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They confer durable resistance to a broad range of diseases by activating intrinsic immune mechanisms in plants. To obtain leads regarding useful compounds, we have screened a chemical library using an established method that allows selective identification of immune-priming compounds. Here, we report the characterisation of one of the isolated chemicals, imprimatinC1 and its structural derivative imprimatinC2. ImprimatinC1 functions as a weak analogue of salicylic acid (SA) and activates the expression of defence-related genes. However, it lacks antagonistic activity toward jasmonic acid. Structure-activity relationship analysis suggests that imprimatinC1 and C2 can be metabolised to 4-chlorobenzoic acid and 3,4-chlorobenzoic acid, respectively, to function in <jats:italic>Arabidopsis<\/jats:italic>. We also found that imprimatinC1 and C2 and their potential functional metabolites acted as partial agonists of SA. Thus, imprimatinC compounds could be useful tools for dissecting SA-dependent signal transduction pathways.<\/jats:p>","DOI":"10.1038\/srep00705","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T09:08:46Z","timestamp":1349341726000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["ImprimatinC1, a novel plant immune-priming compound, functions as a partial agonist of salicylic acid"],"prefix":"10.1038","volume":"2","author":[{"given":"Yoshiteru","family":"Noutoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Jikumaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,4]]},"reference":[{"key":"BFsrep00705_CR1","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.pbi.2010.04.006","volume":"13","author":"K Tsuda","year":"2010","unstructured":"Tsuda, K. & Katagiri, F. 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