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However, little is known about the alterations in <jats:italic>B. microti<\/jats:italic> invaded red blood cells (<jats:italic>Bm<\/jats:italic>-RBCs) at the individual cell level. Through quantitative phase imaging techniques based on laser interferometry, we present the simultaneous measurements of structural, chemical and mechanical modifications in individual mouse <jats:italic>Bm<\/jats:italic>-RBCs. 3-D refractive index maps of individual RBCs and <jats:bold><jats:italic>in situ<\/jats:italic><\/jats:bold> parasite vacuoles are imaged, from which total contents and concentration of dry mass are also precisely quantified. In addition, we examine the dynamic membrane fluctuation of <jats:italic>Bm<\/jats:italic>-RBCs, which provide information on cell membrane deformability.<\/jats:p>","DOI":"10.1038\/srep10827","type":"journal-article","created":{"date-parts":[[2015,6,3]],"date-time":"2015-06-03T16:42:03Z","timestamp":1433349723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Characterizations of individual mouse red blood cells parasitized by Babesia microti using 3-D holographic microscopy"],"prefix":"10.1038","volume":"5","author":[{"given":"HyunJoo","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoohyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Hyeong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ja","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngchan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YongKeun","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,3]]},"reference":[{"key":"BFsrep10827_CR1","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1016\/j.ijpara.2008.03.001","volume":"38","author":"KP Hunfeld","year":"2008","unstructured":"Hunfeld, K. 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