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In this study, we aim to answer a critical question: How much high spatial frequency information is available to the amblyopic visual system? We measured the tilt after-effect following adaption to perceptually resolvable and unresolvable sinewave gratings and showed that gratings with spatial frequency up to 1.5 times the cutoff frequency in grating orientation identification can still produce significant tilt after-effects in adults with amblyopia. Our results suggest that neural connections in the amblyopic visual cortex, at least in V1, may have profoundly developed to represent high spatial frequency information. The demonstration of extant neural connections for high spatial frequencies may have important implications for the development of training protocols for amblyopia treatment. Our paradigm may also serve as a non-invasive probe to diagnose the status of neural connections in other visual deficits.<\/jats:p>","DOI":"10.1038\/srep08728","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T10:19:29Z","timestamp":1425464369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tilt after-effect from high spatial-frequency patterns in the amblyopic eye of adults with anisometropic amblyopia"],"prefix":"10.1038","volume":"5","author":[{"given":"Jiawei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Bing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"BFsrep08728_CR1","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1113\/jphysiol.1970.sp009022","volume":"206","author":"DH Hubel","year":"1970","unstructured":"Hubel, D. 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