{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:24:51Z","timestamp":1791192291344,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T00:00:00Z","timestamp":1422835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/srep08148","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T10:29:19Z","timestamp":1422872959000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients"],"prefix":"10.1038","volume":"5","author":[{"given":"Shiou-Lan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Yu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hsuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Heng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsien","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen Kuang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jau-Shyong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Band","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"BFsrep08148_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0376-8716(02)00013-3","volume":"67","author":"MZ Mintzer","year":"2002","unstructured":"Mintzer, M. Z. & Stitzer, M. L. Cognitive impairment in methadone maintenance patients. Drug Alcohol Depend 67, 41\u201351 (2002).","journal-title":"Drug Alcohol Depend"},{"key":"BFsrep08148_CR2","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.drugalcdep.2009.04.022","volume":"104","author":"J Prosser","year":"2009","unstructured":"Prosser, J., London, E. D. & Galynker, I. I. Sustained attention in patients receiving and abstinent following methadone maintenance treatment for opiate dependence: performance and neuroimaging results. Drug Alcohol Depend 104, 228\u2013240, 10.1016\/j.drugalcdep.2009.04.022 (2009).","journal-title":"Drug Alcohol Depend"},{"key":"BFsrep08148_CR3","doi-asserted-by":"publisher","first-page":"5058","DOI":"10.1523\/JNEUROSCI.0148-10.2010","volume":"30","author":"G Lu","year":"2010","unstructured":"Lu, G. et al. Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors. J Neurosci 30, 5058\u20135070, 10.1523\/JNEUROSCI.0148-10.2010 (2010).","journal-title":"J Neurosci"},{"key":"BFsrep08148_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrn1078","volume":"4","author":"MV Chao","year":"2003","unstructured":"Chao, M. V. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4, 299\u2013309, 10.1038\/nrn1078 (2003).","journal-title":"Nat Rev Neurosci"},{"key":"BFsrep08148_CR5","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/j.1749-6632.1991.tb00196.x","volume":"640","author":"H Thoenen","year":"1991","unstructured":"Thoenen, H., Zafra, F., Hengerer, B. & Lindholm, D. The synthesis of nerve growth factor and brain-derived neurotrophic factor in hippocampal and cortical neurons is regulated by specific transmitter systems. Ann N Y Acad Sci 640, 86\u201390 (1991).","journal-title":"Ann N Y Acad Sci"},{"key":"BFsrep08148_CR6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/0896-6273(90)90166-D","volume":"5","author":"RF Alderson","year":"1990","unstructured":"Alderson, R. F., Alterman, A. L., Barde, Y. A. & Lindsay, R. M. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 5, 297\u2013306 (1990).","journal-title":"Neuron"},{"key":"BFsrep08148_CR7","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.pnpbp.2014.01.012","volume":"51","author":"SL Chen","year":"2014","unstructured":"Chen, S. L. et al. The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese patients with bipolar disorder and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 51, 99\u2013104, 10.1016\/j.pnpbp.2014.01.012 (2014).","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFsrep08148_CR8","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s11481-011-9337-9","volume":"7","author":"SL Chen","year":"2012","unstructured":"Chen, S. L. et al. Low-dose memantine attenuated morphine addictive behavior through its anti-inflammation and neurotrophic effects in rats. J Neuroimmune Pharmacol 7, 444\u2013453, 10.1007\/s11481-011-9337-9 (2012).","journal-title":"J Neuroimmune Pharmacol"},{"key":"BFsrep08148_CR9","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1177\/0269881107078491","volume":"21","author":"F Angelucci","year":"2007","unstructured":"Angelucci, F. et al. Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor. J Psychopharmacol 21, 820\u2013825 (2007).","journal-title":"J Psychopharmacol"},{"key":"BFsrep08148_CR10","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1177\/0269881111411332","volume":"25","author":"A Heberlein","year":"2011","unstructured":"Heberlein, A. et al. Serum levels of BDNF are associated with craving in opiate-dependent patients. J Psychopharmacol 25, 1480\u20131484, 10.1177\/0269881111411332 (2011).","journal-title":"J Psychopharmacol"},{"key":"BFsrep08148_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.neulet.2014.04.048","volume":"571","author":"J Zhang","year":"2014","unstructured":"Zhang, J. et al. Increased serum brain-derived neurotrophic factor levels during opiate withdrawal. Neurosci Lett 571, 61\u201365, 10.1016\/j.neulet.2014.04.048 (2014).","journal-title":"Neurosci Lett"},{"key":"BFsrep08148_CR12","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1126\/science.1168501","volume":"324","author":"H Vargas-Perez","year":"2009","unstructured":"Vargas-Perez, H. et al. Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats. Science 324, 1732\u20131734, 10.1126\/science.1168501 (2009).","journal-title":"Science"},{"key":"BFsrep08148_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.molbrainres.2005.07.008","volume":"140","author":"CY Cheng","year":"2005","unstructured":"Cheng, C. Y. et al. Brain-derived neurotrophic factor (Val66Met) genetic polymorphism is associated with substance abuse in males. Brain Res Mol Brain Res 140, 86\u201390 (2005).","journal-title":"Brain Res Mol Brain Res"},{"key":"BFsrep08148_CR14","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.biopsych.2006.08.025","volume":"61","author":"M Gratacos","year":"2007","unstructured":"Gratacos, M. et al. Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders and schizophrenia. Biol Psychiatry 61, 911\u2013922 (2007).","journal-title":"Biol Psychiatry"},{"key":"BFsrep08148_CR15","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1111\/j.1369-1600.2011.00431.x","volume":"18","author":"MK Greenwald","year":"2013","unstructured":"Greenwald, M. K., Steinmiller, C. L., Sliwerska, E., Lundahl, L. & Burmeister, M. BDNF Val(66)Met genotype is associated with drug-seeking phenotypes in heroin-dependent individuals: a pilot study. Addict Biol 18, 836\u2013845, 10.1111\/j.1369-1600.2011.00431.x (2013).","journal-title":"Addict Biol"},{"key":"BFsrep08148_CR16","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.2217\/pgs.13.217","volume":"14","author":"BS Haerian","year":"2013","unstructured":"Haerian, B. S. BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis. Pharmacogenomics 14, 2055\u20132065, 10.2217\/pgs.13.217 (2013).","journal-title":"Pharmacogenomics"},{"key":"BFsrep08148_CR17","unstructured":"G-power: A Priori, Post Hoc and Compromise Power Analyses for the Macintosh, v. Version 2.1.1. (University of Trier, Trier, Germany, 1996)."},{"key":"BFsrep08148_CR18","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1055\/s-0037-1613072","volume":"87","author":"H Fujimura","year":"2002","unstructured":"Fujimura, H. et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 87, 728\u2013734 (2002).","journal-title":"Thromb Haemost"},{"key":"BFsrep08148_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0014-5793(00)01302-8","volume":"470","author":"T Nakahashi","year":"2000","unstructured":"Nakahashi, T. et al. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 470, 113\u2013117 (2000).","journal-title":"FEBS Lett"},{"key":"BFsrep08148_CR20","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1084\/jem.189.5.865","volume":"189","author":"M Kerschensteiner","year":"1999","unstructured":"Kerschensteiner, M. et al. Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189, 865\u2013870 (1999).","journal-title":"J Exp Med"},{"key":"BFsrep08148_CR21","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1016\/S0028-3908(98)00141-5","volume":"37","author":"W Pan","year":"1998","unstructured":"Pan, W., Banks, W. A., Fasold, M. B., Bluth, J. & Kastin, A. J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37, 1553\u20131561 (1998).","journal-title":"Neuropharmacology"},{"key":"BFsrep08148_CR22","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0304-3940(02)00529-3","volume":"328","author":"F Karege","year":"2002","unstructured":"Karege, F., Schwald, M. & Cisse, M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328, 261\u2013264 (2002).","journal-title":"Neurosci Lett"},{"key":"BFsrep08148_CR23","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1006\/dbio.1994.1250","volume":"165","author":"K Mizuno","year":"1994","unstructured":"Mizuno, K., Carnahan, J. & Nawa, H. Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. Dev Biol 165, 243\u2013256 (1994).","journal-title":"Dev Biol"},{"key":"BFsrep08148_CR24","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2174\/157015909790031210","volume":"7","author":"K Ohira","year":"2009","unstructured":"Ohira, K. & Hayashi, M. A New Aspect of the TrkB Signaling Pathway in Neural Plasticity. Curr Neuropharmacol 7, 276\u2013285 (2009).","journal-title":"Curr Neuropharmacol"},{"key":"BFsrep08148_CR25","doi-asserted-by":"publisher","first-page":"e35217","DOI":"10.1371\/journal.pone.0035217","volume":"7","author":"I Driscoll","year":"2012","unstructured":"Driscoll, I. et al. Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults. PLoS One 7, e35217, 10.1371\/journal.pone.0035217 (2012).","journal-title":"PLoS One"},{"key":"BFsrep08148_CR26","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s00702-005-0397-y","volume":"113","author":"C Laske","year":"2006","unstructured":"Laske, C. et al. Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm 113, 1217\u20131224 (2006).","journal-title":"J Neural Transm"},{"key":"BFsrep08148_CR27","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12017-011-8154-x","volume":"13","author":"BS Diniz","year":"2011","unstructured":"Diniz, B. S. & Teixeira, A. L. Brain-derived neurotrophic factor and Alzheimer's disease: physiopathology and beyond. Neuromolecular Med 13, 217\u2013222, 10.1007\/s12017-011-8154-x (2011).","journal-title":"Neuromolecular Med"},{"key":"BFsrep08148_CR28","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.pnpbp.2013.12.001","volume":"50","author":"J Platenik","year":"2014","unstructured":"Platenik, J. et al. GSK3beta, CREB and BDNF in peripheral blood of patients with Alzheimer's disease and depression. Prog Neuropsychopharmacol Biol Psychiatry 50, 83\u201393, 10.1016\/j.pnpbp.2013.12.001 (2014).","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"BFsrep08148_CR29","doi-asserted-by":"publisher","first-page":"e39358","DOI":"10.1371\/journal.pone.0039358","volume":"7","author":"A Pillai","year":"2012","unstructured":"Pillai, A. et al. Plasma BDNF levels vary in relation to body weight in females. PLoS One 7, e39358, 10.1371\/journal.pone.0039358 (2012).","journal-title":"PLoS One"},{"key":"BFsrep08148_CR30","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.brainres.2008.01.020","volume":"1198","author":"LM Schrott","year":"2008","unstructured":"Schrott, L. M., Franklin, L. M. & Serrano, P. A. Prenatal opiate exposure impairs radial arm maze performance and reduces levels of BDNF precursor following training. Brain Res 1198, 132\u2013140 (2008).","journal-title":"Brain Res"},{"key":"BFsrep08148_CR31","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nrn3119","volume":"12","author":"RZ Goldstein","year":"2011","unstructured":"Goldstein, R. Z. & Volkow, N. D. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci 12, 652\u2013669, 10.1038\/nrn3119 (2011).","journal-title":"Nat Rev Neurosci"},{"key":"BFsrep08148_CR32","doi-asserted-by":"publisher","first-page":"11202","DOI":"10.1073\/pnas.93.20.11202","volume":"93","author":"L Sklair-Tavron","year":"1996","unstructured":"Sklair-Tavron, L. et al. Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons. Proc Natl Acad Sci U S A 93, 11202\u201311207 (1996).","journal-title":"Proc Natl Acad Sci U S A"},{"key":"BFsrep08148_CR33","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1080\/00207450590956549","volume":"115","author":"L Li","year":"2005","unstructured":"Li, L. et al. Postmortem changes in the central nervous system and adrenal medulla of the heroin addicts. Int J Neurosci 115, 1443\u20131449, 10.1080\/00207450590956549 (2005).","journal-title":"Int J Neurosci"},{"key":"BFsrep08148_CR34","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.neulet.2011.03.072","volume":"495","author":"W Jia","year":"2011","unstructured":"Jia, W. et al. Polymorphisms of brain-derived neurotrophic factor associated with heroin dependence. Neurosci Lett 495, 221\u2013224, 10.1016\/j.neulet.2011.03.072 (2011).","journal-title":"Neurosci Lett"},{"key":"BFsrep08148_CR35","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/0888-7543(91)90436-I","volume":"10","author":"PC Maisonpierre","year":"1991","unstructured":"Maisonpierre, P. C. et al. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions and chromosomal localizations. Genomics 10, 558\u2013568 (1991).","journal-title":"Genomics"},{"key":"BFsrep08148_CR36","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0092-8674(03)00035-7","volume":"112","author":"MF Egan","year":"2003","unstructured":"Egan, M. F. et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257\u2013269 (2003).","journal-title":"Cell"},{"key":"BFsrep08148_CR37","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1097\/01.ALC.0000117832.62901.61","volume":"28","author":"SY Huang","year":"2004","unstructured":"Huang, S. Y. et al. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. Alcohol Clin Exp Res 28, 374\u2013384 (2004).","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep08148","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep08148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep08148.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:44:49Z","timestamp":1672965889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep08148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,2]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,7,15]]}},"alternative-id":["BFsrep08148"],"URL":"https:\/\/doi.org\/10.1038\/srep08148","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,2]]},"assertion":[{"value":"5 August 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8148"}}