{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:35:02Z","timestamp":1791304502127,"version":"4.3.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep00495","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T09:20:41Z","timestamp":1341566441000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Pathophysiology of Inhalational Brucellosis in Balb\/c Mice"],"prefix":"10.1038","volume":"2","author":[{"given":"Lisa N.","family":"Henning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen T.","family":"Gillum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Barnewall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Krile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,7,6]]},"reference":[{"key":"BFsrep00495_CR1","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/S1369-5274(00)00165-X","volume":"4","author":"ML Boschiroli","year":"2001","unstructured":"Boschiroli, M. L., Foulongne, V. & O'Callaghan, D. Brucellosis: a worldwide zoonosis. Curr. Opin. Microbiol. 4, 58\u201364 (2001).","journal-title":"Curr. Opin. Microbiol."},{"key":"BFsrep00495_CR2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.47102\/annals-acadmedsg.V37N1p86","volume":"37","author":"T Demirdal","year":"2008","unstructured":"Demirdal, T. & Demirturk, N. Laboratory-acquired brucellosis. Ann. Acad. Med. Singapore 37, 86\u201387 (2008).","journal-title":"Ann. Acad. Med. Singapore"},{"key":"BFsrep00495_CR3","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1258\/td.2008.070446","volume":"39","author":"N Mohandas","year":"2009","unstructured":"Mohandas, N., Balasubramanian, R. & Prasad, S. B. Can brucella endocarditis be treated successfully with medical therapy alone? Trop. Doct. 39, 123\u2013124 (2009).","journal-title":"Trop. Doct."},{"key":"BFsrep00495_CR4","first-page":"E15","volume":"9","author":"P Bossi","year":"2004","unstructured":"Bossi, P. et al. Bichat guidelines for the clinical management of brucellosis and bioterrorism-related brucellosis. Euro. Surveill 9, E15\u2013E16 (2004).","journal-title":"Euro. Surveill"},{"key":"BFsrep00495_CR5","doi-asserted-by":"publisher","first-page":"e469","DOI":"10.1016\/j.ijid.2009.06.031","volume":"14","author":"T Buzgan","year":"2010","unstructured":"Buzgan, T. et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int. J. Infect. Dis. 14, e469\u2013e478 (2010).","journal-title":"Int. J. Infect. Dis."},{"key":"BFsrep00495_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1093\/clinids\/12.6.1060","volume":"12","author":"WH Hall","year":"1990","unstructured":"Hall, W. H. Modern chemotherapy for brucellosis in humans. Rev. Infect. Dis. 12, 1060\u20131099 (1990).","journal-title":"Rev. Infect. Dis."},{"key":"BFsrep00495_CR7","first-page":"271","volume":"55","author":"DK Kochar","year":"2007","unstructured":"Kochar, D. K. et al. Hospital-based case series of 175 cases of serologically confirmed brucellosis in Bikaner. J. Assoc. Physicians India 55, 271\u2013275 (2007).","journal-title":"J. Assoc. Physicians India"},{"key":"BFsrep00495_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1053\/jinf.1999.0586","volume":"40","author":"Z Memish","year":"2000","unstructured":"Memish, Z., Mah, M. W., Al, M. S., Al, S. M. & Khan, M. Y. Brucella bacteraemia: clinical and laboratory observations in 160 patients. J. Infect. 40, 59\u201363 (2000).","journal-title":"J. Infect."},{"key":"BFsrep00495_CR9","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1128\/AAC.39.9.2061","volume":"39","author":"J Solera","year":"1995","unstructured":"Solera, J. et al. Doxycycline-rifampin versus doxycycline-streptomycin in treatment of human brucellosis due to Brucella melitensis. The GECMEI Group. Grupo de Estudio de Castilla-la Mancha de Enfermedades Infecciosas. Antimicrob. Agents Chemother. 39, 2061\u20132067 (1995).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFsrep00495_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1179\/joc.2003.15.1.76","volume":"15","author":"M Almuneef","year":"2003","unstructured":"Almuneef, M. et al. Brucella melitensis bacteremia in children: review of 62 cases. J. Chemother. 15, 76\u201380 (2003).","journal-title":"J. Chemother."},{"key":"BFsrep00495_CR11","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1179\/joc.2003.15.3.248","volume":"15","author":"A Cascio","year":"2003","unstructured":"Cascio, A. et al. Treatment of human brucellosis with rifampin plus minocycline. J. Chemother. 15, 248\u2013252 (2003).","journal-title":"J. Chemother."},{"key":"BFsrep00495_CR12","first-page":"2666","volume":"30","author":"YM El Miedany","year":"2003","unstructured":"El Miedany, Y. M., El, G. M., Baddour, M. & Ahmed, I. Human brucellosis: do we need to revise our therapeutic policy? J. Rheumatol. 30, 2666\u20132672 (2003).","journal-title":"J. Rheumatol."},{"key":"BFsrep00495_CR13","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1517\/13543784.15.10.1141","volume":"15","author":"G Pappas","year":"2006","unstructured":"Pappas, G., Papadimitriou, P., Christou, L. & Akritidis, N. Future trends in human brucellosis treatment. Expert. Opin. Investig. Drugs 15, 1141\u20131149 (2006).","journal-title":"Expert. Opin. Investig. Drugs"},{"key":"BFsrep00495_CR14","first-page":"921","volume":"23","author":"N Saltoglu","year":"2002","unstructured":"Saltoglu, N., Tasova, Y., Inal, A. S., Seki, T. & Aksu, H. S. Efficacy of rifampicin plus doxycycline versus rifampicin plus quinolone in the treatment of brucellosis. Saudi. Med. J. 23, 921\u2013924 (2002).","journal-title":"Saudi. Med. J."},{"key":"BFsrep00495_CR15","doi-asserted-by":"publisher","first-page":"398","DOI":"10.2460\/ajvr.2001.62.398","volume":"62","author":"MG Mense","year":"2001","unstructured":"Mense, M. G. et al. Bacteriologic and histologic features in mice after intranasal inoculation of Brucella melitensis. Am. J. Vet. Res. 62, 398\u2013405 (2001).","journal-title":"Am. J. Vet. Res."},{"key":"BFsrep00495_CR16","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1128\/iai.64.6.2188-2192.1996","volume":"64","author":"RM Crawford","year":"1996","unstructured":"Crawford, R. M. et al. Deletion of purE attenuates Brucella melitensis infection in mice. Infect. Immun. 64, 2188\u20132192 (1996).","journal-title":"Infect. Immun."},{"key":"BFsrep00495_CR17","doi-asserted-by":"publisher","first-page":"4923","DOI":"10.1128\/IAI.00451-07","volume":"75","author":"MM Kahl-McDonagh","year":"2007","unstructured":"Kahl-McDonagh, M. M., Arenas-Gamboa, A. M. & Ficht, T. A. Aerosol infection of BALB\/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challenge. Infect. Immun. 75, 4923\u20134932 (2007).","journal-title":"Infect. Immun."},{"key":"BFsrep00495_CR18","doi-asserted-by":"publisher","first-page":"518323","DOI":"10.1155\/2011\/518323","volume":"2011","author":"TM Silva","year":"2011","unstructured":"Silva, T. M., Costa, E. A., Paixao, T. A., Tsolis, R. M. & Santos, R. L. Laboratory animal models for brucellosis research. J. Biomed. Biotechnol. 2011, 518323 (2011).","journal-title":"J. Biomed. Biotechnol."},{"key":"BFsrep00495_CR19","unstructured":"Hinds, W. C. Aerosol Technology: Properties, Behavior and Measurement of Airborne Particles (Wiley-Interscience, John Wiley & Sons Inc.,1999 01)."},{"key":"BFsrep00495_CR20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1128\/IAI.05878-11","volume":"80","author":"LN Henning","year":"2012","unstructured":"Henning, L. N. et al. Pathophysiology of the rhesus macaque model for inhalational brucellosis. Infect. Immun. 80, 298\u2013310 (2012).","journal-title":"Infect. Immun."},{"key":"BFsrep00495_CR21","doi-asserted-by":"publisher","first-page":"e95","DOI":"10.1086\/378125","volume":"37","author":"G Pappas","year":"2003","unstructured":"Pappas, G. et al. Brucellosis and the respiratory system. Clin. Infect. Dis. 37, e95\u2013e99 (2003).","journal-title":"Clin. Infect. Dis."},{"key":"BFsrep00495_CR22","first-page":"274","volume":"67","author":"S Cay","year":"2009","unstructured":"Cay, S., Cagirci, G., Maden, O., Balbay, Y. & Aydogdu, S. Brucella endocarditis - a registry study. Kardiol. Pol. 67, 274\u2013280 (2009).","journal-title":"Kardiol. Pol."},{"key":"BFsrep00495_CR23","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1136\/pgmj.58.680.346","volume":"58","author":"F Cervantes","year":"1982","unstructured":"Cervantes, F., Bruguera, M., Carbonell, J., Force, L. & Webb, S. Liver disease in brucellosis. A clinical and pathological study of 40 cases. Postgrad. Med. J. 58, 346\u2013350 (1982).","journal-title":"Postgrad. Med. J."},{"key":"BFsrep00495_CR24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/jcp.20.3.267","volume":"20","author":"AC Hunt","year":"1967","unstructured":"Hunt, A. C. & Bothwell, P. W. Histological findings in human brucellosis. J. Clin. Pathol. 20, 267\u2013272 (1967).","journal-title":"J. Clin. Pathol."},{"key":"BFsrep00495_CR25","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1099\/jmm.0.017285-0","volume":"59","author":"SL Yingst","year":"2010","unstructured":"Yingst, S. L., Huzella, L. M., Chuvala, L. & Wolcott, M. A rhesus macaque (Macaca mulatta) model of aerosol-exposure brucellosis (Brucella suis): pathology and diagnostic implications. J. Med. Microbiol. 59, 724\u2013730 (2010).","journal-title":"J. Med. Microbiol."},{"key":"BFsrep00495_CR26","doi-asserted-by":"publisher","first-page":"644","DOI":"10.2460\/ajvr.2004.65.644","volume":"65","author":"MG Mense","year":"2004","unstructured":"Mense, M. G., Borschel, R. H., Wilhelmsen, C. L., Pitt, M. L. & Hoover, D. L. Pathologic changes associated with brucellosis experimentally induced by aerosol exposure in rhesus macaques (Macaca mulatta). Am. J. Vet. Res. 65, 644\u2013652 (2004).","journal-title":"Am. J. Vet. Res."},{"key":"BFsrep00495_CR27","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1056\/NEJMra050570","volume":"352","author":"G Pappas","year":"2005","unstructured":"Pappas, G., Akritidis, N., Bosilkovski, M. & Tsianos, E. Brucellosis. N. Engl. J. Med. 352, 2325\u20132336 (2005).","journal-title":"N. Engl. J. Med."},{"key":"BFsrep00495_CR28","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1863-2378.2007.01063.x","volume":"54","author":"SC Olsen","year":"2007","unstructured":"Olsen, S. C., Waters, W. R. & Stoffregen, W. S. An aerosolized Brucella spp. challenge model for laboratory animals. Zoonoses. Public Health 54, 281\u2013285 (2007).","journal-title":"Zoonoses. Public Health"},{"key":"BFsrep00495_CR29","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1128\/CVI.00029-09","volume":"16","author":"SJ Smither","year":"2009","unstructured":"Smither, S. J. et al. Development and characterization of mouse models of infection with aerosolized Brucella melitensis and Brucella suis. Clin. Vaccine Immunol. 16, 779\u2013783 (2009).","journal-title":"Clin. Vaccine Immunol."},{"key":"BFsrep00495_CR30","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.micpath.2010.10.002","volume":"50","author":"R Warren","year":"2011","unstructured":"Warren, R. et al. Cynomolgus macaque model for pneumonic plague. Microb. Pathog. 50, 12\u201322 (2011).","journal-title":"Microb. Pathog."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep00495","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00495.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T04:41:31Z","timestamp":1672980091000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep00495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,6]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,21]]}},"alternative-id":["BFsrep00495"],"URL":"https:\/\/doi.org\/10.1038\/srep00495","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,6]]},"assertion":[{"value":"19 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"495"}}