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The objective of this study was to examine acquired and innate vagal mechanisms that protect against physical challenges and haemorrhages in 19 athletes and 61 non-athletes. These include examining change in heart rate variability (HF-HRV; an indicator of vagus activity) in response to orthostatic challenge, platelet count (PLT), mean platelet volume (MPV) and single-nucleotide polymorphisms in genes that encode several coagulation factors, PAI-1 and MTHFR. Individual differences in PLT and MPV were significant predictors, with opposite effects, of the profiles of the HF-HRV changes in response to orthostasis. Regular physical training of athletes indirectly (through MPV) modifies the genetic predisposing effects of some haemostatic factors (PAI-1 and MTHFR) on vagal tone and reactivity. Individual differences in vagal tone were also associated with relationships between <jats:italic>Factor 12 C46T<\/jats:italic> and <jats:italic>Factor 11 C22771T<\/jats:italic> genes polymorphisms. 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Its potential significance is promoting advanced protection against haemorrhages in a variety of traumas and injuries, especially in individuals with coagulation deficits.<\/jats:p>","DOI":"10.1038\/srep10703","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T14:27:47Z","timestamp":1432909667000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Resilience to orthostasis and haemorrhage: A pilot study of common genetic and conditioning mechanisms"],"prefix":"10.1038","volume":"5","author":[{"given":"Dmitry M.","family":"Davydov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renad I.","family":"Zhdanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir G.","family":"Dvoenosov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga A.","family":"Kravtsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena N.","family":"Voronina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim L.","family":"Filipenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,29]]},"reference":[{"key":"BFsrep10703_CR1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.cpr.2010.03.003","volume":"30","author":"DM Davydov","year":"2010","unstructured":"Davydov, D. 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