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However, the precise molecular mechanisms underlying these selection machineries, including the involvement of antigen receptor signaling molecules, remain to be elucidated. We found that expression levels of Ig\u03b1 and Ig\u03b2, which are the essential components of B cell antigen-receptor complex, were differentially regulated in GC B cells and that the expression of Ig\u03b2 was more prominently down-regulated in a portion of GC B cells. The suppression of Ig\u03b2 down-regulation reduced the number of GL7<jats:sup>+<\/jats:sup>GC B cells and the affinity maturation in T-dependent responses was markedly impaired. In addition, the disease phenotypes in autoimmune-prone mice were ameliorated by blocking of Ig\u03b2 down-regulation. These results suggest that Ig\u03b2 down-regulation is involved in the normal positive selection in GC and the accumulation of autoreactive B cells in autoimmune-prone mice.<\/jats:p>","DOI":"10.1038\/srep10303","type":"journal-article","created":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T12:47:19Z","timestamp":1431953239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modulation of Ig\u03b2 is essential for the B cell selection in germinal center"],"prefix":"10.1038","volume":"5","author":[{"given":"Kagefumi","family":"Todo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orie","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miwako","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Hikida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,18]]},"reference":[{"key":"BFsrep10303_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev.iy.10.040192.000525","volume":"10","author":"M Reth","year":"1992","unstructured":"Reth, M. 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