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Other aspects of obesity may be more tightly coupled to the dopaminergic system. We characterized obesity-associated behaviors and determined if these related to central D2 receptor (D2R) specific binding independent of BMI. Twenty-two obese and 17 normal-weight participants completed eating- and reward-related questionnaires and underwent PET scans using the D2R-selective and nondisplaceable radioligand (<jats:italic>N<\/jats:italic>-[<jats:sup>11<\/jats:sup>C]methyl)benperidol. Questionnaires were grouped by domain (eating related to emotion, eating related to reward, non-eating behavior motivated by reward or sensitivity to punishment). Normalized, summed scores for each domain were compared between obese and normal-weight groups and correlated with striatal and midbrain D2R binding. Compared to normal-weight individuals, the obese group self-reported higher rates of eating related to both emotion and reward (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), greater sensitivity to punishment (<jats:italic>p<\/jats:italic>\u2009=\u20090.06) and lower non-food reward behavior (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Across normal-weight and obese participants, self-reported emotional eating and non-food reward behavior positively correlated with striatal (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and midbrain (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) D2R binding, respectively. In conclusion, an emotional eating phenotype may reflect altered central D2R function better than other commonly used obesity-related measures such as BMI.<\/jats:p>","DOI":"10.1038\/srep11283","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T13:25:27Z","timestamp":1434115527000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Emotional Eating Phenotype is Associated with Central Dopamine D2 Receptor Binding Independent of Body Mass Index"],"prefix":"10.1038","volume":"5","author":[{"given":"Sarah A.","family":"Eisenstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison N.","family":"Bischoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta M.","family":"Gredysa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Ann V.","family":"Antenor-Dorsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Koller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Al-Lozi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Y.","family":"Pepino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Perlmutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Moerlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Hershey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,12]]},"reference":[{"key":"BFsrep11283_CR1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.2174\/1874473711104030182","volume":"4","author":"KS Burger","year":"2011","unstructured":"Burger, K. 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