{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:40:17Z","timestamp":1791398417590,"version":"4.3.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"},{"start":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T00:00:00Z","timestamp":1420761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep07696","type":"journal-article","created":{"date-parts":[[2015,1,9]],"date-time":"2015-01-09T10:04:41Z","timestamp":1420797881000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis"],"prefix":"10.1038","volume":"5","author":[{"given":"Mai","family":"Takeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyotaro","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Gion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyasu","family":"Tachibana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorihisa","family":"Orita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,9]]},"reference":[{"key":"BFsrep07696_CR1","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1111\/j.1440-1827.2010.02524.x","volume":"60","author":"Y Sato","year":"2010","unstructured":"Sato, Y. et al. IgG4-related disease: Histological overview and pathology of hematological disorders. Pathol Int. 60, 247\u2013258 (2010).","journal-title":"Pathol Int."},{"key":"BFsrep07696_CR2","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1002\/hep.21697","volume":"45","author":"Y Zen","year":"2007","unstructured":"Zen, Y. et al. Th2 and regulatory immune reactions are increased in immunoglobin G4-related sclerosing pancreatitis and cholangitis. Hepatology. 45, 1538\u20131546 (2007).","journal-title":"Hepatology."},{"key":"BFsrep07696_CR3","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/art.33320","volume":"64","author":"A Tanaka","year":"2012","unstructured":"Tanaka, A. et al. Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. Arthritis Rheum. 64, 254\u2013263 (2012).","journal-title":"Arthritis Rheum."},{"key":"BFsrep07696_CR4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s11882-013-0373-9","volume":"13","author":"J Corren","year":"2013","unstructured":"Corren, J. Role of Interleukin-13 in Asthma. Curr Allergy Asthma Rep. 13, 415\u2013420 (2013).","journal-title":"Curr Allergy Asthma Rep."},{"key":"BFsrep07696_CR5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11882-013-0346-z","volume":"13","author":"RG Klein Wolterink","year":"2013","unstructured":"Klein Wolterink, R. G. & Hendriks, R. W. Type 2 innate lymphocytes in allergic airway inflammation. Curr Allergy Asthma Rep. 13, 271\u2013280 (2013).","journal-title":"Curr Allergy Asthma Rep."},{"key":"BFsrep07696_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jaut.2013.07.007","volume":"51","author":"M Moriyama","year":"2014","unstructured":"Moriyama, M. et al. T helper subsets in Sj\u00f6gren's syndrome and IgG4-related dacryoadenitis and sialoadenitis: A critical review. J Autoimmun. 51, 81\u201388 (2014).","journal-title":"J Autoimmun."},{"key":"BFsrep07696_CR7","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1038\/modpathol.2013.236","volume":"27","author":"M Takeuchi","year":"2014","unstructured":"Takeuchi, M. et al. T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease. Mod Pathol. 27, 1126\u20131136 (2014).","journal-title":"Mod Pathol."},{"key":"BFsrep07696_CR8","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","volume":"25","author":"V Deshpande","year":"2012","unstructured":"Deshpande, V. et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 25, 1181\u20131192 (2012).","journal-title":"Mod Pathol."},{"key":"BFsrep07696_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.anl.2011.01.023","volume":"39","author":"T Himi","year":"2012","unstructured":"Himi, T. et al. A novel concept of Mikulicz's disease as IgG4-related disease. Auris Nasus Larynx. 39, 9\u201317 (2012).","journal-title":"Auris Nasus Larynx."},{"key":"BFsrep07696_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/s10165-011-0508-6","volume":"22","author":"H Umehara","year":"2012","unstructured":"Umehara, H. et al. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol. 22, 1\u201314 (2012).","journal-title":"Mod Rheumatol."},{"key":"BFsrep07696_CR11","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1007\/BF02285209","volume":"40","author":"K Yoshida","year":"1995","unstructured":"Yoshida, K. et al. Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis. Dig Dis Sci. 40, 1561\u20131568 (1995).","journal-title":"Dig Dis Sci."},{"key":"BFsrep07696_CR12","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1136\/gut.52.5.683","volume":"52","author":"T Kamisawa","year":"2003","unstructured":"Kamisawa, T. et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut. 52, 683\u2013687 (2003).","journal-title":"Gut."},{"key":"BFsrep07696_CR13","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1615\/CritRevImmunol.2013007046","volume":"33","author":"CB Smarr","year":"2013","unstructured":"Smarr, C. B., Bryce, P. J. & Miller, S. D. Antigen-specific tolerance in immunotherapy of Th2-associated allergic diseases. Crit Rev Immunol. 33, 389\u2013414 (2013).","journal-title":"Crit Rev Immunol."},{"key":"BFsrep07696_CR14","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/all.12320","volume":"69","author":"E Della Torre","year":"2014","unstructured":"Della Torre, E. et al. Prevalence of atopy, eosinophila and IgE elevation in IgG4-related disease. Allergy. 69, 269\u2013272 (2014).","journal-title":"Allergy."},{"key":"BFsrep07696_CR15","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1126\/science.1144603","volume":"317","author":"M van der Neut Kolfschoten","year":"2007","unstructured":"van der Neut Kolfschoten, M. et al. Anti-inflamatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 317, 1554\u20131557 (2007).","journal-title":"Science."},{"key":"BFsrep07696_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1046\/j.0019-2805.2001.01341.x","volume":"105","author":"RC Aalberse","year":"2002","unstructured":"Aalberse, R. C. & Schuurman, J. IgG4 breaking the rules. Immunology. 105, 9\u201319 (2002).","journal-title":"Immunology."},{"key":"BFsrep07696_CR17","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2332\/allergolint.11-CR-0352","volume":"61","author":"S Ito","year":"2012","unstructured":"Ito, S. et al. Three cases of bronchial asthma preceding Igg4-related autoimmune pancreatitis. Allergol Int. 61, 171\u2013174 (2012).","journal-title":"Allergol Int."},{"key":"BFsrep07696_CR18","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3960\/jslrt.53.53","volume":"53","author":"K Oshima","year":"2013","unstructured":"Oshima, K., Sato, Y. & Yoshino, T. A case of IgG4-related dacryoadenitis that regressed without systemic steroid administration. J Clin Exp Hematop. 53, 53\u201356 (2013).","journal-title":"J Clin Exp Hematop."},{"key":"BFsrep07696_CR19","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fimmu.2012.00120","volume":"3","author":"G Gri","year":"2012","unstructured":"Gri, G. et al. Mast cell: an emerging partner in immune interaction. Front Immunol. 3, 120 (2012).","journal-title":"Front Immunol."},{"key":"BFsrep07696_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rmed.2011.09.007","volume":"106","author":"K Amin","year":"2012","unstructured":"Amin, K. The role of mast cells in allergic inflammation. Respir Med. 106, 9\u201314 (2012).","journal-title":"Respir Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep07696.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07696","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07696.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:29:14Z","timestamp":1672954154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep07696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,9]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,7,15]]}},"alternative-id":["BFsrep07696"],"URL":"https:\/\/doi.org\/10.1038\/srep07696","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,9]]},"assertion":[{"value":"12 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7696"}}