{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:28:51Z","timestamp":1791588531065,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep07822","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T10:12:53Z","timestamp":1421403173000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Implication of high risk Human papillomavirus HR-HPV infection in prostate cancer in Indian population- A pioneering case-control analysis"],"prefix":"10.1038","volume":"5","author":[{"given":"Neha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Showket","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Kakkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrawan K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranbir C.","family":"Sobti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mausumi","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"BFsrep07822_CR1","first-page":"397","volume":"11","author":"B Tyagi","year":"2010","unstructured":"Tyagi, B., Manoharan, N. & Raina, V. A case control study on prostate cancer in Delhi. Asian Pac J Cancer Prev 11, 397\u2013401 (2010).","journal-title":"Asian Pac J Cancer Prev"},{"key":"BFsrep07822_CR2","first-page":"141","volume":"9","author":"BB Yeole","year":"2008","unstructured":"Yeole, B. B. Trends in the prostate cancer incidence in India. Asian Pac J Cancer Prev 9, 141\u20134 (2008).","journal-title":"Asian Pac J Cancer Prev"},{"key":"BFsrep07822_CR3","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.eururo.2012.02.054","volume":"61","author":"MM Center","year":"2012","unstructured":"Center, M. M. et al. International variation in prostate cancer incidence and mortality rates. Eur Urol 61, 1079\u201392 (2012).","journal-title":"Eur Urol"},{"key":"BFsrep07822_CR4","first-page":"506","volume":"37","author":"ML Taylor","year":"2005","unstructured":"Taylor, M. L., Mainous, A. G. 3rd & Wells, B. J. Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med 37, 506\u201312 (2005).","journal-title":"Fam Med"},{"key":"BFsrep07822_CR5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.amepre.2009.03.007","volume":"37","author":"VL Shavers","year":"2009","unstructured":"Shavers, V. L., Underwood, W. & Moser, R. P. Race\/ethnicity and the perception of the risk of developing prostate cancer. Am J Prev Med 37, 64\u20137 (2009).","journal-title":"Am J Prev Med"},{"key":"BFsrep07822_CR6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/pros.10157","volume":"53","author":"A Zambrano","year":"2002","unstructured":"Zambrano, A., Kalantari, M., Simoneau, A., Jensen, J. L. & Villarreal, L. P. Detection of human polyomaviruses and papillomaviruses in prostatic tissue reveals the prostate as a habitat for multiple viral infections. Prostate 53, 263\u201376 (2002).","journal-title":"Prostate"},{"key":"BFsrep07822_CR7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1177\/039463200702000223","volume":"20","author":"D Fioriti","year":"2007","unstructured":"Fioriti, D. et al. A case of human polyomavirus Bk infection in a patient affected by late stage prostate cancer: could viral infection be correlated with cancer progression? Int J Immunopathol Pharmacol 20, 405\u201311 (2007).","journal-title":"Int J Immunopathol Pharmacol"},{"key":"BFsrep07822_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/pros.20710","volume":"68","author":"SD Kundu","year":"2008","unstructured":"Kundu, S. D. et al. The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells. Prostate 68, 223\u20139 (2008).","journal-title":"Prostate"},{"key":"BFsrep07822_CR9","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/bjc.2011.271","volume":"105","author":"S Sutcliffe","year":"2011","unstructured":"Sutcliffe, S. et al. Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration. Br J Cancer 105, 602\u20135 (2011).","journal-title":"Br J Cancer"},{"key":"BFsrep07822_CR10","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1111\/j.1365-4632.2004.02503.x","volume":"45","author":"JJ Wu","year":"2006","unstructured":"Wu, J. J., Huang, D. B., Pang, K. R. & Tyring, S. K. Cutaneous metastasis to the chest wall from prostate cancer. Int J Dermatol 45, 946\u20138 (2006).","journal-title":"Int J Dermatol"},{"key":"BFsrep07822_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s004280000234","volume":"437","author":"K Milde-Langosch","year":"2000","unstructured":"Milde-Langosch, K., Riethdorf, S. & Loning, T. Association of human papillomavirus infection with carcinoma of the cervix uteri and its precursor lesions: theoretical and practical implications. Virchows Arch 437, 227\u201333 (2000).","journal-title":"Virchows Arch"},{"key":"BFsrep07822_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1046\/j.1365-2613.2001.00177.x","volume":"82","author":"HR McMurray","year":"2001","unstructured":"McMurray, H. R., Nguyen, D., Westbrook, T. F. & McAnce, D. J. Biology of human papillomaviruses. Int J Exp Pathol 82, 15\u201333 (2001).","journal-title":"Int J Exp Pathol"},{"key":"BFsrep07822_CR13","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.1016\/j.vaccine.2008.03.056","volume":"26","author":"BC Das","year":"2008","unstructured":"Das, B. C., Hussain, S., Nasare, V. & Bharadwaj, M. Prospects and prejudices of human papillomavirus vaccines in India. Vaccine 26, 2669\u201379 (2008).","journal-title":"Vaccine"},{"key":"BFsrep07822_CR14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/carcin\/21.3.427","volume":"21","author":"BE Henderson","year":"2000","unstructured":"Henderson, B. E. & Feigelson, H. S. Hormonal carcinogenesis. Carcinogenesis 21, 427\u201333 (2000).","journal-title":"Carcinogenesis"},{"key":"BFsrep07822_CR15","first-page":"872","volume":"12","author":"HO Adami","year":"2003","unstructured":"Adami, H. O., Kuper, H., Andersson, S. O., Bergstrom, R. & Dillner, J. Prostate cancer risk and serologic evidence of human papilloma virus infection: a population-based case-control study. Cancer Epidemiol Biomarkers Prev 12, 872\u20135 (2003).","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"BFsrep07822_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3109\/00365548.2010.502904","volume":"43","author":"A Aghakhani","year":"2011","unstructured":"Aghakhani, A. et al. The role of human papillomavirus infection in prostate carcinoma. Scand J Infect Dis 43, 64\u20139 (2011).","journal-title":"Scand J Infect Dis"},{"key":"BFsrep07822_CR17","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s12253-010-9357-4","volume":"17","author":"AC Chen","year":"2011","unstructured":"Chen, A. C. et al. Human papillomavirus in benign prostatic hyperplasia and prostatic adenocarcinoma patients. Pathol Oncol Res 17, 613\u20137 (2011).","journal-title":"Pathol Oncol Res"},{"key":"BFsrep07822_CR18","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11845-011-0692-6","volume":"180","author":"Y Lin","year":"2011","unstructured":"Lin, Y. et al. Human papillomavirus 16 or 18 infection and prostate cancer risk: a meta-analysis. Ir J Med Sci 180, 497\u2013503 (2011).","journal-title":"Ir J Med Sci"},{"key":"BFsrep07822_CR19","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1159\/000277592","volume":"84","author":"R Nayyar","year":"2010","unstructured":"Nayyar, R., Sharma, N. & Gupta, N. P. Prognostic factors affecting progression and survival in metastatic prostate cancer. Urol Int 84, 159\u201363 (2010).","journal-title":"Urol Int"},{"key":"BFsrep07822_CR20","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.ygyno.2012.11.041","volume":"128","author":"N Singh","year":"2013","unstructured":"Singh, N. et al. Downregulation of tumor suppressor gene PML in uterine cervical carcinogenesis: impact of human papillomavirus infection (HPV). Gynecol Oncol 128, 420\u20136 (2013).","journal-title":"Gynecol Oncol"},{"key":"BFsrep07822_CR21","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s13402-011-0056-2","volume":"34","author":"RC Sobti","year":"2011","unstructured":"Sobti, R. C. et al. Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis. Cell Oncol (Dordr) 34, 533\u201343 (2011).","journal-title":"Cell Oncol (Dordr)"},{"key":"BFsrep07822_CR22","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1097\/01.pas.0000173646.99337.b1","volume":"29","author":"JI Epstein","year":"2005","unstructured":"Epstein, J. I., Allsbrook, W. C. Jr., Amin, M. B. & Egevad, L. L. The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol 29, 1228\u201342 (2005).","journal-title":"Am J Surg Pathol"},{"key":"BFsrep07822_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/modpathol.2010.159","volume":"24","author":"L Egevad","year":"2011","unstructured":"Egevad, L., Srigley, J. R. & Delahunt, B. International Society of Urological Pathology (ISUP) consensus conference on handling and staging of radical prostatectomy specimens: rationale and organization. Mod Pathol 24, 1\u20135 (2011).","journal-title":"Mod Pathol"},{"key":"BFsrep07822_CR24","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.mehy.2008.03.036","volume":"71","author":"AE Al Moustafa","year":"2008","unstructured":"Al Moustafa, A. E. Involvement of human papillomavirus infections in prostate cancer progression. Med Hypotheses 71, 209\u201311 (2008).","journal-title":"Med Hypotheses"},{"key":"BFsrep07822_CR25","first-page":"633","volume":"30","author":"FS Gazzaz","year":"2009","unstructured":"Gazzaz, F. S. & Mosli, H. A. Lack of detection of human papillomavirus infection by hybridization test in prostatic biopsies. Saudi Med J 30, 633\u20137 (2009).","journal-title":"Saudi Med J"},{"key":"BFsrep07822_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/1471-2407-9-329","volume":"9","author":"S Hussain","year":"2009","unstructured":"Hussain, S. et al. Transcription factor AP-1 in esophageal squamous cell carcinoma: alterations in activity and expression during human Papillomavirus infection. BMC Cancer 9, 329 (2009).","journal-title":"BMC Cancer"},{"key":"BFsrep07822_CR27","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/10799893.2011.553836","volume":"31","author":"S Hussain","year":"2011","unstructured":"Hussain, S. et al. Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valley. J Recept Signal Transduct Res 31, 147\u201356 (2011).","journal-title":"J Recept Signal Transduct Res"},{"key":"BFsrep07822_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/13547500902825274","volume":"14","author":"N Thakur","year":"2009","unstructured":"Thakur, N. et al. Genetic variant of CCND1: association with HPV-mediated cervical cancer in Indian population. Biomarkers 14, 219\u201325 (2009).","journal-title":"Biomarkers"},{"key":"BFsrep07822_CR29","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3109\/10799893.2012.733885","volume":"32","author":"N Singh","year":"2012","unstructured":"Singh, N. et al. Overexpression of signal transducer and activator of transcription (STAT-3 and STAT-5) transcription factors and alteration of suppressor of cytokine signaling (SOCS-1) protein in prostate cancer. J Recept Signal Transduct Res 32, 321\u20137 (2012).","journal-title":"J Recept Signal Transduct Res"},{"key":"BFsrep07822_CR30","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3109\/10799891003786218","volume":"30","author":"RC Sobti","year":"2010","unstructured":"Sobti, R. C. et al. Deregulation of STAT-5 isoforms in the development of HPV-mediated cervical carcinogenesis. J Recept Signal Transduct Res 30, 178\u201388 (2010).","journal-title":"J Recept Signal Transduct Res"},{"key":"BFsrep07822_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11010-009-0133-2","volume":"330","author":"RC Sobti","year":"2009","unstructured":"Sobti, R. C. et al. Overexpression of STAT3 in HPV-mediated cervical cancer in a north Indian population. Mol Cell Biochem 330, 193\u20139 (2009).","journal-title":"Mol Cell Biochem"},{"key":"BFsrep07822_CR32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0304-3835(95)04071-4","volume":"100","author":"Z Naghashfar","year":"1996","unstructured":"Naghashfar, Z., DiPaolo, J. A., Woodworth, C. D. & Passaniti, A. Immortalization of human adult prostatic adenocarcinoma cells by human papilloma virus HPV16 and \u221218 DNA. Cancer Lett 100, 47\u201354 (1996).","journal-title":"Cancer Lett"},{"key":"BFsrep07822_CR33","first-page":"5991","volume":"52","author":"K Anwar","year":"1992","unstructured":"Anwar, K. et al. Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas. Cancer Res 52, 5991\u20136 (1992).","journal-title":"Cancer Res"},{"key":"BFsrep07822_CR34","first-page":"73","volume":"49","author":"S Gherdovich","year":"1997","unstructured":"Gherdovich, S. et al. [Detection of the human papillomavirus in hyperplastic and cancerous prostatic tissue with PCR]. Minerva Urol Nefrol 49, 73\u20137 (1997).","journal-title":"Minerva Urol Nefrol"},{"key":"BFsrep07822_CR35","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1471-2490-5-15","volume":"5","author":"GJ Leiros","year":"2005","unstructured":"Leiros, G. J. et al. Detection of human papillomavirus DNA and p53 codon 72 polymorphism in prostate carcinomas of patients from Argentina. BMC Urol 5, 15 (2005).","journal-title":"BMC Urol"},{"key":"BFsrep07822_CR36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1177\/172460080401900401","volume":"19","author":"F Carozzi","year":"2004","unstructured":"Carozzi, F. et al. Association of human papillomavirus with prostate cancer: analysis of a consecutive series of prostate biopsies. Int J Biol Markers 19, 257\u201361 (2004).","journal-title":"Int J Biol Markers"},{"key":"BFsrep07822_CR37","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1590\/S0074-02762009000400024","volume":"104","author":"RV Silvestre","year":"2009","unstructured":"Silvestre, R. V. et al. Low frequency of human papillomavirus detection in prostate tissue from individuals from Northern Brazil. Mem Inst Oswaldo Cruz 104, 665\u20137 (2009).","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"BFsrep07822_CR38","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/S0090-4295(94)80215-7","volume":"44","author":"H Tu","year":"1994","unstructured":"Tu, H., Jacobs, S. C., Mergner, W. J. & Kyprianou, N. Rare incidence of human papillomavirus types 16 and 18 in primary and metastatic human prostate cancer. Urology 44, 726\u201331 (1994).","journal-title":"Urology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep07822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07822","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep07822.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T21:17:53Z","timestamp":1672953473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep07822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,7,15]]}},"alternative-id":["BFsrep07822"],"URL":"https:\/\/doi.org\/10.1038\/srep07822","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]},"assertion":[{"value":"30 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"7822"}}