Liu G, Zeggini E, Cao M, Chen W et al. Whole genome scan in a complex disease, using 11\u2009245 single nucleotide polymorphisms: comparison with microsatellites. Am J Hum Genet 2004; 75: 54\u201364.","journal-title":"Am J Hum Genet"},{"key":"BF6500396_CR29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0198-8859(94)00079-6","volume":"42","author":"RC Williams","year":"1995","unstructured":"Williams RC, Jacobsson LT, Knowler WC, del Puente A, Kostyu D, McAuley JE et al. Meta-analysis reveals association between most common class II haplotype in full heritage native Americans and rheumatoid arthritis. Hum Immunol 1995; 42: 90\u201394.","journal-title":"Hum Immunol"},{"key":"BF6500396_CR30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/art.1780400219","volume":"40","author":"U Wagner","year":"1997","unstructured":"Wagner U, Kaltenhauser S, Sauer H, Arnold S, Seidel W, Hantzschel H et al. HLA markers and prediction of clinical course and outcome in rheumatoid arthritis. Arthritis Rheum 1997; 40: 341\u2013351.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR31","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/art.10989","volume":"48","author":"D Jawaheer","year":"2003","unstructured":"Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Etzel C . The North American Consortium. Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families. Arthritis Rheum 2003; 48: 906\u2013916.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR32","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1086\/342407","volume":"71","author":"D Jawaheer","year":"2002","unstructured":"Jawaheer D, Li W, Graham RR, Chen W, Damle A, Xiao X et al. Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet 2002; 71: 585\u2013594.","journal-title":"Am J Hum Genet"},{"key":"BF6500396_CR33","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.0105-2896.2005.00243.x","volume":"204","author":"PK Gregersen","year":"2005","unstructured":"Gregersen PK . Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond. Immunol Rev 2005; 204: 74\u201386.","journal-title":"Immunol Rev"},{"key":"BF6500396_CR34","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1186\/ar1777","volume":"7","author":"V Goeb","year":"2005","unstructured":"Goeb V, Dieude P, Vittecoq O, Mejjad O, Menard JF, Thomas M et al. Association between the TNFRII 196 R allele and diagnosis of rheumatoid arthritis. Arthritis Res Ther 2005; 7: 1056\u20131062.","journal-title":"Arthritis Res Ther"},{"key":"BF6500396_CR35","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.humimm.2004.06.010","volume":"65","author":"B Tolusso","year":"2004","unstructured":"Tolusso B, Sacco S, Gremese E, La Torre G, Tomietto P, Ferraccioli GF . Relationship between the tumor necrosis factor receptor II(TNF-R II) gene polymorphism and s-TNF.RII plasma levels in healthy controls and in rheumatoid arthritis. Hum Immunol 2004; 65: 1420\u20131426.","journal-title":"Hum Immunol"},{"key":"BF6500396_CR36","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1002\/art.21287","volume":"52","author":"PE Carreira","year":"2005","unstructured":"Carreira PE, Gonzales-Crespo MR, Ciruelo E, Pablos JL, Santiago B, Gomez-Camara A et al. Polymorphism of the interleukin-1 receptor antagonist gene. Arthritis Rheum 2005; 52: 3015\u20133019.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00002281-200007000-00005","volume":"12","author":"SJ van der Linden","year":"2000","unstructured":"van der Linden SJ, Van der Heijde D . Clinical aspects, outcome assessment, and management of ankylosing spondylitis and postenteric reactive arthritis. Curr Opin Rheumatol 2000; 12: 263\u2013268.","journal-title":"Curr Opin Rheumatol"},{"key":"BF6500396_CR38","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/1529-0131(200007)43:7<1527::AID-ANR17>3.0.CO;2-G","volume":"43","author":"P Ekman","year":"2000","unstructured":"Ekman P, Kirveskari J, Granfors K . Modification of disease outcome in Salmonella-infected patients by HLA-B27. Arthritis Rheum 2000; 43: 1527\u20131534.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR39","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/1529-0131(199804)41:4<588::AID-ART5>3.0.CO;2-0","volume":"41","author":"MA Brown","year":"1998","unstructured":"Brown MA, Pile KD, Kennedy LG, Campbell D, Andrew L, March R et al. A genome-wide screen for susceptibility loci in ankylosing spondylitis. Arthritis Rheum 1998; 41: 588\u2013595.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR40","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1002\/art.11106","volume":"48","author":"MA Brown","year":"2003","unstructured":"Brown MA, Brophy S, Bradbury L, Hamersma J, Timms A, Laval S et al. Identification of major loci controlling clinical manifestations of ankylosing spondylitis. Arthritis Rheum 2003; 48: 2234\u20132239.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR41","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/art.1780401015","volume":"40","author":"MA Brown","year":"1997","unstructured":"Brown MA, Kennedy LG, MacGregor AJ, Darke C, Duncan E, Shatford JL . Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA and the environment. Arthritis Rheum 1997; 40: 1823\u20131828.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR42","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/ard.56.12.741","volume":"56","author":"T Hohler","year":"1997","unstructured":"Hohler T, Schaper T, Schneider PM, Krummenauer F, Rittner C, Meyer zum Buschenfelde KH et al. No primary association between LMP2 polymorphisms and extraspinal manifestations in spondyloarthropathies. Ann Rheum Dis 1997; 56: 741\u2013743.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR43","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1002\/art.20308","volume":"50","author":"G Zhang","year":"2004","unstructured":"Zhang G, Luo J, Bruckel J, Weisman MA, Schumacher HR, Khan MA et al. Genetic studies in familial ankylosing spondylitis susceptibility. Arthritis Rheum 2004; 50: 2246\u20132254.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR44","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1086\/424695","volume":"75","author":"AE Timms","year":"2004","unstructured":"Timms AE, Crane AM, Sims AM, Cordell HJ, Bradbury LA, Abbott A et al. The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis. Am J Hum Genet 2004; 75: 587\u2013595.","journal-title":"Am J Hum Genet"},{"key":"BF6500396_CR45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1136\/ard.55.1.66","volume":"55","author":"C Beyeler","year":"1996","unstructured":"Beyeler C, Armstrong M, Bird HA, Idle JR, Daly AK . Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis et. Ann Rheum Dis 1996; 55: 66\u201368.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR46","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/hmg\/9.11.1563","volume":"9","author":"MA Brown","year":"2000","unstructured":"Brown MA, Edwards S, Hoyle E, Campbell S, Laval S, Daly AK et al. Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis. Hum Mol Genet 2000; 9: 1563\u20131566.","journal-title":"Hum Mol Genet"},{"key":"BF6500396_CR47","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1136\/ard.57.4.209","volume":"57","author":"J O'Dell","year":"1998","unstructured":"O'Dell J, Nepom BS, Haire C, Gersuk VH, Gaur L, Moore GF et al. HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments. Ann Rheum Dis 1998; 57: 209\u2013213.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR48","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1093\/rheumatology\/41.8.892","volume":"41","author":"GF Ferraccioli","year":"2002","unstructured":"Ferraccioli GF, Gremese E, Tomietto P, Favret G, Damato R, Di Poi E . Analysis of improvements, full responses, remission and toxicity in rheumatoid patients treated with step-up combination therapy (methotrexate, cyclosporin A, sulphasalazine) or monotherapy for three years. Rheumatology 2002; 41: 892\u2013898.","journal-title":"Rheumatology"},{"key":"BF6500396_CR49","first-page":"271","volume":"29","author":"MA Gonzales-Gay","year":"2002","unstructured":"Gonzales-Gay MA, Hajeer AH, Garcia-Porrua C, Dababneh A, Thomson W, Ollier WE et al. Patients chosen for treatment with cyclosporine because of severe rheumatoid arthritis are more likely to carry HLA-DRB1 shared epitope alleles and have earlier disease onset. J Rheumatol 2002; 29: 271\u2013275.","journal-title":"J Rheumatol"},{"key":"BF6500396_CR50","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/art.20469","volume":"50","author":"LA Criswell","year":"2004","unstructured":"Criswell LA, Lum RF, Turner KN, Woehl B, Zhu Y, Wang J et al. The influence of genetic variation in the HLA DRB1 and LTA.TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthritis Rheum 2004; 50: 2750\u20132756.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR51","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.20154","volume":"50","author":"A Martinez","year":"2004","unstructured":"Martinez A, Salido M, Bonilla G, Pascual-Salcedo D, Fernandez-Arquero M, de Miguel S et al. Association of the major histocompatibility complex with response to infliximab therapy in rheumatoid arthritis patients. Arthritis Rheum 2004; 50: 1077\u20131082.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR52","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1002\/art.20358","volume":"50","author":"JL Newton","year":"2004","unstructured":"Newton JL, Harney SM, Timms AE, Rockett K, Darke C, Wordsworth BP et al. Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis. Arthritis Rheum 2004; 50: 2122\u20132129.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR53","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/ard.60.1.36","volume":"60","author":"M Rudwailet","year":"2001","unstructured":"Rudwailet M, Siegert S, Yin Z, Eick J, Thiel A, Radbruch A et al. Low T cell production of TNFa and IFNg in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis 2001; 60: 36\u201342.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR54","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1136\/ard.2003.011023","volume":"62","author":"C Keller","year":"2003","unstructured":"Keller C, Webb A, Davis J . Cytokines in the seronegative spondyloarthropathies and their modification by TNF blockade: a brief report and literature review. Ann Rheum Dis 2003; 62: 1128\u20131132.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/03009740510026599","volume":"34","author":"J Braun","year":"2005","unstructured":"Braun J, Baraliakos X, Brandt J, Sieper J . Therapy of ankylosing spondylitis. Scand J Rheumatol 2005; 34: 178\u2013190.","journal-title":"Scand J Rheumatol"},{"key":"BF6500396_CR56","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/ard.60.7.660","volume":"60","author":"P Barrera","year":"2001","unstructured":"Barrera P, Joosten LA, Den Broeder AA, van de Putte LB, van Riel PL, van den Berg WB . Effects of treatment with a fully human anti-tumor necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNF alpha in patients with rheumatoid arthritis. Ann Rheum Dis 2001; 60: 660\u2013669.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s002960050111","volume":"19","author":"O Elkayam","year":"2000","unstructured":"Elkayam O, Yaron I, Shirazi I, Yaron M, Caspi D . Serum levels of IL10, IL6, IL1Ra and sIL2R in patients with psoriatic arthritis. Rheumatol Int 2000; 19: 101\u2013105.","journal-title":"Rheumatol Int"},{"key":"BF6500396_CR58","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/ard.57.11.691","volume":"57","author":"G Partsh","year":"1998","unstructured":"Partsh G, Wagner E, Leeb BF, Broll H, Dunky A, Smolen JS . T cell derived cytokines in psoriatic arthritis synovial fluid. Ann Rheum Dis 1998; 57: 691\u2013693.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR59","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1002\/1529-0131(200006)43:6<1244::AID-ANR7>3.0.CO;2-2","volume":"43","author":"CL Danning","year":"2000","unstructured":"Danning CL, Illei GG, Hitchon C, Greer MR, Boumpas DT, McInnes IB . Macrophage derived cytokine and nuclear factor kB 65 expression in synovial membrane and skin of patients with psoriatic arthritis. Arthritis Rheum 2000; 43: 1244\u20131256.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR60","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/rheumatology\/33.10.927","volume":"33","author":"J Gratacos","year":"1994","unstructured":"Gratacos J, Collado A, Filella X, Sanmarti R, Canete J, Llena J et al. Serum cytokines (IL6, TNF\u03b1, IL1\u03b2, IFN\u03b3) in ankylosing spondylitis: a close correlation between serum IL6 levels and disease activity and severity. Br J Rheumatol 1994; 33: 927\u2013931.","journal-title":"Br J Rheumatol"},{"key":"BF6500396_CR61","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/rheumatology\/36.3.400","volume":"36","author":"P Claudepierre","year":"1997","unstructured":"Claudepierre P, Rymer JC, Authier FJ, Allanore Y, Larget-Piet B, Gherardi R et al. A relationship between TGF\u03b21 or IL6 plasma levels and clinical features of spondyloarthropathies. Br J Rheumatol 1997; 36: 400\u2013401.","journal-title":"Br J Rheumatol"},{"key":"BF6500396_CR62","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/art.1780401010","volume":"40","author":"Z Yin","year":"1997","unstructured":"Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U et al. Crucial role of interleukin-10\/inetrelukin12 balance in the regulation of the type 2T helper cytokine response in reactive arthritis. Arthritis Rheum 1997; 40: 1788\u20131797.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR63","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/1529-0131(199910)42:10<2039::AID-ANR3>3.0.CO;2-6","volume":"42","author":"J Braun","year":"1999","unstructured":"Braun J, Yin Z, Spiller I, Siegert S, Rudwaleit M, Liu L et al. Low secretion of tumor necrosis factor alpha, but not other TH1 or TH2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis. Arthritis Rheum 1999; 42: 2039\u20132044.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR64","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/rheumatology\/keh323","volume":"43","author":"I Butrimiene","year":"2004","unstructured":"Butrimiene I, Jarmalaite S, Ranceva J, Venalis A, Jasiuleviciute L, Zvirbliene A . Different cytokine profiles in patients with chronic and acute reactive arthritis. Rheumatology 2004; 43: 1300\u20131304.","journal-title":"Rheumatology"},{"key":"BF6500396_CR65","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/ard.62.9.793","volume":"62","author":"DD Gladman","year":"2003","unstructured":"Gladman DD . Established criteria for disease controlling drugs in ankylosing spondylitis. Ann Rheum Dis 2003; 62: 793\u2013794.","journal-title":"Ann Rheum Dis"},{"issue":"Suppl","key":"BF6500396_CR66","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/ard.60.90003.iii37","volume":"60","author":"PJ Mease","year":"2001","unstructured":"Mease PJ . Cytokine blockers in psoriatic arthritis. Ann Rheum Dis 2001; 60 (Suppl): 37\u201340.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00002281-200107000-00005","volume":"13","author":"T Hohler","year":"2001","unstructured":"Hohler T, Marker-Hermann E . Psoriatic arthritis: clinical aspects, genetics and the role of T cells. Curr Opin Rheumatol 2001; 13: 273\u2013279.","journal-title":"Curr Opin Rheumatol"},{"key":"BF6500396_CR68","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1046\/j.1523-1747.2000.00001.x","volume":"114","author":"W Kaluza","year":"2000","unstructured":"Kaluza W, Reuss E, Grossmann S, Hug R, Schopf RE, Galle PR et al. Different transcriptional activity and in vitro TNF alpha production in psoriasis patients carrying the TNF alpha 238A promoter polymorphism. J Invest Dermatol 2000; 114: 1180\u20131183.","journal-title":"J Invest Dermatol"},{"key":"BF6500396_CR69","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/1523-1747.ep12337469","volume":"109","author":"T Hohler","year":"1997","unstructured":"Hohler T, Kruger A, Schneider PM, Schopf RE, Knop J, Rittner C . A TNF alpha promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis. J Invest Dermatol 1997; 109: 562\u2013565.","journal-title":"J Invest Dermatol"},{"key":"BF6500396_CR70","first-page":"118","volume":"14","author":"AI Arias","year":"1997","unstructured":"Arias AI, Giles B, Eiermann TH, Sterry W, Pandey JP . Tumor necrosis factor-alpha gene polymorphism in psoriasis. Exp Clin Immunogenet 1997; 14: 118\u2013122.","journal-title":"Exp Clin Immunogenet"},{"key":"BF6500396_CR71","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/rheumatology\/41.5.525","volume":"41","author":"AM Al-Heresh","year":"2002","unstructured":"Al-Heresh AM, Proctor J, Jones SM, Dixey J, Cox B, Welsh K et al. Tumor necrosis factor alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis. Rheumatology 2002; 41: 525\u2013530.","journal-title":"Rheumatology"},{"key":"BF6500396_CR72","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.0022-202X.2004.23556.x","volume":"124","author":"R Mossner","year":"2005","unstructured":"Mossner R, Kingo K, Kleensang A, Kruger U, Konig IR, Silm H et al. Association of TNF-238 and -308 promoter polymorphisms with psoriasis vulgaris and psoriatic arthritis but not with pustulosis palmoplantaris. J Invest Dermatol 2005; 124: 282\u2013284.","journal-title":"J Invest Dermatol"},{"key":"BF6500396_CR73","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0198-8859(98)00099-8","volume":"60","author":"EL Kaijzel","year":"1999","unstructured":"Kaijzel EL, Brinkman BM, van Krugten MV, Smith L, Huizinga TW, Verjans GM et al. Polymorphism within the tumor necrosis factor alpha (TNF) promoter region in patients with ankylosing spondylitis. Hum Immunol 1999; 60: 140\u2013144.","journal-title":"Hum Immunol"},{"key":"BF6500396_CR74","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF03401767","volume":"4","author":"EL Kaijzel","year":"1998","unstructured":"Kaijzel EL, Van Krugten MV, Brinkman BM, Huizinga TW, van der Straaten T, Hazes JM et al. Functional analysis of a human tumor necrosis (TNF-alpha) promoter polymorphism related to joint damage in rheumatoid arthritis. Mol Med 1998; 4: 724\u2013733.","journal-title":"Mol Med"},{"key":"BF6500396_CR75","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1399-0039.1998.tb02978.x","volume":"51","author":"A Fraile","year":"1998","unstructured":"Fraile A, Nieto A, Beraum Y, Vinasco J, Mataran L, Martin J . Tumor necrosis factor gene polymorphisms in ankylosing spondylitis. Tissue Antigens 1998; 51: 386\u2013390.","journal-title":"Tissue Antigens"},{"key":"BF6500396_CR76","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00002281-199907000-00005","volume":"11","author":"R Winchester","year":"1999","unstructured":"Winchester R . Psoriatic arthritis and the spectrum of syndromes related to the SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome. Curr Opin Rheumatol 1999; 11: 251\u2013256.","journal-title":"Curr Opin Rheumatol"},{"key":"BF6500396_CR77","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/art.10935","volume":"48","author":"J Balding","year":"2003","unstructured":"Balding J, Kane D, Livingstone W, Mynett-Johnson L, Bresnihan B, Smith O et al. Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity. Arthritis Rheum 2003; 48: 1408\u20131413.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR78","first-page":"1110","volume":"26","author":"F McGarry","year":"1999","unstructured":"McGarry F, Walker R, Sturrock R, Field M . The \u2212308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27. J Rheumatol 1999; 26: 1110\u20131116.","journal-title":"J Rheumatol"},{"key":"BF6500396_CR79","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/rheumatology\/39.4.445","volume":"39","author":"N Carter","year":"2000","unstructured":"Carter N, Williamson L, Kennedy LG, Brown MA, Wordsworth BP . Susceptibility to ankylosing spondylitis. Rheumatology 2000; 39: 445.","journal-title":"Rheumatology"},{"key":"BF6500396_CR80","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/qjmed\/94.5.237","volume":"94","author":"M Field","year":"2001","unstructured":"Field M . Tumor necrosis factor polymorphisms in rheumatic diseases. Q J Med 2001; 94: 237\u2013246.","journal-title":"Q J Med"},{"key":"BF6500396_CR81","first-page":"1847","volume":"29","author":"M Fabris","year":"2002","unstructured":"Fabris M, Tolusso B, Di Poi E, Assaloni R, Sinigaglia L, Ferraccioli G . Tumor necrosis factor-alpha receptor II polymorphism in patients from Southern Europe with mild-moderate and severe rheumatoid arthritis. J Rheumatol 2002; 29: 1847\u20131850.","journal-title":"J Rheumatol"},{"key":"BF6500396_CR82","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/ard.62.6.526","volume":"62","author":"L Padyukov","year":"2003","unstructured":"Padyukov L, Lampa J, Heimb\u00fcrger M, Ernstam S, Cederholm T, Lundkvist I et al. Genetic markers for the efficacy of tumor necrosis factor blocking therapy in rheumatoid arthritis. Ann Rheum Dis 2003; 62: 526\u2013529.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR83","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/art.20154","volume":"50","author":"A Martinez","year":"2004","unstructured":"Martinez A, Salido M, Bonilla G, Pascual-Salcedo D, Fernandez-Arquero M, de Miguel S et al. Association of the major histocompatibility complex with response to Infliximab therapy in rheumatoid arthritis patients. Arthritis Rheum 2004; 50: 1077\u20131082.","journal-title":"Arthritis Rheum"},{"key":"BF6500396_CR84","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/03009740410005863","volume":"33","author":"M Cuchacovich","year":"2004","unstructured":"Cuchacovich M, Ferreira L, Aliste M, Soto L, Cuenca J, Cruzat A et al. Tumor necrosis factor-a (TNF-a) levels and influence of -308TNF-a promoter polymorphism on the responsiveness to infliximab in patients with rheumatoid arthritis. Scand J Rheumatol 2004; 33: 228\u2013232.","journal-title":"Scand J Rheumatol"},{"key":"BF6500396_CR85","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1002\/art.20469","volume":"50","author":"LA Criswell","year":"2004","unstructured":"Criswell LA, Lum RF, Turner KN, Woehl B, Zhu Y, Wang J et al. The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept. Arthitis Rheum 2004; 50: 2750\u20132756.","journal-title":"Arthitis Rheum"},{"key":"BF6500396_CR86","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/ard.2004.028167","volume":"64","author":"JE Fonseca","year":"2005","unstructured":"Fonseca JE, Carvalho T, Cruz M, Nero P, Sobral M, Mour\u00e3o AF et al. Polymorphism at position \u2212308 of the tumor necrosis factor \u03b1 gene and rheumatoid arthritis pharmacogenetics. Ann Rheum Dis 2005; 64: 793\u2013794.","journal-title":"Ann Rheum Dis"},{"key":"BF6500396_CR87","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/rheumatology\/keh550","volume":"44","author":"CP Kang","year":"2005","unstructured":"Kang CP, Lee KW, Yoo DH, Kang C, Bae SC . The influence of a polymorphism at position \u2212857 of the tumor necrosis factor \u03b1 gene on clinical response to etanercept therapy in rheumatoid arthritis. Rheumatology 2005; 44: 547\u2013552.","journal-title":"Rheumatology"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6500396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500396","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500396.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T00:03:44Z","timestamp":1736381024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6500396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,9]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2,1]]}},"alternative-id":["BF6500396"],"URL":"https:\/\/doi.org\/10.1038\/sj.tpj.6500396","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"type":"print","value":"1470-269X"},{"type":"electronic","value":"1473-1150"}],"subject":[],"published":{"date-parts":[[2006,5,9]]},"assertion":[{"value":"9 May 2006","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}