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We propose a method for drug repositioning that uses the clinical signatures extracted from over 13 years of electronic medical records from a tertiary hospital, including &gt;9.4\u2005M laboratory tests from &gt;530,000 patients, in addition to diverse genomics signatures. Cross-validation using over 17,000 known drug\u2013disease associations shows this approach outperforms various predictive models based on genomics signatures and a well-known \u201cguilt-by-association\u201d method. Interestingly, the prediction suggests that terbutaline sulfate, which is widely used for asthma, is a promising candidate for amyotrophic lateral sclerosis for which there are few therapeutic options. <jats:italic>In vivo<\/jats:italic> tests using zebrafish models found that terbutaline sulfate prevents defects in axons and neuromuscular junction degeneration in a dose-dependent manner. A therapeutic potential of terbutaline sulfate was also observed when axonal and neuromuscular junction degeneration have already occurred in zebrafish model. Cotreatment with a \u03b2<jats:sub>2<\/jats:sub>-adrenergic receptor antagonist, butoxamine, suggests that the effect of terbutaline is mediated by activation of \u03b2<jats:sub>2<\/jats:sub>-adrenergic receptors.<\/jats:p>","DOI":"10.1038\/srep08580","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T12:47:55Z","timestamp":1425559675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records"],"prefix":"10.1038","volume":"5","author":[{"given":"Hyojung","family":"Paik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah-Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Chul","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rae Woong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungho","family":"Suk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyosil","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KiYoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul J.","family":"Butte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"BFsrep08580_CR1","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1093\/bib\/bbr013","volume":"12","author":"JT Dudley","year":"2011","unstructured":"Dudley, J. 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