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Neuroinflammation has been recognized to play an important role in the pathogenesis of various diseases in the central nervous system. Here we investigated the anti-nociceptive and anti-neuroinflammatory effect of curcumin on arthritic pain in rats. We found that repeated oral treatment with curcumin, either before or after complete Freund\u2019s adjuvant (CFA) injection, dose-dependently attenuated CFA-induced mechanical allodynia and thermal hyperalgesia, but had no effect on joint edema. Repeated intrathecal injection of curcumin reversed CFA-induced pain hypersensitivity. Furthermore, such a curcumin treatment reduced CFA-induced activation of glial cells and production of inflammatory mediators [interleukin-1\u03b2 (IL-1\u03b2), monocyte chemoattractant protein-1 (MCP-1) and monocyte inflammatory protein-1 (MIP-1\u03b1)] in the spinal cord. Curcumin also decreased lipopolysaccharide-induced production of IL-1\u03b2, tumor necrosis factor-\u03b1, MCP-1 and MIP-1\u03b1 in cultured astrocytes and microglia. Our results suggest that intrathecal curcumin attenuates arthritic pain by inhibiting glial activation and the production of inflammatory mediators in the spinal cord, suggesting a new application of curcumin for the treatment of arthritic pain.<\/jats:p>","DOI":"10.1038\/srep10278","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T16:37:57Z","timestamp":1432053477000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Intrathecal curcumin attenuates pain hypersensitivity and decreases spinal neuroinflammation in rat model of monoarthritis"],"prefix":"10.1038","volume":"5","author":[{"given":"Jun-Jie","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"BFsrep10278_CR1","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.lfs.2005.12.007","volume":"78","author":"RK Maheshwari","year":"2006","unstructured":"Maheshwari, R. 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