{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:01:14Z","timestamp":1791925274647,"version":"4.3.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T00:00:00Z","timestamp":1148947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pharmacogenomics J"],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1038\/sj.tpj.6500400","type":"journal-article","created":{"date-parts":[[2006,5,30]],"date-time":"2006-05-30T10:25:19Z","timestamp":1148984719000},"page":"123-132","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["PP2A-B\u03b3 subunit and KCNQ2 K+ channels in bipolar disorder"],"prefix":"10.1038","volume":"7","author":[{"given":"M","family":"Borsotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Cavarec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bouillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Romey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Macciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Delaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nasroune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bastucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-L","family":"Sambucy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-J","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Charpagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Jou\u00ebt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"L\u00e9ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lazdunski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Chumakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,5,30]]},"reference":[{"key":"BF6500400_CR1","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1001\/jama.1990.03450190025010","volume":"264","author":"FK Goodwin","year":"1990","unstructured":"Goodwin FK . From the alcohol, drug abuse, and mental health administration. JAMA 1990; 264: 2495.","journal-title":"JAMA"},{"key":"BF6500400_CR2","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1038\/ng0496-427","volume":"12","author":"DH Blackwood","year":"1996","unstructured":"Blackwood DH, He L, Morris SW, McLean A, Whitton C, Thomson M et al. A locus for bipolar affective disorder on chromosome 4p. Nat Genet 1996; 12: 427\u2013430.","journal-title":"Nat Genet"},{"key":"BF6500400_CR3","doi-asserted-by":"publisher","first-page":"5604","DOI":"10.1073\/pnas.96.10.5604","volume":"96","author":"SD Detera-Wadleigh","year":"1999","unstructured":"Detera-Wadleigh SD, Badner JA, Berrettini WH, Yoshikawa T, Goldin LR, Turner G et al. A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci USA 1999; 96: 5604\u20135609.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6500400_CR4","first-page":"404","volume":"1","author":"MH Polymeropoulos","year":"1996","unstructured":"Polymeropoulos MH, Schaffer AA . Scanning the genome with 1772 microsatellite markers in search of a bipolar disorder susceptibility gene. Mol Psychiatr 1996; 1: 404\u2013407.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR5","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/sj.mp.4000420","volume":"3","author":"H Ewald","year":"1998","unstructured":"Ewald H, Degn B, Mors O, Kruse TA . Support for the possible locus on chromosome 4p16 for bipolar affective disorder. Mol Psychiatr 1998; 3: 442\u2013448.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.mp.4001393","volume":"9","author":"TD Als","year":"2004","unstructured":"Als TD, Dahl HA, Flint TJ, Wang AG, Vang M, Mors O et al. Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands. Mol Psychiatr 2004; 9: 93\u201398.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/sj.mp.4000344","volume":"3","author":"RG Swift","year":"1998","unstructured":"Swift RG, Polymeropoulos MH, Torres R, Swift M . Predisposition of Wolfram syndrome heterozygotes to psychiatric illness. Mol Psychiatr 1998; 3: 86\u201391.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0304-3940(02)01334-4","volume":"338","author":"T Kato","year":"2003","unstructured":"Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T et al. No association of mutations and mRNA expression of WFS1\/wolframin with bipolar disorder in humans. Neurosci Lett 2003; 338: 21\u201324.","journal-title":"Neurosci Lett"},{"key":"BF6500400_CR9","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1002\/ajmg.b.20145","volume":"126","author":"R Abou Jamra","year":"2004","unstructured":"Abou Jamra R, Schumacher J, Golla A, Richter C, Otte AC, Schulze TG et al. Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet 2004; 126: 79\u201381.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BF6500400_CR10","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/sj.mp.4000565","volume":"4","author":"G Kirov","year":"1999","unstructured":"Kirov G, Jones I, McCandless F, Craddock N, Owen MJ . Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5. Mol Psychiatr 1999; 4: 558\u2013565.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/1096-8628(2001)9999:9999<::AID-AJMG1163>3.0.CO;2-2","volume":"105","author":"WJ Muir","year":"2001","unstructured":"Muir WJ, Thomson ML, McKeon P, Mynett-Johnson L, Whitton C, Evans KL et al. Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder. Am J Med Genet 2001; 105: 152\u2013158.","journal-title":"Am J Med Genet"},{"key":"BF6500400_CR12","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/(SICI)1096-9861(19980323)392:4<515::AID-CNE8>3.0.CO;2-3","volume":"392","author":"S Strack","year":"1998","unstructured":"Strack S, Zaucha JA, Ebner FF, Colbran RJ, Wadzinski BE . Brain protein phosphatase 2A: developmental regulation and distinct cellular and subcellular localization by B subunits. J Comp Neurol 1998; 392: 515\u2013527.","journal-title":"J Comp Neurol"},{"key":"BF6500400_CR13","doi-asserted-by":"publisher","first-page":"1570","DOI":"10.1096\/fasebj.9.15.8529836","volume":"9","author":"JQ Trojanowski","year":"1995","unstructured":"Trojanowski JQ, Lee VM . Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases. FASEB J 1995; 9: 1570\u20131576.","journal-title":"FASEB J"},{"key":"BF6500400_CR14","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cell.2005.05.012","volume":"122","author":"JM Beaulieu","year":"2005","unstructured":"Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG . An Akt\/beta-arrestin 2\/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005; 122: 261\u2013273.","journal-title":"Cell"},{"key":"BF6500400_CR15","doi-asserted-by":"publisher","first-page":"13675","DOI":"10.1073\/pnas.182412499","volume":"99","author":"I Chumakov","year":"2002","unstructured":"Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci USA 2002; 99: 13675\u201313680.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6500400_CR16","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nn1062","volume":"6","author":"N Hoshi","year":"2003","unstructured":"Hoshi N, Zhang JS, Omaki M, Takeuchi T, Yokoyama S, Wanaverbecq N et al. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nat Neurosci 2003; 6: 564\u2013571.","journal-title":"Nat Neurosci"},{"key":"BF6500400_CR17","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1086\/374317","volume":"72","author":"JJ Gargus","year":"2003","unstructured":"Gargus JJ . Unraveling monogenic channelopathies and their implications for complex polygenic disease. Am J Hum Genet 2003; 72: 785\u2013803.","journal-title":"Am J Hum Genet"},{"key":"BF6500400_CR18","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1126\/science.279.5349.403","volume":"279","author":"C Biervert","year":"1998","unstructured":"Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ et al. A potassium channel mutation in neonatal human epilepsy. Science 1998; 279: 403\u2013406.","journal-title":"Science"},{"key":"BF6500400_CR19","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng0198-25","volume":"18","author":"NA Singh","year":"1998","unstructured":"Singh NA, Charlier C, Stauffer D, DuPont BR, Leach RJ, Melis R et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns. Nat Genet 1998; 18: 25\u201329.","journal-title":"Nat Genet"},{"key":"BF6500400_CR20","first-page":"234","volume":"104","author":"C Biervert","year":"1999","unstructured":"Biervert C, Steinlein OK . Structural and mutational analysis of KCNQ2, the major gene locus for benign familial neonatal convulsions. Hum Genet 1999; 104: 234\u2013240.","journal-title":"Hum Genet"},{"key":"BF6500400_CR21","first-page":"353","volume":"548","author":"S Maljevic","year":"2003","unstructured":"Maljevic S, Lerche C, Seebohm G, Alekov AK, Busch AE, Lerche H . C-terminal interaction of KCNQ2 and KCNQ3 K+ channels. J Physiol 2003; 548: 353\u2013360.","journal-title":"J Physiol"},{"key":"BF6500400_CR22","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1038\/sj.embor.embor715","volume":"4","author":"M Schwake","year":"2003","unstructured":"Schwake M, Jentsch TJ, Friedrich T . A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly. EMBO Rep 2003; 4: 76\u201381.","journal-title":"EMBO Rep"},{"key":"BF6500400_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1113\/jphysiol.2005.094995","volume":"569","author":"K Nakajo","year":"2005","unstructured":"Nakajo K, Kubo Y . Protein kinase C shifts the voltage dependence of KCNQ\/M channels expressed in Xenopus oocytes. J Physiol 2005; 569: 59\u201374.","journal-title":"J Physiol"},{"key":"BF6500400_CR24","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/j.1471-4159.2004.02422.x","volume":"89","author":"RV Bhat","year":"2004","unstructured":"Bhat RV, Budd Haeberlein SL, Avila J . Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 2004; 89: 1313\u20131317.","journal-title":"J Neurochem"},{"key":"BF6500400_CR25","doi-asserted-by":"publisher","first-page":"6791","DOI":"10.1523\/JNEUROSCI.4753-03.2004","volume":"24","author":"WT O'Brien","year":"2004","unstructured":"O'Brien WT, Harper AD, Jove F, Woodgett JR, Maretto S, Piccolo S et al. Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 2004; 24: 6791\u20136798.","journal-title":"J Neurosci"},{"key":"BF6500400_CR26","doi-asserted-by":"crossref","first-page":"15555","DOI":"10.1016\/S0021-9258(18)98436-X","volume":"266","author":"PJ Kennelly","year":"1991","unstructured":"Kennelly PJ, Krebs EG . Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem 1991; 266: 15555\u201315558.","journal-title":"J Biol Chem"},{"key":"BF6500400_CR27","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/25367","volume":"396","author":"BC Schroeder","year":"1998","unstructured":"Schroeder BC, Kubisch C, Stein V, Jentsch TJ . Moderate loss of function of cyclic-AMP-modulated KCNQ2\/KCNQ3 K+ channels causes epilepsy. Nature 1998; 396: 687\u2013690.","journal-title":"Nature"},{"key":"BF6500400_CR28","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/ajmg.b.30108","volume":"133","author":"PM Visscher","year":"2005","unstructured":"Visscher PM, Haley CS, Ewald H, Mors O, Egeland J, Thiel B et al. Joint multi-population analysis for genetic linkage of bipolar disorder or \u2018wellness\u2019 to chromosome 4p. Am J Med Genet B Neuropsychiatr Genet 2005; 133: 18\u201324.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"BF6500400_CR29","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/bj3530417","volume":"353","author":"V Janssens","year":"2001","unstructured":"Janssens V, Goris J . Protein phosphatase 2A: a highly regulated family of serine\/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001; 353: 417\u2013439.","journal-title":"Biochem J"},{"key":"BF6500400_CR30","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/ng1604","volume":"37","author":"D Meyre","year":"2005","unstructured":"Meyre D, Bouatia-Naji N, Tounian A, Samson C, Lecoeur C, Vatin V et al. Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 2005; 37: 863\u2013867.","journal-title":"Nat Genet"},{"key":"BF6500400_CR31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/S0014-5793(98)01296-4","volume":"438","author":"N Tinel","year":"1998","unstructured":"Tinel N, Lauritzen I, Chouabe C, Lazdunski M, Borsotto M . The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3. FEBS Lett 1998; 438: 171\u2013176.","journal-title":"FEBS Lett"},{"key":"BF6500400_CR32","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0014-5793(00)01918-9","volume":"480","author":"N Tinel","year":"2000","unstructured":"Tinel N, Diochot S, Lauritzen I, Barhanin J, Lazdunski M, Borsotto M . M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit. FEBS Lett 2000; 480: 137\u2013141.","journal-title":"FEBS Lett"},{"key":"BF6500400_CR33","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1046\/j.1460-9568.2002.02274.x","volume":"16","author":"K Schmidt","year":"2002","unstructured":"Schmidt K, Kins S, Schild A, Nitsch RM, Hemmings BA, Gotz J . Diversity, developmental regulation and distribution of murine PR55\/B subunits of protein phosphatase 2A. Eur J Neurosci 2002; 16: 2039\u20132048.","journal-title":"Eur J Neurosci"},{"key":"BF6500400_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2006.01.023","volume":"1077","author":"YG Weber","year":"2006","unstructured":"Weber YG, Geiger J, Kampchen K, Landwehrmeyer B, Sommer C, Lerche H . Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain. Brain Res 2006; 1077: 1\u20136.","journal-title":"Brain Res"},{"key":"BF6500400_CR35","doi-asserted-by":"publisher","first-page":"5472","DOI":"10.1093\/emboj\/16.17.5472","volume":"16","author":"C Chouabe","year":"1997","unstructured":"Chouabe C, Neyroud N, Guicheney P, Lazdunski M, Romey G, Barhanin J . Properties of KvLQT1 K+ channel mutations in Romano\u2013Ward and Jervell and Lange\u2013Nielsen inherited cardiac arrhythmias. EMBO J 1997; 16: 5472\u20135479.","journal-title":"EMBO J"},{"key":"BF6500400_CR36","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ng0196-17","volume":"12","author":"Q Wang","year":"1996","unstructured":"Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996; 12: 17\u201323.","journal-title":"Nat Genet"},{"key":"BF6500400_CR37","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1111\/j.1528-1157.2000.tb00302.x","volume":"41","author":"TJ Jentsch","year":"2000","unstructured":"Jentsch TJ, Schroeder BC, Kubisch C, Friedrich T, Stein V . Pathophysiology of KCNQ channels: neonatal epilepsy and progressive deafness. Epilepsia 2000; 41: 1068\u20131069.","journal-title":"Epilepsia"},{"key":"BF6500400_CR38","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/35036198","volume":"1","author":"TJ Jentsch","year":"2000","unstructured":"Jentsch TJ . Neuronal KCNQ potassium channels: physiology and role in disease. Nat Rev Neurosci 2000; 1: 21\u201330.","journal-title":"Nat Rev Neurosci"},{"key":"BF6500400_CR39","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/sj.mp.4001388","volume":"9","author":"D Avramopoulos","year":"2004","unstructured":"Avramopoulos D, Willour VL, Zandi PP, Huo Y, MacKinnon DF, Potash JB et al. Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis. Mol Psychiatr 2004; 9: 191\u2013196.","journal-title":"Mol Psychiatr"},{"key":"BF6500400_CR40","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/j.1469-7793.2001.0347i.x","volume":"531","author":"Z Pan","year":"2001","unstructured":"Pan Z, Selyanko AA, Hadley JK, Brown DA, Dixon JE, McKinnon D . Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents. J Physiol 2001; 531: 347\u2013358.","journal-title":"J Physiol"},{"key":"BF6500400_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000026527","volume":"38","author":"X Xie","year":"1998","unstructured":"Xie X, Hagan RM . Cellular and molecular actions of lamotrigine: possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology 1998; 38: 119\u2013130.","journal-title":"Neuropsychobiology"},{"key":"BF6500400_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nn1375","volume":"8","author":"HC Peters","year":"2005","unstructured":"Peters HC, Hu H, Pongs O, Storm JF, Isbrandt D . Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior. Nat Neurosci 2005; 8: 51\u201360.","journal-title":"Nat Neurosci"},{"key":"BF6500400_CR43","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1124\/mi.4.5.6","volume":"4","author":"JA Quiroz","year":"2004","unstructured":"Quiroz JA, Gould TD, Manji HK . Molecular effects of lithium. Mol Interv 2004; 4: 259\u2013272.","journal-title":"Mol Interv"},{"key":"BF6500400_CR44","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S0896-6273(02)00790-0","volume":"35","author":"BC Suh","year":"2002","unstructured":"Suh BC, Hille B . Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis. Neuron 2002; 35: 507\u2013520.","journal-title":"Neuron"},{"key":"BF6500400_CR45","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0896-6273(03)00125-9","volume":"37","author":"H Zhang","year":"2003","unstructured":"Zhang H, Craciun LC, Mirshahi T, Rohacs T, Lopes CM, Jin T et al. PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents. Neuron 2003; 37: 963\u2013975.","journal-title":"Neuron"},{"key":"BF6500400_CR46","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1038\/nrn1785","volume":"6","author":"P Delmas","year":"2005","unstructured":"Delmas P, Brown DA . Pathways modulating neural KCNQ\/M (Kv7) potassium channels. Nat Rev Neurosci 2005; 6: 850\u2013862.","journal-title":"Nat Rev Neurosci"},{"key":"BF6500400_CR47","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","volume":"93","author":"PS Klein","year":"1996","unstructured":"Klein PS, Melton DA . A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 1996; 93: 8455\u20138459.","journal-title":"Proc Natl Acad Sci USA"},{"key":"BF6500400_CR48","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1001\/archneur.60.4.496","volume":"60","author":"EC Cooper","year":"2003","unstructured":"Cooper EC, Jan LY . M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol 2003; 60: 496\u2013500.","journal-title":"Arch Neurol"},{"key":"BF6500400_CR49","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1124\/mol.104.007112","volume":"67","author":"A Peretz","year":"2005","unstructured":"Peretz A, Degani N, Nachman R, Uziyel Y, Gibor G, Shabat D et al. Meclofenamic acid and diclofenac, novel templates of KCNQ2\/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties. Mol Pharmacol 2005; 67: 1053\u20131066.","journal-title":"Mol Pharmacol"},{"key":"BF6500400_CR50","doi-asserted-by":"publisher","first-page":"7227","DOI":"10.1523\/JNEUROSCI.23-18-07227.2003","volume":"23","author":"GM Passmore","year":"2003","unstructured":"Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA et al. KCNQ\/M currents in sensory neurons: significance for pain therapy. J Neurosci 2003; 23: 7227\u20137236.","journal-title":"J Neurosci"},{"key":"BF6500400_CR51","doi-asserted-by":"publisher","first-page":"41171","DOI":"10.1074\/jbc.M203757200","volume":"277","author":"L Cavarec","year":"2002","unstructured":"Cavarec L, Kamphausen T, Dubourg B, Callebaut I, Lemeunier F, Metivier D et al. Identification and characterization of Moca-cyp. A Drosophila melanogaster nuclear cyclophilin. J Biol Chem 2002; 277: 41171\u201341182.","journal-title":"J Biol Chem"}],"container-title":["The Pharmacogenomics Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/6500400.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500400","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/6500400.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T11:13:20Z","timestamp":1647947600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/6500400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,30]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4,1]]}},"alternative-id":["BF6500400"],"URL":"https:\/\/doi.org\/10.1038\/sj.tpj.6500400","relation":{},"ISSN":["1470-269X","1473-1150"],"issn-type":[{"value":"1470-269X","type":"print"},{"value":"1473-1150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,30]]},"assertion":[{"value":"10 January 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2006","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2006","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2006","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}