{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:56:57Z","timestamp":1791464217853,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T00:00:00Z","timestamp":1391731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep04026","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T11:33:15Z","timestamp":1391772795000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2 and RAD51C Status"],"prefix":"10.1038","volume":"4","author":[{"given":"J. M.","family":"Cunningham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Cicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. B.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Davila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Larson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. M.","family":"Dicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Harrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Winterhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hamidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Konecny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bibikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-B.","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Kalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. M.","family":"Lindor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. L.","family":"Fridley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. P. D.","family":"Pharoah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. L.","family":"Goode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,7]]},"reference":[{"key":"BFsrep04026_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1145\/3386158","volume":"63","author":"R Siegel","year":"2013","unstructured":"Siegel, R., Naishadham, D. & Jemal, A. Cancer statistics, 2013. CA: A Cancer Journal for Clinicians 63, 11\u201330 (2013).","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"BFsrep04026_CR2","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1053\/beog.2002.0296","volume":"16","author":"PD Pharoah","year":"2002","unstructured":"Pharoah, P. D. & Ponder, B. A. The genetics of ovarian cancer. Best Pract Res Clin Obstet Gynaecol. 16, 449\u2013468 (2002).","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"BFsrep04026_CR3","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1126\/science.7545954","volume":"266","author":"Y Miki","year":"1994","unstructured":"Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66\u201371 (1994).","journal-title":"Science"},{"key":"BFsrep04026_CR4","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/378789a0","volume":"378","author":"R Wooster","year":"1995","unstructured":"Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789\u2013792 (1995).","journal-title":"Nature"},{"key":"BFsrep04026_CR5","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1002\/ijc.2910640613","volume":"64","author":"M Aarnio","year":"1995","unstructured":"Aarnio, M., Mecklin, J. P., Aaltonen, L. A., Nystrom-Lahti, M. & Jarvinen, H. J. Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer. 64, 430\u2013433 (1995).","journal-title":"Int J Cancer."},{"key":"BFsrep04026_CR6","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/ng.569","volume":"42","author":"A Meindl","year":"2010","unstructured":"Meindl, A. et al. Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nat Genet. 42, 410\u2013414 (2010).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR7","first-page":"323","volume":"108","author":"A Meindl","year":"2011","unstructured":"Meindl, A., Ditsch, N., Kast, K., Rhiem, K. & Schmutzler, R. K. Hereditary breast and ovarian cancer: new genes, new treatments, new concepts. Dtsch Arztebl Int. 108, 323\u2013330 (2011).","journal-title":"Dtsch Arztebl Int."},{"key":"BFsrep04026_CR8","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/ng.893","volume":"43","author":"C Loveday","year":"2011","unstructured":"Loveday, C. et al. Germline mutations in RAD51D confer susceptibility to ovarian cancer. Nat Genet. 43, 879\u2013882 (2011).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/ng.2566","volume":"45","author":"SE Bojesen","year":"2013","unstructured":"Bojesen, S. E. et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 45, 371\u2013384 (2013).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR10","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1038\/ncomms2613","volume":"4","author":"J Permuth-Wey","year":"2013","unstructured":"Permuth-Wey, J. et al. Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun. 4, 1627 (2013).","journal-title":"Nat Commun."},{"key":"BFsrep04026_CR11","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/ng.2564","volume":"45","author":"PD Pharoah","year":"2013","unstructured":"Pharoah, P. D. et al. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet. 45, 362\u2013370 (2013).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR12","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1038\/ncomms2629","volume":"4","author":"H Shen","year":"2013","unstructured":"Shen, H. et al. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun. 4, 1628 (2013).","journal-title":"Nat Commun."},{"key":"BFsrep04026_CR13","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ng.666","volume":"42","author":"KL Bolton","year":"2010","unstructured":"Bolton, K. L. et al. Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet. 42, 880\u2013884 (2010).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR14","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/ng.668","volume":"42","author":"EL Goode","year":"2010","unstructured":"Goode, E. L. et al. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. Nat Genet. 42, 874\u2013879 (2010).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR15","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ng.424","volume":"41","author":"H Song","year":"2009","unstructured":"Song, H. et al. A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2. Nat Genet. 41, 996\u20131000 (2009).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.molonc.2009.02.001","volume":"3","author":"SJ Ramus","year":"2009","unstructured":"Ramus, S. J. & Gayther, S. A. The contribution of BRCA1 and BRCA2 to ovarian cancer. Mol Oncol. 3, 138\u2013150 (2009).","journal-title":"Mol Oncol."},{"key":"BFsrep04026_CR17","first-page":"2433","volume":"4","author":"A Berchuck","year":"1998","unstructured":"Berchuck, A. et al. Frequency of germline and somatic BRCA1 mutations in ovarian cancer. Clin Cancer Res. 4, 2433\u20132437 (1998).","journal-title":"Clin Cancer Res."},{"key":"BFsrep04026_CR18","first-page":"3622","volume":"56","author":"KA Foster","year":"1996","unstructured":"Foster, K. A. et al. Somatic and germline mutations of the BRCA2 gene in sporadic ovarian cancer. Cancer Res. 56, 3622\u20133625 (1996).","journal-title":"Cancer Res."},{"key":"BFsrep04026_CR19","doi-asserted-by":"crossref","unstructured":"Integrated genomic analyses of ovarian carcinoma. Nature 474, 609\u2013615 (2011).","DOI":"10.1038\/nature10166"},{"key":"BFsrep04026_CR20","first-page":"5329","volume":"60","author":"RL Baldwin","year":"2000","unstructured":"Baldwin, R. L. et al. BRCA1 promoter region hypermethylation in ovarian carcinoma: a population-based study. Cancer Res. 60, 5329\u20135333 (2000).","journal-title":"Cancer Res."},{"key":"BFsrep04026_CR21","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/j.1365-2559.2010.03642.x","volume":"57","author":"GM Bol","year":"2010","unstructured":"Bol, G. M. et al. Methylation profiles of hereditary and sporadic ovarian cancer. Histopathology 57, 363\u2013370 (2010).","journal-title":"Histopathology"},{"key":"BFsrep04026_CR22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/carcin\/21.2.147","volume":"21","author":"T Bianco","year":"2000","unstructured":"Bianco, T., Chenevix-Trench, G., Walsh, D. C., Cooper, J. E. & Dobrovic, A. Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer. Carcinogenesis 21, 147\u2013151 (2000).","journal-title":"Carcinogenesis"},{"key":"BFsrep04026_CR23","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.ygyno.2013.05.003","volume":"130","author":"R Demsky","year":"2013","unstructured":"Demsky, R. et al. Keeping it simple: Genetics referrals for all invasive serous ovarian cancers. Gynecol Oncol. 130, 329\u2013333 (2013).","journal-title":"Gynecol Oncol."},{"key":"BFsrep04026_CR24","first-page":"868","volume":"59","author":"PD Pharoah","year":"1999","unstructured":"Pharoah, P. D., Easton, D. F., Stockton, D. L., Gayther, S. & Ponder, B. A. Survival in familial, BRCA1-associated and BRCA2-associated epithelial ovarian cancer. United Kingdom Coordinating Committee for Cancer Research (UKCCCR) Familial Ovarian Cancer Study Group. Cancer Res. 59, 868\u2013871 (1999).","journal-title":"Cancer Res."},{"key":"BFsrep04026_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cancergen.2012.01.008","volume":"205","author":"J Liu","year":"2012","unstructured":"Liu, J. et al. Clinical characteristics and outcomes of BRCA-associated ovarian cancer: genotype and survival. Cancer Genet. 205, 34\u201341 (2012).","journal-title":"Cancer Genet."},{"key":"BFsrep04026_CR26","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2012.20","volume":"307","author":"KL Bolton","year":"2012","unstructured":"Bolton, K. L. et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. Jama 307, 382\u2013390 (2012).","journal-title":"Jama"},{"key":"BFsrep04026_CR27","doi-asserted-by":"publisher","first-page":"2654","DOI":"10.1200\/JCO.2011.39.8545","volume":"30","author":"K Alsop","year":"2012","unstructured":"Alsop, K. et al. BRCA mutation frequency and patterns of treatment response in BRCA mutation-positive women with ovarian cancer: a report from the Australian Ovarian Cancer Study Group. J Clin Oncol. 30, 2654\u20132663 (2012).","journal-title":"J Clin Oncol."},{"key":"BFsrep04026_CR28","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S1471-4914(02)02434-6","volume":"8","author":"A Tutt","year":"2002","unstructured":"Tutt, A. & Ashworth, A. The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol Med. 8, 571\u2013576 (2002).","journal-title":"Trends Mol Med."},{"key":"BFsrep04026_CR29","doi-asserted-by":"publisher","first-page":"2512","DOI":"10.1200\/JCO.2009.26.9589","volume":"28","author":"PC Fong","year":"2010","unstructured":"Fong, P. C. et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol. 28, 2512\u20132519 (2010).","journal-title":"J Clin Oncol."},{"key":"BFsrep04026_CR30","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.2174\/138161212802002823","volume":"18","author":"AV Tinker","year":"2012","unstructured":"Tinker, A. V. & Gelmon, K. The role of PARP inhibitors in the treatment of ovarian carcinomas. Curr Pharm Des. 18, 3770\u20133774 (2012).","journal-title":"Curr Pharm Des."},{"key":"BFsrep04026_CR31","doi-asserted-by":"publisher","first-page":"18032","DOI":"10.1073\/pnas.1115052108","volume":"108","author":"T Walsh","year":"2011","unstructured":"Walsh, T. et al. Mutations in 12 genes for inherited ovarian, fallopian tube and peritoneal carcinoma identified by massively parallel sequencing. Proc Natl Acad Sci U.S.A. 108, 18032\u201318037 (2011).","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"BFsrep04026_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/1541-7786.1.11.1","volume":"11","author":"J-W Huang","year":"2013","unstructured":"Huang, J. -W., Wang, Y., Dhillon, K. K., Calses, P., Villegas, E., Mitchell, P. S., Tewari, M., Kemp, C. J. & Tanaguchi, T. Sytematic screen identifies miRNAs that target RAD51C and RAD51D to enhance chemotherapy. Mol Cancer Res. 11, 1\u201310 (2013).","journal-title":"Mol Cancer Res."},{"key":"BFsrep04026_CR33","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1158\/1055-9965.EPI-13-0391","volume":"22","author":"M Kobel","year":"2013","unstructured":"Kobel, M. et al. Biomarker-based ovarian carcinoma typing: a histologic investigation in the ovarian tumor tissue analysis consortium. Cancer Epidemiol Biomarkers Prev. 22, 1677\u20131686 (2013).","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"BFsrep04026_CR34","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1038\/nrc1457","volume":"4","author":"N Turner","year":"2004","unstructured":"Turner, N., Tutt, A. & Ashworth, A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 4, 814\u2013819 (2004).","journal-title":"Nat Rev Cancer"},{"key":"BFsrep04026_CR35","doi-asserted-by":"publisher","first-page":"5530","DOI":"10.1200\/JCO.2008.16.1703","volume":"26","author":"DS Tan","year":"2008","unstructured":"Tan, D. S. et al. \u201cBRCAness\u201d syndrome in ovarian cancer: a case-control study describing the clinical features and outcome of patients with epithelial ovarian cancer associated with BRCA1 and BRCA2 mutations. J Clin Oncol. 26, 5530\u20135536 (2008).","journal-title":"J Clin Oncol."},{"key":"BFsrep04026_CR36","doi-asserted-by":"publisher","first-page":"e25632","DOI":"10.1371\/journal.pone.0025632","volume":"6","author":"J Clague","year":"2011","unstructured":"Clague, J. et al. RAD51C germline mutations in breast and ovarian cancer cases from high-risk families. PLoS One 6, e25632 (2011).","journal-title":"PLoS One"},{"key":"BFsrep04026_CR37","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1399-0004.2012.01917.x","volume":"83","author":"F Coulet","year":"2013","unstructured":"Coulet, F. et al. Germline RAD51C mutations in ovarian cancer susceptibility. Clin Genet. 83, 332\u2013336 (2013).","journal-title":"Clin Genet."},{"key":"BFsrep04026_CR38","doi-asserted-by":"publisher","first-page":"4669","DOI":"10.1093\/hmg\/dds308","volume":"21","author":"T Hansmann","year":"2012","unstructured":"Hansmann, T. et al. Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer. Hum Mol Genet. 21, 4669\u20134679 (2012).","journal-title":"Hum Mol Genet."},{"key":"BFsrep04026_CR39","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/ng.2224","volume":"44","author":"C Loveday","year":"2012","unstructured":"Loveday, C. et al. Germline RAD51C mutations confer susceptibility to ovarian cancer. Nat Genet. 44, 475\u2013476 (2012).","journal-title":"Nat Genet."},{"key":"BFsrep04026_CR40","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1038\/bjc.2012.451","volume":"107","author":"V Abkevich","year":"2012","unstructured":"Abkevich, V. et al. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer 107, 1776\u20131782 (2012).","journal-title":"Br J Cancer"},{"key":"BFsrep04026_CR41","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/jnci\/djs494","volume":"105","author":"JR McLaughlin","year":"2013","unstructured":"McLaughlin, J. R. et al. Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2. J Natl Cancer Inst. 105, 141\u2013148 (2013).","journal-title":"J Natl Cancer Inst."},{"key":"BFsrep04026_CR42","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1634\/theoncologist.2012-0028","volume":"17","author":"G Rigakos","year":"2012","unstructured":"Rigakos, G. & Razis, E. BRCAness: Finding the achilles heel in ovarian cancer. Oncologist 17, 956\u2013962 (2012).","journal-title":"Oncologist"},{"key":"BFsrep04026_CR43","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1158\/1055-9965.EPI-11-0455","volume":"20","author":"EL Goode","year":"2011","unstructured":"Goode, E. L. et al. Assessment of hepatocyte growth factor in ovarian cancer mortality. Cancer Epidemiol Biomarkers Prev. 20, 1638\u20131648 (2011).","journal-title":"Cancer Epidemiol Biomarkers Prev."},{"key":"BFsrep04026_CR44","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297\u20131303 (2010).","journal-title":"Genome Res."},{"key":"BFsrep04026_CR45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/bioinformatics\/btr665","volume":"28","author":"DE Larson","year":"2012","unstructured":"Larson, D. E. et al. SomaticSniper: identification of somatic point mutations in whole genome sequencing data. Bioinformatics 28, 311\u2013317 (2012).","journal-title":"Bioinformatics"},{"key":"BFsrep04026_CR46","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1093\/bioinformatics\/btr612","volume":"28","author":"YW Asmann","year":"2012","unstructured":"Asmann, Y. W. et al. TREAT: a bioinformatics tool for variant annotations and visualizations in targeted and exome sequencing data. Bioinformatics 28, 277\u2013278 (2012).","journal-title":"Bioinformatics"},{"key":"BFsrep04026_CR47","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1093\/hmg\/ddt160","volume":"22","author":"MS Cicek","year":"2013","unstructured":"Cicek, M. S. et al. Epigenome-wide ovarian cancer analysis identifies a methylation profile differentiating clear-cell histology with epigenetic silencing of the HERG K+ channel. Hum Mol Genet. 22, 3038\u20133047(2013).","journal-title":"Hum Mol Genet."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep04026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep04026","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep04026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T08:25:21Z","timestamp":1672993521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep04026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,7]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,17]]}},"alternative-id":["BFsrep04026"],"URL":"https:\/\/doi.org\/10.1038\/srep04026","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,7]]},"assertion":[{"value":"9 October 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4026"}}