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Here we aimed to test whether chronic infusion of Ang-(1\u20137) can dose-dependently ameliorate left ventricular remodeling and function in a rat model of diabetic cardiomyopathy and whether the combination of Ang-(1\u20137) and Ang-converting enzyme inhibition may be superior to single therapy. Our results showed that Ang-(1\u20137) treatment dose-dependently ameliorated left ventricular remodeling and dysfunction in diabetic rats by attenuating myocardial fibrosis, myocardial hypertrophy and myocyte apoptosis via both the Mas receptor and angiotensin II type 2 receptor. Furthermore, combining Ang-(1\u20137) with perindopril provided additional cardioprotection relative to single therapy. Ang-(1\u20137) administration provides a novel and promising approach for treatment of diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1038\/srep08794","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T10:15:47Z","timestamp":1425550547000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Combination of angiotensin-(1\u20137) with perindopril is better than single therapy in ameliorating diabetic cardiomyopathy"],"prefix":"10.1038","volume":"5","author":[{"given":"Panpan","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuguo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"BFsrep08794_CR1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1161\/01.RES.0000207406.94146.c2","volume":"98","author":"IG Poornima","year":"2006","unstructured":"Poornima, I. 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