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We have developed a framework that can automatically detect three types of leakage (large focal, punctate focal and vessel segment leakage) and validated it on images from patients with malarial retinopathy. This framework comprises three steps: vessel segmentation, saliency feature generation and leakage detection. We tested the effectiveness of this framework by applying it to images from 20 patients with large focal leak, 10 patients with punctate focal leak and 5,846 vessel segments from 10 patients with vessel leakage. The sensitivity in detecting large focal, punctate focal and vessel segment leakage are 95%, 82% and 81%, respectively, when compared to manual annotation by expert human observers. Our framework has the potential to become a powerful new tool for studying malarial retinopathy and other conditions involving retinal leakage.<\/jats:p>","DOI":"10.1038\/srep10425","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T19:30:34Z","timestamp":1433187034000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Automated Detection of Leakage in Fluorescein Angiography Images with Application to Malarial Retinopathy"],"prefix":"10.1038","volume":"5","author":[{"given":"Yitian","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"J. C. MacCormick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"G. 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