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The present study was designed to investigate the roles and mechanisms of salusin \u03b2 in the paraventricular nucleus (PVN) in attenuating hypertension and hypothalamic inflammation and whether central salusin \u03b2 blockade has protective effects in essential hypertension. Normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were used in this study. The rats were chronic PVN infusion either specific salusin \u03b2 blocker, antisalusin \u03b2 IgG (SIgG), or control IgG (CIgG) for 2 weeks. Hypertensive rats had significantly increased salusin \u03b2 expression compared with normotensive rats. Central blockade of salusin \u03b2 attenuated hypertension, reduced circulating norepinephrine (NE) levels and improved cardiac hypertrophy and function in hypertensive rats. Salusin \u03b2 blockade significantly reduced proinflammatory cytokines (PICs), nuclear factor-kappa B (NF-\u03baB) activity, reactive oxygen species (ROS) levels and altered renin-angiotensin system (RAS) components in the PVN of hypertensive rats. These findings suggest that the beneficial effects of salusin \u03b2 blockade in essential hypertension are possibly due to down-regulate of inflammatory molecules and ROS in the PVN.<\/jats:p>","DOI":"10.1038\/srep11162","type":"journal-article","created":{"date-parts":[[2015,7,29]],"date-time":"2015-07-29T09:04:43Z","timestamp":1438160683000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Central blockade of salusin \u03b2 attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats"],"prefix":"10.1038","volume":"5","author":[{"given":"Hong-Bao","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Nian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Ming","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,29]]},"reference":[{"key":"BFsrep11162_CR1","doi-asserted-by":"publisher","first-page":"e52569","DOI":"10.1371\/journal.pone.0052569","volume":"7","author":"D Agarwal","year":"2012","unstructured":"Agarwal, D. et al. 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