{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:45:43Z","timestamp":1791398743634,"version":"4.3.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep00778","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T14:56:44Z","timestamp":1351522604000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes"],"prefix":"10.1038","volume":"2","author":[{"given":"Fabrizia","family":"Foglia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Jayne","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Dem\u0117","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Fragneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Barlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"BFsrep00778_CR1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1099\/jmm.0.46548-0","volume":"55","author":"DA Enoch","year":"2006","unstructured":"Enoch, D. A., Ludlam, H. A. & Brown, N. M. Invasive fungal infections: a review of epidemiology and management options. J Med. Microbiol. 55, 809\u2013818 (2006).","journal-title":"J Med. Microbiol."},{"key":"BFsrep00778_CR2","doi-asserted-by":"publisher","first-page":"809","DOI":"10.3314\/jjmm.48.1","volume":"48","author":"DW Warnock","year":"2007","unstructured":"Warnock, D. W. Trends in the epidemiology of invasive fungal infections. J. Med. Mycol. 48, 809\u2013818 (2007).","journal-title":"J. Med. Mycol."},{"key":"BFsrep00778_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1439-0507.2009.01691.x","volume":"52","author":"C Lass-Flo","year":"2009","unstructured":"Lass-Flo, C. The changing face of epidemiology of invasive fungal disease in Europe. Mycoses 52, 197\u2013205 (2009).","journal-title":"Mycoses"},{"key":"BFsrep00778_CR4","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1128\/CMR.11.2.382","volume":"11","author":"TC White","year":"1998","unstructured":"White, T. C., Marr, K. A. & Bowden, R. A. Clinical, cellular and molecular factors that contribute to antifungal drug resistance. Clinical Microbiol. Rev. 11, 382\u2013402 (1998).","journal-title":"Clinical Microbiol. Rev."},{"key":"BFsrep00778_CR5","doi-asserted-by":"crossref","unstructured":"Vandeputte, P., Ferrari, S. & Coste, A. T. Antifungal resistance and new strategies to control fungal infections. Int. J. Microbiol. 2012, Article ID 713687 (2012).","DOI":"10.1155\/2012\/713687"},{"key":"BFsrep00778_CR6","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.amjmed.2011.11.001","volume":"125","author":"MA Pfaller","year":"2012","unstructured":"Pfaller, M. A. Antifungal drug resistance: mechanisms, epidemiology and consequences for treatment. Am. J. Med. 125 (Suppl 1), S3\u2013S13 (2012).","journal-title":"Am. J. Med."},{"key":"BFsrep00778_CR7","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1128\/JCM.06440-11","volume":"50","author":"JH Shin","year":"2012","unstructured":"Shin, J. H. et al. Detection of amphotericin B resistance in Candida haemulonii and closely related species by use of the Etest, Vitek-2 yeast susceptibility system and CLSI and EUCAST broth microdilution methods. J Clinical Microbiol. 50, 1852\u20135 (2012).","journal-title":"J Clinical Microbiol."},{"key":"BFsrep00778_CR8","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1128\/JCM.37.7.2343-2345.1999","volume":"37","author":"DA Sutton","year":"1999","unstructured":"Sutton, D. A. et al. In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole. J. Clinical Microbiol. 37, 2343\u20132345 (1999).","journal-title":"J. Clinical Microbiol."},{"key":"BFsrep00778_CR9","first-page":"1","volume":"2012","author":"I Hadrich","year":"2012","unstructured":"Hadrich, I. et al. Amphotericin B resistance is associated with fatal Aspergillus flavus infection. Medical Mycology 2012, EPUB 1\u20136 (2012).","journal-title":"Medical Mycology"},{"key":"BFsrep00778_CR10","doi-asserted-by":"crossref","unstructured":"Gallis, H. A., Drew, R. H. & Pickard, W. W. Amphotericin B: 30 years of clinical experience. Rev. Infect. Diseases 12, 308\u2013329.","DOI":"10.1093\/clinids\/12.2.308"},{"key":"BFsrep00778_CR11","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jac\/49.suppl_1.37","volume":"49","author":"G Deray","year":"2002","unstructured":"Deray, G. Amphotericin B nephrotoxicity. J. Antimicr. Chemother. 49 (Suppl. S1), 37\u201341 (2002).","journal-title":"J. Antimicr. Chemother."},{"key":"BFsrep00778_CR12","first-page":"377","volume":"2","author":"A Finkelstein","year":"1973","unstructured":"Finkelstein, A. & Holz, R. Aqueous pores created in thin lipid membranes by the polyene antibiotics nystatin and amphotericin B. Membranes 2, 377\u2013348 (1973).","journal-title":"Membranes"},{"key":"BFsrep00778_CR13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1128\/AAC.4.3.309","volume":"4","author":"C-C Hsuchen","year":"1973","unstructured":"Hsuchen, C.-C. & Feingold, D. S. Selective membrane toxicity of the polyene antibiotics: studies on lecithin model membranes (liposomes). Antimicrob. Agents Chemother. 4, 309\u2013315 (1973).","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFsrep00778_CR14","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1085\/jgp.65.4.515","volume":"65","author":"A Marty","year":"1975","unstructured":"Marty, A. & Finkelstein, A. Pores formed by nystatin. differences in its one-side and two-side action. J. Gen. Physiol. 65, 515\u2013526 (1975).","journal-title":"J. Gen. Physiol."},{"key":"BFsrep00778_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/0005-2736(92)90113-Z","volume":"1108","author":"BE Cohen","year":"1992","unstructured":"Cohen, B. E. A sequential mechanism for the formation of aqueous channels by amphotericin-B in liposomes \u2013 the effect of sterols and phospholipid-composition, Biochim. Biophys. Acta - Biomembranes 1108, 49\u201358 (1992).","journal-title":"Biophys. Acta - Biomembranes"},{"key":"BFsrep00778_CR16","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0005-2736(98)00134-5","volume":"1375","author":"BV Cotero","year":"1998","unstructured":"Cotero, B. V., Rebolledo-Antunez, S. & Ortega-Blake, I. On the role of sterol in the formation of the amphotericin B channel. Biochim. Biophys. Acta - Biomembranes 1375, 43\u201351 (1998).","journal-title":"Biochim. Biophys. Acta - Biomembranes"},{"key":"BFsrep00778_CR17","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1016\/S0006-3495(03)74656-6","volume":"85","author":"B Venegas","year":"2003","unstructured":"Venegas, B., Gonz\u00e1lez-Dami\u00e1n, J., Celis, H. & Ortega-Blake, I. Amphotericin B channels in the bacterial membrane: role of sterol and temperature. Biophys. J. 85, 2323\u20132332 (2003).","journal-title":"Biophys. J."},{"key":"BFsrep00778_CR18","doi-asserted-by":"publisher","first-page":"11797","DOI":"10.1021\/bi980290k","volume":"37","author":"MM Wang","year":"1998","unstructured":"Wang, M. M., Sugar, I. P. & Chong, P. L. G. Role of the sterol superlattice in the partitioning of the antifungal drug nystatin into lipid membranes. Biochem. 37, 11797\u201311805 (1998).","journal-title":"Biochem."},{"key":"BFsrep00778_CR19","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1073\/pnas.1117280109","volume":"109","author":"KC Gray","year":"2012","unstructured":"Gray, K. C. et al. Amphotericin primarily kills yeast by simply binding ergosterol. Proc. Natl. Acad. Sci. (U.S.A) 109, 2234\u20132239 (2012).","journal-title":"Proc. Natl. Acad. Sci. (U.S.A)"},{"key":"BFsrep00778_CR20","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1016\/j.bbamem.2011.02.012","volume":"1808","author":"FF Foglia","year":"2010","unstructured":"Foglia, F. F. et al. Small angle neutron scattering studies of the effects of amphotericin B on phospholipid and phospholipid-sterol membrane structure. Biochim. Biophys. Acta - Biomembranes 1808, 1574\u20131580 (2010).","journal-title":"Biochim. Biophys. Acta - Biomembranes"},{"key":"BFsrep00778_CR21","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0005-2736(95)00117-L","volume":"1238","author":"JA Urbina","year":"1995","unstructured":"Urbina, J. A. et al. Molecular order and dynamics of phosphatidylcholine bilayer membranes in the presence of cholesterol, ergosterol and lanosterol: a comparitive study using 2H, 13C and 31P-NMR spectroscopy. Biochim. Biophys. Acta \u2013 Biomembranes 1238, 163\u2013176 (1995).","journal-title":"Biochim. Biophys. Acta \u2013 Biomembranes"},{"key":"BFsrep00778_CR22","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bpc.2006.05.015","volume":"123","author":"HW Katarzyna","year":"2006","unstructured":"Katarzyna, H. W. & Patrycja, D. L. Interaction between nystatin and natural membrane lipids in Langmuir monolayers - The role of a phospholipid in the mechanism of polyenes' mode of action. Biophys. Chem. 123, 154\u2013161 (2006).","journal-title":"Biophys. Chem."},{"key":"BFsrep00778_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.colsurfa.2005.05.052","volume":"270","author":"J Minones","year":"2005","unstructured":"Minones, J., Conde, O., Dynarowicz-Latka, P. & Casas, M. Penetration of amphotericin B into DOPC monolayers containing sterols of cellular membranes. Colloids & Surfaces A 270, 129\u2013137 (2005).","journal-title":"Colloids & Surfaces A"},{"key":"BFsrep00778_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.chemphyslip.2007.03.007","volume":"147","author":"M Herec","year":"2007","unstructured":"Herec, M., Islamov, A., Kuklin, A., Gago\u015b, M. & Gruszecki, W. I. Effect of antibiotic amphotericin B on structural and dynamic properties of lipid membranes formed with egg yolk phosphatidylcholine. Chem. Phys. Lipids 147, 78\u201386 (2007).","journal-title":"Chem. Phys. Lipids"},{"key":"BFsrep00778_CR25","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/09687860500287832","volume":"22","author":"M Gago\u015b","year":"2005","unstructured":"Gago\u015b, M., Gabrielska, J., Dalla Serra, M. & Gruszecki, W. I. Binding of antibiotic amphotericin B to lipid membranes: monomolecular layer technique and linear dichroism-FTIR studies. Mol. Membrane Biol. 22, 433\u2013442 (2005).","journal-title":"Mol. Membrane Biol."},{"key":"BFsrep00778_CR26","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/0005-2736(78)90276-6","volume":"511","author":"P van Hoogevest","year":"1978","unstructured":"van Hoogevest, P. & de Kruijff, B. Effect of amphotericin on cholesterol-containing liposomes of egg phosphatidylcholine and didocosenoyl phosphatidylcholine. Biochim. Biophys. Acat \u2013 Biomembranes 511, 397\u2013407 (1978).","journal-title":"Biochim. Biophys. Acat \u2013 Biomembranes"},{"key":"BFsrep00778_CR27","doi-asserted-by":"publisher","first-page":"10667","DOI":"10.1021\/ja051597r","volume":"127","author":"N Matsumori","year":"2005","unstructured":"Matsumori, N., Sawada, Y. & Murata, M. Mycosamine Orientation of amphotericin B controlling interaction with ergosterol: sterol-dependent activity of conformation-restricted derivatives with an amino-carbonyl bridge. J. Am. Chem. Soc. 127, 10667\u201310675 (2005).","journal-title":"J. Am. Chem. Soc."},{"key":"BFsrep00778_CR28","doi-asserted-by":"crossref","unstructured":"Schneck, E. et al. Mechanical properties of interacting lipopolysaccharide membranes from bacteria mutants studied by specular and off-specular neutron scattering. Phys. Rev. E 80, 041929\/1 (2009).","DOI":"10.1103\/PhysRevE.80.041929"},{"key":"BFsrep00778_CR29","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/S0006-3495(93)81475-9","volume":"64","author":"S Tristram-Nagle","year":"1993","unstructured":"Tristram-Nagle, S. et al. Biophys. J. 64, 1097\u2013??? (1993).","journal-title":"Biophys. J."},{"key":"BFsrep00778_CR30","doi-asserted-by":"publisher","first-page":"3324","DOI":"10.1016\/S0006-3495(02)75333-2","volume":"83","author":"S Tristram-Nagle","year":"2002","unstructured":"Tristram-Nagle, S., Liu, Y., Legleiter, J. & Nagle, J. F. Structure of gel pahse DMPC determined by X-ray diffraction. Biophys. J. 83, 3324\u20133335 (2002).","journal-title":"Biophys. J."},{"key":"BFsrep00778_CR31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/0022-2836(79)90403-0","volume":"133","author":"NP Franks","year":"1979","unstructured":"Franks, N. P. & Lieb, W. R. Structures of lipid bilayers and the effects of general anaesthetics: X-ray and neutron diffraction study. J. Mol. Biol. 133, 469\u2013500 (1979).","journal-title":"J. Mol. Biol."},{"key":"BFsrep00778_CR32","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s00232-008-9151-3","volume":"227","author":"X Han","year":"2009","unstructured":"Han, X. & Hirstova, K. Viewing the bilayer hydrophobic core using neutron diffraction. J. Membrane Biol. 227, 123\u2013131 (2009).","journal-title":"J. Membrane Biol."},{"key":"BFsrep00778_CR33","unstructured":"www.ncnr.nist.gov\/instruments\/bt1\/neutron.html"},{"key":"BFsrep00778_CR34","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0006-3495(83)84352-5","volume":"43","author":"EP Gogol","year":"1983","unstructured":"Gogol, E. P., Engelman, D. M. & Zaccai, G. Neutron diffraction analysis of cytochrom b5 reconstituted in deuterated lipid bilayers. Biophys. J. 43, 285\u2013292 (1983).","journal-title":"Biophys. J."},{"key":"BFsrep00778_CR35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1073\/pnas.72.1.376","volume":"72","author":"G Zaccai","year":"1975","unstructured":"Zaccai, G., Blasie, J. K. & Schoenborn, B. P. Neutron diffraction studies on location of water in lecithin bilayer model membranes. Proc. Natl. Acad. Sci. (USA) 72, 376\u2013380 (1975).","journal-title":"Proc. Natl. Acad. Sci. (USA)"},{"key":"BFsrep00778_CR36","doi-asserted-by":"publisher","first-page":"3421","DOI":"10.1021\/bi00434a042","volume":"28","author":"RE Jacobs","year":"1989","unstructured":"Jacobs, R. E. & White, S. H. The nature of the hydrophobic binding of small peptides at the bilayer interface \u2013 implications for the insertion of transbilayer helices. Biochem. 28, 3421\u20133437 (1989).","journal-title":"Biochem."},{"key":"BFsrep00778_CR37","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0022-2836(76)80068-X","volume":"100","author":"DL Worcester","year":"1976","unstructured":"Worcester, D. L. & Frank, N. P. Structural analysis of hydrated egg lecithin and cholesterol bilayers 2. Neutron diffraction. J. Mol. Biol. 100, 359\u2013378 (1976).","journal-title":"J. Mol. Biol."},{"key":"BFsrep00778_CR38","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1021\/la001382p","volume":"17","author":"A L\u00e9onard","year":"2001","unstructured":"L\u00e9onard, A. et al. Location of cholesterol in DMPC membranes: a comparative study by neutron diffraction and molecular mechanics simulation. Langmuir 17, 2019\u20132030 (2001).","journal-title":"Langmuir"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep00778","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00778.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T04:14:22Z","timestamp":1672978462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep00778"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,21]]}},"alternative-id":["BFsrep00778"],"URL":"https:\/\/doi.org\/10.1038\/srep00778","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]},"assertion":[{"value":"23 July 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"778"}}