{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:07:37Z","timestamp":1790744857576,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T00:00:00Z","timestamp":1433462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High-mobility group box 1 (HMGB1) mobilizes platelet-derived growth factor receptor alpha-positive (PDGFR\u03b1<jats:sup>+<\/jats:sup>) mesenchymal cells from bone marrow (BM) into circulation. However, whether HMGB1-induced endogenous PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cells stimulate skin regeneration has been unclear. Here, we investigated the functions of the HMGB1\/BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cell axis in the regeneration of mouse skin grafts. We found that intravenous HMGB1 administration induced an accumulation of endogenous BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cells followed by significant inflammatory suppression in the grafts. In contrast, mice with reduced BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cells showed massive inflammation of the grafts compared to mice that had normal levels of these cells even after HMGB1 administration, suggesting that BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cells contribute to the HMGB1-induced anti-inflammatory effect. We also found that intravenously administered HMGB1 augmented the local migration of BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cells from circulation to skin graft by inducing the expression of CXCR4, an SDF-1 receptor, on these cells. Finally, we showed the therapeutic activity of the HMGB1\/BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cell axis in an allergic contact dermatitis model. The results illustrated the contribution of the HMGB1\/BM-PDGFR\u03b1<jats:sup>+<\/jats:sup> mesenchymal cell axis in suppressing the inflammation of injured\/inflamed skin. These findings may provide future perspectives on the use of HMGB1-based medicines for intractable diseases.<\/jats:p>","DOI":"10.1038\/srep11008","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T15:19:20Z","timestamp":1433517560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFR\u03b1+ mesenchymal cells from bone marrow"],"prefix":"10.1038","volume":"5","author":[{"given":"Eriko","family":"Aikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasufumi","family":"Kaneda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuto","family":"Tamai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,5]]},"reference":[{"key":"BFsrep11008_CR1","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.bbrc.2013.02.008","volume":"432","author":"T Osmanov","year":"2013","unstructured":"Osmanov, T., Ugrinova, I. & Pasheva, E. The chaperone like function of the nonhistone protein HMGB1. Biochem Biophys Res Commun 432, 231\u2013235 (2013).","journal-title":"Biochem Biophys Res Commun"},{"key":"BFsrep11008_CR2","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1189\/jlb.0806540","volume":"81","author":"D Tang","year":"2007","unstructured":"Tang, D. et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1. J Leukoc Biol 81, 741\u2013747 (2007).","journal-title":"J Leukoc Biol"},{"key":"BFsrep11008_CR3","doi-asserted-by":"publisher","first-page":"7506","DOI":"10.4049\/jimmunol.174.12.7506","volume":"174","author":"IE Dumitriu","year":"2005","unstructured":"Dumitriu, I. E. et al. Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products. 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