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Treatment of melioidosis is suboptimal and developing improved melioidosis therapies requires animal models. In this report, we exposed male BALB\/c mice to various amounts of aerosolized <jats:italic>B. pseudomallei<\/jats:italic> 1026b to determine lethality. After establishing a median lethal dose (LD<jats:sub>50<\/jats:sub>) of 2,772 colony forming units (cfu)\/animal, we tested the ability of doxycycline administered 6\u2005hours after exposure to a uniformly lethal dose of ~20 LD<jats:sub>50<\/jats:sub> to prevent death and eliminate bacteria from the lung and spleens. Tissue bacterial burdens were examined by PCR analysis. We found that 100% of mice treated with doxycycline survived and <jats:italic>B. pseudomallei<\/jats:italic> DNA was not amplified from the lungs or spleens of most surviving mice. We conclude the BALB\/c mouse is a useful model of melioidosis. Furthermore, the data generated in this mouse model indicate that doxycycline is likely to be effective in post-exposure prophylaxis of melioidosis.<\/jats:p>","DOI":"10.1038\/srep01146","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T10:08:30Z","timestamp":1359367710000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of Post Exposure Administration of Doxycycline in a Murine Model of Inhalational Melioidosis"],"prefix":"10.1038","volume":"3","author":[{"given":"H. 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