{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T18:21:20Z","timestamp":1768501280911,"version":"3.49.0"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep07820","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T10:01:29Z","timestamp":1421402489000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway"],"prefix":"10.1038","volume":"5","author":[{"given":"Kun","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinli","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"BFsrep07820_CR1","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nri2395","volume":"8","author":"A Uccelli","year":"2008","unstructured":"Uccelli, A., Moretta, L. & Pistoia, V. Mesenchymal stem cells in health and disease. Nat. Rev. Immunol. 8, 726\u2013736 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"BFsrep07820_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.3727\/096368912X655172","volume":"22","author":"SH Chou","year":"2013","unstructured":"Chou, S. H. et al. Mesenchymal stem cell insights: prospects in hematological transplantation. Cell Transplant. 22, 711\u2013721 (2013).","journal-title":"Cell Transplant."},{"key":"BFsrep07820_CR3","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/S0140-6736(04)16104-7","volume":"363","author":"K Le Blanc","year":"2004","unstructured":"Le Blanc, K. et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363, 1439\u20131441 (2004).","journal-title":"Lancet"},{"key":"BFsrep07820_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1749-6632.2012.06667.x","volume":"1266","author":"ME Bernardo","year":"2012","unstructured":"Bernardo, M. E. & Fibbe, W. E. Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders. Ann. N. Y. Acad. Sci. 1266, 107\u2013117 (2012).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"BFsrep07820_CR5","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.bbmt.2011.07.023","volume":"18","author":"L von Bahr","year":"2012","unstructured":"von Bahr, L. et al. Long-term complications, immunologic effects and role of passage for outcome in mesenchymal stromal cell therapy. Biol. Blood Marrow Transplant. 18, 557\u2013564 (2012).","journal-title":"Biol. Blood Marrow Transplant."},{"key":"BFsrep07820_CR6","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1600-0609.2012.01824.x","volume":"89","author":"U Forslow","year":"2012","unstructured":"Forslow, U. et al. Treatment with mesenchymal stromal cells is a risk factor for pneumonia-related death after allogeneic hematopoietic stem cell transplantation. Eur. J. Haematol. 89, 220\u2013227 (2012).","journal-title":"Eur. J. Haematol."},{"key":"BFsrep07820_CR7","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/sj.bmt.1705368","volume":"37","author":"M Sundin","year":"2006","unstructured":"Sundin, M. et al. Mesenchymal stem cells are susceptible to human herpesviruses, but viral DNA cannot be detected in the healthy seropositive individual. Bone Marrow Transplant. 37, 1051\u20131059 (2006).","journal-title":"Bone Marrow Transplant."},{"key":"BFsrep07820_CR8","doi-asserted-by":"publisher","first-page":"e71412","DOI":"10.1371\/journal.pone.0071412","volume":"8","author":"S Avanzi","year":"2013","unstructured":"Avanzi, S. et al. Susceptibility of human placenta derived mesenchymal stromal\/stem cells to human herpesviruses infection. PLoS One 8, e71412 (2013).","journal-title":"PLoS One"},{"key":"BFsrep07820_CR9","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1182\/blood-2004-02-0693","volume":"104","author":"CH Parsons","year":"2004","unstructured":"Parsons, C. H., Szomju, B. & Kedes, D. H. Susceptibility of human fetal mesenchymal stem cells to Kaposi sarcoma-associated herpesvirus. Blood 104, 2736\u20132738 (2004).","journal-title":"Blood"},{"key":"BFsrep07820_CR10","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1172\/JCI58530","volume":"122","author":"T Jones","year":"2012","unstructured":"Jones, T. et al. Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV. J. Clin. Invest. 122, 1076\u20131081 (2012).","journal-title":"J. Clin. Invest."},{"key":"BFsrep07820_CR11","doi-asserted-by":"publisher","first-page":"898630","DOI":"10.1155\/2014\/898630","volume":"2014","author":"R Meisel","year":"2014","unstructured":"Meisel, R. et al. Cytomegalovirus infection impairs immunosuppressive and antimicrobial effector functions of human multipotent mesenchymal stromal cells. Mediators Inflamm. 2014, 898630 (2014).","journal-title":"Mediators Inflamm."},{"key":"BFsrep07820_CR12","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nrc2888","volume":"10","author":"EA Mesri","year":"2010","unstructured":"Mesri, E. A., Cesarman, E. & Boshoff, C. Kaposi's sarcoma and its associated herpesvirus. Nat. Rev. Cancer 10, 707\u2013719 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"BFsrep07820_CR13","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1158\/1078-0432.CCR-0670-3","volume":"10","author":"MP Thompson","year":"2004","unstructured":"Thompson, M. P. & Kurzrock, R. Epstein-Barr virus and cancer. Clin. Cancer Res. 10, 803\u2013821 (2004).","journal-title":"Clin. Cancer Res."},{"key":"BFsrep07820_CR14","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783\u2013801 (2006).","journal-title":"Cell"},{"key":"BFsrep07820_CR15","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1084\/jem.20030162","volume":"198","author":"J Lund","year":"2003","unstructured":"Lund, J., Sato, A., Akira, S., Medzhitov, R. & Iwasaki, A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513\u2013520 (2003).","journal-title":"J. Exp. Med."},{"key":"BFsrep07820_CR16","doi-asserted-by":"publisher","first-page":"7767","DOI":"10.4049\/jimmunol.179.11.7767","volume":"179","author":"S Varani","year":"2007","unstructured":"Varani, S. et al. Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells. J. Immunol. 179, 7767\u20137776 (2007).","journal-title":"J. Immunol."},{"key":"BFsrep07820_CR17","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.4049\/jimmunol.0903736","volume":"185","author":"S Fiola","year":"2010","unstructured":"Fiola, S., Gosselin, D., Takada, K. & Gosselin, J. TLR9 contributes to the recognition of EBV by primary monocytes and plasmacytoid dendritic cells. J. Immunol. 185, 3620\u20133631 (2010).","journal-title":"J. Immunol."},{"key":"BFsrep07820_CR18","doi-asserted-by":"publisher","first-page":"11416","DOI":"10.1073\/pnas.0403555101","volume":"101","author":"H Hochrein","year":"2004","unstructured":"Hochrein, H. et al. Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways. Proc. Natl. Acad. Sci. U. S. A. 101, 11416\u201311421 (2004).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"BFsrep07820_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nri2690","volume":"10","author":"V Hornung","year":"2010","unstructured":"Hornung, V. & Latz, E. Intracellular DNA recognition. Nat. Rev. Immunol. 10, 123\u2013130 (2010).","journal-title":"Nat. Rev. Immunol."},{"key":"BFsrep07820_CR20","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.immuni.2013.05.004","volume":"38","author":"SR Paludan","year":"2013","unstructured":"Paludan, S. R. & Bowie, A. G. Immune sensing of DNA. Immunity 38, 870\u2013880 (2013).","journal-title":"Immunity"},{"key":"BFsrep07820_CR21","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1128\/JVI.01748-09","volume":"84","author":"VR DeFilippis","year":"2010","unstructured":"DeFilippis, V. R., Alvarado, D., Sali, T., Rothenburg, S. & Fruh, K. Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1. J. Virol. 84, 585\u2013598 (2010).","journal-title":"J. Virol."},{"key":"BFsrep07820_CR22","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.chom.2011.04.008","volume":"9","author":"N Kerur","year":"2011","unstructured":"Kerur, N. et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9, 363\u2013375 (2011).","journal-title":"Cell Host Microbe"},{"key":"BFsrep07820_CR23","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/nature06013","volume":"448","author":"A Takaoka","year":"2007","unstructured":"Takaoka, A. et al. DAI (DLM-1\/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448, 501\u2013505 (2007).","journal-title":"Nature"},{"key":"BFsrep07820_CR24","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature07725","volume":"458","author":"V Hornung","year":"2009","unstructured":"Hornung, V. et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514\u2013518 (2009).","journal-title":"Nature"},{"key":"BFsrep07820_CR25","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.1932","volume":"11","author":"L Unterholzner","year":"2010","unstructured":"Unterholzner, L. et al. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997\u20131004 (2010).","journal-title":"Nat. Immunol."},{"key":"BFsrep07820_CR26","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1038\/ni.2091","volume":"12","author":"Z Zhang","year":"2011","unstructured":"Zhang, Z. et al. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12, 959\u2013965 (2011).","journal-title":"Nat. Immunol."},{"key":"BFsrep07820_CR27","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1126\/science.1232458","volume":"339","author":"L Sun","year":"2013","unstructured":"Sun, L., Wu, J., Du, F., Chen, X. & Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786\u2013791 (2013).","journal-title":"Science"},{"key":"BFsrep07820_CR28","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1126\/science.1229963","volume":"339","author":"J Wu","year":"2013","unstructured":"Wu, J. et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339, 826\u2013830 (2013).","journal-title":"Science"},{"key":"BFsrep07820_CR29","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1038\/nature08476","volume":"461","author":"H Ishikawa","year":"2009","unstructured":"Ishikawa, H., Ma, Z. & Barber, G. N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461, 788\u2013792 (2009).","journal-title":"Nature"},{"key":"BFsrep07820_CR30","doi-asserted-by":"publisher","first-page":"ra20","DOI":"10.1126\/scisignal.2002521","volume":"5","author":"Y Tanaka","year":"2012","unstructured":"Tanaka, Y. & Chen, Z. J. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. Sci. Signal. 5, ra20 (2012).","journal-title":"Sci. Signal."},{"key":"BFsrep07820_CR31","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1146\/annurev-immunol-032713-120231","volume":"32","author":"WM Schneider","year":"2014","unstructured":"Schneider, W. M., Chevillotte, M. D. & Rice, C. M. Interferon-stimulated genes: a complex web of host defenses. Annu. Rev. Immunol. 32, 513\u2013545 (2014).","journal-title":"Annu. Rev. Immunol."},{"key":"BFsrep07820_CR32","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","volume":"11","author":"VA Rathinam","year":"2010","unstructured":"Rathinam, V. A. et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11, 395\u2013402 (2010).","journal-title":"Nat. Immunol."},{"key":"BFsrep07820_CR33","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1182\/blood-2006-06-028704","volume":"109","author":"M Pevsner-Fischer","year":"2007","unstructured":"Pevsner-Fischer, M. et al. Toll-like receptors and their ligands control mesenchymal stem cell functions. Blood 109, 1422\u20131432 (2007).","journal-title":"Blood"},{"key":"BFsrep07820_CR34","doi-asserted-by":"publisher","first-page":"e15369","DOI":"10.1371\/journal.pone.0015369","volume":"5","author":"HS Kim","year":"2010","unstructured":"Kim, H. S. et al. Implication of NOD1 and NOD2 for the differentiation of multipotent mesenchymal stem cells derived from human umbilical cord blood. PLoS One 5, e15369 (2010).","journal-title":"PLoS One"},{"key":"BFsrep07820_CR35","doi-asserted-by":"publisher","first-page":"e967","DOI":"10.1038\/cddis.2013.504","volume":"4","author":"K Yang","year":"2013","unstructured":"Yang, K. et al. Functional RIG-I-like receptors control the survival of mesenchymal stem cells. Cell Death Dis. 4, e967 (2013).","journal-title":"Cell Death Dis."},{"key":"BFsrep07820_CR36","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s00281-011-0267-7","volume":"33","author":"I Marigo","year":"2011","unstructured":"Marigo, I. & Dazzi, F. The immunomodulatory properties of mesenchymal stem cells. Semin. Immunopathol. 33, 593\u2013602 (2011).","journal-title":"Semin. Immunopathol."},{"key":"BFsrep07820_CR37","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/bmt.2011.81","volume":"47","author":"ME Bernardo","year":"2012","unstructured":"Bernardo, M. E., Pagliara, D. & Locatelli, F. Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine? Bone Marrow Transplant. 47, 164\u2013171 (2012).","journal-title":"Bone Marrow Transplant."},{"key":"BFsrep07820_CR38","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1054\/blre.2000.0140","volume":"14","author":"JP Allain","year":"2000","unstructured":"Allain, J. P. Emerging viral infections relevant to transfusion medicine. Blood Rev. 14, 173\u2013181 (2000).","journal-title":"Blood Rev."},{"key":"BFsrep07820_CR39","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1056\/NEJM200011093431905","volume":"343","author":"M Luppi","year":"2000","unstructured":"Luppi, M. et al. Bone marrow failure associated with human herpesvirus 8 infection after transplantation. N. Engl. J. Med. 343, 1378\u20131385 (2000).","journal-title":"N. Engl. J. Med."},{"key":"BFsrep07820_CR40","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.bbmt.2011.12.579","volume":"18","author":"R Dulery","year":"2012","unstructured":"Dulery, R. et al. Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study. Biol. Blood Marrow Transplant. 18, 1080\u20131089 (2012).","journal-title":"Biol. Blood Marrow Transplant."},{"key":"BFsrep07820_CR41","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1016\/j.transproceed.2005.07.007","volume":"37","author":"A Behzad-Behbahani","year":"2005","unstructured":"Behzad-Behbahani, A. et al. Risk of viral transmission via bone marrow progenitor cells versus umbilical cord blood hematopoietic stem cells in bone marrow transplantation. Transplant. Proc. 37, 3211\u20133212 (2005).","journal-title":"Transplant. Proc."},{"key":"BFsrep07820_CR42","doi-asserted-by":"publisher","first-page":"6890","DOI":"10.4049\/jimmunol.173.11.6890","volume":"173","author":"L Malmgaard","year":"2004","unstructured":"Malmgaard, L., Melchjorsen, J., Bowie, A. G., Mogensen, S. C. & Paludan, S. R. Viral activation of macrophages through TLR-dependent and -independent pathways. J. Immunol. 173, 6890\u20136898 (2004).","journal-title":"J. Immunol."},{"key":"BFsrep07820_CR43","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1182\/blood-2003-08-2674","volume":"103","author":"A Krug","year":"2004","unstructured":"Krug, A. et al. Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood 103, 1433\u20131437 (2004).","journal-title":"Blood"},{"key":"BFsrep07820_CR44","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1128\/JVI.01007-10","volume":"85","author":"JA West","year":"2011","unstructured":"West, J. A., Gregory, S. M., Sivaraman, V., Su, L. & Damania, B. Activation of plasmacytoid dendritic cells by Kaposi's sarcoma-associated herpesvirus. J. Virol. 85, 895\u2013904 (2011).","journal-title":"J. Virol."},{"key":"BFsrep07820_CR45","doi-asserted-by":"publisher","first-page":"438","DOI":"10.4049\/jimmunol.180.1.438","volume":"180","author":"S Guggemoos","year":"2008","unstructured":"Guggemoos, S. et al. TLR9 contributes to antiviral immunity during gammaherpesvirus infection. J. Immunol. 180, 438\u2013443 (2008).","journal-title":"J. Immunol."},{"key":"BFsrep07820_CR46","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1126\/science.1244040","volume":"341","author":"XD Li","year":"2013","unstructured":"Li, X. D. et al. Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science 341, 1390\u20131394 (2013).","journal-title":"Science"},{"key":"BFsrep07820_CR47","doi-asserted-by":"publisher","first-page":"e1002498","DOI":"10.1371\/journal.ppat.1002498","volume":"8","author":"GR Gariano","year":"2012","unstructured":"Gariano, G. R. et al. The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog. 8, e1002498 (2012).","journal-title":"PLoS Pathog."},{"key":"BFsrep07820_CR48","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.4049\/jimmunol.0802466","volume":"182","author":"AK Miyahira","year":"2009","unstructured":"Miyahira, A. K., Shahangian, A., Hwang, S., Sun, R. & Cheng, G. TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections. J. Immunol. 182, 2248\u20132257 (2009).","journal-title":"J. Immunol."},{"key":"BFsrep07820_CR49","doi-asserted-by":"publisher","first-page":"6832","DOI":"10.1128\/JVI.03460-13","volume":"88","author":"HR Kang","year":"2014","unstructured":"Kang, H. R. et al. Murine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon response. J. Virol. 88, 6832\u20136846 (2014).","journal-title":"J. Virol."},{"key":"BFsrep07820_CR50","doi-asserted-by":"publisher","first-page":"e1002292","DOI":"10.1371\/journal.ppat.1002292","volume":"7","author":"RS Leang","year":"2011","unstructured":"Leang, R. S. et al. The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. PLoS Pathog. 7, e1002292 (2011).","journal-title":"PLoS Pathog."},{"key":"BFsrep07820_CR51","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2010.04.018","volume":"141","author":"E Dixit","year":"2010","unstructured":"Dixit, E. et al. Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141, 668\u2013681 (2010).","journal-title":"Cell"},{"key":"BFsrep07820_CR52","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/ni.2475","volume":"14","author":"M Hasan","year":"2013","unstructured":"Hasan, M. et al. Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat. Immunol. 14, 61\u201371 (2013).","journal-title":"Nat. Immunol."},{"key":"BFsrep07820_CR53","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nature12862","volume":"505","author":"JW Schoggins","year":"2014","unstructured":"Schoggins, J. W. et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 505, 691\u2013695 (2014).","journal-title":"Nature"},{"key":"BFsrep07820_CR54","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.cellimm.2011.06.014","volume":"271","author":"J Lei","year":"2011","unstructured":"Lei, J. et al. Ligation of TLR2 and TLR4 on murine bone marrow-derived mesenchymal stem cells triggers differential effects on their immunosuppressive activity. Cell. Immunol. 271, 147\u2013156 (2011).","journal-title":"Cell. Immunol."},{"key":"BFsrep07820_CR55","doi-asserted-by":"publisher","first-page":"e1003697","DOI":"10.1371\/journal.ppat.1003697","volume":"9","author":"J Wang","year":"2013","unstructured":"Wang, J. et al. MicroRNA-155 promotes autophagy to eliminate intracellular mycobacteria by targeting Rheb. PLoS Pathog. 9, e1003697 (2013).","journal-title":"PLoS Pathog."},{"key":"BFsrep07820_CR56","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/infdis\/jiu002","volume":"210","author":"K Yang","year":"2014","unstructured":"Yang, K. et al. miR-155 suppresses bacterial clearance in Pseudomonas aeruginosa-induced keratitis by targeting Rheb. J. Infect. Dis. 210, 89\u201398 (2014).","journal-title":"J. Infect. Dis."},{"key":"BFsrep07820_CR57","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1128\/JVI.01717-08","volume":"83","author":"LM Gargano","year":"2009","unstructured":"Gargano, L. M., Forrest, J. C. & Speck, S. H. Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo. J. Virol. 83, 1474\u20131482 (2009).","journal-title":"J. Virol."},{"key":"BFsrep07820_CR58","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/nature07710","volume":"458","author":"T Fernandes-Alnemri","year":"2009","unstructured":"Fernandes-Alnemri, T., Yu, J. W., Datta, P., Wu, J. & Alnemri, E. S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509\u2013513 (2009).","journal-title":"Nature"},{"key":"BFsrep07820_CR59","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.chom.2008.12.013","volume":"5","author":"S Hwang","year":"2009","unstructured":"Hwang, S. et al. Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response. Cell Host Microbe 5, 166\u2013178 (2009).","journal-title":"Cell Host Microbe"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep07820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07820","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07820.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:17:56Z","timestamp":1672953476000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep07820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,7,15]]}},"alternative-id":["BFsrep07820"],"URL":"https:\/\/doi.org\/10.1038\/srep07820","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]},"assertion":[{"value":"17 October 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7820"}}