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Moreover, recent studies have reported that a number of 3\u2032-UTR polymorphisms potentially bind to specific microRNAs in a variety of cancers. The aim of this study was to investigate the association of four <jats:italic>MTHFR<\/jats:italic> polymorphisms, 2572C&gt;A [rs4846049], 4869C&gt;G [rs1537514], 5488C&gt;T [rs3737967] and 6685T&gt;C [rs4846048] with colorectal cancer (CRC) in Koreans. A total of 850 participants (450 CRC patients and 400 controls) were enrolled in the study. The genotyping of <jats:italic>MTHFR<\/jats:italic> 3\u2032-UTR polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism analysis or TaqMan allelic discrimination assay. We found that <jats:italic>MTHFR<\/jats:italic> 2572C&gt;A, 4869C&gt;G and 5488C&gt;T genotypes were substantially associated with CRC susceptibility. Of the potentially susceptible polymorphisms, <jats:italic>MTHFR<\/jats:italic> 2572C&gt;A was associated with increased homocysteine and decreased folate levels in the plasma based on <jats:italic>MTHFR<\/jats:italic> 677CC. Our study provides the evidences for 3\u2032-UTR variants in <jats:italic>MTHFR<\/jats:italic> gene as potential biomarkers for use in CRC prevention.<\/jats:p>","DOI":"10.1038\/srep11006","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T14:02:46Z","timestamp":1433512966000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Genetic variants in 3\u2032-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans"],"prefix":"10.1038","volume":"5","author":[{"given":"Young Joo","family":"Jeon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Woo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung O","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Geun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisu","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Gyu","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doyeun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"BFsrep11006_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3322\/caac.20006","volume":"59","author":"A Jemal","year":"2009","unstructured":"Jemal, A. et al. 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