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Previously we showed that Rcs phosphorelay negatively regulates transcription of <jats:italic>hmsT<\/jats:italic> in <jats:italic>Y<\/jats:italic>. <jats:italic>pestis<\/jats:italic> and its ancestor <jats:italic>Yersinia pseudotuberculosis<\/jats:italic>. In this study, we show that Rcs positively regulates <jats:italic>hmsCDE<\/jats:italic> operon (encoding HmsD) in <jats:italic>Y<\/jats:italic>. <jats:italic>pestis<\/jats:italic>; while in the presence of functional <jats:italic>rcsA<\/jats:italic>, Rcs represses <jats:italic>hmsCDE<\/jats:italic> operon in <jats:italic>Y<\/jats:italic>. <jats:italic>pseudotuberculosis<\/jats:italic>. Loss of <jats:italic>rcsA<\/jats:italic>'s function in <jats:italic>Y<\/jats:italic>. <jats:italic>pestis<\/jats:italic> not only causes derepression of <jats:italic>hmsT<\/jats:italic> but also causes activation of <jats:italic>hmsD<\/jats:italic>, which may account for the increased biofilm formation in <jats:italic>Y<\/jats:italic>. <jats:italic>pestis<\/jats:italic>. In addition, differential regulation of the two DGCs, HmsT and HmsD by Rcs may help <jats:italic>Y<\/jats:italic>. <jats:italic>pestis<\/jats:italic> to adapt to different environment.<\/jats:p>","DOI":"10.1038\/srep08412","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T10:04:44Z","timestamp":1423735484000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Differential regulation of the hmsCDE operon in Yersinia pestis and Yersinia pseudotuberculosis by the Rcs phosphorelay system"],"prefix":"10.1038","volume":"5","author":[{"given":"Xiao-Peng","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gai-Xian","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Jian","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Cheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"BFsrep08412_CR1","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.mib.2012.02.003","volume":"15","author":"I Chouikha","year":"2012","unstructured":"Chouikha, I. & Hinnebusch, B. 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