{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:04:03Z","timestamp":1791270243988,"version":"4.1.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T00:00:00Z","timestamp":1354233600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep00898","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T05:05:29Z","timestamp":1354251929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":364,"title":["Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice"],"prefix":"10.1038","volume":"2","author":[{"given":"Francisco","family":"Pan-Montojo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Arnhold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"O'Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Marsico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Verbavatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Rodrigo-Angulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Gille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H. W.","family":"Funk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Reichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,30]]},"reference":[{"key":"BFsrep00898_CR1","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1007\/BF00294234","volume":"79","author":"K Wakabayashi","year":"1990","unstructured":"Wakabayashi, K., Takahashi, H., Ohama, E. & Ikuta, F. Parkinson's disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol 79, 581\u2013583 (1990).","journal-title":"Acta Neuropathol"},{"key":"BFsrep00898_CR2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neulet.2005.11.012","volume":"396","author":"H Braak","year":"2006","unstructured":"Braak, H., de Vos, R. A., Bohl, J. & Del Tredici, K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 396, 67\u201372 (2006).","journal-title":"Neurosci Lett"},{"key":"BFsrep00898_CR3","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s00401-007-0193-x","volume":"113","author":"H Braak","year":"2007","unstructured":"Braak, H., Sastre, M., Bohl, J. R., de Vos, R. A. & Del Tredici, K. Parkinson's disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons. Acta Neuropathol 113, 421\u2013429 (2007).","journal-title":"Acta Neuropathol"},{"key":"BFsrep00898_CR4","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/42166","volume":"388","author":"MG Spillantini","year":"1997","unstructured":"Spillantini, M. G. et al. Alpha-synuclein in Lewy bodies. Nature 388, 839\u2013840 (1997).","journal-title":"Nature"},{"key":"BFsrep00898_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","volume":"318","author":"H Braak","year":"2004","unstructured":"Braak, H., Ghebremedhin, E., Rub, U., Bratzke, H. & Del Tredici, K. Stages in the development of Parkinson's disease-related pathology. Cell Tissue Res 318, 121\u2013134 (2004).","journal-title":"Cell Tissue Res"},{"key":"BFsrep00898_CR6","doi-asserted-by":"crossref","unstructured":"Wolters, E. & Braak, H. Parkinson's disease: premotor clinico-pathological correlations. J Neural Transm Suppl 309\u2013319 (2006).","DOI":"10.1007\/978-3-211-45295-0_47"},{"key":"BFsrep00898_CR7","doi-asserted-by":"crossref","unstructured":"Hawkes, C. H., Del Tredici, K. & Braak, H. A timeline for Parkinson's disease. Parkinsonism Relat Disord 16, 79\u201384.","DOI":"10.1016\/j.parkreldis.2009.08.007"},{"key":"BFsrep00898_CR8","doi-asserted-by":"publisher","first-page":"e8762","DOI":"10.1371\/journal.pone.0008762","volume":"5","author":"F Pan-Montojo","year":"2010","unstructured":"Pan-Montojo, F. et al. Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice. PLoS One 5, e8762 (2010).","journal-title":"PLoS One"},{"key":"BFsrep00898_CR9","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nm1746","volume":"14","author":"JY Li","year":"2008","unstructured":"Li, J. Y. et al. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med 14, 501\u2013503 (2008).","journal-title":"Nat Med"},{"key":"BFsrep00898_CR10","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nm1747","volume":"14","author":"JH Kordower","year":"2008","unstructured":"Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B. & Olanow, C. W. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 14, 504\u2013506 (2008).","journal-title":"Nat Med"},{"key":"BFsrep00898_CR11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nrn2477","volume":"9","author":"P Brundin","year":"2008","unstructured":"Brundin, P., Li, J. Y., Holton, J. L., Lindvall, O. & Revesz, T. Research in motion: the enigma of Parkinson's disease pathology spread. Nat Rev Neurosci 9, 741\u2013745 (2008).","journal-title":"Nat Rev Neurosci"},{"key":"BFsrep00898_CR12","doi-asserted-by":"publisher","first-page":"13010","DOI":"10.1073\/pnas.0903691106","volume":"106","author":"P Desplats","year":"2009","unstructured":"Desplats, P. et al. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106, 13010\u201313015 (2009).","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFsrep00898_CR13","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.nbd.2011.01.029","volume":"42","author":"L Alvarez-Erviti","year":"2011","unstructured":"Alvarez-Erviti, L. et al. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol Dis 42, 360\u2013367 (2011).","journal-title":"Neurobiol Dis"},{"key":"BFsrep00898_CR14","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1055\/s-2006-951621","volume":"26","author":"MT Lorincz","year":"2006","unstructured":"Lorincz, M. T. Clinical implications of Parkinson's disease genetics. Semin Neurol 26, 492\u2013498 (2006).","journal-title":"Semin Neurol"},{"key":"BFsrep00898_CR15","doi-asserted-by":"crossref","unstructured":"Amaravadi, R. K. et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 17, 654\u2013666.","DOI":"10.1158\/1078-0432.CCR-10-2634"},{"key":"BFsrep00898_CR16","doi-asserted-by":"crossref","unstructured":"Lebovitz, C. B., Bortnik, S. B. & Gorski, S. M. Here, there be dragons: charting autophagy-related alterations in human tumors. Clin Cancer Res 18, 1214\u20131226.","DOI":"10.1158\/1078-0432.CCR-11-2465"},{"key":"BFsrep00898_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1097\/00001648-199905000-00023","volume":"10","author":"H Checkoway","year":"1999","unstructured":"Checkoway, H. & Nelson, L. M. Epidemiologic approaches to the study of Parkinson's disease etiology. Epidemiology 10, 327\u2013336 (1999).","journal-title":"Epidemiology"},{"key":"BFsrep00898_CR18","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1212\/WNL.50.5.1346","volume":"50","author":"JM Gorell","year":"1998","unstructured":"Gorell, J. M., Johnson, C. C., Rybicki, B. A., Peterson, E. L. & Richardson, R. J. The risk of Parkinson's disease with exposure to pesticides, farming, well water and rural living. Neurology 50, 1346\u20131350 (1998).","journal-title":"Neurology"},{"key":"BFsrep00898_CR19","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1289\/ehp.1002839","volume":"119","author":"CM Tanner","year":"2011","unstructured":"Tanner, C. M. et al. Rotenone, paraquat and Parkinson's disease. Environ Health Perspect 119, 866\u2013872 (2011).","journal-title":"Environ Health Perspect"},{"key":"BFsrep00898_CR20","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jneumeth.2006.06.001","volume":"158","author":"C Monville","year":"2006","unstructured":"Monville, C., Torres, E. M. & Dunnett, S. B. Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model. J Neurosci Methods 158, 219\u2013223 (2006).","journal-title":"J Neurosci Methods"},{"key":"BFsrep00898_CR21","doi-asserted-by":"crossref","unstructured":"Greene, J. G., Noorian, A. R. & Srinivasan, S. Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease. Exp Neurol (2009).","DOI":"10.1016\/j.expneurol.2009.04.023"},{"key":"BFsrep00898_CR22","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1212\/WNL.42.4.726","volume":"42","author":"LL Edwards","year":"1992","unstructured":"Edwards, L. L., Quigley, E. M. & Pfeiffer, R. F. Gastrointestinal dysfunction in Parkinson's disease: frequency and pathophysiology. Neurology 42, 726\u2013732 (1992).","journal-title":"Neurology"},{"key":"BFsrep00898_CR23","first-page":"161","volume":"152","author":"EA Ling","year":"1987","unstructured":"Ling, E. A., Shieh, J. Y., Wen, C. Y., Yick, T. Y. & Wong, W. C. The dorsal motor nucleus of the vagus nerve of the hamster: ultrastructure of vagal neurons and their responses to vagotomy. J Anat 152, 161\u2013172 (1987).","journal-title":"J Anat"},{"key":"BFsrep00898_CR24","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","volume":"110","author":"H Braak","year":"2003","unstructured":"Braak, H., Rub, U., Gai, W. P. & Del Tredici, K. Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen. J Neural Transm 110, 517\u2013536 (2003).","journal-title":"J Neural Transm"},{"key":"BFsrep00898_CR25","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.expneurol.2010.07.004","volume":"225","author":"K Prasad","year":"2010","unstructured":"Prasad, K. & Richfield, E. K. Number and nuclear morphology of TH+ and TH\u2212 neurons in the mouse ventral midbrain using epifluorescence stereology. Exp Neurol 225, 328\u2013340 (2010).","journal-title":"Exp Neurol"},{"key":"BFsrep00898_CR26","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1385\/JMN:22:3:199","volume":"22","author":"S Ltic","year":"2004","unstructured":"Ltic, S. et al. Alpha-synuclein is expressed in different tissues during human fetal development. J Mol Neurosci 22, 199\u2013204 (2004).","journal-title":"J Mol Neurosci"},{"key":"BFsrep00898_CR27","doi-asserted-by":"crossref","unstructured":"Hasegawa, T. et al. The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of alpha-synuclein. PLoS One 6, e29460.","DOI":"10.1371\/journal.pone.0029460"},{"key":"BFsrep00898_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0012-1606(82)90232-9","volume":"93","author":"RB Campenot","year":"1982","unstructured":"Campenot, R. B. Development of sympathetic neurons in compartmentalized cultures. Il Local control of neurite growth by nerve growth factor. Dev Biol 93, 1\u201312 (1982).","journal-title":"Dev Biol"},{"key":"BFsrep00898_CR29","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/S0076-6879(79)58146-4","volume":"58","author":"RB Campenot","year":"1979","unstructured":"Campenot, R. B. Independent control of the local environment of somas and neurites. Methods Enzymol 58, 302\u2013307 (1979).","journal-title":"Methods Enzymol"},{"key":"BFsrep00898_CR30","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1038\/nmeth.1236","volume":"5","author":"S Pautot","year":"2008","unstructured":"Pautot, S., Wyart, C. & Isacoff, E. Y. Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods 5, 735\u2013740 (2008).","journal-title":"Nat Methods"},{"key":"BFsrep00898_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1196\/annals.1332.015","volume":"1035","author":"P Vernier","year":"2004","unstructured":"Vernier, P. et al. The degeneration of dopamine neurons in Parkinson's disease: insights from embryology and evolution of the mesostriatocortical system. Ann N Y Acad Sci 1035, 231\u2013249 (2004).","journal-title":"Ann N Y Acad Sci"},{"key":"BFsrep00898_CR32","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/81834","volume":"3","author":"R Betarbet","year":"2000","unstructured":"Betarbet, R. et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3, 1301\u20131306 (2000).","journal-title":"Nat Neurosci"},{"key":"BFsrep00898_CR33","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1016\/S1353-8020(03)00023-3","volume":"9 Suppl 2","author":"JT Greenamyre","year":"2003","unstructured":"Greenamyre, J. T., Betarbet, R. & Sherer, T. B. The rotenone model of Parkinson's disease: genes, environment and mitochondria. Parkinsonism Relat Disord 9 Suppl 2, S59\u201364 (2003).","journal-title":"Parkinsonism Relat Disord"},{"key":"BFsrep00898_CR34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neulet.2005.01.024","volume":"380","author":"H Miwa","year":"2005","unstructured":"Miwa, H., Kubo, T., Suzuki, A., Nishi, K. & Kondo, T. Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition. Neurosci Lett 380, 93\u201398 (2005).","journal-title":"Neurosci Lett"},{"key":"BFsrep00898_CR35","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/BF00237968","volume":"206","author":"RM Klein","year":"1980","unstructured":"Klein, R. M. & McKenzie, J. C. Pattern of crypt cell proliferation in the pre- and post-closure ileum of the neonatal rat: effects of sympathectomy. Cell Tissue Res 206, 387\u2013394 (1980).","journal-title":"Cell Tissue Res"},{"key":"BFsrep00898_CR36","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0165-1838(89)90162-8","volume":"26","author":"GE Holle","year":"1989","unstructured":"Holle, G. E., Granat, T., Reiser, S. B. & Holle, F. Effects of superior mesenteric and coeliac ganglionectomy on the small intestinal mucosa in the Hanford mini pig. I. Histological and enzyme-histochemical study. J Auton Nerv Syst 26, 135\u2013145 (1989).","journal-title":"J Auton Nerv Syst"},{"key":"BFsrep00898_CR37","first-page":"G391","volume":"277","author":"J Santos","year":"1999","unstructured":"Santos, J. et al. Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat. Am J Physiol 277, G391\u2013399 (1999).","journal-title":"Am J Physiol"},{"key":"BFsrep00898_CR38","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1440-1746.2004.03508.x","volume":"20","author":"V Bhatia","year":"2005","unstructured":"Bhatia, V. & Tandon, R. K. Stress and the gastrointestinal tract. J Gastroenterol Hepatol 20, 332\u2013339 (2005).","journal-title":"J Gastroenterol Hepatol"},{"key":"BFsrep00898_CR39","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.nbd.2011.01.024","volume":"42","author":"V Francardo","year":"2011","unstructured":"Francardo, V. et al. Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease. Neurobiol Dis 42, 327\u2013340 (2011).","journal-title":"Neurobiol Dis"},{"key":"BFsrep00898_CR40","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/1750-1326-7-42","volume":"7","author":"KM Danzer","year":"2012","unstructured":"Danzer, K. M. et al. Exosomal cell-to-cell transmission of alpha synuclein oligomers. Mol Neurodegener 7, 42 (2012).","journal-title":"Mol Neurodegener"},{"key":"BFsrep00898_CR41","doi-asserted-by":"publisher","first-page":"9220","DOI":"10.1523\/JNEUROSCI.2617-07.2007","volume":"27","author":"KM Danzer","year":"2007","unstructured":"Danzer, K. M. et al. Different species of alpha-synuclein oligomers induce calcium influx and seeding. The Journal of neuroscience : the official journal of the Society for Neuroscience 27, 9220\u20139232 (2007).","journal-title":"The Journal of neuroscience : the official journal of the Society for Neuroscience"},{"key":"BFsrep00898_CR42","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1385\/JMN:18:3:229","volume":"18","author":"H Elkon","year":"2002","unstructured":"Elkon, H. et al. Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase. J Mol Neurosci 18, 229\u2013238 (2002).","journal-title":"J Mol Neurosci"},{"key":"BFsrep00898_CR43","first-page":"693761","volume":"2011","author":"AR Esteves","year":"2011","unstructured":"Esteves, A. R., Arduino, D. M., Silva, D. F., Oliveira, C. R. & Cardoso, S. M. Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD. Parkinsons Dis 2011, 693761 (2011).","journal-title":"Parkinsons Dis"},{"key":"BFsrep00898_CR44","doi-asserted-by":"publisher","first-page":"e42545","DOI":"10.1371\/journal.pone.0042545","volume":"7","author":"F Schmidt","year":"2012","unstructured":"Schmidt, F. et al. Single-channel electrophysiology reveals a distinct and uniform pore complex formed by alpha-synuclein oligomers in lipid membranes. PLoS One 7, e42545 (2012).","journal-title":"PLoS One"},{"key":"BFsrep00898_CR45","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1083\/jcb.201009132","volume":"192","author":"WS Choi","year":"2011","unstructured":"Choi, W. S., Palmiter, R. D. & Xia, Z. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. J Cell Biol 192, 873\u2013882 (2011).","journal-title":"J Cell Biol"},{"key":"BFsrep00898_CR46","doi-asserted-by":"publisher","first-page":"11172","DOI":"10.1073\/pnas.0603838103","volume":"103","author":"L Rajendran","year":"2006","unstructured":"Rajendran, L. et al. Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A 103, 11172\u201311177 (2006).","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep00898","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep00898.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T23:25:35Z","timestamp":1672961135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep00898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,30]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,21]]}},"alternative-id":["BFsrep00898"],"URL":"https:\/\/doi.org\/10.1038\/srep00898","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,30]]},"assertion":[{"value":"5 April 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"898"}}