{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:10:26Z","timestamp":1789917026479,"version":"4.0.1"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T00:00:00Z","timestamp":1373587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Microchimeric cells of fetal origin persistent in the maternal circulation post-partum are associated with protection against invasive breast cancer. Here using quantitative genomic methods, we evaluated for the presence of male fetal microchimerism in buffy coat cells from women with a prior history of breast carcinomas in situ (CIS) and in healthy controls. Fetal microchimerism was detected in 75 of 88 controls (85%) and in 57 of 89 CIS patients (64%). The odds ratio for protection against non-invasive breast disease was 0.26 (95% confidence interval 0.12\u20130.56; p &lt; 0.001 adjusted for age and body mass index). Similar to women with invasive breast cancer, women with CIS who are naturally at high risk for future invasive disease were deficient for fetal microchimerism. In addition to autologous anti-tumor immune responses, the maintenance of haploidentical microchimerism may impart an allogeneic edge in immunosurveillance.<\/jats:p>","DOI":"10.1038\/srep02192","type":"journal-article","created":{"date-parts":[[2013,7,12]],"date-time":"2013-07-12T09:04:06Z","timestamp":1373619846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["In Situ Breast Cancer and Microchimerism"],"prefix":"10.1038","volume":"3","author":[{"given":"Jinny K.","family":"Eun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Guthrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Zirpoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. K.","family":"Gadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,12]]},"reference":[{"key":"BFsrep02192_CR1","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/jnci\/djr027","volume":"103","author":"IL Wapnir","year":"2011","unstructured":"Wapnir, I. L. et al. Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for DCIS. J Natl Cancer Inst 103, 478\u2013488 (2011).","journal-title":"J Natl Cancer Inst"},{"key":"BFsrep02192_CR2","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/(SICI)1097-0215(19980729)77:3<330::AID-IJC3>3.0.CO;2-P","volume":"77","author":"M Lambe","year":"1998","unstructured":"Lambe, M. et al. Parity, age at first birth and the risk of carcinoma in situ of the breast. Int J Cancer 77, 330\u2013332 (1998).","journal-title":"Int J Cancer"},{"key":"BFsrep02192_CR3","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1038\/sj.onc.1207899","volume":"23","author":"MC Pike","year":"2004","unstructured":"Pike, M. C., Pearce, C. L. & Wu, A. H. Prevention of cancers of the breast, endometrium and ovary. Oncogene 23, 6379\u20136391 (2004).","journal-title":"Oncogene"},{"key":"BFsrep02192_CR4","doi-asserted-by":"publisher","first-page":"e1706","DOI":"10.1371\/journal.pone.0001706","volume":"3","author":"VK Gadi","year":"2008","unstructured":"Gadi, V. K., Malone, K. E., Guthrie, K. A., Porter, P. L. & Nelson, J. L. Case-control study of fetal microchimerism and breast cancer. PLoS ONE 3, e1706 (2008).","journal-title":"PLoS ONE"},{"key":"BFsrep02192_CR5","doi-asserted-by":"publisher","first-page":"9035","DOI":"10.1158\/0008-5472.CAN-06-4209","volume":"67","author":"VK Gadi","year":"2007","unstructured":"Gadi, V. K. & Nelson, J. L. Fetal microchimerism in women with breast cancer. Cancer Res 67, 9035\u20139038 (2007).","journal-title":"Cancer Res"},{"key":"BFsrep02192_CR6","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10549-009-0548-1","volume":"121","author":"VK Gadi","year":"2010","unstructured":"Gadi, V. K. Fetal microchimerism in breast from women with and without breast cancer. Breast Cancer Res Treat 121, 241\u2013244 (2010).","journal-title":"Breast Cancer Res Treat"},{"key":"BFsrep02192_CR7","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/j.ejca.2012.02.006","volume":"48","author":"M Kamper-Jorgensen","year":"2012","unstructured":"Kamper-Jorgensen, M. et al. Opposite effects of microchimerism on breast and colon cancer. European journal of cancer 48, 2227\u20132235 (2012).","journal-title":"European journal of cancer"},{"key":"BFsrep02192_CR8","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1158\/1055-9965.EPI-06-0628","volume":"15","author":"CB Ambrosone","year":"2006","unstructured":"Ambrosone, C. B., Nesline, M. K. & Davis, W. Establishing a cancer center data bank and biorepository for multidisciplinary research. Cancer Epidemiol Biomarkers Prev 15, 1575\u20131577 (2006).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep02192_CR9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.exphem.2008.03.020","volume":"36","author":"GL Gilmore","year":"2008","unstructured":"Gilmore, G. L., Haq, B., Shadduck, R. K., Jasthy, S. L. & Lister, J. Fetal-maternal microchimerism in normal parous females and parous female cancer patients. Exp Hematol 36, 1073\u20131077 (2008).","journal-title":"Exp Hematol"},{"key":"BFsrep02192_CR10","doi-asserted-by":"publisher","first-page":"4084","DOI":"10.1200\/JCO.2012.42.0281","volume":"30","author":"M Guo","year":"2012","unstructured":"Guo, M. et al. HLA-mismatched stem-cell microtransplantation as postremission therapy for acute myeloid leukemia: long-term follow-up. J Clin Oncol 30, 4084\u20134090 (2012).","journal-title":"J Clin Oncol"},{"key":"BFsrep02192_CR11","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1182\/blood-2002-01-0295","volume":"100","author":"NC Lambert","year":"2002","unstructured":"Lambert, N. C. et al. Male microchimerism in healthy women and women with scleroderma: cells or circulating DNA? A quantitative answer. Blood 100, 2845\u20132851 (2002).","journal-title":"Blood"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep02192","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep02192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep02192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:34:08Z","timestamp":1672983248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep02192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,12]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,12,20]]}},"alternative-id":["BFsrep02192"],"URL":"https:\/\/doi.org\/10.1038\/srep02192","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,12]]},"assertion":[{"value":"4 February 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2192"}}