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Current methods for vocal analysis suffer from a lack of standardization, creating ambiguity in cross-laboratory and cross-species comparisons. Here, we present VoICE (Vocal Inventory Clustering Engine), an approach to grouping vocal elements by creating a high dimensionality dataset through scoring spectral similarity between all vocalizations within a recording session. This dataset is then subjected to hierarchical clustering, generating a dendrogram that is pruned into meaningful vocalization \u201ctypes\u201d by an automated algorithm. When applied to birdsong, a key model for vocal learning, VoICE captures the known deterioration in acoustic properties that follows deafening, including altered sequencing. In a mammalian neurodevelopmental model, we uncover a reduced vocal repertoire of mice lacking the autism susceptibility gene,<jats:italic>Cntnap2.<\/jats:italic>VoICE will be useful to the scientific community as it can standardize vocalization analyses across species and laboratories.<\/jats:p>","DOI":"10.1038\/srep10237","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T12:29:02Z","timestamp":1432816142000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["VoICE: A semi-automated pipeline for standardizing vocal analysis across models"],"prefix":"10.1038","volume":"5","author":[{"given":"Zachary D.","family":"Burkett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy F.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pe\u00f1agarikano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H.","family":"Geschwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,28]]},"reference":[{"key":"BFsrep10237_CR1","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1146\/annurev.neuro.22.1.567","volume":"22","author":"AJ Doupe","year":"1999","unstructured":"Doupe, A. 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