{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:36:23Z","timestamp":1767152183557,"version":"build-2238731810"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mirror neuron system(MNS) based therapy has been employed to treat stroke induced movement disorders. However, its potential effects on patients with hemispatial neglect were uninvestigated. The present study set out to test the therapeutic efficiency of video watching of series of hand actions\/movements (protocol A) in two patients with left hemispatial neglect, due to the right hemisphere stroke. The video containing dynamic landscape of natural scene or cities but not human\/animals was used as the protocol B. The \u201cABA\u201d training procedure for 3 weeks therefore allows us to internally control the individual differences. Before and after each week of training, the Chinese behavioral inattention test- Hongkong version (CBIT-HK) was implemented to evaluate the hemispatial neglect severity. Functional magnetic resonance imaging (fMRI) experiment was implemented in two health subjects to reveal the difference of brain activation between protocol A and B. The results showed that protocol A rather than protocol B significantly improved the CBIT-HK scores at first and third weeks, respectively. Protocol A induced more bilateral activations including right inferior parietal lobe (supramarginal gyrus), which belongs to MNS and is also critical region resulting to hemineglect. Conclusion: MNS activation can provide a novel therapy for hemispatial neglect patients.<\/jats:p>","DOI":"10.1038\/srep08664","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T05:16:27Z","timestamp":1425273387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Mirror neuron therapy for hemispatial neglect patients"],"prefix":"10.1038","volume":"5","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangtong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti-Fei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlei","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"BFsrep08664_CR1","first-page":"13","volume":"75","author":"A Parton","year":"2004","unstructured":"Parton, A., Malhotra, P. & Husain, M. Hemispatial neglect. J Neurol Neurosurg Psychiatry 75, 13\u201321 (2004).","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"BFsrep08664_CR2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1093\/ageing\/22.1.46","volume":"22","author":"SP Stone","year":"1993","unstructured":"Stone, S. P., Halligan, P. W. & Greenwood, R. J. The incidence of neglect phenomena and related disorders in patients with an acute right or left hemisphere stroke. Age Ageing 22, 46\u201352 (1993).","journal-title":"Age Ageing"},{"key":"BFsrep08664_CR3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1097\/00002060-199703000-00007","volume":"76","author":"PM Pedersen","year":"1997","unstructured":"Pedersen, P. M., Jorgensen, H. S., Nakayama, H., Raaschou, H. O. & Olsen, T. S. Hemineglect in acute stroke--incidence and prognostic implications. The Copenhagen Stroke Study. Am J Phys Med Rehabil 76, 122\u2013127 (1997).","journal-title":"Am J Phys Med Rehabil"},{"key":"BFsrep08664_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1212\/01.WNL.0000133011.10689.CE","volume":"63","author":"JM Ringman","year":"2004","unstructured":"Ringman, J. M., Saver, J. L., Woolson, R. F., Clarke, W. R. & Adams, H. P. Frequency, risk factors, anatomy and course of unilateral neglect in an acute stroke cohort. Neurology 63, 468\u2013474 (2004).","journal-title":"Neurology"},{"key":"BFsrep08664_CR5","doi-asserted-by":"publisher","first-page":"S52","DOI":"10.1006\/nimg.2001.0822","volume":"14","author":"G Vallar","year":"2001","unstructured":"Vallar, G. Extrapersonal visual unilateral spatial neglect and its neuroanatomy. Neuroimage 14, S52\u201358, 10.1006\/nimg.2001.0822 (2001).","journal-title":"Neuroimage"},{"key":"BFsrep08664_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S1364-6613(03)00032-9","volume":"7","author":"PW Halligan","year":"2003","unstructured":"Halligan, P. W., Fink, G. R., Marshall, J. C. & Vallar, G. Spatial cognition: evidence from visual neglect. Trends Cogn Sci 7, 125\u2013133 (2003).","journal-title":"Trends Cogn Sci"},{"key":"BFsrep08664_CR7","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1093\/brain\/awg200","volume":"126","author":"DJ Mort","year":"2003","unstructured":"Mort, D. J. et al. The anatomy of visual neglect. Brain 126, 1986\u20131997, 10.1093\/brain\/awg200 (2003).","journal-title":"Brain"},{"key":"BFsrep08664_CR8","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/j.apmr.2011.03.018","volume":"92","author":"M Di Monaco","year":"2011","unstructured":"Di Monaco, M. et al. Severity of unilateral spatial neglect is an independent predictor of functional outcome after acute inpatient rehabilitation in individuals with right hemispheric stroke. Arch Phys Med Rehabil 92, 1250\u20131256, 10.1016\/j.apmr.2011.03.018 (2011).","journal-title":"Arch Phys Med Rehabil"},{"key":"BFsrep08664_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev.neuro.27.070203.144230","volume":"27","author":"G Rizzolatti","year":"2004","unstructured":"Rizzolatti, G. & Craighero, L. The mirror-neuron system. Annu Rev Neurosci 27, 169\u2013192, 10.1146\/annurev.neuro.27.070203.144230 (2004).","journal-title":"Annu Rev Neurosci"},{"key":"BFsrep08664_CR10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/dev.20504","volume":"54","author":"SL Small","year":"2012","unstructured":"Small, S. L., Buccino, G. & Solodkin, A. The mirror neuron system and treatment of stroke. Dev Psychobiol 54, 293\u2013310, 10.1002\/dev.20504 (2012).","journal-title":"Dev Psychobiol"},{"key":"BFsrep08664_CR11","first-page":"313","volume":"48","author":"P Sale","year":"2012","unstructured":"Sale, P. & Franceschini, M. Action observation and mirror neuron network: a tool for motor stroke rehabilitation. Eur J Phys Rehabil Med 48, 313\u2013318 (2012).","journal-title":"Eur J Phys Rehabil Med"},{"key":"BFsrep08664_CR12","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nrneurol.2013.222","volume":"9","author":"SL Small","year":"2013","unstructured":"Small, S. L., Buccino, G. & Solodkin, A. Brain repair after stroke--a novel neurological model. Nat Rev Neurol 9, 698\u2013707, 10.1038\/nrneurol.2013.222 (2013).","journal-title":"Nat Rev Neurol"},{"key":"BFsrep08664_CR13","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2340\/16501977-0020","volume":"39","author":"S de Vries","year":"2007","unstructured":"de Vries, S. & Mulder, T. Motor imagery and stroke rehabilitation: a critical discussion. J Rehabil Med 39, 5\u201313, 10.2340\/16501977-0020 (2007).","journal-title":"J Rehabil Med"},{"key":"BFsrep08664_CR14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1002\/ana.21198","volume":"62","author":"M Iacoboni","year":"2007","unstructured":"Iacoboni, M. & Mazziotta, J. C. Mirror neuron system: basic findings and clinical applications. Ann Neurol 62, 213\u2013218, 10.1002\/ana.21198 (2007).","journal-title":"Ann Neurol"},{"key":"BFsrep08664_CR15","doi-asserted-by":"publisher","first-page":"e38610","DOI":"10.1371\/journal.pone.0038610","volume":"7","author":"P Marangolo","year":"2012","unstructured":"Marangolo, P., Cipollari, S., Fiori, V., Razzano, C. & Caltagirone, C. Walking but not barking improves verb recovery: implications for action observation treatment in aphasia rehabilitation. PLoS One 7, e38610, 10.1371\/journal.pone.0038610 (2012).","journal-title":"PLoS One"},{"key":"BFsrep08664_CR16","doi-asserted-by":"publisher","first-page":"3824","DOI":"10.1016\/j.neuropsychologia.2010.09.025","volume":"48","author":"P Marangolo","year":"2010","unstructured":"Marangolo, P. et al. Improving language without words: first evidence from aphasia. Neuropsychologia 48, 3824\u20133833, 10.1016\/j.neuropsychologia.2010.09.025 (2010).","journal-title":"Neuropsychologia"}],"updated-by":[{"DOI":"10.1038\/srep12654","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep08664","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep08664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep08664.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:57:17Z","timestamp":1672919837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep08664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,2]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,8,14]]}},"alternative-id":["BFsrep08664"],"URL":"https:\/\/doi.org\/10.1038\/srep08664","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,2]]},"assertion":[{"value":"12 October 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2015","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8664"}}