{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:49:03Z","timestamp":1788518943218,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"},{"start":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T00:00:00Z","timestamp":1392681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep04114","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T10:09:54Z","timestamp":1392718194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Does DcR1 (TNF-related apoptosis-inducing-ligand Receptor 3) have any role in human AMD pathogenesis?"],"prefix":"10.1038","volume":"4","author":[{"given":"Akshay","family":"Anand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amod","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudesh","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeru","family":"Jindal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind K.","family":"Bhatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh K.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan K.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,18]]},"reference":[{"key":"BFsrep04114_CR1","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1289\/ehp.7567","volume":"113","author":"RC Brown","year":"2005","unstructured":"Brown, R. C., Lockwood, A. H. & Sonawane, B. R. Neurodegenerative Diseases, An Overview of Environmental Risk Factors. Environ Health Perspect 113, 1250\u20131256 (2005).","journal-title":"Environ Health Perspect"},{"key":"BFsrep04114_CR2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/bjo.87.3.312","volume":"87","author":"CG Owen","year":"2003","unstructured":"Owen, C. G., Fletcher, A. E., Donoghue, M. & Rudnicka, A. R. How big is the burden of visual loss caused by age related macular degeneration in the United Kingdom? Br J Ophthalmol. 87, 312\u2013317 (2003).","journal-title":"Br J Ophthalmol."},{"key":"BFsrep04114_CR3","doi-asserted-by":"publisher","first-page":"441","DOI":"10.4103\/0301-4738.36479","volume":"55","author":"R Azad","year":"2007","unstructured":"Azad, R., Chandra, P. & Gupta, R. The economic implications of the use of anti-vascular endothelial growth factor drugs in age-related macular degeneration. Indian Journal of Ophthalmology. 55, 441\u2013443 (2007).","journal-title":"Indian Journal of Ophthalmology."},{"key":"BFsrep04114_CR4","doi-asserted-by":"publisher","first-page":"e4160","DOI":"10.1371\/journal.pone.0004160","volume":"4","author":"AL Wang","year":"2008","unstructured":"Wang, A. L. et al. Autophagy and exosomes in the aged retinal pigment epithelium, Possible relevance to drusen formation and age-related macular degeneration. PLoS ONE 4, e4160 (2008).","journal-title":"PLoS ONE"},{"key":"BFsrep04114_CR5","doi-asserted-by":"publisher","first-page":"8350","DOI":"10.1167\/iovs.12-10495","volume":"53","author":"S Bhattacharya","year":"2012","unstructured":"Bhattacharya, S., Chaum, S., Johnson, D. A. & Johnson, L. R. Age-Related Susceptibility to Apoptosis in Human Retinal Pigment Epithelial Cells Is Triggered by Disruption of p53\u2013Mdm2 Association. Invest. Ophthalmol. 53, 8350\u20138366 (2012).","journal-title":"Invest. Ophthalmol."},{"key":"BFsrep04114_CR6","doi-asserted-by":"publisher","first-page":"e70193","DOI":"10.1371\/journal.pone.0070193","volume":"8","author":"NK Sharma","year":"2013","unstructured":"Sharma, N. K. et al. Association between CFH Y402H polymorphism and age related macular degeneration in North Indian cohort. PLoS ONE 8, e70193 (2013).","journal-title":"PLoS ONE"},{"key":"BFsrep04114_CR7","doi-asserted-by":"publisher","first-page":"256","DOI":"10.2174\/156720212803530681","volume":"9","author":"NK Sharma","year":"2012","unstructured":"Sharma, N. K. et al. Single Nucleotide Polymorphism and Serum Levels Of VEGFR2 are Associated With Age Related Macular Degeneration. Curr Neurovasc Res. 9, 256\u201365 (2012).","journal-title":"Curr Neurovasc Res."},{"key":"BFsrep04114_CR8","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1089\/dna.2012.1786","volume":"31","author":"NK Sharma","year":"2012","unstructured":"Sharma, N. K. et al. New Biomarker for Neovascular Age Related Macular Degeneration, Eotaxin-2. DNA Cell Biol. 31, 1618\u20131627 (2012).","journal-title":"DNA Cell Biol."},{"key":"BFsrep04114_CR9","doi-asserted-by":"publisher","first-page":"e49905","DOI":"10.1371\/journal.pone.0049905","volume":"7","author":"A Anand","year":"2012","unstructured":"Anand, A. et al. Single Nucleotide Polymorphisms in MCP-1 and Its Receptor Are Associated with the Risk of Age Related Macular Degeneration. PLoS ONE 7, e49905 (2012).","journal-title":"PLoS ONE"},{"key":"BFsrep04114_CR10","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1001\/jamaophthalmol.2013.713","volume":"131","author":"R Klein","year":"2013","unstructured":"Klein, R. et al. Risk alleles in CFH and ARMS2 and the long-term natural history of age-related macular degeneration, the Beaver Dam Eye Study. JAMA Ophthalmol. 131, 383\u201392 (2013).","journal-title":"JAMA Ophthalmol."},{"key":"BFsrep04114_CR11","first-page":"782","volume":"8","author":"WR Johnstone","year":"2008","unstructured":"Johnstone, W. R., Frew, A. J. & Smyth, M. J. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nature 8, 782\u2013798 (2008).","journal-title":"Nature"},{"key":"BFsrep04114_CR12","first-page":"705","volume":"20","author":"GS Hageman","year":"2001","unstructured":"Hageman, G. S. et al. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog. Retin. Eye Res. 20, 705\u2013732 (2001).","journal-title":"Eye Res."},{"key":"BFsrep04114_CR13","doi-asserted-by":"publisher","first-page":"14682","DOI":"10.1073\/pnas.222551899","volume":"99","author":"JW Crabb","year":"2002","unstructured":"Crabb, J. W. et al. Drusen proteome analysis: an approach to the etiology of age-related macular degeneration. Proc. Natl. Acad. Sci. 99, 14682\u201314687 (2002).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"BFsrep04114_CR14","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1001\/archopht.120.11.1435","volume":"120","author":"JL Dunaief","year":"2002","unstructured":"Dunaief, J. L., Dentchev, T., Ying, G. & Milam, A. H. The Role of Apoptosis in Age-Related Macular Degeneration. Arch Ophthalmol. 120,1435\u20131442 (2002).","journal-title":"Arch Ophthalmol."},{"key":"BFsrep04114_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1044-579X(02)00131-1","volume":"13","author":"N Ozoren","year":"2003","unstructured":"Ozoren, N. & El-Deiry, W. S. Cell surface death receptor signaling in normal and cancer cells. Semin Cancer Biol. 13, 135\u2013147 (2003).","journal-title":"Semin Cancer Biol."},{"key":"BFsrep04114_CR16","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1053\/jhep.2000.16266","volume":"32","author":"T Yamanaka","year":"2000","unstructured":"Yamanaka, T. et al. Chemotherapeutic agents augment TRAIL-induced apoptosis in human hepatocellular carcinoma cell lines. Hepatology 32, 482\u2013490 (2000).","journal-title":"Hepatology"},{"key":"BFsrep04114_CR17","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.1038\/onc.2008.52","volume":"27","author":"F Toscano","year":"2008","unstructured":"Toscano, F. et al. P53-mediated upregulation of DcR1 impairs oxaliplatin\/TRAIL-induced synergistic anti-tumour potential in colon cancer cells. Oncogene 27, 4161\u201371(2008).","journal-title":"Oncogene"},{"key":"BFsrep04114_CR18","doi-asserted-by":"publisher","first-page":"4170","DOI":"10.1172\/JCI67315","volume":"123","author":"SH Chavala","year":"2013","unstructured":"Chavala, S. H. et al. Retinal angiogenesis suppression through small molecule activation of p53. J Clin Invest. 123, 4170\u20134181 (2013).","journal-title":"J Clin Invest."},{"key":"BFsrep04114_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0042-6989(01)00146-8","volume":"42","author":"B Chang","year":"2002","unstructured":"Chang, B. et al. Retinal degeneration mutants in the mouse. Vision Res. 42, 517\u201325 (2002).","journal-title":"Vision Res."},{"key":"BFsrep04114_CR20","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.1093\/hmg\/ddn295","volume":"17","author":"B Chang","year":"2008","unstructured":"Chang, B. et al. Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Hum Mol Genet. 17, 3929\u201341 (2008).","journal-title":"Hum Mol Genet."},{"key":"BFsrep04114_CR21","first-page":"3149","volume":"41","author":"NL Hawes","year":"2000","unstructured":"Hawes, N. L. et al. Retinal degeneration 6 (rd6): a new mouse model for human retinitis punctata albescens. Invest Ophthalmol Vis Sci. 41, 3149\u201357 (2000).","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"BFsrep04114_CR22","doi-asserted-by":"crossref","unstructured":"Li, Z. Y. & Milam, A. H. Apoptosis in retinitis pigmentosa. Anderson RELaVail MMHollyfield JGeds.Degenerative Diseases of the Retina. New York, NY Plenum Press 1\u20138 (1995).","DOI":"10.1007\/978-1-4615-1897-6_1"},{"key":"BFsrep04114_CR23","first-page":"411","volume":"94","author":"GZ Xu","year":"1996","unstructured":"Xu, G. Z., Li, W. W. & Tso, M. O. Apoptosis in human retinal degenerations. Trans Am Ophthalmol Soc. 94, 411\u2013430 (1996).","journal-title":"Trans Am Ophthalmol Soc."},{"key":"BFsrep04114_CR24","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1001\/archopht.1997.01100160201010","volume":"115","author":"MS Kerrigan","year":"1997","unstructured":"Kerrigan, M. S., Zack, D. J., Quigley, H. A., Smith, S. D. & Pease, M. E. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch Ophthalmol. 115, 1031\u20131035 (1997).","journal-title":"Arch Ophthalmol."},{"key":"BFsrep04114_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","volume":"108","author":"RW Johnstone","year":"2002","unstructured":"Johnstone, R. W., Ruefli, A. A. & Lowe, S. W. Apoptosis, a link between cancer genetics and chemotherapy. Cell 108, 153\u2013164 (2002).","journal-title":"Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep04114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep04114","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep04114.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T08:15:29Z","timestamp":1672992929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep04114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,18]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,12,17]]}},"alternative-id":["BFsrep04114"],"URL":"https:\/\/doi.org\/10.1038\/srep04114","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,18]]},"assertion":[{"value":"2 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"4114"}}