{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T19:01:41Z","timestamp":1761418901675},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"},{"start":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T00:00:00Z","timestamp":1378339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep02590","type":"journal-article","created":{"date-parts":[[2013,9,5]],"date-time":"2013-09-05T09:06:18Z","timestamp":1378371978000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The molecular and clinicopathologic characteristics of bilateral breast cancer"],"prefix":"10.1038","volume":"3","author":[{"given":"S. F.","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. W.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,9,5]]},"reference":[{"key":"BFsrep02590_CR1","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.breast.2011.09.007","volume":"21","author":"L Schwentner","year":"2012","unstructured":"Schwentner, L. et al. Survival of patients with bilateral versus unilateral breast cancer and impact of guideline adherent adjuvant treatment: a multi-centre cohort study of 5292 patients. Breast 21(2), 171 (2012).","journal-title":"Breast"},{"key":"BFsrep02590_CR2","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/jso.23113","volume":"106","author":"CC Parker","year":"2012","unstructured":"Parker, C. C., Kim, R. H., Li, B. D. & Chu, Q. D. The chemokine receptor CXCR4 as a novel independent prognostic marker for node-positive breast cancer patients. J Surg Oncol 106(4), 393 (2012).","journal-title":"J Surg Oncol"},{"key":"BFsrep02590_CR3","doi-asserted-by":"crossref","unstructured":"Chen, H. W. et al. Cytoplasmic CXCR4 high-expression exhibits distinct poor clinicopathological characteristics and predicts poor prognosis in triple-negative breast cancer. Curr Mol Med (2013).","DOI":"10.2174\/1566524011313030010"},{"key":"BFsrep02590_CR4","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.canlet.2007.01.005","volume":"253","author":"L Hao","year":"2007","unstructured":"Hao, L. et al. Recombination of CXCR4, VEGF and MMP-9 predicting lymph node metastasis in human breast cancer. Cancer Lett 253(1), 34 (2007).","journal-title":"Cancer Lett"},{"key":"BFsrep02590_CR5","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.ejso.2011.05.006","volume":"37","author":"SM Schmid","year":"2011","unstructured":"Schmid, S. M. et al. Prognosis of early-stage synchronous bilateral invasive breast cancer. Eur J Surg Oncol 37(7), 623 (2011).","journal-title":"Eur J Surg Oncol"},{"key":"BFsrep02590_CR6","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/1471-2407-11-114","volume":"11","author":"S Alkner","year":"2011","unstructured":"Alkner, S. et al. Prediction of outcome after diagnosis of metachronous contralateral breast cancer. Bmc Cancer 11, 114 (2011).","journal-title":"Bmc Cancer"},{"key":"BFsrep02590_CR7","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"A Muller","year":"2001","unstructured":"Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410(6824), 50 (2001).","journal-title":"Nature"},{"key":"BFsrep02590_CR8","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1056\/NEJMoa020128","volume":"347","author":"B Fisher","year":"2002","unstructured":"Fisher, B. et al. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy and total mastectomy followed by irradiation. N Engl J Med 347(8), 567 (2002).","journal-title":"N Engl J Med"},{"key":"BFsrep02590_CR9","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1007\/s00432-011-1141-7","volume":"138","author":"YX Shi","year":"2012","unstructured":"Shi, Y. X. et al. Comparison of clinicopathological characteristics and prognoses between bilateral and unilateral breast cancer. J Cancer Res Clin Oncol 138(4), 705 (2012).","journal-title":"J Cancer Res Clin Oncol"},{"key":"BFsrep02590_CR10","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3727\/096504011X12935427587966","volume":"19","author":"T Wang","year":"2011","unstructured":"Wang, T. et al. The risk factors and prognosis of bilateral primary breast cancer: a comparative study with unilateral breast cancer. Oncol Res 19(3\u20134), 171 (2011).","journal-title":"Oncol Res"},{"key":"BFsrep02590_CR11","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.1007\/s00268-010-0683-1","volume":"34","author":"SP Leong","year":"2010","unstructured":"Leong, S. P. et al. Is breast cancer the same disease in Asian and Western countries? World J Surg 34(10), 2308 (2010).","journal-title":"World J Surg"},{"key":"BFsrep02590_CR12","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1038\/bjc.2011.120","volume":"104","author":"K Metcalfe","year":"2011","unstructured":"Metcalfe, K. et al. Predictors of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. Br J Cancer 104(9), 1384 (2011).","journal-title":"Br J Cancer"},{"key":"BFsrep02590_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S1470-2045(05)70174-1","volume":"6","author":"M Hartman","year":"2005","unstructured":"Hartman, M. et al. Genetic implications of bilateral breast cancer: a population based cohort study. Lancet Oncol 6(6), 377 (2005).","journal-title":"Lancet Oncol"},{"key":"BFsrep02590_CR14","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1111\/j.1524-4741.2010.00976.x","volume":"16","author":"HD Vuoto","year":"2010","unstructured":"Vuoto, H. D. et al. Bilateral breast carcinoma: clinical characteristics and its impact on survival. Breast J 16(6), 625 (2010).","journal-title":"Breast J"},{"key":"BFsrep02590_CR15","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.breast.2010.10.004","volume":"20","author":"KR Beckmann","year":"2011","unstructured":"Beckmann, K. R. et al. Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. Breast 20(2), 158 (2011).","journal-title":"Breast"},{"key":"BFsrep02590_CR16","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10549-010-1057-y","volume":"126","author":"EA Kheirelseid","year":"2011","unstructured":"Kheirelseid, E. A. et al. Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. Breast Cancer Res Treat 126(1), 131 (2011).","journal-title":"Breast Cancer Res Treat"},{"key":"BFsrep02590_CR17","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","volume":"90","author":"B Fisher","year":"1998","unstructured":"Fisher, B. et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90(18), 1371 (1998).","journal-title":"J Natl Cancer Inst"},{"key":"BFsrep02590_CR18","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10549-006-9455-x","volume":"105","author":"HM Verkooijen","year":"2007","unstructured":"Verkooijen, H. M. et al. Survival after bilateral breast cancer: results from a population-based study. Breast Cancer Res Treat 105(3), 347 (2007).","journal-title":"Breast Cancer Res Treat"},{"key":"BFsrep02590_CR19","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s12032-010-9785-8","volume":"29","author":"R Diaz","year":"2012","unstructured":"Diaz, R. et al. Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience. Med Oncol 29(1), 16 (2012).","journal-title":"Med Oncol"},{"key":"BFsrep02590_CR20","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10549-010-1057-y","volume":"126","author":"EA Kheirelseid","year":"2011","unstructured":"Kheirelseid, E. A. et al. Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. Breast Cancer Res Treat 126(1), 131 (2011).","journal-title":"Breast Cancer Res Treat"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep02590","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep02590.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep02590.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:14:03Z","timestamp":1672982043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep02590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,5]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,12,20]]}},"alternative-id":["BFsrep02590"],"URL":"https:\/\/doi.org\/10.1038\/srep02590","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,5]]},"assertion":[{"value":"23 July 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"2590"}}